Maier, Ilko L.

[["dc.bibliographiccitation.firstpage","372"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","International Journal of Stroke"],["dc.bibliographiccitation.lastpage","380"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Alegiani, Anna C"],["dc.contributor.author","Dorn, Franziska"],["dc.contributor.author","Herzberg, Moriz"],["dc.contributor.author","Wollenweber, Frank A"],["dc.contributor.author","Kellert, Lars"],["dc.contributor.author","Siebert, Eberhard"],["dc.contributor.author","Nolte, Christian H"],["dc.contributor.author","von Rennenberg, Regina"],["dc.contributor.author","Hattingen, Elke"],["dc.contributor.author","Petzold, Gabor C"],["dc.contributor.author","Bode, Felix J"],["dc.contributor.author","Pfeilschifter, Waltraud"],["dc.contributor.author","Schäfer, Jan H"],["dc.contributor.author","Wagner, Marlies"],["dc.contributor.author","Röther, Joachim"],["dc.contributor.author","Eckert, Bernd"],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Pham, Mirko"],["dc.contributor.author","Boeckh-Behrens, Tobias"],["dc.contributor.author","Wunderlich, Silke"],["dc.contributor.author","Bernkopf, Kathleen"],["dc.contributor.author","Reich, Arno"],["dc.contributor.author","Wiesmann, Martin"],["dc.contributor.author","Mpotsaris, Anastasios"],["dc.contributor.author","Psychogios, Marios"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Berrouschot, Jörg"],["dc.contributor.author","Bormann, Albrecht"],["dc.contributor.author","Limmroth, Volker"],["dc.contributor.author","Spreer, Joachim"],["dc.contributor.author","Petersen, Martina"],["dc.contributor.author","Krause, Lars"],["dc.contributor.author","Lowens, Stephan"],["dc.contributor.author","Kraemer, Christoffer"],["dc.contributor.author","Zweynert, Sarah"],["dc.contributor.author","Lange, Kristin S"],["dc.contributor.author","Thonke, Sven"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Papanagiotou, Panagiotis"],["dc.contributor.author","Alber, Burkhard"],["dc.contributor.author","Braun, Michael"],["dc.contributor.author","Fiehler, Jens"],["dc.contributor.author","Gerloff, Christian"],["dc.contributor.author","Dichgans, Martin"],["dc.contributor.author","Thomalla, Götz"],["dc.date.accessioned","2020-12-10T18:38:36Z"],["dc.date.available","2020-12-10T18:38:36Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1177/1747493018806199"],["dc.identifier.eissn","1747-4949"],["dc.identifier.issn","1747-4930"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77382"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Neurosurgery: Pediatrics"],["dc.bibliographiccitation.lastpage","7"],["dc.contributor.author","Lu, Victor M."],["dc.contributor.author","Luther, Evan M."],["dc.contributor.author","Silva, Michael A."],["dc.contributor.author","Elarjani, Turki"],["dc.contributor.author","Abdelsalam, Ahmed"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Al Kasab, Sami"],["dc.contributor.author","Jabbour, Pascal M."],["dc.contributor.author","Kim, Joon-Tae"],["dc.contributor.author","Wolfe, Stacey Q."],["dc.contributor.author","Starke, Robert M."],["dc.date.accessioned","2022-09-01T09:51:05Z"],["dc.date.available","2022-09-01T09:51:05Z"],["dc.date.issued","2022"],["dc.description.abstract","OBJECTIVE\n Although younger adults have been shown to have better functional outcomes after mechanical thrombectomy (MT) for acute ischemic stroke (AIS), the significance of this relationship in the adolescent and young adult (AYA) population is not well defined given its undefined rarity. Correspondingly, the goal of this study was to determine the prognostic significance of age in this specific demographic following MT for large-vessel occlusions.\n \n \n METHODS\n A prospectively maintained international multi-institutional database, STAR (Stroke Thrombectomy and Aneurysm Registry), was reviewed for all patients aged 12–18 (adolescent) and 19–25 (young adult) years. Parameters were compared using chi-square and t-test analyses, and associations were interrogated using regression analyses.\n \n \n RESULTS\n Of 7192 patients in the registry, 41 (0.6%) satisfied all criteria, with a mean age of 19.7 ± 3.3 years. The majority were male (59%) and young adults (61%) versus adolescents (39%). The median prestroke modified Rankin Scale (mRS) score was 0 (range 0–2). Strokes were most common in the anterior circulation (88%), with the middle cerebral artery being the most common vessel (59%). The mean onset-to–groin puncture and groin puncture–to-reperfusion times were 327 ± 229 and 52 ± 42 minutes, respectively. The mean number of passes was 2.2 ± 1.2, with 61% of the cohort achieving successful reperfusion. There were only 3 (7%) cases of reocclusion. The median mRS score at 90 days was 2 (range 0–6). Between the adolescent and young adult subgroups, the median mRS score at last follow-up was statistically lower in the adolescent subgroup (1 vs 2, p = 0.03), and older age was significantly associated with a higher mRS at 90 days (coefficient 0.33, p < 0.01).\n \n \n CONCLUSIONS\n Although rare, MT for AIS in the AYA demographic is both safe and effective. Even within this relatively young demographic, age remains significantly associated with improved functional outcomes. The implication of age-dependent stroke outcomes after MT within the AYA demographic needs greater validation to develop effective age-specific protocols for long-term care across both pediatric and adult centers."],["dc.identifier.doi","10.3171/2022.7.PEDS22250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113878"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1933-0715"],["dc.relation.issn","1933-0707"],["dc.title","Prognostic significance of age within the adolescent and young adult acute ischemic stroke population after mechanical thrombectomy: insights from STAR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","362"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Stroke"],["dc.bibliographiccitation.lastpage","372"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Peter, Carolin"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2021-06-01T10:48:59Z"],["dc.date.available","2021-06-01T10:48:59Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.5853/jos.2018.00605"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86121"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","2287-6405"],["dc.relation.issn","2287-6391"],["dc.title","Outcome Prediction Using Perfusion Parameters and Collateral Scores of Multi-Phase and Single-Phase CT Angiography in Acute Stroke: Need for One, Two, Three, or Thirty Scans?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e2241291"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","JAMA Network Open"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Porto, Guilherme B. F."],["dc.contributor.author","Chen, Ching-Jen"],["dc.contributor.author","Al Kasab, Sami"],["dc.contributor.author","Essibayi, Muhammed Amir"],["dc.contributor.author","Almallouhi, Eyad"],["dc.contributor.author","Hubbard, Zachary"],["dc.contributor.author","Chalhoub, Reda"],["dc.contributor.author","Alawieh, Ali"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Park, Min S."],["dc.contributor.authorgroup","Stroke Thrombectomy and Aneurysm Registry (STAR) Collaborators"],["dc.date.accessioned","2022-12-01T08:30:58Z"],["dc.date.available","2022-12-01T08:30:58Z"],["dc.date.issued","2022"],["dc.description.abstract","Importance\r\n There is substantial controversy with regards to the adequacy and use of noncontrast head computed tomography (NCCT) for late-window acute ischemic stroke in selecting candidates for mechanical thrombectomy.\r\n \r\n \r\n Objective\r\n To assess clinical outcomes of patients with acute ischemic stroke presenting in the late window who underwent mechanical thrombectomy stratified by NCCT admission in comparison with selection by CT perfusion (CTP) and diffusion-weighted imaging (DWI).\r\n \r\n \r\n Design, Setting, and Participants\r\n In this multicenter retrospective cohort study, prospectively maintained Stroke Thrombectomy and Aneurysm (STAR) database was used by selecting patients within the late window of acute ischemic stroke and emergent large vessel occlusion from 2013 to 2021. Patients were selected by NCCT, CTP, and DWI. Admission Alberta Stroke Program Early CT Score (ASPECTS) as well as confounding variables were adjusted. Follow-up duration was 90 days. Data were analyzed from November 2021 to March 2022.\r\n \r\n \r\n Exposures\r\n Selection by NCCT, CTP, or DWI.\r\n \r\n \r\n Main Outcomes and Measures\r\n Primary outcome was functional independence (modified Rankin scale 0-2) at 90 days.\r\n \r\n \r\n Results\r\n \r\n Among 3356 patients, 733 underwent late-window mechanical thrombectomy. The median (IQR) age was 69 (58-80) years, 392 (53.5%) were female, and 449 (65.1%) were White. A total of 419 were selected with NCCT, 280 with CTP, and 34 with DWI. Mean (IQR) admission ASPECTS were comparable among groups (NCCT, 8 [7-9]; CTP, 8 [7-9]; DWI 8, [7-9];\r\n P\r\n  = .37). There was no difference in the 90-day rate of functional independence (aOR, 1.00; 95% CI, 0.59-1.71;\r\n P\r\n  = .99) after adjusting for confounders. Symptomatic intracerebral hemorrhage (NCCT, 34 [8.6%]; CTP, 37 [13.5%]; DWI, 3 [9.1%];\r\n P\r\n  = .12) and mortality (NCCT, 78 [27.4%]; CTP, 38 [21.1%]; DWI, 7 [29.2%];\r\n P\r\n  = .29) were similar among groups.\r\n \r\n \r\n \r\n Conclusions and Relevance\r\n In this cohort study, comparable outcomes were observed in patients in the late window irrespective of neuroimaging selection criteria. Admission NCCT scan may triage emergent large vessel occlusion in the late window."],["dc.identifier.doi","10.1001/jamanetworkopen.2022.41291"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118031"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2574-3805"],["dc.title","Association of Noncontrast Computed Tomography and Perfusion Modalities With Outcomes in Patients Undergoing Late-Window Stroke Thrombectomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10.1212/WNL.0000000000013049"],["dc.bibliographiccitation.journal","Neurology"],["dc.contributor.author","Katsanos, Aristeidis H"],["dc.contributor.author","Malhotra, Konark"],["dc.contributor.author","Ahmed, Niaz"],["dc.contributor.author","Seitidis, Georgios"],["dc.contributor.author","Mistry, Eva A."],["dc.contributor.author","Mavridis, Dimitris"],["dc.contributor.author","Kim, Joon-Tae"],["dc.contributor.author","Veroniki, Argie"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Matusevicius, Marius"],["dc.contributor.author","Tsivgoulis, Georgios"],["dc.date.accessioned","2021-12-01T09:23:05Z"],["dc.date.available","2021-12-01T09:23:05Z"],["dc.date.issued","2021"],["dc.description.abstract","Objective: To explore the association between blood pressure (BP) levels after endovascular thrombectomy (EVT) and the clinical outcomes of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). Methods: A study was eligible if it enrolled AIS patients older than 18 years, with an LVO treated with either successful or unsuccessful EVT, and provided either individual or mean 24-hour systolic BP values after the end of the EVT procedure. Individual patient data from all studies were analyzed using a generalized linear mixed-effects model. Results: A total of 5874 patients (mean age: 69±14 years, 50% women, median NIHSS on admission: 16) from 7 published studies were included. Increasing mean systolic BP levels per 10 mm Hg during the first 24 hours after the end of the EVT were associated with a lower odds of functional improvement (unadjusted common OR=0.82, 95%CI:0.80-0.85; adjusted common OR=0.88, 95%CI:0.84-0.93) and modified Ranking Scale score≤2 (unadjusted OR=0.82, 95%CI:0.79-0.85; adjusted OR=0.87, 95%CI:0.82-0.93), and a higher odds of all-cause mortality (unadjusted OR=1.18, 95%CI:1.13-1.24; adjusted OR=1.15, 95%CI:1.06-1.23) at 3 months. Higher 24-hour mean systolic BP levels were also associated with an increased likelihood of early neurological deterioration (unadjusted OR=1.14, 95%CI:1.07-1.21; adjusted OR=1.14, 95%CI:1.03-1.24) and a higher odds of symptomatic intracranial hemorrhage (unadjusted OR=1.20, 95%CI:1.09-1.29; adjusted OR=1.20, 95%CI:1.03-1.38) after EVT. Conclusion: Increased mean systolic BP levels in the first 24 hours after EVT are independently associated with a higher odds of symptomatic intracranial hemorrhage, early neurological deterioration, three-month mortality, and worse three-month functional outcomes."],["dc.description.abstract","Objective: To explore the association between blood pressure (BP) levels after endovascular thrombectomy (EVT) and the clinical outcomes of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). Methods: A study was eligible if it enrolled AIS patients older than 18 years, with an LVO treated with either successful or unsuccessful EVT, and provided either individual or mean 24-hour systolic BP values after the end of the EVT procedure. Individual patient data from all studies were analyzed using a generalized linear mixed-effects model. Results: A total of 5874 patients (mean age: 69±14 years, 50% women, median NIHSS on admission: 16) from 7 published studies were included. Increasing mean systolic BP levels per 10 mm Hg during the first 24 hours after the end of the EVT were associated with a lower odds of functional improvement (unadjusted common OR=0.82, 95%CI:0.80-0.85; adjusted common OR=0.88, 95%CI:0.84-0.93) and modified Ranking Scale score≤2 (unadjusted OR=0.82, 95%CI:0.79-0.85; adjusted OR=0.87, 95%CI:0.82-0.93), and a higher odds of all-cause mortality (unadjusted OR=1.18, 95%CI:1.13-1.24; adjusted OR=1.15, 95%CI:1.06-1.23) at 3 months. Higher 24-hour mean systolic BP levels were also associated with an increased likelihood of early neurological deterioration (unadjusted OR=1.14, 95%CI:1.07-1.21; adjusted OR=1.14, 95%CI:1.03-1.24) and a higher odds of symptomatic intracranial hemorrhage (unadjusted OR=1.20, 95%CI:1.09-1.29; adjusted OR=1.20, 95%CI:1.03-1.38) after EVT. Conclusion: Increased mean systolic BP levels in the first 24 hours after EVT are independently associated with a higher odds of symptomatic intracranial hemorrhage, early neurological deterioration, three-month mortality, and worse three-month functional outcomes."],["dc.identifier.doi","10.1212/WNL.0000000000013049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94554"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1526-632X"],["dc.relation.issn","0028-3878"],["dc.title","Blood Pressure After Endovascular Thrombectomy and Outcomes in Patients With Acute Ischemic Stroke: An Individual Patient Data Meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18"],["dc.bibliographiccitation.issue","1-2"],["dc.bibliographiccitation.journal","Cerebrovascular Diseases"],["dc.bibliographiccitation.lastpage","25"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2018-04-23T11:48:23Z"],["dc.date.available","2018-04-23T11:48:23Z"],["dc.date.issued","2017"],["dc.description.abstract","Background: Endovascular treatment (EVT) has been shown to significantly improve functional outcome in patients with acute large cerebral vessel occlusions. To date, no evidence-based recommendations on blood pressure management after successful EVT exist. Previous studies showed an association between high pre-EVT systolic blood pressure (SBP) and functional outcome, but do not answer the question on how to manage blood pressure after successful recanalization. The purpose of this study was to determine the role of blood pressure measurements as a predictor for early functional outcome in patients with successful EVT. Methods: Prospectively derived data from patients with acute large vessel occlusion within the anterior circulation and EVT was analyzed in this monocentric study. Mean systolic- and maximum SBP as well as SBP-peaks have been obtained for the first 24 h after successful EVT. Predictive value of SBP for discharge modified Rankin Scale (mRS) ≤2 has been investigated using logistic regression models. Results: From 168 patients with successful EVT, 74 (44%) had a favorable outcome with an mRS ≤2. Mean- (127 vs. 131 mm Hg, p = 0.035) and maximum SBP (157 vs. 169 mm Hg, p < 0.001) as well as the number of SBP-peaks (0 vs. 1.5, p = 0.004) were lower in patients with favorable outcomes. Multivariable logistic regression showed high mean- and maximum SBP to predict unfavorable outcomes. Cutoff mean SBP was 141 mm Hg and maximum SBP 159 mm Hg. Conclusions: High SBP in the first 24 h after recanalization of acute anterior cerebral vessel occlusions is associated with unfavorable functional outcome. Interventional studies are needed to determine the role of SBP management as a modifiable parameter in the early phase after successful EVT."],["dc.identifier.doi","10.1159/000484720"],["dc.identifier.gro","3142065"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13499"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","1015-9770"],["dc.title","High Systolic Blood Pressure after Successful Endovascular Treatment Affects Early Functional Outcome in Acute Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","932"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","936"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Anadani, Mohammad"],["dc.contributor.author","Arthur, Adam S."],["dc.contributor.author","Alawieh, Ali"],["dc.contributor.author","Orabi, Yser"],["dc.contributor.author","Alexandrov, Andrei"],["dc.contributor.author","Goyal, Nitin"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Kim, Joon-tae"],["dc.contributor.author","Keyrouz, Saleh G."],["dc.contributor.author","de Havenon, Adam"],["dc.contributor.author","Petersen, Nils H."],["dc.contributor.author","Pandhi, Abhi"],["dc.contributor.author","Swisher, Christa B."],["dc.contributor.author","Inamullah, Ovais"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Kodali, Sreeja"],["dc.contributor.author","Giles, James A."],["dc.contributor.author","Allen, Michelle"],["dc.contributor.author","Wolfe, Stacey Q."],["dc.contributor.author","Tsivgoulis, Georgios"],["dc.contributor.author","Cagle, Bradley A."],["dc.contributor.author","Oravec, Chesney S."],["dc.contributor.author","Gory, Benjamin"],["dc.contributor.author","De Marini, Pierre"],["dc.contributor.author","Kan, Peter"],["dc.contributor.author","Rahman, Shareena"],["dc.contributor.author","Richard, Sébastien"],["dc.contributor.author","Nascimento, Fábio A."],["dc.contributor.author","Spiotta, Alejandro"],["dc.date.accessioned","2021-04-14T08:32:51Z"],["dc.date.available","2021-04-14T08:32:51Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1136/neurintsurg-2019-015561"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84037"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1759-8486"],["dc.relation.issn","1759-8478"],["dc.title","Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","525"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of NeuroInterventional Surgery"],["dc.bibliographiccitation.lastpage","529"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hesse, Amélie Carolina"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Kemmling, André"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Hokamp, Nils Große"],["dc.contributor.author","Frischmuth, Isabelle"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Buhk, Jan-Hendrik"],["dc.contributor.author","Tran, Julia"],["dc.contributor.author","Fiehler, Jens"],["dc.contributor.author","Mpotsaris, Anastasios"],["dc.contributor.author","Schramm, Peter"],["dc.contributor.author","Berlis, Ansgar"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2020-12-10T18:37:18Z"],["dc.date.available","2020-12-10T18:37:18Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1136/neurintsurg-2017-013394"],["dc.identifier.eissn","1759-8486"],["dc.identifier.issn","1759-8478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76905"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Comparing different thrombectomy techniques in five large-volume centers: a ‘real world’ observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","396"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JAMA Neurology"],["dc.bibliographiccitation.lastpage","401"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Arsava, E. Murat"],["dc.contributor.author","Kim, Gyeong-Moon"],["dc.contributor.author","Oliveira-Filho, Jamary"],["dc.contributor.author","Gungor, Levent"],["dc.contributor.author","Noh, Hyun Jin"],["dc.contributor.author","Lordelo, Morgana de Jesus"],["dc.contributor.author","Avery, Ross"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Ay, Hakan"],["dc.date.accessioned","2018-11-07T10:16:15Z"],["dc.date.available","2018-11-07T10:16:15Z"],["dc.date.issued","2016"],["dc.description.abstract","IMPORTANCE Approximately half of recurrent strokes occur within days and weeks of an ischemic stroke. It is imperative to identify patients at imminent risk of recurrent stroke because recurrent events lead to prolonged hospitalization, worsened functional outcome, and increased mortality. OBJECTIVE To test the validity of a prognostic score that was exclusively developed to predict early risk of stroke recurrence in a multicenter setting. DESIGN, SETTING, AND PARTICIPANTS This hospital-based cohort study examined patients with and without magnetic resonance imaging-confirmed recurrent stroke within 90 days after an ischemic stroke. The study was performed at 3 teaching hospitals in the United States, Brazil, and South Korea and comprised adult patients admitted within 72 hours of symptom onset with amagnetic resonance imaging-confirmed diagnosis of acute ischemic stroke. Recruitment to the US cohort was performed from June 1, 2009, through April 30, 2011. Recruitment to the Korean and Brazilian cohorts was performed from January 1, 2007, through December 31, 2011. Data analysis was performed from June 1, 2013, to December 31, 2014. MAIN OUTCOMES AND MEASURES The primary outcome was recurrent ischemic stroke as defined by a clinical incident that was clearly attributable to a new area of brain infarction occurring within the 90 days of index infarction. An investigator who was masked to the patient's recurrence status calculated the Recurrence Risk Estimator (RRE) score for each patient based on information available after initial line of testing in the emergency department. We assessed the predictive performance of the RRE by computing the area under the receiver operating characteristic curve. RESULTS The study included 1468 consecutive patients with 59 recurrent ischemic stroke events. The median age of the patients was 69 (interquartile range, 58-79) years, and 633 (43.1%) were female. The cumulative 90-day recurrence rate was 4.2%(95% CI, 3.2%-5.2%). The mean RRE score was 2.2 (95% CI, 1.9-2.5) in patients with recurrence and 1.0 (95% CI, 1.0-1.1) in patients without. The risk of recurrence increased with a higher RRE score (log-rank test, P < .001). The area under the receiver operating characteristic curve for discrimination was 0.76 (95% CI, 0.70-0.82). The RRE identified 710 patients (48.4%) in the study population as high risk (>10%) or low risk (<1%). The sensitivity and specificity were 38% and 93% for identifying low-risk subsets and 41% and 90% for identifying high-risk subsets, respectively. CONCLUSIONS AND RELEVANCE This study confirms the validity of the RRE score in a multicenter cohort of patients with diverse characteristics. Our findings suggest that the RRE could be useful in identifying high-and low-risk patients for targeted stroke prevention."],["dc.description.sponsorship","National Institutes of Health [R01-NS059710]"],["dc.identifier.doi","10.1001/jamaneurol.2015.4949"],["dc.identifier.isi","000373789400011"],["dc.identifier.pmid","26926383"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41000"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","2168-6157"],["dc.relation.issn","2168-6149"],["dc.title","Prediction of Early Recurrence After Acute Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","300"],["dc.bibliographiccitation.journal","Journal of the neurological sciences"],["dc.bibliographiccitation.lastpage","304"],["dc.bibliographiccitation.volume","372"],["dc.contributor.author","Maier, Ilko L."],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Schnieder, Marlena"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Kleinknecht, Alexander"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Psychogios, Marios"],["dc.contributor.author","Liman, Jan"],["dc.date.accessioned","2018-01-09T10:18:58Z"],["dc.date.available","2018-01-09T10:18:58Z"],["dc.date.issued","2017"],["dc.description.abstract","Although endovascular treatment for proximal cerebral vessel occlusion is very effective, it remains controversial if intravenous thrombolysis (IVT) prior to endovascular treatment is superior compared to endovascular treatment alone. In this study we compared functional outcomes and recanalization rates of endovascularly treated stroke patients with and without bridging IVT."],["dc.identifier.doi","10.1016/j.jns.2016.12.001"],["dc.identifier.pmid","28017233"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11576"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-5883"],["dc.title","Bridging-therapy with intravenous recombinant tissue plasminogen activator improves functional outcome in patients with endovascular treatment in acute stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]