Bohnsack, Markus T.

[["dc.bibliographiccitation.firstpage","1115"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"],["dc.bibliographiccitation.lastpage","1130"],["dc.bibliographiccitation.volume","1803"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.date.accessioned","2022-03-01T11:44:46Z"],["dc.date.available","2022-03-01T11:44:46Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1016/j.bbamcr.2010.06.005"],["dc.identifier.pii","S0167488910001758"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103114"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0167-4889"],["dc.title","The evolution of protein targeting and translocation systems"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e54084"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Missbach, Sandra"],["dc.contributor.author","Weis, Benjamin L."],["dc.contributor.author","Martin, Roman"],["dc.contributor.author","Simm, Stefan"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.editor","Lafontaine, Denis"],["dc.date.accessioned","2022-03-01T11:44:11Z"],["dc.date.available","2022-03-01T11:44:11Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1371/journal.pone.0054084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102952"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1932-6203"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","40S Ribosome Biogenesis Co-Factors Are Essential for Gametophyte and Embryo Development"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1043"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","The Plant Journal"],["dc.bibliographiccitation.lastpage","1056"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Weis, Benjamin L."],["dc.contributor.author","Missbach, Sandra"],["dc.contributor.author","Marzi, Julian"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.date.accessioned","2018-11-07T09:32:01Z"],["dc.date.available","2018-11-07T09:32:01Z"],["dc.date.issued","2014"],["dc.description.abstract","Ribosome biogenesis involves a large ensemble of trans-acting factors, which catalyse rRNA processing, ribosomal protein association and ribosomal subunit assembly. The circularly permuted GTPase Lsg1 is such a ribosome biogenesis factor, which is involved in maturation of the pre-60S ribosomal subunit in yeast. We identified two orthologues of Lsg1 in Arabidopsis thaliana. Both proteins differ in their C-terminus, which is highly charged in atLSG1-2 but missing in atLSG1-1. This C-terminus of atLSG1-2 contains a functional nuclear localization signal in a part of the protein that also targets atLSG1-2 to the nucleolus. Furthermore, only atLSG1-2 is physically associated with ribosomes suggesting its function in ribosome biogenesis. Homozygous T-DNA insertion lines are viable for both LSG1 orthologues. In plants lacking atLSG1-2 18S rRNA precursors accumulate and a 20S pre-rRNA is detected, while the amount of pre-rRNAs that lead to the 25S and 5.8S rRNA is not changed. Thus, our results suggest that pre-60S subunit maturation is important for the final steps of pre-40S maturation in plants. In addition, the lsg1-2 mutants show severe developmental defects, including triple cotyledons and upward curled leaves, which link ribosome biogenesis to early plant and leaf development."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB902]"],["dc.identifier.doi","10.1111/tpj.12703"],["dc.identifier.isi","000346280700009"],["dc.identifier.pmid","25319368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31653"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-313X"],["dc.relation.issn","0960-7412"],["dc.title","The 60S associated ribosome biogenesis factor LSG1-2 is required for 40S maturation in Arabidopsis thaliana"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","583"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Molecular Cell"],["dc.bibliographiccitation.lastpage","592"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Martin, Roman"],["dc.contributor.author","Granneman, Sander"],["dc.contributor.author","Ruprecht, Maike"],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.author","Tollervey, David"],["dc.date.accessioned","2022-03-01T11:45:16Z"],["dc.date.available","2022-03-01T11:45:16Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1016/j.molcel.2009.09.039"],["dc.identifier.pii","S1097276509006996"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103272"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","1097-2765"],["dc.title","Prp43 Bound at Different Sites on the Pre-rRNA Performs Distinct Functions in Ribosome Synthesis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Yeast"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Martin, Roman"],["dc.contributor.author","Straub, Annika U."],["dc.contributor.author","Hackert, Philipp"],["dc.contributor.author","Ruprecht, Maike"],["dc.contributor.author","Simm, S."],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.author","Bohnsack, M."],["dc.contributor.author","Simm, Stefan"],["dc.contributor.author","Bohnsack, Markus T."],["dc.date.accessioned","2018-11-07T09:20:12Z"],["dc.date.available","2018-11-07T09:20:12Z"],["dc.date.issued","2013"],["dc.format.extent","100"],["dc.identifier.isi","000327927400151"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28829"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.eventlocation","Frankfurt Main, GERMANY"],["dc.relation.issn","1097-0061"],["dc.relation.issn","0749-503X"],["dc.title","RNA helicase function in yeast ribosome biogenesis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","209"],["dc.bibliographiccitation.journal","FEBS Journal"],["dc.bibliographiccitation.lastpage","210"],["dc.bibliographiccitation.volume","282"],["dc.contributor.author","Heininger, A. U."],["dc.contributor.author","Hackert, Philipp"],["dc.contributor.author","Andreou, Alexandra-Zoi"],["dc.contributor.author","Boon, K.-L."],["dc.contributor.author","Prior, M."],["dc.contributor.author","Schmidt, B."],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Sloan, Katherine E."],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.author","Deckers, Markus"],["dc.contributor.author","Lührmann, Reinhard"],["dc.contributor.author","Enderlein, Jörg"],["dc.contributor.author","Klostermeier, Dagmar"],["dc.contributor.author","Rehling, Peter"],["dc.contributor.author","Bohnsack, Markus T."],["dc.date.accessioned","2018-11-07T09:54:51Z"],["dc.date.available","2018-11-07T09:54:51Z"],["dc.date.issued","2015"],["dc.identifier.isi","000362570603174"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36625"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.eventlocation","Berlin, GERMANY"],["dc.relation.issn","1742-4658"],["dc.relation.issn","1742-464X"],["dc.title","Sequestering and protein cofactor competition regulate a multifunctional RNA helicase in different pathways"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","415"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","RNA"],["dc.bibliographiccitation.lastpage","425"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Weis, Benjamin L."],["dc.contributor.author","Palm, Denise"],["dc.contributor.author","Missbach, Sandra"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.date.accessioned","2018-11-07T10:00:39Z"],["dc.date.available","2018-11-07T10:00:39Z"],["dc.date.issued","2015"],["dc.description.abstract","Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for orthologs of yeast BRX1, a protein involved in maturation of the large ribosomal subunit. Both atBRX1 proteins, encoded by AT3G15460 and AT1G52930, respectively, are mainly localized in the nucleolus and are ubiquitously expressed throughout plant development and in various tissues. Mutant plant lines for both factors show a delay in development and pointed leaves can be observed in the brx1-2 mutant, implying a link between ribosome biogenesis and plant development. In addition, the pre-rRNA processing is affected in both mutants. Analysis of the pre-rRNA intermediates revealed that early processing steps can occur either in the 5' external transcribed spacer (ETS) or internal transcribed spacer 1 (ITS1). Interestingly, we also find that in xrn2 mutants, early processing events can be bypassed and removal of the 5' ETS is initiated by cleavage at the P' processing site. While the pathways of pre-rRNA processing are comparable to those of yeast and mammalian cells, the balance between the two processing pathways is different in plants. Furthermore, plant-specific steps such as an additional processing site in the 5' ETS, likely post-transcriptional processing of the early cleavage sites and accumulation of a 5' extended 5.8S rRNA not observed in other eukaryotes can be detected."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SFB902/B8, SFB902/B9]"],["dc.identifier.doi","10.1261/rna.047563.114"],["dc.identifier.isi","000349848800009"],["dc.identifier.pmid","25605960"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37856"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cold Spring Harbor Lab Press, Publications Dept"],["dc.relation.issn","1469-9001"],["dc.relation.issn","1355-8382"],["dc.title","atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Biomolecular NMR Assignments"],["dc.bibliographiccitation.lastpage","50"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Veith, Thomas"],["dc.contributor.author","Wurm, Jan Philip"],["dc.contributor.author","Duchardt-Ferner, Elke"],["dc.contributor.author","Weis, Benjamin"],["dc.contributor.author","Martin, Roman"],["dc.contributor.author","Safferthal, Charlotta"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.author","Wöhnert, Jens"],["dc.date.accessioned","2022-03-01T11:44:39Z"],["dc.date.available","2022-03-01T11:44:39Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1007/s12104-011-9323-4"],["dc.identifier.pii","9323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103078"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1874-270X"],["dc.relation.issn","1874-2718"],["dc.title","Backbone and side chain NMR resonance assignments for an archaeal homolog of the endonuclease Nob1 involved in ribosome biogenesis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","553"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","564"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Sloan, Katherine E."],["dc.contributor.author","Leisegang, Matthias S."],["dc.contributor.author","Doebele, Carmen"],["dc.contributor.author","Ramirez, Ana S."],["dc.contributor.author","Simm, Stefan"],["dc.contributor.author","Safferthal, Charlotta"],["dc.contributor.author","Kretschmer, Jens"],["dc.contributor.author","Schorge, Tobias"],["dc.contributor.author","Markoutsa, Stavroula"],["dc.contributor.author","Haag, Sara"],["dc.contributor.author","Karas, Michael"],["dc.contributor.author","Ebersberger, Ingo"],["dc.contributor.author","Schleiff, Enrico"],["dc.contributor.author","Watkins, Nicholas J."],["dc.contributor.author","Bohnsack, Markus T."],["dc.date.accessioned","2018-11-07T10:03:32Z"],["dc.date.available","2018-11-07T10:03:32Z"],["dc.date.issued","2015"],["dc.description.abstract","Translation fidelity and efficiency require multiple ribosomal (r)RNA modifications that are mostly mediated by small nucleolar (sno)RNPs during ribosome production. Overlapping basepairing of snoRNAs with pre-rRNAs often necessitates sequential and efficient association and dissociation of the snoRNPs, however, how such hierarchy is established has remained unknown so far. Here, we identify several late-acting snoRNAs that bind pre-40S particles in human cells and show that their association and function in pre-40S complexes is regulated by the RNA helicase DDX21. We map DDX21 crosslinking sites on pre-rRNAs and show their overlap with the basepairing sites of the affected snoRNAs. While DDX21 activity is required for recruitment of the late-acting snoRNAs SNORD56 and SNORD68, earlier snoRNAs are not affected by DDX21 depletion. Together, these observations provide an understanding of the timing and ordered hierarchy of snoRNP action in pre-40S maturation and reveal a novel mode of regulation of snoRNP function by an RNA helicase in human cells."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2014"],["dc.identifier.doi","10.1093/nar/gku1291"],["dc.identifier.isi","000350207100052"],["dc.identifier.pmid","25477391"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11460"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38490"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.title","The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","650"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Plant Science"],["dc.bibliographiccitation.lastpage","654"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Lehmann, Petra"],["dc.contributor.author","Bohnsack, Markus T."],["dc.contributor.author","Schleiff, Enrico"],["dc.date.accessioned","2022-03-01T11:45:22Z"],["dc.date.available","2022-03-01T11:45:22Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1016/j.plantsci.2011.01.006"],["dc.identifier.pii","S0168945211000239"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103305"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0168-9452"],["dc.title","The functional domains of the chloroplast unusual positioning protein 1"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]