Schliehe-Diecks, Susanne

[["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.volume","65"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Albrecht, Christina"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Baniel, Alice"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Kappeler, Peter M."],["dc.contributor.author","Brameier, Markus"],["dc.date.accessioned","2018-11-07T09:17:22Z"],["dc.date.available","2018-11-07T09:17:22Z"],["dc.date.issued","2013"],["dc.format.extent","905"],["dc.identifier.doi","10.1007/s00251-013-0737-2"],["dc.identifier.isi","000326923600009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28149"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1211"],["dc.relation.issn","0093-7711"],["dc.title","Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing (vol 64, pg 895, 2012)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4071"],["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Molecular Ecology"],["dc.bibliographiccitation.lastpage","4086"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Baniel, Alice"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Kappeler, Peter"],["dc.date.accessioned","2017-09-07T11:48:23Z"],["dc.date.available","2017-09-07T11:48:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Sexual selection theory suggests that choice for partners carrying dissimilar genes at the major histocompatibility complex (MHC) may play a role in maintaining genetic variation in animal populations by limiting inbreeding or improving the immunity of future offspring. However, it is often difficult to establish whether the observed MHC dissimilarity among mates drives mate choice or represents a by-product of inbreeding avoidance based on MHC-independent cues. Here, we used 454-sequencing and a 10-year study of wild grey mouse lemurs (Microcebus murinus), small, solitary primates from western Madagascar, to compare the relative importance on the mate choice of two MHC class II genes, DRB and DQB, that are equally variable but display contrasting patterns of selection at the molecular level, with DRB under stronger diversifying selection. We further assessed the effect of the genetic relatedness and of the spatial distance among candidate mates on the detection of MHC-dependent mate choice. Our results reveal inbreeding avoidance, along with disassortative mate choice at DRB, but not at DQB. DRB-disassortative mate choice remains detectable after excluding all related dyads (characterized by a relatedness coefficient r > 0), but varies slightly with the spatial distance among candidate mates. These findings suggest that the observed deviations from random mate choice at MHC are driven by functionally important MHC genes (like DRB) rather than passively resulting from inbreeding avoidance and further emphasize the need for taking into account the spatial and genetic structure of the population in correlative tests of MHC-dependent mate choice."],["dc.identifier.doi","10.1111/mec.12349"],["dc.identifier.gro","3150791"],["dc.identifier.pmid","23889546"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7582"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.issn","0962-1083"],["dc.title","MHC-disassortative mate choice and inbreeding avoidance in a solitary primate"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","128"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Evolutionary Biology"],["dc.bibliographiccitation.lastpage","140"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Kappeler, Peter"],["dc.contributor.author","Kraus, Cornelia"],["dc.date.accessioned","2018-02-12T10:26:53Z"],["dc.date.available","2018-02-12T10:26:53Z"],["dc.date.issued","2016"],["dc.description.abstract","Inbreeding depression may be common in nature, reflecting either the failure of inbreeding avoidance strategies, or inbreeding tolerance when avoidance is costly. The combined assessment of inbreeding risk, avoidance and depression is therefore fundamental to evaluate the inbreeding strategy of a population, i.e., how individuals respond to the risk of inbreeding. Here, we use the demographic and genetic monitoring of 10 generations of wild grey mouse lemurs (Microcebus murinus), small primates from Madagascar with overlapping generations, to examine their inbreeding strategy. Grey mouse lemurs have retained ancestral mammalian traits including solitary lifestyle, polygynandry and male-biased dispersal, and may therefore offer a representative example of the inbreeding strategy of solitary mammals. The occurrence of close kin among candidate mates was frequent in young females (~37%, most often the father) and uncommon in young males (~6%) due to male-biased dispersal. However, close kin consistently represented a tiny fraction of candidate mates (<1%) across age and sex categories. Mating biases favouring partners with intermediate relatedness were detectable in yearling females and adult males, possibly partly caused by avoidance of daughter-father matings. Finally, inbreeding depression, assessed as the effect of heterozygosity on survival, was undetectable using a capture-mark-recapture study. Overall, these results indicate that sex-biased dispersal is a primary inbreeding avoidance mechanism at the population level, and mating biases represent an additional strategy that may mitigate residual inbreeding costs at the individual level. Combined, these mechanisms explain the rarity of inbreeding and the lack of detectable inbreeding depression in this large, genetically diverse population. This article is protected by copyright. All rights reserved."],["dc.identifier.doi","10.1111/jeb.12992"],["dc.identifier.pmid","27790777"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12143"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.title","The inbreeding strategy of a solitary primate,Microcebus murinus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","895"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","913"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Huchard, Elise"],["dc.contributor.author","Albrecht, Christina"],["dc.contributor.author","Schliehe-Diecks, Susanne"],["dc.contributor.author","Baniel, Alice"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Kappeler, Peter M."],["dc.contributor.author","Brameier, Markus"],["dc.date.accessioned","2017-09-07T11:48:24Z"],["dc.date.available","2017-09-07T11:48:24Z"],["dc.date.issued","2012"],["dc.description.abstract","The critical role of major histocompatibility complex (MHC) genes in disease resistance, along with their putative function in sexual selection, reproduction and chemical ecology, make them an important genetic system in evolutionary ecology. Studying selective pressures acting on MHC genes in the wild nevertheless requires population-wide genotyping, which has long been challenging because of their extensive polymorphism. Here, we report on large-scale genotyping of the MHC class II loci of the grey mouse lemur (Microcebus murinus) from a wild population in western Madagascar. The second exons from MHC-DRB and -DQB of 772 and 672 individuals were sequenced, respectively, using a 454 sequencing platform, generating more than 800,000 reads. Sequence analysis, through a stepwise variant validation procedure, allowed reliable typing of more than 600 individuals. The quality of our genotyping was evaluated through three independent methods, namely genotyping the same individuals by both cloning and 454 sequencing, running duplicates, and comparing parent-offspring dyads; each displaying very high accuracy. A total of 61 (including 20 new) and 60 (including 53 new) alleles were detected at DRB and DQB genes, respectively. Both loci were non-duplicated, in tight linkage disequilibrium and in Hardy-Weinberg equilibrium, despite the fact that sequence analysis revealed clear evidence of historical selection. Our results highlight the potential of 454 sequencing technology in attempts to investigate patterns of selection shaping MHC variation in contemporary populations. The power of this approach will nevertheless be conditional upon strict quality control of the genotyping data."],["dc.identifier.doi","10.1007/s00251-012-0649-6"],["dc.identifier.gro","3150796"],["dc.identifier.pmid","22948859"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8796"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7588"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.issn","0093-7711"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]