Schu, Peter Valentin

[["dc.bibliographiccitation.firstpage","5274"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","22"],["dc.contributor.affiliation","Strazic Geljic, Ivana; \t\t \r\n\t\t Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, Ivana.StrazicGeljic@fidelta.eu\t\t \r\n\t\t Fidelta Ltd., Prilaz baruna Filipovica 29, 10000 Zagreb, Croatia, Ivana.StrazicGeljic@fidelta.eu"],["dc.contributor.affiliation","Kucan Brlic, Paola; \t\t \r\n\t\t Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, paola.kucan@medri.uniri.hr\t\t \r\n\t\t Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, paola.kucan@medri.uniri.hr"],["dc.contributor.affiliation","Musak, Lucija; \t\t \r\n\t\t Fidelta Ltd., Prilaz baruna Filipovica 29, 10000 Zagreb, Croatia, Lucija.Musak@fidelta.eu"],["dc.contributor.affiliation","Karner, Dubravka; \t\t \r\n\t\t Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, dubravka.karner@medri.uniri.hr"],["dc.contributor.affiliation","Ambriović-Ristov, Andreja; \t\t \r\n\t\t Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia, Andreja.Ambriovic.Ristov@irb.hr"],["dc.contributor.affiliation","Jonjic, Stipan; \t\t \r\n\t\t Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, stipan.jonjic@medri.uniri.hr\t\t \r\n\t\t Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, stipan.jonjic@medri.uniri.hr"],["dc.contributor.affiliation","Schu, Peter; \t\t \r\n\t\t Department of Cellular Biochemistry, University Medical Center, Georg-August-University Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany, pschu@gwdg.de"],["dc.contributor.affiliation","Rovis, Tihana Lenac; \t\t \r\n\t\t Center for Proteomics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia, tihana.lenac@uniri.hr"],["dc.contributor.author","Strazic Geljic, Ivana"],["dc.contributor.author","Kucan Brlic, Paola"],["dc.contributor.author","Musak, Lucija"],["dc.contributor.author","Karner, Dubravka"],["dc.contributor.author","Ambriović-Ristov, Andreja"],["dc.contributor.author","Jonjic, Stipan"],["dc.contributor.author","Schu, Peter"],["dc.contributor.author","Rovis, Tihana Lenac"],["dc.date.accessioned","2021-07-05T15:00:46Z"],["dc.date.available","2021-07-05T15:00:46Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-06T07:02:16Z"],["dc.description.abstract","Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP-interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies."],["dc.description.abstract","Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP-interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies."],["dc.identifier.doi","10.3390/ijms22105274"],["dc.identifier.pii","ijms22105274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87897"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1422-0067"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]