Braus, Gerhard H.

[["dc.bibliographiccitation.firstpage","S91"],["dc.bibliographiccitation.journal","Medical Mycology"],["dc.bibliographiccitation.lastpage","S94"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Braus, Gerhard H."],["dc.contributor.author","Sasse, Christoph"],["dc.contributor.author","Krappmann, Sven"],["dc.date.accessioned","2018-11-07T09:22:02Z"],["dc.date.available","2018-11-07T09:22:02Z"],["dc.date.issued","2006"],["dc.description.abstract","Supply of all amino acids required for translation is crucial for the synthesis of new proteins. Fungal amino acid biosynthesis has to be coordinated with amino acid uptake as well as protein degradation. A global regulator that connects amino acid biosynthesis and developmental programs is the transcription factor CpcA/Gcn4p. This transcriptional activator is conserved within the fungal kingdom and the cellular levels of this protein are carefully regulated. Deletion of the encoding cpcA gene in the opportunistic pathogen Aspergillus fumigatus results in impaired virulence in immuno-compromised mice, suggesting a role of the cross-pathway control system in fungal pathogenicity."],["dc.identifier.doi","10.1080/13693780600898029"],["dc.identifier.isi","000242601400017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29246"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Taylor & Francis Ltd"],["dc.publisher.place","Abingdon"],["dc.relation.conference","2nd Advances against Aspergillosis Conference"],["dc.relation.eventlocation","Athens, GREECE"],["dc.relation.issn","1369-3786"],["dc.title","Amino acid acquisition, cross-pathway control, and virulence in Aspergillus"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","398"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","408"],["dc.bibliographiccitation.volume","307"],["dc.contributor.author","Amarsaikhan, Nansalmaa"],["dc.contributor.author","Albrecht-Eckardt, Daniela"],["dc.contributor.author","Sasse, Christoph"],["dc.contributor.author","Braus, Gerhard H."],["dc.contributor.author","Ogel, Zumrut B."],["dc.contributor.author","Kniemeyer, Olaf"],["dc.date.accessioned","2020-12-10T14:24:37Z"],["dc.date.available","2020-12-10T14:24:37Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.ijmm.2017.07.011"],["dc.identifier.issn","1438-4221"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72303"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Proteomic profiling of the antifungal drug response of Aspergillus fumigatus to voriconazole"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Liu, Li"],["dc.contributor.author","Sasse, Christoph"],["dc.contributor.author","Dirnberger, Benedict"],["dc.contributor.author","Valerius, Oliver"],["dc.contributor.author","Fekete-Szücs, Enikő"],["dc.contributor.author","Harting, Rebekka"],["dc.contributor.author","Nordzieke, Daniela E"],["dc.contributor.author","Pöggeler, Stefanie"],["dc.contributor.author","Karlovsky, Petr"],["dc.contributor.author","Gerke, Jennifer"],["dc.contributor.author","Braus, Gerhard H"],["dc.date.accessioned","2021-12-01T09:24:08Z"],["dc.date.available","2021-12-01T09:24:08Z"],["dc.date.issued","2021"],["dc.description.abstract","Fungal Hülle cells with nuclear storage and developmental backup functions are reminiscent of multipotent stem cells. In the soil, Hülle cells nurse the overwintering fruiting bodies of Aspergillus nidulans . The genome of A. nidulans harbors genes for the biosynthesis of xanthones. We show that enzymes and metabolites of this biosynthetic pathway accumulate in Hülle cells under the control of the regulatory velvet complex, which coordinates development and secondary metabolism. Deletion strains blocked in the conversion of anthraquinones to xanthones accumulate emodins and are delayed in maturation and growth of fruiting bodies. Emodin represses fruiting body and resting structure formation in other fungi. Xanthones are not required for sexual development but exert antifeedant effects on fungivorous animals such as springtails and woodlice. Our findings reveal a novel role of Hülle cells in establishing secure niches for A. nidulans by accumulating metabolites with antifeedant activity that protect reproductive structures from animal predators."],["dc.description.abstract","Fungal Hülle cells with nuclear storage and developmental backup functions are reminiscent of multipotent stem cells. In the soil, Hülle cells nurse the overwintering fruiting bodies of Aspergillus nidulans . The genome of A. nidulans harbors genes for the biosynthesis of xanthones. We show that enzymes and metabolites of this biosynthetic pathway accumulate in Hülle cells under the control of the regulatory velvet complex, which coordinates development and secondary metabolism. Deletion strains blocked in the conversion of anthraquinones to xanthones accumulate emodins and are delayed in maturation and growth of fruiting bodies. Emodin represses fruiting body and resting structure formation in other fungi. Xanthones are not required for sexual development but exert antifeedant effects on fungivorous animals such as springtails and woodlice. Our findings reveal a novel role of Hülle cells in establishing secure niches for A. nidulans by accumulating metabolites with antifeedant activity that protect reproductive structures from animal predators."],["dc.identifier.doi","10.7554/eLife.68058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94858"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2050-084X"],["dc.title","Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","693"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Fungal Genetics and Biology"],["dc.bibliographiccitation.lastpage","704"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Sasse, Christoph"],["dc.contributor.author","Bignell, Elaine M."],["dc.contributor.author","Hasenberg, Mike"],["dc.contributor.author","Haynes, Ken"],["dc.contributor.author","Gunzer, Matthias"],["dc.contributor.author","Braus, Gerhard H."],["dc.contributor.author","Krappmann, Sven"],["dc.date.accessioned","2018-11-07T11:15:29Z"],["dc.date.available","2018-11-07T11:15:29Z"],["dc.date.issued","2008"],["dc.description.abstract","Aspergillosis is a disease determined by various factors that influence fungal growth and fitness. A conserved signal transduction cascade linking environmental stress to amino acid homeostasis is the Cross-Pathway Control (CPC) system that acts via phosphorylation of the translation initiation factor eIF2 by a sensor kinase to elevate expression of a transcription factor. Ingestion of Aspergillus fumigatus conidia by macrophages does not trigger this stress response, suggesting that their phagosomal microenvironment is not deficient in amino acids. The cpcC gene encodes the CPC eIF2 alpha kinase, and deletion mutants show increased sensitivity towards amino acid starvation. CpcC is specifically required for the CPC response but has limited influence on the amount of phosphorylated eIF2 alpha. Strains deleted for the cpcC locus are not impaired in virulence in a murine model of pulmonary aspergillosis. Accordingly, basal expression of the Cross-Pathway Control transcriptional activator appears sufficient to support aspergillosis in this disease model. (c) 2008 Elsevier Inc. All rights reserved."],["dc.description.sponsorship","Medical Research Council [G0501164]"],["dc.identifier.doi","10.1016/j.fgb.2007.12.008"],["dc.identifier.isi","000255153600012"],["dc.identifier.pmid","18249572"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54377"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1096-0937"],["dc.relation.issn","1087-1845"],["dc.title","Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]