Ferrea, Enrico

[["dc.bibliographiccitation.artnumber","jcs.182089"],["dc.bibliographiccitation.journal","Journal of Cell Science"],["dc.contributor.author","Valente, Pierluigi"],["dc.contributor.author","Lignani, Gabriele"],["dc.contributor.author","Medrihan, Lucian"],["dc.contributor.author","Bosco, Federica"],["dc.contributor.author","Contestabile, Andrea"],["dc.contributor.author","Lippiello, Pellegrino"],["dc.contributor.author","Ferrea, Enrico"],["dc.contributor.author","Schachner, Melitta"],["dc.contributor.author","Benfenati, Fabio"],["dc.contributor.author","Giovedì, Silvia"],["dc.contributor.author","Baldelli, Pietro"],["dc.date.accessioned","2022-10-06T13:26:14Z"],["dc.date.available","2022-10-06T13:26:14Z"],["dc.date.issued","2016"],["dc.description.abstract","L1 is a trans-membrane glycoprotein subserving neuron-neuron adhesion via homophilic and heterophilic interactions. Although experimental evidences have implicated L1 in axonal outgrowth, fasciculation and pathfinding, its contribution to voltage-gated sodium channels (NaChs) function and membrane excitability has remained unknown. Here, we show that firing rate, single cell spiking frequency and Na+ current density are all reduced in hippocampal excitatory neurons from L1-deficient mice both in culture and in slices, due to an overall reduced membrane expression of NaChs.\n Remarkably, normal firing activity was restored when L1 was reintroduced into L1-deficient excitatory neurons, indicating that abnormal firing patterns are not related to developmental abnormalities, but are a direct consequence of L1 deletion. Moreover, L1-deficiency leads to impairment of action potential (AP) initiation, most likely due to the loss of the interaction of L1 with Ankyrin G that produces the delocalization of NaChs at the at the axonal initial segment. We conclude that L1 contributes to functional expression and localization of NaChs to the neuronal plasma membrane, ensuring correct initiation of AP and normal firing activity."],["dc.identifier.doi","10.1242/jcs.182089"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115033"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1477-9137"],["dc.relation.issn","0021-9533"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated sodium channels"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","18045"],["dc.bibliographiccitation.issue","29"],["dc.bibliographiccitation.journal","Journal of Biological Chemistry"],["dc.bibliographiccitation.lastpage","18055"],["dc.bibliographiccitation.volume","290"],["dc.contributor.author","Cesca, Fabrizia"],["dc.contributor.author","Satapathy, Annyesha"],["dc.contributor.author","Ferrea, Enrico"],["dc.contributor.author","Nieus, Thierry"],["dc.contributor.author","Benfenati, Fabio"],["dc.contributor.author","Scholz-Starke, Joachim"],["dc.date.accessioned","2022-10-06T13:34:35Z"],["dc.date.available","2022-10-06T13:34:35Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1074/jbc.M115.654699"],["dc.identifier.pii","S0021925820424007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115942"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0021-9258"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Functional Interaction between the Scaffold Protein Kidins220/ARMS and Neuronal Voltage-Gated Na+ Channels"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ferrea, E."],["dc.contributor.author","Franke, J."],["dc.contributor.author","Morel, P."],["dc.contributor.author","Gail, A."],["dc.date.accessioned","2022-07-01T07:34:52Z"],["dc.date.available","2022-07-01T07:34:52Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Neurorehabilitation in patients suffering from motor deficits relies on relearning or re-adapting motor skills. Yet our understanding of motor learning is based mostly on results from one or two-dimensional experimental paradigms with highly confined movements. Since everyday movements are conducted in three-dimensional space, it is important to further our understanding about the effect that gravitational forces or perceptual anisotropy might or might not have on motor learning along all different dimensions relative to the body. Here we test how well existing concepts of motor learning generalize to movements in 3D. We ask how a subject’s variability in movement planning and sensory perception influences motor adaptation along three different body axes. To extract variability and relate it to adaptation rate, we employed a novel hierarchical two-state space model using Bayesian modeling via Hamiltonian Monte Carlo procedures. Our results show that differences in adaptation rate occur between the coronal, sagittal and horizontal planes and can be explained by the Kalman gain, i.e., a statistically optimal solution integrating planning and sensory information weighted by the inverse of their variability. This indicates that optimal integration theory for error correction holds for 3D movements and explains adaptation rate variation between movements in different planes."],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship","Federal Ministry for Education and Research, Germany"],["dc.description.sponsorship","Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung"],["dc.identifier.doi","10.1038/s41598-022-13866-y"],["dc.identifier.pii","13866"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112030"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-581"],["dc.relation.eissn","2045-2322"],["dc.relation.haserratum","/handle/2/113626"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Statistical determinants of visuomotor adaptation along different dimensions during naturalistic 3D reaches"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Ferrea, E."],["dc.contributor.author","Franke, J."],["dc.contributor.author","Morel, P."],["dc.contributor.author","Gail, A."],["dc.date.accessioned","2022-09-01T09:50:07Z"],["dc.date.available","2022-09-01T09:50:07Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1038/s41598-022-16148-9"],["dc.identifier.pii","16148"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113626"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2045-2322"],["dc.relation.iserratumof","/handle/2/112030"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Author Correction: Statistical determinants of visuomotor adaptation along different dimensions during naturalistic 3D reaches"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","jn.00504.2017"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.contributor.author","Ferrea, Enrico"],["dc.contributor.author","Suriya-Arunroj, Lalitta"],["dc.contributor.author","Hoehl, Dirk"],["dc.contributor.author","Thomas, Uwe"],["dc.contributor.author","Gail, Alexander"],["dc.date.accessioned","2018-01-17T13:11:01Z"],["dc.date.available","2018-01-17T13:11:01Z"],["dc.date.issued","2017"],["dc.description.abstract","Acute neuronal recordings performed with metal microelectrodes in non-human primates allow investigating the neural substrate of complex cognitive behaviors. Yet, the daily re-insertion and positioning of the electrodes prevents recording from many neurons simultaneously, limiting the suitability of these types of recordings for brain-computer-interface applications or for large-scale population statistical methods on a trial-by-trial basis. In contrast, chronically implanted multi-electrode arrays offer the opportunity to record from many neurons simultaneously, but immovable electrodes prevent optimization of the signal during and after implantation and cause the tissue response to progressively impair the transduced signal quality, thereby limiting the number of different neurons that can be recorded over the lifetime of the implant. Semi-chronically implanted matrices of electrodes, instead, allow individually movable electrodes in depth and achieve higher channel count compared to acute methods, hence partially overcome these limitations. Existing semi-chronic systems with higher channel count lack computerized control of electrode movements, leading to limited user-friendliness and uncertainty in depth-positioning. Here we demonstrate a chronically-implantable Adaptive Multi-Electrode Positioning (AMEP) system with detachable drive for computerized depth-adjustment of individual electrodes over several millimeters. This semi-chronic 16-channel system is designed to optimize the simultaneous yield of units in an extended period following implantation since the electrodes can be independently depth-adjusted with minimal effort and their signal quality continuously assessed. Importantly, the electrode array is designed to remain within a chronic recording chamber for a prolonged time, or can be used for acute recordings with high signal-to-noise ratio in the cerebral cortex of non-human primates."],["dc.identifier.doi","10.1152/jn.00504.2017"],["dc.identifier.pmid","29187552"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/11704"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.relation.eissn","1522-1598"],["dc.title","Implantable computer-controlled adaptive multi-electrode positioning system (AMEP)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]