Papiol, Sergi

[["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Cearns, Micah"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Tekola-Ayele, Fasil"],["dc.contributor.author","Hsu, Yi-Hsiang"],["dc.contributor.author","Baune, Bernhard T."],["dc.date.accessioned","2020-12-10T18:09:37Z"],["dc.date.available","2020-12-10T18:09:37Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1038/s41380-020-0689-5"],["dc.identifier.eissn","1476-5578"],["dc.identifier.issn","1359-4184"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73707"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association of polygenic score for major depression with response to lithium in patients with bipolar disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","S1300"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.lastpage","S1301"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Comes, Ashley"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Andlauer, Till"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Kondofersky, Ivan"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Senner, Fanny"],["dc.contributor.author","Sivalingam, Sugirthan"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:56Z"],["dc.date.available","2020-12-10T14:23:56Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2018.08.426"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72083"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","SU62THE ROLE OF ENVIRONMENTAL STRESS AND DNA METHYLATION IN THE LONGITUDINAL COURSE OF BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JAMA Psychiatry"],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Degenhardt, Franziska"],["dc.contributor.author","Tekola-Ayele, Fasil"],["dc.contributor.author","Hsu, Yi-Hsiang"],["dc.contributor.author","Shekhtman, Tatyana"],["dc.contributor.author","Baune, Bernhard T."],["dc.date.accessioned","2020-12-10T14:05:46Z"],["dc.date.available","2020-12-10T14:05:46Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1001/jamapsychiatry.2017.3433"],["dc.identifier.issn","2168-622X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/69650"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder"],["dc.title.alternative","A Genome-Wide Association Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","17823"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Le Clerc, Sigrid"],["dc.contributor.author","Lombardi, Laura"],["dc.contributor.author","Baune, Bernhard T."],["dc.contributor.author","Amare, Azmeraw T."],["dc.contributor.author","Schubert, Klaus Oliver"],["dc.contributor.author","Hou, Liping"],["dc.contributor.author","Clark, Scott R."],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Cearns, Micah"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Tamouza, Ryad"],["dc.date.accessioned","2021-10-01T09:57:45Z"],["dc.date.available","2021-10-01T09:57:45Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1 11:01 classical allele, associated with a better response to Li ( p  < 1 × 10 −3 ; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response."],["dc.description.abstract","Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1 11:01 classical allele, associated with a better response to Li ( p  < 1 × 10 −3 ; FDR < 0.09 in the recessive model). Alanine or Leucine at position 74 of the HLA-DRB1 heavy chain was associated with a good response while Arginine or Glutamic acid with a poor response. As these variants have been implicated in common inflammatory/autoimmune processes, our findings strongly suggest that HLA-mediated low inflammatory background may contribute to the efficient response to Li in BD patients, while an inflammatory status overriding Li anti-inflammatory properties would favor a weak response."],["dc.identifier.doi","10.1038/s41598-021-97140-7"],["dc.identifier.pii","97140"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89908"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","2045-2322"],["dc.title","HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","S951"],["dc.bibliographiccitation.journal","European Neuropsychopharmacology"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Adorjan, Kristina"],["dc.contributor.author","Papiol, Sergi"],["dc.contributor.author","Gade, Katrin"],["dc.contributor.author","Malzahn, Dörthe"],["dc.contributor.author","Sherva, Richard"],["dc.contributor.author","Budde, Monika"],["dc.contributor.author","Aldinger, Fanny"],["dc.contributor.author","Kalman, Janos"],["dc.contributor.author","Heilbronner, Urs"],["dc.contributor.author","Anderson-Schmidt, Heike"],["dc.contributor.author","Pogarell, Oliver"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Gelernter, Joel"],["dc.contributor.author","Schulze, Thomas"],["dc.date.accessioned","2020-12-10T14:23:55Z"],["dc.date.available","2020-12-10T14:23:55Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.euroneuro.2017.08.302"],["dc.identifier.issn","0924-977X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72073"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","POLYGENIC RISK BURDEN AND CANNABIS USE COMORBIDITY IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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