Binder, Lutz

[["dc.bibliographiccitation.firstpage","754"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Health Psychology"],["dc.bibliographiccitation.lastpage","763"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Nagel, Jonas"],["dc.contributor.author","Chavanon, Mira-Lynn"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Pieper, Annekatrin"],["dc.contributor.author","Wachter, Rolf"],["dc.contributor.author","Edelmann, Frank"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.date.accessioned","2022-01-11T14:05:40Z"],["dc.date.available","2022-01-11T14:05:40Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1037/hea0001128"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/97719"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-507"],["dc.relation.eissn","1930-7810"],["dc.relation.issn","0278-6133"],["dc.title","How family history of premature myocardial infarction affects patients at cardiovascular risk."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","98"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of Hematology"],["dc.bibliographiccitation.lastpage","103"],["dc.bibliographiccitation.volume","82"],["dc.contributor.author","Schuttrumpf, S."],["dc.contributor.author","Binder, L."],["dc.contributor.author","Hagemann, T."],["dc.contributor.author","Berkovic, D."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Binder, Claudia"],["dc.date.accessioned","2018-11-07T10:41:02Z"],["dc.date.available","2018-11-07T10:41:02Z"],["dc.date.issued","2003"],["dc.description.abstract","Plasma concentrations of procalcitonin (PCT) have been shown to be elevated in bacterial and fungal infections. In contrast to C-reactive protein (CRP), PCT is not elevated in inflammations of noninfectious origin. Febrile inflammatory conditions are frequent in patients with hemato-oncological diseases. A reliable marker to discriminate infectious inflammations from drug-related and tumor-associated fever is still lacking. To evaluate the impact of PCT in this setting, PCT and CRP were prospectively measured in 95 febrile hemato-oncological patients. Infections could be identified in 40 of 95 patients: 38 of 95 had fever of unknown origin (FUO), 9 patients were suspected to suffer from drug-related fever, and 8 patients from tumor-associated fever. In the noninfection group (drug-related and tumor-associated fever), PCT levels were significantly lower than in patients with infections (P<0.001) or FUO (P<0.001). Differences were still highly significant comparing patients with suspected drug-related or tumor-associated fever alone with the infection or the FUO cohort. All eight patients with tumor-associated fever as well as eight of the nine patients with drug-related fever had PCT levels within the normal range (<0.5 mu g/l). CRP values only partially allowed discrimination between the various subgroups. Differences were significant between patients with drug-related fever and the infection (P=0.001) or FUO group (P=0.004). However, as CRP levels were far above the normal range also in the patients with drug-related fever, the significance of individual values was rather limited. In conclusion, PCT may provide useful additional information to assess the clinical significance of febrile conditions. PCT may facilitate the decision on when to initiate antimicrobial or cytotoxic therapy."],["dc.identifier.doi","10.1007/s00277-002-0584-y"],["dc.identifier.isi","000181574600007"],["dc.identifier.pmid","12601488"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46448"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-0584"],["dc.relation.issn","0939-5555"],["dc.title","Procalcitonin: a useful discriminator between febrile conditions of different origin in hemato-oncological patients?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","von Lewinski, Dirk"],["dc.contributor.author","Sander, Josemir W."],["dc.contributor.author","Schenker, W."],["dc.contributor.author","Wiesenthal, T."],["dc.contributor.author","Hess, Georg"],["dc.contributor.author","Binder, L."],["dc.date.accessioned","2018-11-07T09:50:05Z"],["dc.date.available","2018-11-07T09:50:05Z"],["dc.date.issued","2002"],["dc.format.extent","683"],["dc.identifier.isi","000179142703409"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35641"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","American-Heart-Association Abstracts From Scientific Sessions"],["dc.relation.eventlocation","CHICAGO, ILLINOIS"],["dc.relation.issn","0009-7322"],["dc.title","NT-pro brain natriuretic peptide as marker for severity and prognosis of left ventricular dysfunction"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Binder, L."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Hruska, N."],["dc.contributor.author","Hess, Georg"],["dc.contributor.author","Konstantinides, Stavros V."],["dc.date.accessioned","2018-11-07T10:13:47Z"],["dc.date.available","2018-11-07T10:13:47Z"],["dc.date.issued","2002"],["dc.format.extent","580"],["dc.identifier.isi","000179753302165"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40501"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.publisher.place","London"],["dc.relation.conference","Congress of the European-Society-of-Cardiology"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0195-668X"],["dc.title","NT-pro brain natriuretic peptide as novel marker for diagnosis and prognosis of acute pulmonary embolism"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.journal","Forensic Science International"],["dc.bibliographiccitation.lastpage","73"],["dc.bibliographiccitation.volume","287"],["dc.contributor.author","Grapp, Marcel"],["dc.contributor.author","Kaufmann, Christoph"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Binder, Lutz"],["dc.date.accessioned","2020-12-10T14:24:10Z"],["dc.date.available","2020-12-10T14:24:10Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.forsciint.2018.03.039"],["dc.identifier.issn","0379-0738"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72169"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Systematic forensic toxicological analysis by liquid-chromatography-quadrupole-time-of-flight mass spectrometry in serum and comparison to gas chromatography-mass spectrometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychosomatic Medicine"],["dc.bibliographiccitation.volume","78"],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Beutel, Manfred E."],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Deter, Hans-Christian"],["dc.contributor.author","Petrowski, Katja"],["dc.contributor.author","Ronel, Joram"],["dc.contributor.author","Soellner, Wolfgang"],["dc.contributor.author","de Zwaan, Martina"],["dc.contributor.author","Albus, Christian"],["dc.date.accessioned","2018-11-07T10:15:43Z"],["dc.date.available","2018-11-07T10:15:43Z"],["dc.date.issued","2016"],["dc.format.extent","A129"],["dc.identifier.isi","000373949800418"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40867"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","74th Annual Meeting of the American-Psychosomatic-Society"],["dc.relation.eventlocation","Denver, CO"],["dc.relation.issn","1534-7796"],["dc.relation.issn","0033-3174"],["dc.title","ASSOCIATIONS OF N-TERMINAL PRO-B TYPE NATRIURETIC PEPTIDE (NT-PROBNP) WITH ANXIETY, COPING, AND QUALITY OF LIFE IN DEPRESSED PATIENTS WITH CORONARY ARTERY DISEASE (CAD)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Molecular and Cellular Cardiology"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Binder, L."],["dc.contributor.author","Herrmann-Lingen, Christoph"],["dc.contributor.author","Hruska, N."],["dc.contributor.author","Hess, Georg"],["dc.contributor.author","Konstantinides, Stavros V."],["dc.date.accessioned","2018-11-07T10:28:41Z"],["dc.date.available","2018-11-07T10:28:41Z"],["dc.date.issued","2002"],["dc.format.extent","A50"],["dc.identifier.doi","10.1016/S0022-2828(02)90926-0"],["dc.identifier.isi","000176496800204"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43481"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Ltd- Elsevier Science Ltd"],["dc.publisher.place","London"],["dc.relation.issn","1095-8584"],["dc.relation.issn","0022-2828"],["dc.title","NT-proBNP as novel marker for diagnosis and severity of acute pulmonary embolism"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Dogan, Ahmet"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Oellerich, Michael"],["dc.date.accessioned","2018-11-07T11:00:31Z"],["dc.date.available","2018-11-07T11:00:31Z"],["dc.date.issued","2007"],["dc.format.extent","518"],["dc.identifier.isi","000248359200201"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50935"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","10th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology"],["dc.relation.eventlocation","Nice, FRANCE"],["dc.relation.issn","0163-4356"],["dc.title","Simultaneous determination of clozapine, olanzapine and quetiapine using the waters quattro micro((R)) system with a ESI interface"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Kockskaemper, Anke"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Kleta, Sibylle"],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Binder, L."],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T11:24:44Z"],["dc.date.available","2018-11-07T11:24:44Z"],["dc.date.issued","2009"],["dc.format.extent","170"],["dc.identifier.isi","000208702602083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56472"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Echocardiographic diagnosis of diastolic dysfunction: E/e is superior to complex algorithms in predicting a clinical impairment in exercise capacity"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","632"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Therapeutic Drug Monitoring"],["dc.bibliographiccitation.lastpage","643"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Streit, Frank"],["dc.contributor.author","Binder, Lutz"],["dc.contributor.author","Hafke, Angelika"],["dc.contributor.author","Brandhorst, Gunnar"],["dc.contributor.author","Braulke, Friederike"],["dc.contributor.author","Haase, Detlef"],["dc.contributor.author","Armbrust, Thomas"],["dc.contributor.author","Cameron, Silke"],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Oellerich, Michael"],["dc.contributor.author","Walson, Philip D."],["dc.date.accessioned","2018-11-07T08:51:25Z"],["dc.date.available","2018-11-07T08:51:25Z"],["dc.date.issued","2011"],["dc.description.abstract","Objectives: Trough total imatinib (t-IM) concentrations have been reported to be associated with therapeutic and toxic responses in patients with chronic myelogenous leukemia (CML) and gastrointestinal stromal tumor (GIST). Little is known about the relationships between effects and concentrations of either unbound imatinib (f-IM) or imatinib's major metabolite, N-desmethyl imatinib (NDI). In part, this is because of the lack of a single, validated, well-described clinically useful assay for these measurements. The authors report the development and application of such an assay. Materials and Methods: A single liquid-chromatography tandem-mass-spectrometry assay was used to monitor t-IM, f-IM, and t-NDI concentrations in CML and GIST patients treated at a tertiary German teaching hospital. The assay was also validated for measuring other kinase inhibitors, including t-nilotinib, sunitinib, and erlotinib. Ultrafiltration assays were validated and used to measure f-IM and to compare free fractions to plasma alpha(1)-acid glycoprotein concentrations (AGP). Results: The assays were linear over a working range (in micrograms per liter) of 8.4-8370, 8.3-4165, and 1.0-250 and had within-and between-run coefficient of variance of <7%, <12%, and <9% for t-IM, t-NDI, and f-IM, respectively. The f-IM assay was reproducible despite high (25.2%-31.6%) but concentration-independent binding to ultrafiltration devices. Clinically relevant results, such as nondetectable (ND) t-IM (<8.4 mu g/L) in non-responders and >1500 mu g/L in patients with major toxicity, were found. Of 156 total samples from 68 adult CML patients and 127 total samples from 42 adult GIST, only 48 samples from 22 CML patients and 40 samples from 20 GIST patients were trough samples with adequate dosing and collection information. More than half (27 of 48 CML and 24 of 40 GIST) had t-IM concentrations >= 10% below recommended target concentrations (1002 mu g/L for CML and 1100 mu g/L for GIST). Concentrations.50% over targets were also found in 6 of 48 CML and 4 of 40 GIST samples. Wide variations in concentrations of t-IM (range, ND to 2973 mu g/L), t-NDI (range, ND to 659 mu g/L), f-IM (range, 8.3-262 mu g/L), and t-IM:f-IM ratios (range, 2.6%-14%) were found both between and within patients. A statistically significant association (Spearman correlation coefficient and P value for all samples, r = 0.290 and P = 0.023; for trough only, r = -0.585 and P = 0.028) was found between AGP and f-IM concentrations but wide interpatient and intrapatient variations made individual predictions unreliable. Conclusions: The liquid-chromatography tandem-mass-spectrometry methods developed provided information useful to understand individual responses to therapy even though necessary sampling and dosing information was often not available. Wide unpredictable variations in t-IM, t-NDI, and f-IM were found. Clinical outcome trials are needed to examine whether f-IM or NDI monitoring can improve the ability to predict individual responses."],["dc.description.sponsorship","Novartis Pharma GmbH, Nuernberg, Germany"],["dc.identifier.doi","10.1097/FTD.0b013e3182263ac4"],["dc.identifier.isi","000295083000009"],["dc.identifier.pmid","21912334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21930"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0163-4356"],["dc.title","Use of Total and Unbound Imatinib and Metabolite LC-MS/MS Assay to Understand Individual Responses in CML and GIST Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]