Gholami, Azam

[["dc.bibliographiccitation.artnumber","063007"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Gholami, A."],["dc.contributor.author","Steinbock, Oliver"],["dc.contributor.author","Zykov, Vladimir"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2018-11-07T09:55:55Z"],["dc.date.available","2018-11-07T09:55:55Z"],["dc.date.issued","2015"],["dc.description.abstract","The slime mold Dictyostelium discoideum is a well known model system for the study of biological pattern formation. In the natural environment, aggregating populations of starving Dictyostelium discoideum cells may experience fluid flows that can profoundly change the underlying wave generation process. Here we study the effect of advection on the pattern formation in a colony of homogeneously distributed Dictyostelium discoideum cells described by the standard Martiel-Goldbeter model. The external flow advects the signaling molecule cyclic adenosine monophosphate (cAMP) downstream, while the chemotactic cells attached to the solid substrate are not transported with the flow. The evolution of small perturbations in cAMP concentrations is studied analytically in the linear regime and by corresponding numerical simulations. We show that flow can significantly influence the dynamics of the system and lead to a flow-driven instability that initiate downstream traveling cAMP waves. We also show that boundary conditions have a significant effect on the observed patterns and can lead to a new kind of instability."],["dc.identifier.doi","10.1088/1367-2630/17/6/063007"],["dc.identifier.isi","000358926900001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13644"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36856"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.title","Flow-driven instabilities during pattern formation of Dictyostelium discoideum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","093040"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Gholami, A."],["dc.contributor.author","Zykov, Vladimir"],["dc.contributor.author","Steinbock, Oliver"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2018-11-07T09:51:29Z"],["dc.date.available","2018-11-07T09:51:29Z"],["dc.date.issued","2015"],["dc.description.abstract","Dictyostelium discoideum (D.d.) is a valuable model organism to study self-organization and pattern formation in biology. Recently we reported flow-driven waves in experiments with uniformly distributed populations of signaling amobae, D.d., and carried out a theoretical study in a onedimensional model. In this work, we perform two-dimensional numerical simulations using the well-known Martiel-Golbeter model to study the effect of the flow profile and intrinsic noise on the flow-driven waves. We show that, in the presence of flow, a persistence noise due to spontaneous cell firing events can lead to sustained structures that fill the whole length of the system. We also show that external periodic stimuli of cyclic adenosine monophosphate can induce 1: 1 and 2: 1 entrainments which are in agreement with our experimental observations."],["dc.identifier.doi","10.1088/1367-2630/17/9/093040"],["dc.identifier.isi","000367363300001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35928"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1367-2630"],["dc.title","Flow-driven two-dimensional waves in colonies of Dictyostelium discoideum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","018103"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Gholami, A."],["dc.contributor.author","Steinbock, Oliver"],["dc.contributor.author","Zykov, Vladimir"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2018-11-07T10:02:21Z"],["dc.date.available","2018-11-07T10:02:21Z"],["dc.date.issued","2015"],["dc.description.abstract","We report experiments on flow-driven waves in a microfluidic channel containing the signaling slime mold Dictyostelium discoideum. The observed cyclic adenosine monophosphate (cAMP) wave trains developed spontaneously in the presence of flow and propagated with the velocity proportional to the imposed flow velocity. The period of the wave trains was independent of the flow velocity. Perturbations of flow-driven waves via external periodic pulses of the signaling agent cAMP induced 1 : 1, 2 : 1, 3 : 1, and 1 : 2 frequency responses, reminiscent of Arnold tongues in forced oscillatory systems. We expect our observations to be generic to active media governed by reaction-diffusion-advection dynamics, where spatially bound autocatalytic processes occur under flow conditions."],["dc.identifier.doi","10.1103/PhysRevLett.114.018103"],["dc.identifier.isi","000352068300026"],["dc.identifier.pmid","25615506"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12790"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38204"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 3.0"],["dc.subject.mesh","Cyclic AMP"],["dc.subject.mesh","Dictyostelium"],["dc.subject.mesh","Microfluidic Analytical Techniques"],["dc.subject.mesh","Models, Biological"],["dc.subject.mesh","Signal Transduction"],["dc.title","Flow-Driven Waves and Phase-Locked Self-Organization in Quasi-One-Dimensional Colonies of Dictyostelium discoideum"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]