Legler, Tobias J.

[["dc.bibliographiccitation.artnumber","023"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Jacobs Journal of Hematology"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Budde, Holger"],["dc.contributor.author","Thieringer, Lena"],["dc.contributor.author","Riggert, Joachim"],["dc.contributor.author","Legler, Tobias J."],["dc.date.accessioned","2019-07-10T08:12:01Z"],["dc.date.available","2019-07-10T08:12:01Z"],["dc.date.issued","2015"],["dc.description.abstract","Background Graft-versus-host disease (GvHD) is still one of the most challenging complications after allogeneic hematopoietic stem cell transplantation. Steroid-resistant or steroid-refractory patients with acute GvHD have limited therapeutic options and there is a strong demand in clinics for new therapeutic approaches. Due to the published anti-inflammatory effects of heparin, we hypothesized that either unfractionated (UFH) or low-molecular-weight heparin (LMWH) could be a novel treatment option for patients with acute GvHD. Methods We performed dose finding studies with both UFH and LMWH via intravenous (iv) and subcutaneous (sc) routes of application in a mouse model of acute GvHD. Survival rates, clinical GvHD score, CD4+ and CD8+ T cell levels were determined. Results Iv administration of UFH caused slightly but no statistically improved survival rates or clinical scores of the GvHD animals. Neither sc administration of UFH, nor sc or iv administration of LMWH was linked to improved survival or clinical GvHD score. CD4+ and CD8+ T cell levels were not influenced by UFH or LMWH treatment. Conclusion UFH seems to be more effective than LMWH. However, the therapeutic effect of UFH on acute GvHD is limited and heparin alone is probably not sufficient for the therapy of acute GvHD."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2015"],["dc.format.extent","6"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13468"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60844"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","2380-1646"],["dc.rights.access","openAccess"],["dc.subject","GvHD; Heparins; Immune-Suppression; Bone Marrow Transplantation"],["dc.subject.ddc","610"],["dc.title","Anti-Inflammatory Effects of Heparin: Do they Influence Murine Acute GvHD?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]