Tröltzsch, Markus

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Orofacial Pain"],["dc.bibliographiccitation.lastpage","371"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Berndt, Ronald"],["dc.contributor.author","Woodlock, Timothy"],["dc.contributor.author","Messlinger, Karl"],["dc.contributor.author","Troeltzsch, Markus"],["dc.date.accessioned","2018-11-07T09:20:21Z"],["dc.date.available","2018-11-07T09:20:21Z"],["dc.date.issued","2013"],["dc.description.abstract","Cutaneous mastocytosis (CM) has been associated with urticaria, itching, and pain of the affected regions. Although the occurrence of CM in the facial skin is rare, it may be a cause of chronic facial pain, and pain characteristics may mistakenly be interpreted as trigeminal nerve pathology. However, the dermatological appearance of the different variants of cutaneous mastocytosis is distinct and should be considered as an uncommon differential diagnosis in an orofacial pain diagnostic algorithm. This article presents a case of telangiectasia macularis eruptiva perstans, a rare type of cutaneous mastocytosis, as the underlying cause of chronic facial pain, erythema, and swelling."],["dc.identifier.isi","000326428200010"],["dc.identifier.pmid","24171187"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28862"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","1945-3396"],["dc.relation.issn","1064-6655"],["dc.title","Cutaneous Mastocytosis as a Rare Differential Diagnosis for Unilateral Chronic Facial Pain and Erythema: A Case Report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1522"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1529"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Pache, Christoph"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Kaeppler, Gabriele"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.contributor.author","Probst, Florian"],["dc.date.accessioned","2018-11-07T09:50:58Z"],["dc.date.available","2018-11-07T09:50:58Z"],["dc.date.issued","2015"],["dc.description.abstract","The purpose of the study was to analyze the causative pathology associated with symptomatic unilateral maxillary sinusitis requiring surgical treatment. A retrospective review of all patients that have been treated surgically for unilateral symptomatic maxillary sinusitis between 2006 and 2013 at a single institution was performed. Demographic, anamnesis, clinical, radiological, microbiological and histological data were gathered and analyzed. The patients were allocated into groups depending on the underlying cause of the disease. Descriptive and inferential statistics were computed (level of significance: p <= 0.05). The study sample was composed of 174 patients (72 female; 102 male) with a mean age of 52.7 years (SD 16.9). Most cases (130; 75%) were triggered by odontogenic pathology following dentoalveolar surgical interventions (83/130 patients; 64%). Other etiological factors for odontogenic unilateral sinusitis were periapical (23/130 cases; 18%) and periodontal pathology (13/130 cases; 10%). Rhinogenic factors for sinusitis were detected in 13 patients (7.5%) and dental implant-associated unilateral maxillary sinusitis was diagnosed in nine patients (5.2%). Four patients (2.3%) had undergone previous sinus augmentation surgery. A leading cause for the sinus infection could not be identified in 18 patients (10%) who all had a history of midfacial surgery. Medication-related osteonecrosis of the jaw (8) and squamous cell carcinoma (2) were incidental findings. There were no differences in the clinical appearance of the disease with respect to its etiology. Odontogenic causes for maxillary sinusitis must be considered especially in unilateral cases. Maxillary dental implants may induce symptomatic unilateral maxillary sinusitis. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.jcms.2015.07.021"],["dc.identifier.isi","000362604000032"],["dc.identifier.pmid","26319958"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35819"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1878-4119"],["dc.relation.issn","1010-5182"],["dc.title","Etiology and clinical characteristics of symptomatic unilateral maxillary sinusitis: A review of 174 cases"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","236"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Prosthetic Dentistry"],["dc.bibliographiccitation.lastpage","241"],["dc.bibliographiccitation.volume","113"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Probst, Florian"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.date.accessioned","2018-11-07T10:00:18Z"],["dc.date.available","2018-11-07T10:00:18Z"],["dc.date.issued","2015"],["dc.description.abstract","Advanced maxillary medication-related osteonecrosis of the jaw can cause extensive hard and soft tissue destruction that results in long-term oroantral fistulae. The surgical treatment of medication-related osteonecrosis of the jaw may relieve acute symptoms and eliminate the signs of inflammation, but the primary and sustained plastic closure of these defects can challenge both the clinician and the patients. Although the use of obturator prostheses for maxillary defects after ablative oncologic surgery is well documented, studies about this treatment for similar medication-related osteonecrosis of the jaw related defects are missing. This presentation of clinical situations describes the use of obturators as a conservative alternative to repetitive surgery for the rehabilitation of selected maxillary defects with oroantral communications."],["dc.identifier.isi","000351117400012"],["dc.identifier.pmid","25444286"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37773"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","1097-6841"],["dc.relation.issn","0022-3913"],["dc.title","Conservative management of medication-related osteonecrosis of the maxilla with an obturator prosthesis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1945"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Journal of Cranio-Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1951"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Cagna, David"],["dc.contributor.author","Staehler, Philip"],["dc.contributor.author","Probst, Florian"],["dc.contributor.author","Kaeppler, Gabriele"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.date.accessioned","2018-11-07T10:04:56Z"],["dc.date.available","2018-11-07T10:04:56Z"],["dc.date.issued","2016"],["dc.description.abstract","The purpose of this study was to examine the behavior of dental implants in patients diagnosed with MRONJ and to analyze the characteristics of peri-implant MRONJ. It was hypothesized that peri-implant parameters are not associated with peri-implant MRONJ. A retrospective study design was selected to address the research purpose. Patients with confirmed MRONJ and the simultaneous presence of dental implants who presented between 2010 and 2016 served as the study cohort. Predefined inclusion and exclusion criteria were applied. Demographic, clinical and radiological data were collected and analyzed statistically with respect to the variable scale (significance level p <= 0.05). The study sample was composed of 34 patients (female: 16; male: 18; average age: 70.6 years) with a total of 117 dental implants the majority of whom had received antiresorptive drug therapy within oncologic treatment protocols. Peri-implant MRONJ occurred in 15 patients (44%). Signs of peri-implantitis (present around 46/117 implants; 39%) appeared to be associated with the occurrence of peri-implant MRONJ. Patients receiving antiresorptive drugs in high doses seem to be at risk of developing MRONJ in the vicinity of dental implants. Peri-implantitis may be associated with the etiology of peri-implant MRONJ. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.jcms.2016.09.018"],["dc.identifier.isi","000391904100013"],["dc.identifier.pmid","27836551"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38799"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Churchill Livingstone"],["dc.relation.issn","1878-4119"],["dc.relation.issn","1010-5182"],["dc.title","Clinical features of peri-implant medication-related osteonecrosis of the jaw: Is there an association to peri-implantitis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1618"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery"],["dc.bibliographiccitation.lastpage","1629"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Kauffmann, Philipp"],["dc.contributor.author","Gruber, Rudolph"],["dc.contributor.author","Brockmeyer, Phillipp"],["dc.contributor.author","Moser, Norman"],["dc.contributor.author","Rau, Anna"],["dc.contributor.author","Schliephake, Henning"],["dc.date.accessioned","2018-06-25T07:48:54Z"],["dc.date.available","2018-06-25T07:48:54Z"],["dc.date.issued","2016-10"],["dc.description.abstract","To evaluate the efficacy of grafting materials in lateral and vertical ridge augmentations."],["dc.identifier.doi","10.1016/j.jcms.2016.07.028"],["dc.identifier.pmid","27622971"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15135"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4119"],["dc.title","Clinical efficacy of grafting materials in alveolar ridge augmentation: A systematic review"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","79"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","86"],["dc.bibliographiccitation.volume","74"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Knoesel, Thomas"],["dc.contributor.author","Woodlock, Timothy"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Pianka, Alix"],["dc.contributor.author","Probst, Florian Andreas"],["dc.contributor.author","Mast, Gerson"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.date.accessioned","2018-11-07T10:21:37Z"],["dc.date.available","2018-11-07T10:21:37Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: To determine the proportion of patients with cervical metastases caused by maxillary oral squamous cell carcinoma (OSCC) and to identify any clinical or pathologic parameters that might be associated with the occurrence of metastatic neck disease. Materials and Methods: A retrospective cohort study of all patients managed with primary surgical resection of maxillary OSCC at the authors' institution from 2006 through 2013 was performed. Cervical lymph node dissection and adjuvant therapy were performed as warranted by preoperative staging examinations or histopathologic evaluation or as recommended after multidisciplinary consultation, and regular follow-up protocols were followed. In this analysis, each maxillary OSCC was assigned to an anterior or a posterior anatomic group based on the location of the primary lesion, with the anatomic tumor location serving as the predictor variable and the occurrence of cervical lymph node metastases as the outcome variable. Descriptive and inferential statistics were calculated with a significance level set at a P value less than .05 and post hoc power analyses were performed. Results: The study sample was composed of 92 patients (38 women, 54 men; average age, 60.9 yr). Overall, 27 patients developed cervical metastases (29.3%). Neck disease was present in 15 patients (16.3%) at initial presentation. Delayed cervical metastases were diagnosed in 12 patients (13%) and manifested after an average period of 11.17 months. The anatomic location of the OSCC within the maxillary structures (anterior vs posterior) and the histologic grade greatly influenced the occurrence of metastatic neck disease. No associations were found for the variables tumor size and resection status. Conclusion: In this series, cervical lymph node metastases were frequent and to some degree predictable based on anatomic location and tumor grade. (C) 2016 American Association of Oral and Maxillofacial Surgeons"],["dc.identifier.doi","10.1016/j.joms.2015.07.011"],["dc.identifier.isi","000367357900012"],["dc.identifier.pmid","26259692"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42128"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1531-5053"],["dc.relation.issn","0278-2391"],["dc.title","Are There Clinical or Pathological Parameters of Maxillary Oral Squamous Cell Carcinoma With an Influence on the Occurrence of Neck Node Metastasis? An Appraisal of 92 Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","75"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Pache, Christoph"],["dc.contributor.author","Probst, Florian Andreas"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.date.accessioned","2018-11-07T09:47:12Z"],["dc.date.available","2018-11-07T09:47:12Z"],["dc.date.issued","2014"],["dc.description.abstract","Purpose: The current recommendations for the treatment of bacterial salivary gland infections are mainly empirical. Therefore, an evidence-based literature review was conducted to identify antibiotics with favorable pharmacokinetics in saliva and to establish recommendations for the antibiotic treatment of sialadenitis. Materials and Methods: The authors performed a systematic review of the pertinent literature published from 1985 to 2013. If the predefined inclusion criteria were met, the articles were screened for various variables: antibiotic type, mode of administration, type of examined saliva, peak salivary antibiotic concentrations, biochemical methodology, and minimal inhibitory concentrations of bacteria implicated in sialadenitis (Staphylococcus aureus, Viridans streptococci, various gram-negative strains, and anaerobes). Results: The review included 18 studies. The systematic analysis of the reported results concurred that intravenously administered cephalosporins achieve the highest concentrations in saliva, followed by orally administered cephalosporins and fluoroquinolones. These concentrations exceed the minimal inhibitory concentrations of the bacteria of interest. Phenoxymethylpenicillin and tetracyclines are not secreted in the saliva at bactericidal levels. The antibiotic peak salivary levels depended on the type of saliva examined (parotid vs submandibular vs minor salivary gland) and the biochemical method of measurement (high-performance liquid chromatography vs bioassay). Conclusion: Cephalosporins and fluoroquinolones display superior pharmacokinetics in saliva and cover the spectrum of all bacteria implicated in sialadenitis. Within the limitations of this review, they can be recommended for the treatment of bacterial salivary gland infections. (C) 2014 American Association of Oral and Maxillofacial Surgeons"],["dc.identifier.doi","10.1016/j.joms.2013.06.214"],["dc.identifier.isi","000328604500015"],["dc.identifier.pmid","23992785"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35057"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1531-5053"],["dc.relation.issn","0278-2391"],["dc.title","Antibiotic Concentrations in Saliva: A Systematic Review of the Literature, With Clinical Implications for the Treatment of Sialadenitis"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","795"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","QUINTESSENCE INTERNATIONAL"],["dc.bibliographiccitation.lastpage","802"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Messlinger, Karl"],["dc.contributor.author","Brodine, Brian"],["dc.contributor.author","Gassling, Volker"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.date.accessioned","2018-11-07T09:34:19Z"],["dc.date.available","2018-11-07T09:34:19Z"],["dc.date.issued","2014"],["dc.description.abstract","Objective: To investigate the efficacy of conservative dental treatment (occlusal splint and pharmacologic therapy) and invasive therapy (prosthetic restorations) in the treatment of tension-type headache (TTH). Method and Materials: The study sample was composed of 70 patients who presented with symptomatic TTH and were assigned to three treatment groups according to their treatment needs. Group A (30 patients): a conservative treatment protocol with a combination of an occlusal splint and analgesic and muscle relaxant medication. Group B (10 patients): invasive prosthodontic procedures. Group C (30 patients): patients who refused any type of treatment but consented to the study served as a control group. Pain quality was measured with the Headache Impact Test (HIT-6). The statistical analysis was performed with the Wilcoxon rank test (P <= .05). Results: Conservative treatment with splints and analgesic medication and invasive treatment by prosthetic rehabilitation relieved the TTH symptoms. The patients who received treatment experienced a significant reduction in their discomfort after 6 months (P <= .01), whereas the patients who refused therapy remained, on average, at the same pain level (P <= .117). In group A, the HIT-6 score was reduced for 26 patients, and in group B for 8 patients. In group C a reduction of HIT-6 scores was observed in 10 patients. Conclusion: Conservative or invasive occlusal adjustments may serve as a useful tool in the treatment of TTH."],["dc.identifier.doi","10.3290/j.qi.a32245"],["dc.identifier.isi","000343920000011"],["dc.identifier.pmid","25019119"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32148"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Quintessence Publishing Co Inc"],["dc.relation.issn","1936-7163"],["dc.relation.issn","0033-6572"],["dc.title","A comparison of conservative and invasive dental approaches in the treatment of tension-type headache"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1291"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","1300"],["dc.bibliographiccitation.volume","72"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Knoesel, Thomas"],["dc.contributor.author","Eichinger, Christina"],["dc.contributor.author","Probst, Florian"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Woodlock, Timothy"],["dc.contributor.author","Mast, Gerson"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Otto, Sven"],["dc.date.accessioned","2018-11-07T09:38:18Z"],["dc.date.available","2018-11-07T09:38:18Z"],["dc.date.issued","2014"],["dc.description.abstract","Purpose: To analyze clinicopathologic parameters of oral squamous cell carcinoma (OSCC) in different age groups. We hypothesized that clinical and pathologic parameters of OSCCs will vary in different age groups. Materials and Methods: A retrospective cohort study was performed. All patients who were treated for a primary manifestation of OSCC at a single institution from 2001 to 2012 were reviewed and allocated to predefined age groups (predictor variable) as follows: young (<= 40 years), middle-aged (40-80 years), and very elderly (>= 80 years). The following outcome variables were recorded: demographic parameters, classic risk factors, tumor location and size, neck node involvement, histopathologic and therapeutic details, and association with human papillomavirus (HPV). The descriptive statistics were computed. Parametric and nonparametric tests were used for additional analysis. The significance level was set at P <.05. Results: We reviewed 739 patients and identified 11 (1.4%) young (mean age 34.2 +/- 2.8 years) and 17 (2.3%) very elderly patients (mean age 83.1 +/- 1.2 years). The predilection site for OSCC was the oral tongue (63%) in young patients, the floor of the mouth (52%) in middle-aged patients, and the alveolar process (60%) in very elderly patients. One patient in the young group (9%) and 8 patients in the very elderly group (47%) had been exposed to risk factors; however, all of the examined middle-aged patients had had such exposure. The association of OSCC with HPV was distributed equally among the age groups. No age-related differences in the histopathologic parameters of OSCC were found. Conclusions: The features of OSCC that vary at different ages are the anatomic predilection site and the association with classic risk factors. HPV was not an age-related independent risk factor for OSCC development in the present study. (C) 2014 American Association of Oral and Maxillofacial Surgeons"],["dc.identifier.doi","10.1016/j.joms.2014.01.009"],["dc.identifier.isi","000338424500013"],["dc.identifier.pmid","24813775"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33042"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1531-5053"],["dc.relation.issn","0278-2391"],["dc.title","Clinicopathologic Features of Oral Squamous Cell Carcinoma: Do They Vary in Different Age Groups?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","969"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Oral and Maxillofacial Surgery"],["dc.bibliographiccitation.lastpage","977"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Troeltzsch, Matthias"],["dc.contributor.author","Woodlock, Timothy"],["dc.contributor.author","Pianka, Alix"],["dc.contributor.author","Otto, Sven"],["dc.contributor.author","Troeltzsch, Markus"],["dc.contributor.author","Ehrenfeld, Michael"],["dc.contributor.author","Knoesel, Thomas"],["dc.date.accessioned","2018-11-07T10:23:57Z"],["dc.date.available","2018-11-07T10:23:57Z"],["dc.date.issued","2017"],["dc.description.abstract","Purpose: To examine oral squamous cell carcinoma (OSCC) specimens for programmed death ligand-1 (PD-L1) expression and presence of programmed death-1 (PD-1)-positive tumor-infiltrating lymphocytes (TILs) and to determine possible clinicopathologic implications. It was hypothesized that PD-L1 expression and PD-1-positive TIL presence in OSCC would have no clinical relevance. Materials and Methods: The authors implemented a retrospective cohort study design. The study cohort was chosen in compliance with predefined inclusion criteria. Demographic, clinical, and histopathologic data were gathered. Tissue microarrays were obtained from paraffin-embedded OSCC specimens and analyzed immunohistochemically for PD-L1 expression and PD-1-positive TIL infiltration. PD-L1 positivity of OSCC specimens served as the predictor variable and neck node metastasis served as the primary outcome variable. Descriptive and inferential statistics were computed and the significance level was set at a P value less than or equal to .05. Results: The study sample was composed of 88 patients (48 men, 40 women; mean age, 61.34 yr). Marked PD-L1 expression was detected in 29% of OSCC specimens (26 of 88) and 83% of specimens (73 of 88) exhibited a high rate of PD-1-positive TIL infiltration. PD-L1 positivity of OSCC samples was significantly associated with the anatomic origin of OSCC (P = .039), presence of cervical metastasis (P = .039), and high PD-L1-positive TIL infiltration (P = .033). Conclusion: A considerable proportion of OSCCs exhibited marked PD-L1 expression. This could be associated with clinical parameters. PD-L1 expression in OSCC might differ depending on its anatomic origin. PD-1-positive TILs could be detected in most OSCC specimens. These findings might indicate a potential role for the PD-1 and PD-L1 pathway in OSCC.(C) 2016 American Association of Oral and Maxillofacial Surgeons"],["dc.identifier.doi","10.1016/j.joms.2016.11.006"],["dc.identifier.isi","000404554600021"],["dc.identifier.pmid","27916470"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42564"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","W B Saunders Co-elsevier Inc"],["dc.relation.issn","1531-5053"],["dc.relation.issn","0278-2391"],["dc.title","Is There Evidence for the Presence and Relevance of the PD-1/PD-L1 Pathway in Oral Squamous Cell Carcinoma? Hints From an Immunohistochemical Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]