Zimmermann, Jasper L.

[["dc.bibliographiccitation.firstpage","1423"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Kidney International"],["dc.bibliographiccitation.lastpage","1432"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Schramm, L."],["dc.contributor.author","La, M."],["dc.contributor.author","Heidbreder, E."],["dc.contributor.author","Hecker, M."],["dc.contributor.author","Beckman, J. S."],["dc.contributor.author","Lopau, K."],["dc.contributor.author","Zimmermann, J."],["dc.contributor.author","Rendl, J."],["dc.contributor.author","Reiners, C."],["dc.contributor.author","Winderl, S."],["dc.contributor.author","Wanner, C."],["dc.contributor.author","Schmidt, HHHW"],["dc.date.accessioned","2018-11-07T10:30:57Z"],["dc.date.available","2018-11-07T10:30:57Z"],["dc.date.issued","2002"],["dc.description.abstract","Background. The \"L-arginine paradox\" refers to situations where L-arginine (L-Arg) supplementation stimulates nitric oxide (NO) synthesis, despite saturating intracellular concentrations. This paradox is frequently observed in acute renal failure (ARF). First, the effects of L-Arg on renal function of rats with ARF were studied. Based on the promising results from these initial studies, the second part of our study searched for a form of ARF in humans that could be studied easily under conditions with little variance and yet was linked with endothelial dysfunction. Thus, we investigated the effects of L-Arg supplementation immediately after kidney transplantation in 54 patients. Methods. In uranyl nitrate-induced ARF in rats the effects of L-Arg and L-NNA (inhibitor of nitric oxide synthase; NOS) on glomerular filtration rate (GFR), renal plasma flow (RPF), blood pressure (BP) and NOx (NO2- + NO3-) excretion were examined. Tissue L-Arg levels, NOS activities, immunodetection of NOS and superoxide dismutase (SOD), activities of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and xanthine oxidase, and nitrotyrosine immunoreactive protein (NT-IR) were determined and compared to sham operated animals. Secondly, in a randomized, double-blind study, the effects of L-Arg on GFR and RPF were investigated in 54 kidney transplant recipients, receiving IV L-Arg for three days. GFR and RPF were measured on days 1, 3, 5 and 10 by scintigraphy. Results. In experimental ARF, decreased RPF and GFR were associated with reduced tissue L-Arg levels, endothelial NOS-III expression, NO formation and NOx excretion. Reduction in GFR, RPF and NO, excretion were reversed upon administration of exogenous L-Arg. There also was a loss of Cu,Zn-SOD, a key enzyme against oxidative stress, and an elevation of NT-IR, an indicator of nitrosative stress and suggested marker for pathological actions of NO. However, NT-IR was not dependent on de novo NO synthesis and not related to the functional effects of L-Arg administration. In kidney transplant recipients receiving organs with a short cold ischemia time (CIT) and from young donors, that is, those with a higher likelihood of a functional endothelium, early administration of L-Arg improved renal function. Conclusion. Both experimental and clinical data show that L-Arg deficiency and endothelial dysfunction are pathomechanistically relevant in ARE The data suggest a therapeutic potential for the administration of L-Arg in ARF and kidney transplantation, at least in patients receiving kidneys with shorter CIT and from younger donors."],["dc.identifier.doi","10.1046/j.1523-1755.2002.00268.x"],["dc.identifier.isi","000174465100024"],["dc.identifier.pmid","11918749"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43984"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.relation.issn","0085-2538"],["dc.title","L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]