Tietze, Lutz Friedjan

[["dc.bibliographiccitation.firstpage","193"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arkivoc"],["dc.bibliographiccitation.lastpage","210"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Liu, Deshan"],["dc.date.accessioned","2019-07-10T08:13:58Z"],["dc.date.available","2019-07-10T08:13:58Z"],["dc.date.issued","2008"],["dc.description.abstract","A multi-step synthesis of the aminonaphthalene derivate 1 as a key intermediate in the synthesis of the duocarmycin based prodrug 2 for a selective treatment of cancer in a microreactor is described. The conditions for the synthesis in the batch mode were adjusted for application in a microreactor and the results of both methods were compared showing that the transformations in the microreactor in most cases give similar or even better results with the advantage of a continuous-flow production, higher safety and faster reactions with an empirical accelerating factor of F = 3–10."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8412"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61393"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1551-7004"],["dc.rights.access","openAccess"],["dc.subject","Biphasic reactions; continuous flow reaction; Friedel-Crafts acylation; microreactor; olefination; Curtius rearrangement"],["dc.subject.ddc","540"],["dc.title","Continuous-flow microreactor multi-step synthesis of an aminonaphthalene derivative as starting material for the preparation of novel anticancer agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]