Tietze, Lutz Friedjan

[["dc.bibliographiccitation.firstpage","434"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Chemistry of Heterocyclic Compounds"],["dc.bibliographiccitation.lastpage","445"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Bischoff, Matthias"],["dc.contributor.author","Khan, Taukeer A."],["dc.contributor.author","Liu, Deshan"],["dc.date.accessioned","2018-11-07T10:25:14Z"],["dc.date.available","2018-11-07T10:25:14Z"],["dc.date.issued","2017"],["dc.description.abstract","The fused heterocyclic indolizinoquinolinone system is a key structural feature of several highly bioactive alkaloids, including camptothecin. Camptothecin has been efficiently obtained by a three- or four-component domino Knoevenagel / hetero-Diels-Alder reaction of aldehyde, Meldrum's acid, and enol ether in the presence or absence of alcohol, followed by reductive cleavage of the amine protecting group. The obtained products were further transformed along several different routes leading to camptothecin."],["dc.identifier.doi","10.1007/s10593-017-2070-4"],["dc.identifier.isi","000401912500008"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1573-8353"],["dc.relation.issn","0009-3122"],["dc.title","Synthesis of indolizinoquinolinones through three- and four-component domino Knoevenagel/hetero-Diels-Alder reactions: novel access to (+)-camptothecin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","193"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arkivoc"],["dc.bibliographiccitation.lastpage","210"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Liu, Deshan"],["dc.date.accessioned","2019-07-10T08:13:58Z"],["dc.date.available","2019-07-10T08:13:58Z"],["dc.date.issued","2008"],["dc.description.abstract","A multi-step synthesis of the aminonaphthalene derivate 1 as a key intermediate in the synthesis of the duocarmycin based prodrug 2 for a selective treatment of cancer in a microreactor is described. The conditions for the synthesis in the batch mode were adjusted for application in a microreactor and the results of both methods were compared showing that the transformations in the microreactor in most cases give similar or even better results with the advantage of a continuous-flow production, higher safety and faster reactions with an empirical accelerating factor of F = 3–10."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8412"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61393"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1551-7004"],["dc.rights.access","openAccess"],["dc.subject","Biphasic reactions; continuous flow reaction; Friedel-Crafts acylation; microreactor; olefination; Curtius rearrangement"],["dc.subject.ddc","540"],["dc.title","Continuous-flow microreactor multi-step synthesis of an aminonaphthalene derivative as starting material for the preparation of novel anticancer agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]