Tietze, Lutz Friedjan

[["dc.bibliographiccitation.artnumber","cmdc.202100222"],["dc.bibliographiccitation.firstpage","3300"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","ChemMedChem"],["dc.bibliographiccitation.lastpage","3305"],["dc.bibliographiccitation.volume","16"],["dc.contributor.affiliation","Raad, Farah S.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Khan, Taukeer A.; 2\r\nDZHK (German Center for Cardiovascular Research) – Partner site Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Esser, Tilman U.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Hudson, James E.; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Seth, Bhakti Irene; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Fujita, Buntaro; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Gandamala, Ravi; 3\r\nInstitute of Organic and Biomolecular Chemistry\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.affiliation","Tietze, Lutz F.; 2\r\nDZHK (German Center for Cardiovascular Research) – Partner site Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Zimmermann, Wolfram-Hubertus; 1\r\nInstitute of Pharmacology and Toxicology\r\nUniversity Medical Center\r\nGeorg-August-University\r\nGöttingen Germany"],["dc.contributor.author","Raad, Farah S."],["dc.contributor.author","Khan, Taukeer A."],["dc.contributor.author","Esser, Tilman U."],["dc.contributor.author","Hudson, James E."],["dc.contributor.author","Seth, Bhakti Irene"],["dc.contributor.author","Fujita, Buntaro"],["dc.contributor.author","Gandamala, Ravi"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Zimmermann, Wolfram H."],["dc.date.accessioned","2021-10-01T09:58:46Z"],["dc.date.available","2021-10-01T09:58:46Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T00:45:29Z"],["dc.description.abstract","Abstract Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone morphogenetic protein 4 (BMP4) is key for early cardiac mesoderm induction in hPSC and subsequent cardiomyocyte derivation. Small‐molecular BMP4 mimetics may help to standardize cardiomyocyte derivation from hPSCs. Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction. To test this, we set up a two‐tiered screening strategy, (1) for directed differentiation of hPSCs with commercially available chalcones (4’‐hydroxychalcone [4’HC] and Isoliquiritigen) and 24 newly synthesized chalcone derivatives, and (2) a functional screen to assess the propensity of the obtained cardiomyocytes to self‐organize into contractile engineered human myocardium (EHM). We identified 4’HC, 4‐fluoro‐4’‐methoxychalcone, and 4‐fluoro‐4’‐hydroxychalcone as similarly effective in cardiac mesoderm induction, but only 4’HC as an effective replacement for BMP4 in the derivation of contractile EHM‐forming cardiomyocytes."],["dc.description.abstract","Have a little heart: A screen for mesoderm inducing chalcones in human pluripotent stem cell cultures identified 4’‐hydroxychalcone (4’HC) as an effective replacement for bone‐morphogenetic protein 4 (BMP4) in supporting the derivation of engineered heart muscle (EHM)‐formation competent cardiomyocytes. image"],["dc.description.sponsorship","German Center for Cardiovascular Research"],["dc.description.sponsorship","German Federal Ministry for Science and Education"],["dc.description.sponsorship","German Research Foundation http://dx.doi.org/10.13039/501100001659"],["dc.description.sponsorship","Fondation Leducq http://dx.doi.org/10.13039/501100001674"],["dc.identifier.doi","10.1002/cmdc.202100222"],["dc.identifier.pmid","34309224"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90137"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/432"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","1860-7187"],["dc.relation.issn","1860-7179"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Chalcone‐Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","134"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Toxins"],["dc.bibliographiccitation.lastpage","150"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Krewer, Birgit"],["dc.contributor.author","von Hof, J. Marian"],["dc.contributor.author","Frauendorf, Holm"],["dc.contributor.author","Schuberth, Ingrid"],["dc.date.accessioned","2018-11-07T11:21:49Z"],["dc.date.available","2018-11-07T11:21:49Z"],["dc.date.issued","2009"],["dc.description.abstract","The natural antibiotics CC-1065 and the duocarmycins are highly cytotoxic compounds which however are not suitable for cancer therapy due to their general toxicity. We have developed glycosidic prodrugs of seco-analogues of these antibiotics for a selective cancer therapy using conjugates of glycohydrolases and tumour-selective monoclonal antibodies for the liberation of the drugs from the prodrugs predominantly at the tumour site. For the determination of structure activity relationships of the different seco-drugs, experiments addressing their interaction with synthetic DNA were performed. Using electrospray mass spectrometry and high performance liquid chromatography, the experiments revealed a correlation of the stability of these drugs with their cytotoxicity in cell culture investigations. Furthermore, it was shown that the drugs bind to AT-rich regions of double-stranded DNA and the more cytotoxic drugs induce DNA fragmentation at room temperature in several of the selected DNA double-strands. Finally, an explanation for the very high cytotoxicity of CC-1065, the duocarmycins and analogous drugs is given."],["dc.identifier.doi","10.3390/toxins1020134"],["dc.identifier.isi","000208434400006"],["dc.identifier.pmid","22069536"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55867"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","2072-6651"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","437"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Analytical and Bioanalytical Chemistry"],["dc.bibliographiccitation.lastpage","448"],["dc.bibliographiccitation.volume","395"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Krewer, Birgit"],["dc.contributor.author","Frauendorf, Holm"],["dc.date.accessioned","2018-11-07T11:24:30Z"],["dc.date.available","2018-11-07T11:24:30Z"],["dc.date.issued","2009"],["dc.description.abstract","One of the main problems of anti-cancer therapy is an insufficient differentiation between normal and malignant cells by the known anti-proliferant agents. The antibody-directed enzyme prodrug therapy is a promising approach for a selective treatment of cancer, in which a non-toxic prodrug is enzymatically converted into a highly cytotoxic drug at the surface of malignant cells by a targeted antibody-enzyme conjugate. The transformations and the stability of a very promising novel prodrug and its corresponding cytotoxic derivative were now investigated in detail by high-performance liquid chromatography (HPLC)-mass spectrometry (MS). In order to determine the time-dependent DNA alkylation efficiency and the sequence selectivity of the novel compounds, DNA binding studies using direct electrospray-Fourier transform ion cyclotron resonance-MS (ESI-FTICR-MS) have been performed. These measurements were accompanied by HPLC analyses followed by MS of the separated species to confirm the results of the direct ESI-FTICR-MS measurements. The sites of DNA alkylation could be identified unambiguously by the mass spectrometric fragmentation pattern of the alkylated oligodeoxynucleotides as well as by the results of HPLC followed by MS. A combination of all techniques applied led to a better understanding of the mode of action of the new therapeutics and might be used for an estimation of the cytotoxicity of different prodrugs and drugs since the alkylation efficiency correlates with the bioactivity of the compounds in cell culture investigations."],["dc.identifier.doi","10.1007/s00216-009-2963-x"],["dc.identifier.isi","000269006500020"],["dc.identifier.pmid","19641906"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3483"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56421"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.conference","27th International Symposium on Chromatography"],["dc.relation.eventlocation","Munster, GERMANY"],["dc.relation.issn","1618-2642"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Investigation of the transformations of a novel anti-cancer agent combining HPLC, HPLC-MS and direct ESI-HRMS analyses"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","721"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","European Biophysics Journal"],["dc.bibliographiccitation.lastpage","733"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Pardo, Luis A."],["dc.contributor.author","Hartung, Franziska"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Stühmer, Walter"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2018-11-07T10:07:59Z"],["dc.date.available","2018-11-07T10:07:59Z"],["dc.date.issued","2016"],["dc.description.abstract","The K(v)10.1 (Eag1) voltage-gated potassium channel represents a promising molecular target for novel cancer therapies or diagnostic purposes. Physiologically, it is only expressed in the brain, but it was found overexpressed in more than 70 % of tumours of diverse origin. Furthermore, as a plasma membrane protein, it is easily accessible to extracellular interventions. In this study we analysed the feasibility of the anti-K(v)10.1 monoclonal antibody mAb62 to target tumour cells in vitro and in vivo and to deliver therapeutics to the tumour. Using time-domain near infrared fluorescence (NIRF) imaging in a subcutaneous MDA-MB-435S tumour model in nude mice, we showed that mAb62-Cy5.5 specifically accumulates at the tumour for at least 1 week in vivo with a maximum intensity at 48 h. Blocking experiments with an excess of unlabelled mAb62 and application of the free Cy5.5 fluorophore demonstrate specific binding to the tumour. Ex vivo NIRF imaging of whole tumours as well as NIRF imaging and microscopy of tumour slices confirmed the accumulation of the mAb62-Cy5.5 in tumours but not in brain tissue. Moreover, mAb62 was conjugated to the prodrug-activating enzyme beta-D-galactosidase (beta-gal; mAb62-beta-gal). The beta-gal activity of the mAb62-beta-gal conjugate was analysed in vitro on K(v)10.1-expressing MDAMB-435S cells in comparison to control AsPC-1 cells. We show that the mAb62-beta-gal conjugate possesses high beta-gal activity when bound to K(v)10.1-expressing MDA-MB-435S cells. Moreover, using the beta-gal activatable NIRF probe DDAOG, we detected mAb62-beta-gal activity in vivo over the tumour area. In summary, we could show that the anti-K(v)10.1 antibody is a promising tool for the development of novel concepts of targeted cancer therapy."],["dc.identifier.doi","10.1007/s00249-016-1152-z"],["dc.identifier.isi","000384822200012"],["dc.identifier.pmid","27444284"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13779"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39387"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","1432-1017"],["dc.relation.issn","0175-7571"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","In vivo imaging of tumour xenografts with an antibody targeting the potassium channel K(v)10.1"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Planta"],["dc.bibliographiccitation.volume","231"],["dc.contributor.author","Schubert, Maria"],["dc.contributor.author","Melnikova, Anna N."],["dc.contributor.author","Mesecke, Nikola"],["dc.contributor.author","Zubkova, Elena K."],["dc.contributor.author","Fortte, Rocco"],["dc.contributor.author","Batashev, Denis R."],["dc.contributor.author","Barth, Inga"],["dc.contributor.author","Sauer, Norbert"],["dc.contributor.author","Gamalei, Yuri V."],["dc.contributor.author","Mamushina, Natalia S."],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Voitsekhovskaja, Olga V."],["dc.contributor.author","Pawlowski, Katharina"],["dc.date.accessioned","2018-11-07T08:46:36Z"],["dc.date.available","2018-11-07T08:46:36Z"],["dc.date.issued","2010"],["dc.format.extent","523"],["dc.identifier.doi","10.1007/s00425-009-1085-1"],["dc.identifier.isi","000273626500003"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20731"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.iserratumof","/handle/2/20729"],["dc.relation.issn","0032-0935"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Erratum to: Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata (vol 231, pg 507, 2010)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","erratum_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","193"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Arkivoc"],["dc.bibliographiccitation.lastpage","210"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Liu, Deshan"],["dc.date.accessioned","2019-07-10T08:13:58Z"],["dc.date.available","2019-07-10T08:13:58Z"],["dc.date.issued","2008"],["dc.description.abstract","A multi-step synthesis of the aminonaphthalene derivate 1 as a key intermediate in the synthesis of the duocarmycin based prodrug 2 for a selective treatment of cancer in a microreactor is described. The conditions for the synthesis in the batch mode were adjusted for application in a microreactor and the results of both methods were compared showing that the transformations in the microreactor in most cases give similar or even better results with the advantage of a continuous-flow production, higher safety and faster reactions with an empirical accelerating factor of F = 3–10."],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8412"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61393"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1551-7004"],["dc.rights.access","openAccess"],["dc.subject","Biphasic reactions; continuous flow reaction; Friedel-Crafts acylation; microreactor; olefination; Curtius rearrangement"],["dc.subject.ddc","540"],["dc.title","Continuous-flow microreactor multi-step synthesis of an aminonaphthalene derivative as starting material for the preparation of novel anticancer agents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","821"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.lastpage","837"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Panknin, Olaf"],["dc.contributor.author","Krewer, Birgit"],["dc.contributor.author","Major, Felix"],["dc.contributor.author","Schuberth, Ingrid"],["dc.date.accessioned","2018-11-07T11:15:34Z"],["dc.date.available","2018-11-07T11:15:34Z"],["dc.date.issued","2008"],["dc.description.abstract","A novel carbamate prodrug 2 containing a pentagastrin moiety was synthesized. 2 was designed as a detoxified analogue of the highly cytotoxic natural antibiotic duocarmycin SA (1) for the use in a targeted prodrug monotherapy of cancers expressing cholecystokinin (CCK-B)/gastrin receptors. The synthesis of prodrug 2 was performed using a palladium-catalyzed carbonylation of bromide 6, followed by a radical cyclisation to give the pharmacophoric unit 10, coupling of 10 to the DNA-binding subunit 15 and transformation of the resulting seco-drug 3b into the carbamate 2 via addition of a pentagastrin moiety."],["dc.identifier.doi","10.3390/ijms9050821"],["dc.identifier.isi","000256308000009"],["dc.identifier.pmid","19325786"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54393"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mdpi Ag"],["dc.relation.issn","1661-6596"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological evaluation of a novel pentagastrin-toxin conjugate designed for a targeted prodrug monotherapy of cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","22"],["dc.bibliographiccitation.journal","Arkivoc"],["dc.bibliographiccitation.lastpage","28"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Vanden Eynde, Jean Jacques"],["dc.contributor.author","Labuche, Nadège"],["dc.contributor.author","Van Haverbeke, Yves"],["dc.contributor.author","Tietze, Lutz"],["dc.date.accessioned","2019-07-10T08:13:57Z"],["dc.date.available","2019-07-10T08:13:57Z"],["dc.date.issued","2003"],["dc.description.abstract","Nine novel ethyl 2-amino-4,6-diarylpyrimidine-5-carboxylates have been synthesized in modest to good yields by a five-step procedure that involves building of the heterocyclic moiety on a solid support derived from Merrifield’s resin and final displacement with an amine."],["dc.identifier.fs","21935"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8383"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61389"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1551-7004"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","540"],["dc.title","Polymer-assisted synthesis of ethyl 2-amino-4,6-diarylpyrimidine-5-carboxylates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","507"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Planta"],["dc.bibliographiccitation.lastpage","521"],["dc.bibliographiccitation.volume","231"],["dc.contributor.author","Schubert, Maria"],["dc.contributor.author","Melnikova, Anna N."],["dc.contributor.author","Mesecke, Nikola"],["dc.contributor.author","Zubkova, Elena K."],["dc.contributor.author","Fortte, Rocco"],["dc.contributor.author","Batashev, Denis R."],["dc.contributor.author","Barth, Inga"],["dc.contributor.author","Sauer, Norbert"],["dc.contributor.author","Gamalei, Yuri V."],["dc.contributor.author","Mamushina, Natalia S."],["dc.contributor.author","Tietze, Lutz Friedjan"],["dc.contributor.author","Voitsekhovskaja, Olga V."],["dc.contributor.author","Pawlowski, Katharina"],["dc.date.accessioned","2018-11-07T08:46:35Z"],["dc.date.available","2018-11-07T08:46:35Z"],["dc.date.issued","2010"],["dc.description.abstract","Datisca glomerata forms nitrogen-fixing root nodules in symbiosis with soil actinomycetes from the genus Frankia. Analysis of sugars in roots, nodules and leaves of D. glomerata revealed the presence of two novel compounds that were identified as alpha-l-rhamnopyranoside-(1 -> 6)-d-glucose (rutinose) and alpha-l-rhamnopyranoside-(1 -> 6)-1-O-beta-d-methylglucose (methylrutinose). Rutinose has been found previously as a/the glycoside part of several flavonoid glycosides, e.g. rutin, also of datiscin, the main flavonoid of Datisca cannabina, but had not been reported as free sugar. Time course analyses suggest that both rutinose and methylrutinose might play a role in transient carbon storage in sink organs and, to a lesser extent, in source leaves. Their concentrations show that they can accumulate in the vacuole. Rutinose, but not methylrutinose, was accepted as a substrate by the tonoplast disaccharide transporter SUT4 from Arabidopsis. In vivo C-14-labeling and the study of uptake of exogenous sucrose and rutinose from the leaf apoplast showed that neither rutinose nor methylrutinose appreciably participate in phloem translocation of carbon from source to sink organs, despite rutinose being found in the apoplast at significant levels. A model for sugar metabolism in D. glomerata is presented."],["dc.identifier.doi","10.1007/s00425-009-1049-5"],["dc.identifier.isi","000273626500002"],["dc.identifier.pmid","19915863"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/4035"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20729"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.haserratum","/handle/2/20731"],["dc.relation.issn","1432-2048"],["dc.relation.issn","0032-0935"],["dc.rights.access","openAccess"],["dc.subject.ddc","570"],["dc.title","Two novel disaccharides, rutinose and methylrutinose, are involved in carbon metabolism in Datisca glomerata"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","12"],["dc.bibliographiccitation.journal","Arkivoc"],["dc.bibliographiccitation.lastpage","21"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Tietze, Lutz F."],["dc.contributor.author","Böhnke, Niels"],["dc.contributor.author","Brasche, Gordon"],["dc.date.accessioned","2019-07-10T08:13:57Z"],["dc.date.available","2019-07-10T08:13:57Z"],["dc.date.issued","2007"],["dc.description.abstract","A synthesis of 2-acetoxy-D-forosamine (4) starting from 1,2-O-propylidene-α-D-abequose (3,6- dideoxy-1,2-O-propylidene-α-D-xylo-hexopyranose) (5) was developed by introduction of an azide moiety at C-4 with inversion of configuration. The 2-acetoxy group in 4 allows a β-selective glycosidation of a secondary alcohol moiety which is necessary in the total synthesis of spinosyns."],["dc.identifier.fs","44677"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8384"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61390"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1551-7004"],["dc.relation.orgunit","Fakultät für Chemie"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","540"],["dc.title","Preparation of (2R)-2-acetoxy-D-forosamine for the total synthesis of spinosyns"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]