Jacobshagen, Claudius

[["dc.bibliographiccitation.artnumber","A1203"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Sibbing, Dirk"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Geisler, Tobias"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Kiss, Robert"],["dc.contributor.author","Komócsi, András"],["dc.contributor.author","Parma, Radoslaw"],["dc.contributor.author","Gori, Tommaso"],["dc.contributor.author","Felix, Stephan"],["dc.contributor.author","Schwinger, Robert"],["dc.contributor.author","Neumann, Franz-Josef"],["dc.contributor.author","Hausleiter, Joerg"],["dc.contributor.author","Baylacher, Monika"],["dc.contributor.author","Koltowski, Lukasz"],["dc.contributor.author","Mehilli, Julinda"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Massberg, Steffen"],["dc.date.accessioned","2020-06-16T13:50:21Z"],["dc.date.available","2020-06-16T13:50:21Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/S0735-1097(18)31744-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66384"],["dc.relation.issn","0735-1097"],["dc.title","Age And Outcomes Following Guided De-Escalation Of Antiplatelet Treatment In Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Results Of A Randomized Multicentre Trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1656"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","1667"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Krieg, Anne"],["dc.contributor.author","Gawaz, Meinrad"],["dc.contributor.author","Massberg, Steffen"],["dc.contributor.author","Baylacher, Monika"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Stimpfle, Fabian"],["dc.contributor.author","Hromek, Julia"],["dc.contributor.author","Vogelgesang, Anja"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Sibbing, Dirk"],["dc.contributor.author","Geisler, Tobias"],["dc.date.accessioned","2020-06-16T13:49:59Z"],["dc.date.available","2020-06-16T13:49:59Z"],["dc.date.issued","2018-09"],["dc.description.abstract"," Phenotype-guided de-escalation (PGDE) of P2Y12-inhibitor treatment with an early switch from prasugrel to clopidogrel was identified as an effective alternative treatment strategy in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). The Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Genotyping Substudy aimed to investigate whether CYP2C19 genotypes correlate with on-treatment platelet reactivity (PR) in ACS patients treated with clopidogrel or prasugrel and thus might be useful for guidance of early de-escalation of anti-platelet treatment."],["dc.identifier.doi","10.1055/s-0038-1667337"],["dc.identifier.pmid","30103241"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66380"],["dc.language.iso","en"],["dc.relation.eissn","2567-689X"],["dc.relation.issn","0340-6245"],["dc.title","Genotype-Phenotype Association and Impact on Outcomes following Guided De-Escalation of Anti-Platelet Treatment in Acute Coronary Syndrome Patients: The TROPICAL-ACS Genotyping Substudy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1527"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","1538"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Kupka, Danny"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Geisler, Tobias"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Löw, Anja"],["dc.contributor.author","Orban, Martin"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Kiss, Robert Gabor"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Beuthner, Bo Eric"],["dc.contributor.author","Hein-Rothweiler, Ralph"],["dc.contributor.author","Baylacher, Monika"],["dc.contributor.author","Rizas, Konstantinos"],["dc.contributor.author","Massberg, Steffen"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Sibbing, Dirk"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.date.accessioned","2020-06-16T13:24:14Z"],["dc.date.available","2020-06-16T13:24:14Z"],["dc.date.issued","2019-09"],["dc.description.abstract"," This prespecified analysis of the TROPICAL-ACS trial aimed to assess the impact of gender on clinical outcomes and platelet reactivity (PR) following guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients."],["dc.identifier.doi","10.1055/s-0039-1692441"],["dc.identifier.pmid","31226717"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66375"],["dc.language.iso","en"],["dc.relation.eissn","2567-689X"],["dc.relation.issn","0340-6245"],["dc.title","Gender and Outcomes following Guided De-Escalation of Antiplatelet Treatment in Acute Coronary Syndrome Patients: The TROPICAL-ACS Gender Substudy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A1204"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Geisler, Tobias"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Stimpfle, Fabian"],["dc.contributor.author","Krieg, Anne"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Gawaz, Meinrad"],["dc.contributor.author","Massberg, Steffen"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Sibbing, Dirk"],["dc.date.accessioned","2020-06-16T13:50:16Z"],["dc.date.available","2020-06-16T13:50:16Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/S0735-1097(18)31745-5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66383"],["dc.relation.issn","0735-1097"],["dc.title","Genoytype-Phenotype Association And Impact On Outcomes Following Guided De-Escalation Of Antiplatelet Therapy In Acute Coronary Syndrome Patients"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","427"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Thrombosis and Thrombolysis"],["dc.bibliographiccitation.lastpage","435"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Koltowski, Lukasz"],["dc.contributor.author","Tomaniak, Mariusz"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Rymuza, Bartosz"],["dc.contributor.author","Kowara, Michal"],["dc.contributor.author","Parma, Radoslaw"],["dc.contributor.author","Komosa, Anna"],["dc.contributor.author","Klopotowski, Mariusz"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Gori, Tommaso"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Massberg, Steffen"],["dc.contributor.author","Lesiak, Maciej"],["dc.contributor.author","Filipiak, Krzysztof J."],["dc.contributor.author","Witkowski, Adam"],["dc.contributor.author","Opolski, Grzegorz"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Sibbing, Dirk"],["dc.date.accessioned","2019-07-09T11:51:05Z"],["dc.date.available","2019-07-09T11:51:05Z"],["dc.date.issued","2019"],["dc.description.abstract","To investigate the safety and efficacy of an early platelet function testing (PFT)-guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) with bioresorbable vascular scaffolds (BVS). Early DAPT de-escalation is a new non-inferior alternative to 12-months DAPT in patients with biomarker positive ACS treated with stent implantation. In this post-hoc analysis of the TROPICAL-ACS trial, which randomized 2610 ACS patients to a PFT-guided DAPT de-escalation (switch from prasugrel to clopidogrel) or to control group (uniform prasugrel), we compared clinical outcomes of patients (n = 151) who received a BVS during the index PCI. The frequency of the primary endpoint (cardiovascular death, myocardial infarction, stroke or BARC ≥ 2 bleeding) was 8.8% (n = 6) in the de-escalation group vs. 12.0% (n = 10) in the control group (HR 0.72, 95% CI 0.26-1.98, p = 0.52) at 12 months. One early definite stent thrombosis (ST) occurred in the control group (day 19) and 1 possible ST (sudden cardiovascular death) in the de-escalation group (day 86), both despite prasugrel treatment and in a background of high on-treatment platelet reactivity assessed at day 14 after randomization (ADP-induced platelet aggregation values of 108 U and 59 U, respectively). A PFT-guided DAPT de-escalation strategy could potentially be a safe and effective strategy in ACS patients with BVS implantation but the level of platelet inhibition may be of particular importance. This hypothesis-generating post-hoc analysis requires verification in larger studies with upcoming BVS platforms."],["dc.identifier.doi","10.1007/s11239-019-01811-2"],["dc.identifier.pmid","30739305"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59873"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]