Jacobshagen, Claudius

[["dc.bibliographiccitation.artnumber","A1203"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of the American College of Cardiology"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Sibbing, Dirk"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Geisler, Tobias"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Merkely, Bela"],["dc.contributor.author","Kiss, Robert"],["dc.contributor.author","Komócsi, András"],["dc.contributor.author","Parma, Radoslaw"],["dc.contributor.author","Gori, Tommaso"],["dc.contributor.author","Felix, Stephan"],["dc.contributor.author","Schwinger, Robert"],["dc.contributor.author","Neumann, Franz-Josef"],["dc.contributor.author","Hausleiter, Joerg"],["dc.contributor.author","Baylacher, Monika"],["dc.contributor.author","Koltowski, Lukasz"],["dc.contributor.author","Mehilli, Julinda"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Massberg, Steffen"],["dc.date.accessioned","2020-06-16T13:50:21Z"],["dc.date.available","2020-06-16T13:50:21Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/S0735-1097(18)31744-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66384"],["dc.relation.issn","0735-1097"],["dc.title","Age And Outcomes Following Guided De-Escalation Of Antiplatelet Treatment In Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Results Of A Randomized Multicentre Trial"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","188"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Thrombosis and Haemostasis"],["dc.bibliographiccitation.lastpage","195"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Sibbing, Dirk"],["dc.contributor.author","Aradi, Dániel"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Trenk, Dietmar"],["dc.contributor.author","Geisler, Tobias"],["dc.contributor.author","Orban, Martin"],["dc.contributor.author","Gori, Tommaso"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Merkely, Béla"],["dc.contributor.author","Kiss, Róbert"],["dc.contributor.author","Komócsi, András"],["dc.contributor.author","Dézsi, Csaba A."],["dc.contributor.author","Thalmeier, Andreas"],["dc.contributor.author","Löw, Anja"],["dc.contributor.author","Holdt, Lesca"],["dc.contributor.author","Teupser, Daniel"],["dc.contributor.author","Ince, Hüseyin"],["dc.contributor.author","Felix, Stephan B."],["dc.contributor.author","Parma, Radoslaw"],["dc.contributor.author","Malek, Lukasz"],["dc.contributor.author","Horstkotte, Jan"],["dc.contributor.author","Baylacher, Monika"],["dc.contributor.author","Schwinger, Robert"],["dc.contributor.author","Rieber, Johannes"],["dc.contributor.author","Mudra, Harald"],["dc.contributor.author","Hausleiter, Jörg"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Neumann, Franz-Josef"],["dc.contributor.author","Koltowski, Lukasz"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Mehilli, Julinda"],["dc.contributor.author","Massberg, Steffen"],["dc.date.accessioned","2020-12-10T18:37:53Z"],["dc.date.available","2020-12-10T18:37:53Z"],["dc.date.issued","2017"],["dc.description.abstract","Outcomes of acute coronary syndrome (ACS) patients undergoing per cutaneous coronary intervention (PCI) have been significantly improved with the use of potent P2Y(12) receptor inhibitors like prasugrel. While most of the ischaemic risk reduction for prasugrel versus clopidogrel was demonstrated in the early treatment period, the risk of bleeding became particularly prominent during the chronic course of therapy. It may therefore be a valid approach to substitute prasugrel for clopidogrel in the early phase of chronic antiplatelet treatment after PCI. In the Testing Responsiveness To Platelet Inhibition On Chronic Antiplatelet Treatment For Acute Coronary Syndromes (TROPICAL-ACS) trial, we aim to compare standard prasugrel therapy with a de-escalating antiplatelet treatment approach guided by platelet function testing (PFT). The study is an investigator-initiated European multicentre, randomised clinical trial in biomarker-positive ACS patients after successful PCI. Two thousand six hundred patients will be randomised prior to hospital discharge in a 1:1 fashion to either receive standard prasugrel therapy (control group) or de-escalating therapy (one-week prasugrel followed by one-week clopidogrel and PFT-guided maintenance therapy from day 14 after hospital discharge, monitoring group). Patients of the monitoring group with high on-clopidogrel platelet reactivity (HPR) based on Multiplate analyzer testing (HPR: 46U per consensus definition) will be switched back to prasugrel, whereas those Without HPR (<46 U) will continue clopidogrel treatment. The overall study treatment duration will be one year in both groups. The primary endpoint of the study is net clinical benefit (combined incidence of cardiovascular death, myocardial infarction, stroke and bleeding >= grade 2 according to BARC criteria) one-year after randomisation. TROPICAL-ACS is the first large-scale, randomised controlled trial assessing the clinical value of a PFT-guided de-escalation of antiplatelet treatment in biomarker positive ACS patients undergoing PCI."],["dc.identifier.doi","10.1160/TH16-07-0557"],["dc.identifier.eissn","2567-689X"],["dc.identifier.isi","000391350600023"],["dc.identifier.issn","0340-6245"],["dc.identifier.pmid","27652610"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14297"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77130"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0340-6245"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","A randomised trial on platelet function-guided de-escalation of antiplatelet treatment in ACS patients undergoing PCI Rationale and design of the Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment for Acute Coronary Syndromes (TROPICAL-ACS) Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","427"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Thrombosis and Thrombolysis"],["dc.bibliographiccitation.lastpage","435"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Koltowski, Lukasz"],["dc.contributor.author","Tomaniak, Mariusz"],["dc.contributor.author","Gross, Lisa"],["dc.contributor.author","Rymuza, Bartosz"],["dc.contributor.author","Kowara, Michal"],["dc.contributor.author","Parma, Radoslaw"],["dc.contributor.author","Komosa, Anna"],["dc.contributor.author","Klopotowski, Mariusz"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Gori, Tommaso"],["dc.contributor.author","Aradi, Daniel"],["dc.contributor.author","Huber, Kurt"],["dc.contributor.author","Hadamitzky, Martin"],["dc.contributor.author","Massberg, Steffen"],["dc.contributor.author","Lesiak, Maciej"],["dc.contributor.author","Filipiak, Krzysztof J."],["dc.contributor.author","Witkowski, Adam"],["dc.contributor.author","Opolski, Grzegorz"],["dc.contributor.author","Huczek, Zenon"],["dc.contributor.author","Sibbing, Dirk"],["dc.date.accessioned","2019-07-09T11:51:05Z"],["dc.date.available","2019-07-09T11:51:05Z"],["dc.date.issued","2019"],["dc.description.abstract","To investigate the safety and efficacy of an early platelet function testing (PFT)-guided de-escalation of dual antiplatelet treatment (DAPT) in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) with bioresorbable vascular scaffolds (BVS). Early DAPT de-escalation is a new non-inferior alternative to 12-months DAPT in patients with biomarker positive ACS treated with stent implantation. In this post-hoc analysis of the TROPICAL-ACS trial, which randomized 2610 ACS patients to a PFT-guided DAPT de-escalation (switch from prasugrel to clopidogrel) or to control group (uniform prasugrel), we compared clinical outcomes of patients (n = 151) who received a BVS during the index PCI. The frequency of the primary endpoint (cardiovascular death, myocardial infarction, stroke or BARC ≥ 2 bleeding) was 8.8% (n = 6) in the de-escalation group vs. 12.0% (n = 10) in the control group (HR 0.72, 95% CI 0.26-1.98, p = 0.52) at 12 months. One early definite stent thrombosis (ST) occurred in the control group (day 19) and 1 possible ST (sudden cardiovascular death) in the de-escalation group (day 86), both despite prasugrel treatment and in a background of high on-treatment platelet reactivity assessed at day 14 after randomization (ADP-induced platelet aggregation values of 108 U and 59 U, respectively). A PFT-guided DAPT de-escalation strategy could potentially be a safe and effective strategy in ACS patients with BVS implantation but the level of platelet inhibition may be of particular importance. This hypothesis-generating post-hoc analysis requires verification in larger studies with upcoming BVS platforms."],["dc.identifier.doi","10.1007/s11239-019-01811-2"],["dc.identifier.pmid","30739305"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59873"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Guided de-escalation of DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention with BVS implantation: a post-hoc analysis from the randomized TROPICAL-ACS trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]