Jacobshagen, Claudius

[["dc.bibliographiccitation.firstpage","286"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","EuroIntervention"],["dc.bibliographiccitation.lastpage","293"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Korte, Kerstin Pia"],["dc.contributor.author","Bleckmann, Annalen"],["dc.contributor.author","Huenlich, Mark"],["dc.contributor.author","Danner, Bernhard"],["dc.contributor.author","Schoendube, Friedrich"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Schillinger, Wolfgang"],["dc.date.accessioned","2021-06-01T10:48:55Z"],["dc.date.available","2021-06-01T10:48:55Z"],["dc.date.issued","2017"],["dc.description.abstract","AIMS: The objective of this study was to examine the impact of guideline-defined subtypes of severe aortic stenosis (AS) on long-term outcomes after TAVI. METHODS AND RESULTS: Four hundred (400) consecutive patients who underwent TAVI (203 transapical, 197 transfemoral) at our institution 8/2008-3/2013 were followed systematically (for up to seven years). One hundred and forty-seven (147) individuals suffered from NEF-HG AS (LV-EF ≥50%, high Pmean ≥40 mmHg), 63 from LEF-HG AS (LV-EF <50%, high gradient), 77 from PLF-LG AS (LV-EF ≥50%, low gradient, stroke volume index [SVI] <35 ml/m²), and 81 from LEF-LG AS (LV-EF <50%, low gradient). LEF-LG status was associated with the highest all-cause and cardiovascular mortality and MACCE rate, whereas NEF-HG patients exhibited the best outcome (i.e., median survival 5.1 years in NEF-HG vs. 1.3 years in LEF-LG, p=0.0006; or vs. 3.3 years in PLF-LG, p=0.02). In multivariate analysis, LEF-LG status emerged as the outcome predictor with the highest hazard ratio for all-cause mortality (HR 2.86, p=0.003), cardiovascular mortality (HR 6.53, p<0.0001), and MACCE (HR 2.44, p=0.007), whereas neither baseline EF nor SVI <35 ml/m² independently predicted these endpoints. CONCLUSIONS: These findings suggest that an assessment of LV-EF alone for outcome prediction after TAVI is inadequate; it is the guideline-defined subtype of AS that determines outcome."],["dc.identifier.doi","10.4244/EIJ-D-16-00801"],["dc.identifier.gro","3142338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86102"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","final"],["dc.relation.issn","1774-024X"],["dc.title","Long-term outcomes after TAVI in patients with different types of aortic stenosis: the conundrum of low flow, low gradient and low ejection fraction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","413"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","415"],["dc.bibliographiccitation.volume","139"],["dc.contributor.author","Di Vece, Davide"],["dc.contributor.author","Citro, Rodolfo"],["dc.contributor.author","Cammann, Victoria L."],["dc.contributor.author","Kato, Ken"],["dc.contributor.author","Gili, Sebastiano"],["dc.contributor.author","Szawan, Konrad A."],["dc.contributor.author","Micek, Jozef"],["dc.contributor.author","Jurisic, Stjepan"],["dc.contributor.author","Ding, Katharina J."],["dc.contributor.author","Bacchi, Beatrice"],["dc.contributor.author","Schwyzer, Moritz"],["dc.contributor.author","Candreva, Alessandro"],["dc.contributor.author","Bossone, Eduardo"],["dc.contributor.author","D’Ascenzo, Fabrizio"],["dc.contributor.author","Sarcon, Annahita"],["dc.contributor.author","Franke, Jennifer"],["dc.contributor.author","Napp, L. Christian"],["dc.contributor.author","Jaguszewski, Milosz"],["dc.contributor.author","Noutsias, Michel"],["dc.contributor.author","Münzel, Thomas"],["dc.contributor.author","Knorr, Maike"],["dc.contributor.author","Heiner, Susanne"],["dc.contributor.author","Katus, Hugo A."],["dc.contributor.author","Burgdorf, Christof"],["dc.contributor.author","Schunkert, Heribert"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Bauersachs, Johann"],["dc.contributor.author","Tschöpe, Carsten"],["dc.contributor.author","Pieske, Burkert M."],["dc.contributor.author","Rajan, Lawrence"],["dc.contributor.author","Michels, Guido"],["dc.contributor.author","Pfister, Roman"],["dc.contributor.author","Cuneo, Alessandro"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Hasenfuβ, Gerd"],["dc.contributor.author","Karakas, Mahir"],["dc.contributor.author","Koenig, Wolfgang"],["dc.contributor.author","Rottbauer, Wolfgang"],["dc.contributor.author","Said, Samir M."],["dc.contributor.author","Braun-Dullaeus, Ruediger C."],["dc.contributor.author","Banning, Adrian"],["dc.contributor.author","Cuculi, Florim"],["dc.contributor.author","Kobza, Richard"],["dc.contributor.author","Fischer, Thomas A."],["dc.contributor.author","Vasankari, Tuija"],["dc.contributor.author","Airaksinen, K.E. Juhani"],["dc.contributor.author","Opolski, Grzegorz"],["dc.contributor.author","Dworakowski, Rafal"],["dc.contributor.author","MacCarthy, Philip"],["dc.contributor.author","Kaiser, Christoph"],["dc.contributor.author","Osswald, Stefan"],["dc.contributor.author","Galiuto, Leonarda"],["dc.contributor.author","Crea, Filippo"],["dc.contributor.author","Dichtl, Wolfgang"],["dc.contributor.author","Empen, Klaus"],["dc.contributor.author","Felix, Stephan B."],["dc.contributor.author","Delmas, Clément"],["dc.contributor.author","Lairez, Olivier"],["dc.contributor.author","El-Battrawy, Ibrahim"],["dc.contributor.author","Akin, Ibrahim"],["dc.contributor.author","Borggrefe, Martin"],["dc.contributor.author","Gilyarova, Ekaterina"],["dc.contributor.author","Shilova, Alexandra"],["dc.contributor.author","Gilyarov, Mikhail"],["dc.contributor.author","Horowitz, John"],["dc.contributor.author","Kozel, Martin"],["dc.contributor.author","Tousek, Petr"],["dc.contributor.author","Widimský, Petr"],["dc.contributor.author","Winchester, David E."],["dc.contributor.author","Ukena, Christian"],["dc.contributor.author","Di Mario, Carlo"],["dc.contributor.author","Prasad, Abhiram"],["dc.contributor.author","Böhm, Michael"],["dc.contributor.author","Bax, Jeroen J."],["dc.contributor.author","Lüscher, Thomas F."],["dc.contributor.author","Ruschitzka, Frank"],["dc.contributor.author","Ghadri, Jelena R."],["dc.contributor.author","Templin, Christian"],["dc.date.accessioned","2020-12-10T18:38:02Z"],["dc.date.available","2020-12-10T18:38:02Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.118.036164"],["dc.identifier.eissn","1524-4539"],["dc.identifier.issn","0009-7322"],["dc.identifier.pmid","30586690"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77171"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Outcomes Associated With Cardiogenic Shock in Takotsubo Syndrome"],["dc.title.alternative","Results From the International Takotsubo Registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","385"],["dc.bibliographiccitation.journal","Die medizinische Welt"],["dc.bibliographiccitation.lastpage","390"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Maier, Lars"],["dc.date.accessioned","2020-06-16T14:28:15Z"],["dc.date.available","2020-06-16T14:28:15Z"],["dc.date.issued","2006"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66396"],["dc.title","Strategic management of acute pulmonary embolism"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","143"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Cardiovascular Surgery"],["dc.bibliographiccitation.lastpage","145"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Andrási, Terézia B"],["dc.contributor.author","Danner, Bernhard C"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Schöndube, Friedrich A"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.date.accessioned","2020-06-16T14:16:53Z"],["dc.date.available","2020-06-16T14:16:53Z"],["dc.date.issued","2018-02"],["dc.identifier.doi","10.23736/S0021-9509.17.09788-9"],["dc.identifier.pmid","29231677"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66387"],["dc.language.iso","en"],["dc.relation.eissn","1827-191X"],["dc.title","Transfemoral aortic valve implantation after cardiac transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","521"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","528"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Grebe, Cornelia"],["dc.contributor.author","Klingebiel, Theda-Maria"],["dc.contributor.author","Grau, Simon Philipp"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Didie, Michael"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Seidler, Tim"],["dc.date.accessioned","2017-09-07T11:44:13Z"],["dc.date.available","2017-09-07T11:44:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Aims The calcineurin and nuclear factor of activated T cells (NFAT) pathway can mediate pro-hypertrophic signalling in the heart. Recently, it has been shown that dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) phosphorylates NFAT, which limits calcineurin/NFAT signal transduction in T cells and hypertrophy in cultured cardiomyocytes. The hypothesis tested in this study was that DYRK1A prevents calcineurin/NFAT-mediated cardiac hypertrophy in vivo. Methods and results In cultured rat cardiomyocytes, adenovirus-mediated overexpression of DYRK1A antagonized calcineurin-mediated nuclear NFAT translocation and the phenylephrine-induced hypertrophic growth response. To test the ability of DYRK1A to reduce hypertrophic cardiac growth in vivo, we created tetracycline-repressible Dyrk1a transgenic mice to avoid the cardiac developmental defects associated with embryonic DYRK1A expression. However, in the mouse model, histological determination of myocyte diameter, heart weight/body weight ratio, and echocardiographic measurements revealed that myocardial expression of DYRK1A failed to reduce hypertrophy induced via aortic banding or co-expression of calcineurin. This discrepancy is explained, at least in part, by insufficient long-term inhibition of NFAT and the activation of DYRK1A-resistant maladaptive genes in vivo. Conclusion Isolated augmentation of DYRK1A can be compensated for in vivo, and this may significantly limit anti-hypertrophic interventions aimed at enhancing DYRK1A activity."],["dc.identifier.doi","10.1093/cvr/cvr023"],["dc.identifier.gro","3142722"],["dc.identifier.isi","000290820200018"],["dc.identifier.pmid","21273244"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/157"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0008-6363"],["dc.title","Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","78"],["dc.bibliographiccitation.issue","1, Suppl."],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Unsoeld, B"],["dc.contributor.author","Schotola, H"],["dc.contributor.author","Jacobshagen, C."],["dc.contributor.author","Koegler, H"],["dc.contributor.author","Hasenfuss, G."],["dc.date.accessioned","2020-06-16T14:27:58Z"],["dc.date.available","2020-06-16T14:27:58Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1016/S1567-4215(06)80222-5"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66393"],["dc.relation.issn","1567-4215"],["dc.title","360 Age-dependent changes in contractile function and passive elastic properties of myocardium of mice lacking muscle LIM protein (MLP)"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","330"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","337"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","D'Ascenzo, Fabrizio"],["dc.contributor.author","Gili, Sebastiano"],["dc.contributor.author","Bertaina, Maurizio"],["dc.contributor.author","Iannaccone, Mario"],["dc.contributor.author","Cammann, Victoria L"],["dc.contributor.author","Di Vece, Davide"],["dc.contributor.author","Kato, Ken"],["dc.contributor.author","Saglietto, Andrea"],["dc.contributor.author","Szawan, Konrad A"],["dc.contributor.author","Frangieh, Antonio H"],["dc.contributor.author","Boffini, Beatrice"],["dc.contributor.author","Annaratone, Margherita"],["dc.contributor.author","Sarcon, Annahita"],["dc.contributor.author","Levinson, Rena A"],["dc.contributor.author","Franke, Jennifer"],["dc.contributor.author","Napp, L Christian"],["dc.contributor.author","Jaguszewski, Milosz"],["dc.contributor.author","Noutsias, Michel"],["dc.contributor.author","Münzel, Thomas"],["dc.contributor.author","Knorr, Maike"],["dc.contributor.author","Heiner, Susanne"],["dc.contributor.author","Katus, Hugo A"],["dc.contributor.author","Burgdorf, Christof"],["dc.contributor.author","Schunkert, Heribert"],["dc.contributor.author","Thiele, Holger"],["dc.contributor.author","Bauersachs, Johann"],["dc.contributor.author","Tschöpe, Carsten"],["dc.contributor.author","Pieske, Burkert M"],["dc.contributor.author","Rajan, Lawrence"],["dc.contributor.author","Michels, Guido"],["dc.contributor.author","Pfister, Roman"],["dc.contributor.author","Cuneo, Alessandro"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Karakas, Mahir"],["dc.contributor.author","Koenig, Wolfgang"],["dc.contributor.author","Rottbauer, Wolfgang"],["dc.contributor.author","Said, Samir M"],["dc.contributor.author","Braun-Dullaeus, Ruediger C"],["dc.contributor.author","Banning, Adrian"],["dc.contributor.author","Cuculi, Florim"],["dc.contributor.author","Kobza, Richard"],["dc.contributor.author","Fischer, Thomas A"],["dc.contributor.author","Vasankari, Tuija"],["dc.contributor.author","Airaksinen, K E Juhani"],["dc.contributor.author","Opolski, Grzegorz"],["dc.contributor.author","Dworakowski, Rafal"],["dc.contributor.author","MacCarthy, Philip"],["dc.contributor.author","Kaiser, Christoph"],["dc.contributor.author","Osswald, Stefan"],["dc.contributor.author","Galiuto, Leonarda"],["dc.contributor.author","Crea, Filippo"],["dc.contributor.author","Dichtl, Wolfgang"],["dc.contributor.author","Franz, Wolfgang M"],["dc.contributor.author","Empen, Klaus"],["dc.contributor.author","Felix, Stephan B"],["dc.contributor.author","Delmas, Clément"],["dc.contributor.author","Lairez, Olivier"],["dc.contributor.author","El-Battrawy, Ibrahim"],["dc.contributor.author","Akin, Ibrahim"],["dc.contributor.author","Borggrefe, Martin"],["dc.contributor.author","Horowitz, John D"],["dc.contributor.author","Kozel, Martin"],["dc.contributor.author","Tousek, Petr"],["dc.contributor.author","Widimský, Petr"],["dc.contributor.author","Gilyarova, Ekaterina"],["dc.contributor.author","Shilova, Alexandra"],["dc.contributor.author","Gilyarov, Mikhail"],["dc.contributor.author","Biondi-Zoccai, Giuseppe"],["dc.contributor.author","Winchester, David E"],["dc.contributor.author","Ukena, Christian"],["dc.contributor.author","Neuhaus, Michael"],["dc.contributor.author","Bax, Jeroen J"],["dc.contributor.author","Prasad, Abhiram"],["dc.contributor.author","Di Mario, Carlo"],["dc.contributor.author","Böhm, Michael"],["dc.contributor.author","Gasparini, Mauro"],["dc.contributor.author","Ruschitzka, Frank"],["dc.contributor.author","Bossone, Eduardo"],["dc.contributor.author","Citro, Rodolfo"],["dc.contributor.author","Rinaldi, Mauro"],["dc.contributor.author","De Ferrari, Gaetano Maria"],["dc.contributor.author","Lüscher, Thomas"],["dc.contributor.author","Ghadri, Jelena R"],["dc.contributor.author","Templin, Christian"],["dc.date.accessioned","2020-06-16T13:21:44Z"],["dc.date.available","2020-06-16T13:21:44Z"],["dc.date.issued","2020-02"],["dc.description.abstract","The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS)."],["dc.identifier.doi","10.1002/ejhf.1698"],["dc.identifier.pmid","31863563"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66369"],["dc.language.iso","en"],["dc.relation.eissn","1879-0844"],["dc.relation.issn","1388-9842"],["dc.title","Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Schuster, Manfred"],["dc.contributor.author","Loibner, Hans"],["dc.contributor.author","Becker, Alexander"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Kuba, Keiji"],["dc.contributor.author","Imai, Yumiko"],["dc.contributor.author","Penninger, Josef"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:09:55Z"],["dc.date.available","2018-11-07T11:09:55Z"],["dc.date.issued","2008"],["dc.format.extent","S947"],["dc.identifier.isi","000262104503504"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53105"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","81st Annual Scientific Session of the American-Heart-Association"],["dc.relation.eventlocation","New Orleans, LA"],["dc.relation.issn","0009-7322"],["dc.title","Angiotensin-Converting-Enzyme 2 (rhACE2) Potently Attenuates the Negative Hemodynamic Effects of Angiotensin II (ATII) and Improves Post-Myocardial Infarction (MI) Remodeling"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Maier, Lars. S."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T11:11:18Z"],["dc.date.available","2018-11-07T11:11:18Z"],["dc.date.issued","2008"],["dc.format.extent","265"],["dc.identifier.isi","000208702501245"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53401"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.publisher.place","Oxford"],["dc.relation.issn","0195-668X"],["dc.title","Large volume, ice-cold intravenous fluid for therapeutic hypothermia does not compromise the respiratory situation in patients after cardiac arrest"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]