Fernández Busnadiego, Rubén

[["dc.contributor.author","Saha, Itika"],["dc.contributor.author","Yuste-Checa, Patricia"],["dc.contributor.author","Silva Padilha, Miguel Da"],["dc.contributor.author","Guo, Qiang"],["dc.contributor.author","Körner, Roman"],["dc.contributor.author","Holthusen, Hauke"],["dc.contributor.author","Trinkaus, Victoria A."],["dc.contributor.author","Dudanova, Irina"],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.contributor.author","Baumeister, Wolfgang"],["dc.contributor.author","Sanders, David W."],["dc.contributor.author","Gautam, Saurabh"],["dc.contributor.author","Diamond, Marc I."],["dc.contributor.author","Ulrich Hartl, F."],["dc.contributor.author","Hipp, Mark S."],["dc.date.accessioned","2022-04-06T12:10:37Z"],["dc.date.available","2022-04-06T12:10:37Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1101/2022.02.18.481043"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/106453"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/449"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.workinggroup","RG Fernández-Busnadiego (Structural Cell Biology)"],["dc.title","The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Riemenschneider, Henrick"],["dc.contributor.author","Guo, Qiang"],["dc.contributor.author","Bader, Jakob"],["dc.contributor.author","Frottin, Frédéric"],["dc.contributor.author","Farny, Daniel"],["dc.contributor.author","Kleinberger, Gernot"],["dc.contributor.author","Haass, Christian"],["dc.contributor.author","Mann, Matthias"],["dc.contributor.author","Hartl, F. Ulrich"],["dc.contributor.author","Baumeister, Wolfgang"],["dc.contributor.author","Hipp, Mark S."],["dc.contributor.author","Meissner, Felix"],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.contributor.author","Edbauer, Dieter"],["dc.date.accessioned","2022-02-23T16:35:41Z"],["dc.date.available","2022-02-23T16:35:41Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1101/2021.03.15.435268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100379"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/288"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.workinggroup","RG Fernández-Busnadiego (Structural Cell Biology)"],["dc.title","Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","179"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","187.e10"],["dc.bibliographiccitation.volume","171"],["dc.contributor.author","Bäuerlein, Felix J.B."],["dc.contributor.author","Saha, Itika"],["dc.contributor.author","Mishra, Archana"],["dc.contributor.author","Kalemanov, Maria"],["dc.contributor.author","Martínez-Sánchez, Antonio"],["dc.contributor.author","Klein, Rüdiger"],["dc.contributor.author","Dudanova, Irina"],["dc.contributor.author","Hipp, Mark S."],["dc.contributor.author","Hartl, F. Ulrich"],["dc.contributor.author","Baumeister, Wolfgang"],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.date.accessioned","2022-03-01T11:45:03Z"],["dc.date.available","2022-03-01T11:45:03Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.cell.2017.08.009"],["dc.identifier.pii","S0092867417309340"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103197"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0092-8674"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","In Situ Architecture and Cellular Interactions of PolyQ Inclusions"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Trinkaus, Victoria A."],["dc.contributor.author","Riera-Tur, Irene"],["dc.contributor.author","Martínez-Sánchez, Antonio"],["dc.contributor.author","Bäuerlein, Felix J. B."],["dc.contributor.author","Guo, Qiang"],["dc.contributor.author","Arzberger, Thomas"],["dc.contributor.author","Baumeister, Wolfgang"],["dc.contributor.author","Dudanova, Irina"],["dc.contributor.author","Hipp, Mark S."],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.date.accessioned","2021-06-01T09:41:39Z"],["dc.date.available","2021-06-01T09:41:39Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were long thought to consist mainly of α-Syn fibrils, but recent reports pointed to intracellular membranes as the major inclusion component. Here, we use cryo-electron tomography (cryo-ET) to image neuronal α-Syn inclusions in situ at molecular resolution. We show that inclusions seeded by α-Syn aggregates produced recombinantly or purified from patient brain consist of α-Syn fibrils crisscrossing a variety of cellular organelles. Using gold-labeled seeds, we find that aggregate seeding is predominantly mediated by small α-Syn fibrils, from which cytoplasmic fibrils grow unidirectionally. Detailed analysis of membrane interactions revealed that α-Syn fibrils do not contact membranes directly, and that α-Syn does not drive membrane clustering. Altogether, we conclusively demonstrate that neuronal α-Syn inclusions consist of α-Syn fibrils intermixed with membranous organelles, and illuminate the mechanism of aggregate seeding and cellular interaction."],["dc.identifier.doi","10.1038/s41467-021-22108-0"],["dc.identifier.pmid","33854052"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84996"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/276"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.eissn","2041-1723"],["dc.relation.workinggroup","RG Fernández-Busnadiego (Structural Cell Biology)"],["dc.rights","CC BY 4.0"],["dc.title","In situ architecture of neuronal α-Synuclein inclusions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Trinkaus, Victoria A."],["dc.contributor.author","Riera-Tur, Irene"],["dc.contributor.author","Martínez-Sánchez, Antonio"],["dc.contributor.author","Bäuerlein, Felix J. B."],["dc.contributor.author","Guo, Qiang"],["dc.contributor.author","Arzberger, Thomas"],["dc.contributor.author","Baumeister, Wolfgang"],["dc.contributor.author","Dudanova, Irina"],["dc.contributor.author","Hipp, Mark S."],["dc.contributor.author","Hartl, F. Ulrich"],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.date.accessioned","2022-02-23T13:16:14Z"],["dc.date.available","2022-02-23T13:16:14Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1101/2020.08.07.234138"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/100363"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/164"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation.workinggroup","RG Fernández-Busnadiego (Structural Cell Biology)"],["dc.title","In situ architecture of neuronal α-Synuclein inclusions"],["dc.type","preprint"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","696"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cell"],["dc.bibliographiccitation.lastpage","705.e12"],["dc.bibliographiccitation.volume","172"],["dc.contributor.author","Guo, Qiang"],["dc.contributor.author","Lehmer, Carina"],["dc.contributor.author","Martínez-Sánchez, Antonio"],["dc.contributor.author","Rudack, Till"],["dc.contributor.author","Beck, Florian"],["dc.contributor.author","Hartmann, Hannelore"],["dc.contributor.author","Pérez-Berlanga, Manuela"],["dc.contributor.author","Frottin, Frédéric"],["dc.contributor.author","Hipp, Mark S."],["dc.contributor.author","Hartl, F. Ulrich"],["dc.contributor.author","Fernández Busnadiego, Rubén"],["dc.date.accessioned","2022-03-01T11:45:04Z"],["dc.date.available","2022-03-01T11:45:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.cell.2017.12.030"],["dc.identifier.pii","S0092867417315106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103198"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","0092-8674"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]