Wahl, Markus C.

[["dc.bibliographiccitation.artnumber","e03895"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Andlauer, Till F. M."],["dc.contributor.author","Scholz-Kornehl, Sabrina"],["dc.contributor.author","Tian, Rui"],["dc.contributor.author","Kirchner, Marieluise"],["dc.contributor.author","Babikir, Husam A."],["dc.contributor.author","Depner, Harald"],["dc.contributor.author","Loll, Bernhard"],["dc.contributor.author","Quentin, Christine"],["dc.contributor.author","Gupta, Varun K."],["dc.contributor.author","Holt, Matthew G."],["dc.contributor.author","Dipt, Shubham"],["dc.contributor.author","Cressy, Michael"],["dc.contributor.author","Wahl, Markus C."],["dc.contributor.author","Fiala, Andre"],["dc.contributor.author","Selbach, Matthias"],["dc.contributor.author","Schwaerzel, Martin"],["dc.contributor.author","Sigrist, Stephan J."],["dc.date.accessioned","2018-11-07T09:32:39Z"],["dc.date.available","2018-11-07T09:32:39Z"],["dc.date.issued","2014"],["dc.description.abstract","CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short-and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation."],["dc.identifier.doi","10.7554/eLife.03895"],["dc.identifier.isi","000209685200001"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31798"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elife Sciences Publications Ltd"],["dc.relation.issn","2050-084X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Drep-2 is a novel synaptic protein important for learning and memory"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]