Muhammad, Hayat

[["dc.bibliographiccitation.firstpage","2101"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Cellular and Molecular Life Sciences"],["dc.bibliographiccitation.lastpage","2107"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Muhammad, Hayat"],["dc.contributor.author","Rais, Yoach"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Ornan, Efrat Monsonego"],["dc.date.accessioned","2018-11-07T09:08:53Z"],["dc.date.available","2018-11-07T09:08:53Z"],["dc.date.issued","2012"],["dc.description.abstract","The primary cilium is an immotile, solitary, and microtubule-based structure that projects from cell surfaces into the extracellular environment. The primary cilium functions as a dual sensor, as mechanosensors and chemosensors. The primary cilia coordinate several essential cell signaling pathways that are mainly involved in cell division and differentiation. A primary cilium malfunction can result in several human diseases. Mechanical loading is sense by mechanosensitive cells in nearly all tissues and organs. With this sensation, the mechanical signal is further transduced into biochemical signals involving pathways such as Akt, PKA, FAK, ERK, and MAPK. In this review, we focus on the fundamental functional and structural features of primary cilia in chondrocytes and chondrogenic cells."],["dc.identifier.doi","10.1007/s00018-011-0911-3"],["dc.identifier.isi","000305268300001"],["dc.identifier.pmid","22241332"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8073"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26133"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Basel"],["dc.relation.issn","1420-682X"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The primary cilium as a dual sensor of mechanochemical signals in chondrocytes"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","789"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Stem Cell Reports"],["dc.bibliographiccitation.lastpage","803"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Muhammad, Hayat"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Bode, Christa"],["dc.contributor.author","Roth, Moritz"],["dc.contributor.author","Albert, Julius"],["dc.contributor.author","von der Heyde, Silvia"],["dc.contributor.author","Rosen, Vicki"],["dc.contributor.author","Miosge, Nicolai"],["dc.date.accessioned","2018-08-20T12:45:38Z"],["dc.date.available","2018-08-20T12:45:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Degeneration of the knee joint during osteoarthritis often begins with meniscal lesions. Meniscectomy, previously performed extensively after meniscal injury, is now obsolete because of the inevitable osteoarthritis that occurs following this procedure. Clinically, meniscus self-renewal is well documented as long as the outer, vascularized meniscal ring remains intact. In contrast, regeneration of the inner, avascular meniscus does not occur. Here, we show that cartilage tissue harvested from the avascular inner human meniscus during the late stages of osteoarthritis harbors a unique progenitor cell population. These meniscus progenitor cells (MPCs) are clonogenic and multipotent and exhibit migratory activity. We also determined that MPCs are likely to be controlled by canonical transforming growth factor β (TGF-β) signaling that leads to an increase in SOX9 and a decrease in RUNX2, thereby enhancing the chondrogenic potential of MPC. Therefore, our work is relevant for the development of novel cell biological, regenerative therapies for meniscus repair."],["dc.identifier.doi","10.1016/j.stemcr.2014.08.010"],["dc.identifier.pmid","25418724"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15440"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","2213-6711"],["dc.rights","CC BY-NC-ND 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/3.0"],["dc.title","Human Migratory Meniscus Progenitor Cells Are Controlled via the TGF-β Pathway"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]