Gefeller, Olaf

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Archives of Allergy and Immunology"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:20:04Z"],["dc.date.available","2018-11-07T11:20:04Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Nickel, cobalt and chromium are some of the most common causes of type IV sensitizations and subsequent allergic contact dermatitis. Accurate diagnosis of contact sensitization to these metal salts is made possible through standardized patch testing; however, patch tests with metal allergens may be influenced by meteorological conditions at the time of testing. We aimed to investigate how patch test reactions to these metals relate to outdoor temperature and humidity at the time of testing. Methods: Clinical patch test results from 61,435 patients tested at Austrian and German dermatology departments participating in a contact sensitization surveillance network (www.ivdk.org) from 1993 through 2001 were evaluated with weather data measured near the testing location and at the time of testing. Test reactions and ambient temperature and humidity were examined with multinomial logistic regression models. Results: The odds of irritant and doubtful reactions to all 3 ionized metals increased during cold/arid conditions, and the odds of weak allergic (positive) reactions to nickel and cobalt also increased during cold/dry weather. Strong allergic reactions were essentially independent of weather conditions. Conclusions: The increase in irritant and doubtful reactions coinciding with decreasing temperature and humidity may be the result of an overall increase in skin irritation brought about by these ambient conditions. The observed increases in erythematous and infiltrated ('weak allergic') reactions may be due to doubtful reactions increasing in intensity and being (falsely) classified as positive during colder and drier conditions. Copyright (c) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000142047"],["dc.identifier.isi","000260236900009"],["dc.identifier.pmid","18594154"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55444"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-2438"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Patch Test Results with Metals and Meteorological Conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","316"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Scandinavian Journal of Work Environment & Health"],["dc.bibliographiccitation.lastpage","321"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T11:12:45Z"],["dc.date.available","2018-11-07T11:12:45Z"],["dc.date.issued","2008"],["dc.description.abstract","Objectives An accurate diagnosis of (occupational) contact sensitization by patch testing is a prerequisite for efficient preventive management. However, previously observed seasonal fluctuations in patch-test reactions indicate some influence of meteorological conditions. The present analysis aims at quantifying the possible impact of temperature and humidity on patch-test reactions to occupationally related allergens. Methods Clinical data from 61 780 patients tested with standard series allergens potentially related to occupational exposure from 1993 through 2001 were collected by a contact sensitization surveillance network. The association between the patch-test results and meteorological data (air temperature and humidity) collected at the time and the approximate location of the testing was analyzed in a multinomial logistic regression analysis. Results For three allergens (a dye and two biocides), the odds of irritant or doubtful allergic reactions increased during cold and and conditions. Two of them (p-phenylenediamine and formaldehyde) also showed an association between weak positive allergic reactions and such weather. In contrast, reactions to various adhesive, plastic. and rubber-related allergens were not associated with weather conditions. Conclusions An overall increase in skin irritation, brought on by cold and dry conditions, may instigate an increase in positive reactions by leading doubtful allergic reactions to be (falsely) categorized as allergic for at least two of the considered allergens. For the most part. however. weather conditions were not associated with reactions to Occupational allergens. Thus the validity of patch testing does not largely seem to be compromised by ambient meteorological conditions."],["dc.identifier.isi","000260101000009"],["dc.identifier.pmid","18815718"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53734"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Scand J Work Env Health"],["dc.relation.issn","0355-3140"],["dc.title","Meteorological conditions and the diagnosis of occupationally related contact sensitizations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","675"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","681"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T08:40:49Z"],["dc.date.available","2018-11-07T08:40:49Z"],["dc.date.issued","2010"],["dc.description.abstract","To analyse the association between occupation (represented by job title) and contact allergy to thiuram vulcanising agents based on data of a clinical registry (IVDK, www.ivdk.org). Clinical, demographic and allergy patch test data of all patients tested between 1992 and 2006 with the thiuram mix (1% in petrolatum) as part of the baseline series was analysed (n = 121,051). Poisson regression analysis was used to quantify the association between different occupations (and other relevant factors) and a positive patch test reaction to the thiuram mix. Furthermore, the time trend of sensitisation prevalence was analysed in high-risk occupational subgroups identified. In comparison to a largely unexposed reference group (office workers and teachers), rubber manufacturers had a significantly elevated risk (prevalence ratio (PR): 5.1, 95% confidence interval (CI) 2.0-10.5). However, health care workers such as physicians and dentists (PR: 3.8, 95% CI: 3.0-4.8) or nursing staff (PR: 3.0, 95% CI: 2.5-3.6) as well as meat and fish processors (PR 3.5, 95% CI: 2.2-5.3) and cleaners (PR 3.1, 95% CI: 2.5-3.8) were found to have a high sensitisation risk as well. In case of health care workers, a significant downward trend during the study period was observed; while in food processors and cleaners, sensitisation prevalence remained largely stable. The adjusted multifactorial analysis identified occupations yet unknown to be associated with elevated thiuram contact allergy risk, e.g., food processors and cleaners. Thus, (i) further in-depth research can be targeted and (ii) efforts to prevent sensitisation to thiurams focussed, e.g., by limiting thiuram concentrations in products to a residual level which is technically inevitable."],["dc.identifier.doi","10.1007/s00420-009-0503-9"],["dc.identifier.isi","000279833900009"],["dc.identifier.pmid","20041260"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4990"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19322"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-0131"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Contact allergy to thiurams: multifactorial analysis of clinical surveillance data collected by the IVDK network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]