Gefeller, Olaf

[["dc.bibliographiccitation.firstpage","734"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","158"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Hegewald, J."],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:16:21Z"],["dc.date.available","2018-11-07T11:16:21Z"],["dc.date.issued","2008"],["dc.description.abstract","Background Fluctuating irritability of the skin induced by low ambient temperature and humidity may compromise the reproducibility of patch testing. Objectives To assess the impact of temperature and absolute humidity at the time of patch testing on the occurrence of irritant or doubtful (IR/?), weak positive (+) and (strong) positive (++/+++) reactions, respectively, among 12 allergens included in the German Standard Series. Methods Analysis of clinical data collected in the surveillance network IVDK (http://www.ivdk.org) between January 1993 and December 2001 (n = 73 691 patients) combined with meteorological data obtained by the national services in Germany and Austria. Multinomial logistic regression analysis was used to estimate the risk associated with temperature, absolute humidity and vapour pressure, respectively, adjusted for sex, age, atopic dermatitis and duration of patch test application. Results For low temperature and humidity, a relevant increase of IR/? reaction frequency was observed in the cases of paraben mix and (chloro-) methylisothiazolinone. Both IR/? and + reactions were significantly increased with respect to the allergens fragrance mix, oil of turpentine, methyldibromo glutaronitrile + phenoxyethanol and particularly formaldehyde, while ++/+++ reactions were hardly affected by weather conditions. Conclusions The observed increase of IR/? reactions may be due to epidermal barrier function impairment. The impact of dry/cold weather on + reactions in terms of possibly false-positive reactions is restricted to few allergens. In the case of + reactions of unknown relevance, a re-test under warm conditions or verification tests such as the repeated open application test or the provocative use test may be recommendable."],["dc.identifier.doi","10.1111/j.1365-2133.2008.08448.x"],["dc.identifier.isi","000254122100010"],["dc.identifier.pmid","18284398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54567"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0007-0963"],["dc.title","The impact of meteorological conditions on patch test results with 12 standard series allergens (fragrances, biocides, topical ingredients)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","32"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","39"],["dc.bibliographiccitation.volume","47"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T10:20:08Z"],["dc.date.available","2018-11-07T10:20:08Z"],["dc.date.issued","2002"],["dc.description.abstract","Clinical epidemiology (CE) is considered unable to estimate morbidity concerning either contact sensitization (CS) or allergic contact dermatitis (ACD) at the population level. Drug-utilization research (DUR) methods estimate the morbidity of suitable diseases based on prescription data for disease-specific drugs. Our objective was to estimate population figures for incidence and prevalence of ACD and CS based on sales data for patch test material in Germany and on patient data from the Information Network of Departments of Dermatology (IVDK). Approximately 600,000 standard series are sold per year in Germany, according to the 2 main manufacterers. This raw sales figure was corrected for certain effects (discarded preparations, proportion of formerly patch-tested patients, proportion of patients with ACD seeking medical advice) to obtain an estimate of the denominator of patients eligible for patch testing annually, and combined with patch test results from the Information Network of Departments of Dermatology (IVDK). In 17.8% (of 9,266 IVDK patients) ACD was established. Extrapolated to the general population, an incidence of ACD of between 1.7 and 7 per 1000 per year was estimated, depending on whether conservative or more liberal assumptions concerning the above effects were made. Of 78,067 IVDK patients tested between 1992 and 2000, 46.8% had at least 1 positive reaction (+ to + + +), and 22.7% had at least 1 stronger positive reaction (+ + or + + +).The 9-year prevalence of CS was estimated to lie between 4.0% and 16.6% for the first outcome, and between 2.0% and 8.1% for the second. Concerning single allergens, 1.9-4.5 million individuals are probably sensitized to nickel, and 1.4-3.4 million to fragrance mix among the German population of 82 million inhabitants. The morbidity data found in this study are in good accordance with data from population-based epidemiological studies. In comparison to these, the CE-DUR approach seems to be an economically feasible method to estimate continuously the population impact of ACD and CS."],["dc.identifier.doi","10.1034/j.1600-0536.2002.470107.x"],["dc.identifier.isi","000177965400007"],["dc.identifier.pmid","12225411"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41815"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley"],["dc.relation.issn","1600-0536"],["dc.relation.issn","0105-1873"],["dc.title","Epidemiology of contact allergy: an estimation of morbidity employing the clinical epidemiology and drug-utilization research (CE-DUR) approach"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","47"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","56"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T10:46:34Z"],["dc.date.available","2018-11-07T10:46:34Z"],["dc.date.issued","2004"],["dc.description.abstract","The present guidelines aim to support clinical researchers in adequately presenting data on contact allergy, and to use statistical tests appropriate for their data. A description of the mode of selection of patients, and of their relevant demographic details, is an essential prerequisite for the correct interpretation of study results. Proportions and rates, if regarded as estimate of these parameters of a target populations, should normally be supplemented with confidence intervals to address precision. Concordance, i.e., agreement between two ratings in a dependent sample, must be quantified with a chance-corrected measure such as Cohen's kappa coefficient. If the diagnostic quality of an outcome is being assessed, standard measures like sensitivity and specificity, as well as the prevalence-dependent positive and negative predictive values should be calculated. Often, contact allergy to a certain substance depends on several factors. In this situation, depending on the research question, techniques like stratification, standardization or multifactorial analysis should be employed. With increasing complexity of statistical description and analysis, consulting with a biostatistician is often mandatory."],["dc.identifier.doi","10.1111/j.0105-1873.2004.00406.x"],["dc.identifier.isi","000223954200001"],["dc.identifier.pmid","15373843"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47778"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Guidelines for the descriptive presentation and statistical analysis of contact allergy data"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Archives of Allergy and Immunology"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:20:04Z"],["dc.date.available","2018-11-07T11:20:04Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Nickel, cobalt and chromium are some of the most common causes of type IV sensitizations and subsequent allergic contact dermatitis. Accurate diagnosis of contact sensitization to these metal salts is made possible through standardized patch testing; however, patch tests with metal allergens may be influenced by meteorological conditions at the time of testing. We aimed to investigate how patch test reactions to these metals relate to outdoor temperature and humidity at the time of testing. Methods: Clinical patch test results from 61,435 patients tested at Austrian and German dermatology departments participating in a contact sensitization surveillance network (www.ivdk.org) from 1993 through 2001 were evaluated with weather data measured near the testing location and at the time of testing. Test reactions and ambient temperature and humidity were examined with multinomial logistic regression models. Results: The odds of irritant and doubtful reactions to all 3 ionized metals increased during cold/arid conditions, and the odds of weak allergic (positive) reactions to nickel and cobalt also increased during cold/dry weather. Strong allergic reactions were essentially independent of weather conditions. Conclusions: The increase in irritant and doubtful reactions coinciding with decreasing temperature and humidity may be the result of an overall increase in skin irritation brought about by these ambient conditions. The observed increases in erythematous and infiltrated ('weak allergic') reactions may be due to doubtful reactions increasing in intensity and being (falsely) classified as positive during colder and drier conditions. Copyright (c) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000142047"],["dc.identifier.isi","000260236900009"],["dc.identifier.pmid","18594154"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55444"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-2438"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Patch Test Results with Metals and Meteorological Conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","38"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T10:42:14Z"],["dc.date.available","2018-11-07T10:42:14Z"],["dc.date.issued","2003"],["dc.description.abstract","To quantify the independent impact of potential risk factors for nickel contact allergy (NCA), a multifactorial Poisson regression analysis of standardized anamnestic and patch test data (with nickel sulfate, 5% in petrolatum) was performed, comprising 74 940 patients assessed in the 33 German and Austrian contact dermatitis units of the Information Network of Departments of Dermatology (IVDK) between 1992 and 2000. NCA was observed in 15.5% patients. Female sex was the strongest risk factor (prevalence ratio 3.74, 95% CI: 3.51-3.98). Risk increased monotonically and significantly with decreasing age. Atopic dermatitis was not a risk factor. The year of patch test had no influence on NCA risk. Significant variation of risk between occupations was observed. In conclusion, our multifactorial analysis was able to quantify the impact of established risk factors and additionally address other, e.g. occupational, factors yet unidentified."],["dc.identifier.doi","10.1034/j.1600-0536.46.s4.29_102.x"],["dc.identifier.isi","000181633600006"],["dc.identifier.pmid","12641576"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46742"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Munksgaard"],["dc.relation.issn","0105-1873"],["dc.title","Risk factors for contact allergy to nickel - results of a multifactorial analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S32"],["dc.bibliographiccitation.journal","Das Gesundheitswesen"],["dc.bibliographiccitation.lastpage","S34"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Schwanitz, H. J."],["dc.date.accessioned","2018-11-07T09:19:22Z"],["dc.date.available","2018-11-07T09:19:22Z"],["dc.date.issued","2001"],["dc.description.abstract","The incidence of occupational dermatitis of the hands is particularly high in the hairdressing trade. To elucidate the role of various risk factors, and to ultimately improve primary prevention of occupational hand dermatitis, a prospective cohort study was conducted between 1992 and 1997, including 2352 hairdressing trainees. Already six weeks after the start of training (median) 35.4% had - usually mild - irritant skin changes, mainly involving the interdigital web spaces. These were associated with subsequent, possibly more severe, hand dermatitis. Reduced exposure to wet work, i.e., improved skin protection with gloves, often led to the resolution of dermatitis of the hands. In conclusion, early irritant skin damage is a sentinel event that heralds possibly disabling occupational skin disease and should prompt adequate preventive measures."],["dc.identifier.isi","000168118500008"],["dc.identifier.pmid","11329916"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28618"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0941-3790"],["dc.title","Prevention of skin damage in hairdressers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","146"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Contact Dermatitis"],["dc.bibliographiccitation.lastpage","152"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Land, M."],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T09:18:43Z"],["dc.date.available","2018-11-07T09:18:43Z"],["dc.date.issued","2001"],["dc.description.abstract","There is conflicting evidence concerning seasonal variability of patch test results and no evidence concerning the influence of season on weak-positive, possibly false-positive, irritant reactions, which was analysed in the present study. Data collected in the German Information Network of Departments of Dermatology (IVDK) 1992 to 1997 were combined with external environmental data on temperature and absolute humidity in Germany, and bivariate as well as logistic regression analyses performed concerning the association between reactivity to selected allergens and air temperature and absolute humidity on the respective days of patch testing. Between 39,239 and 41,629 patients had been tested with the 4 allergens considered here. Only formaldehyde exhibited a distinct increase in questionable or irritant as well as weak-positive reactions associated with dry, cold weather. Methylchlorosiothiazolinone/methylisothiazolinone and lanolin alcohol showed only a weak, and epoxy resin no, association with climatic conditions. The results indicate that weak-positive reactions, at least to formaldehyde as a prototype of an allergen which is at the same time a marginal irritant, may sometimes be irritant rather than allergic. Patients showing these should be re-tested to improve the poor reproducibility observed with this allergen."],["dc.identifier.doi","10.1034/j.1600-0536.2001.044003146.x"],["dc.identifier.isi","000166952500003"],["dc.identifier.pmid","11217986"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28468"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Munksgaard Int Publ Ltd"],["dc.relation.issn","0105-1873"],["dc.title","Another look at seasonal variation in patch test results - A multifactorial analysis of surveillance data of the IVDK"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","255"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Flavour and Fragrance Journal"],["dc.bibliographiccitation.lastpage","263"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Fiessler, Cornelia"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T09:55:28Z"],["dc.date.available","2018-11-07T09:55:28Z"],["dc.date.issued","2015"],["dc.description.abstract","Fragrances are among the most common contact sensitizers. Changes in exposure lead to subsequent changes of sensitization incidence; patterns of exposure may be reflected in certain surrogate markers such as affected anatomical site or occupation. The objective of this study was to provide current results on sensitization prevalences to the fragrance allergy screening markers of the patch test baseline series, on time trends and on risk factors associated with sensitization. Data of all patients tested between 1999 and 2012 with fragrance mix I (8% petrolatum (pet.) n=130325), fragrance mix II (14% pet., since 2005, n=81290), Myroxylon pereirae resin (25% pet., n=130258) and oil of turpentine (10% pet., n=131595), respectively, in the Information Network of Departments of Dermatology (IVDK, ) were subject to descriptive and log-binomial regression analysis. Overall, 16.31% of patients had a positive patch test reaction to at least one of the four markers. The prevalence to each of the four single markers was 8.71, 4.87, 8.36 and 1.95%. A peculiar downward trend of FM I until around 2006/2007 with subsequent increase, both significant, was noted. Mostly, sensitization risk was higher in older patients and females, and was to a varying extent associated with certain anatomical sites. The mostly stable or even increasing time trends warrant further in-depth research into causative exposures, addressing the effectiveness of (self-) regulation, aggregate exposure and cocktail effect'. Copyright (c) 2015 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/ffj.3242"],["dc.identifier.isi","000356008100001"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36747"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1099-1026"],["dc.relation.issn","0882-5734"],["dc.title","Contact sensitization to fragrance mix I and II, to Myroxylon pereirae resin and oil of tupentine: multifactorial analysis of risk factors based on data of the IVDK network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Schwitulla, Judith"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Uter, Wolfgang"],["dc.date.accessioned","2018-11-07T08:57:22Z"],["dc.date.available","2018-11-07T08:57:22Z"],["dc.date.issued","2011"],["dc.format.extent","168"],["dc.identifier.isi","000288955201013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23383"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Polysensitization on Contact Allergy - A recent Analysis of Data-IVDK"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8-9"],["dc.bibliographiccitation.journal","Das Gesundheitswesen"],["dc.bibliographiccitation.volume","63"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Geier, Johannes"],["dc.contributor.author","Schnuch, Axel"],["dc.date.accessioned","2018-11-07T08:48:24Z"],["dc.date.available","2018-11-07T08:48:24Z"],["dc.date.issued","2001"],["dc.format.extent","A81"],["dc.identifier.isi","000171117100231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21199"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.issn","0941-3790"],["dc.title","Occupational and non-occupational risk factors for nickel allergy - Results of a multivariate analysis of data from the Informationsverbund Dermatologischer Kliniken"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]