Gefeller, Olaf

[["dc.bibliographiccitation.firstpage","235"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Archives of Allergy and Immunology"],["dc.bibliographiccitation.lastpage","240"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Kraenke, Birger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Pfahlberg, Annette"],["dc.date.accessioned","2018-11-07T11:20:04Z"],["dc.date.available","2018-11-07T11:20:04Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: Nickel, cobalt and chromium are some of the most common causes of type IV sensitizations and subsequent allergic contact dermatitis. Accurate diagnosis of contact sensitization to these metal salts is made possible through standardized patch testing; however, patch tests with metal allergens may be influenced by meteorological conditions at the time of testing. We aimed to investigate how patch test reactions to these metals relate to outdoor temperature and humidity at the time of testing. Methods: Clinical patch test results from 61,435 patients tested at Austrian and German dermatology departments participating in a contact sensitization surveillance network (www.ivdk.org) from 1993 through 2001 were evaluated with weather data measured near the testing location and at the time of testing. Test reactions and ambient temperature and humidity were examined with multinomial logistic regression models. Results: The odds of irritant and doubtful reactions to all 3 ionized metals increased during cold/arid conditions, and the odds of weak allergic (positive) reactions to nickel and cobalt also increased during cold/dry weather. Strong allergic reactions were essentially independent of weather conditions. Conclusions: The increase in irritant and doubtful reactions coinciding with decreasing temperature and humidity may be the result of an overall increase in skin irritation brought about by these ambient conditions. The observed increases in erythematous and infiltrated ('weak allergic') reactions may be due to doubtful reactions increasing in intensity and being (falsely) classified as positive during colder and drier conditions. Copyright (c) 2008 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000142047"],["dc.identifier.isi","000260236900009"],["dc.identifier.pmid","18594154"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9354"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55444"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1018-2438"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Patch Test Results with Metals and Meteorological Conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","26"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","36"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wüstenberg, Torsten"],["dc.contributor.author","Begemann, Martin"],["dc.contributor.author","Bartels, Claudia"],["dc.contributor.author","Gefeller, Olaf"],["dc.contributor.author","Stawicki, S."],["dc.contributor.author","Hinze-Selch, D."],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Aldenhoff, Josef B."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Nave, Klaus-Armin"],["dc.contributor.author","Ehrenreich, Hanhelore"],["dc.date.accessioned","2017-09-07T11:46:27Z"],["dc.date.available","2017-09-07T11:46:27Z"],["dc.date.issued","2011"],["dc.description.abstract","Neurodevelopmental abnormalities together with neurodegenerative processes contribute to schizophrenia, an etiologically heterogeneous, complex disease phenotype that has been difficult to model in animals. The neurodegenerative component of schizophrenia is best documented by magnetic resonance imaging (MRI), demonstrating progressive cortical gray matter loss over time. No treatment exists to counteract this slowly proceeding atrophy. The hematopoietic growth factor erythropoietin (EPO) is neuroprotective in animals. Here, we show by voxel-based morphometry in 32 human subjects in a placebo-controlled study that weekly high-dose EPO for as little as 3 months halts the progressive atrophy in brain areas typically affected in schizophrenia, including hippocampus, amygdala, nucleus accumbens, and several neocortical areas. Specifically, gray matter protection is highly associated with improvement in attention and memory functions. These findings suggest that a neuroprotective strategy is effective against common pathophysiological features of schizophrenic patients, and strongly encourage follow-up studies to optimize EPO treatment dose and duration."],["dc.identifier.doi","10.1038/mp.2010.51"],["dc.identifier.gro","3150516"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6267"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7289"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject","hematopoietic growth factor; neuroregeneration; neuroprotection; voxel-based morphometry; brain atrophy; cognition; schizophrenia"],["dc.title","Recombinant human erythropoietin delays loss of gray matter in chronic schizophrenia"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","675"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","International Archives of Occupational and Environmental Health"],["dc.bibliographiccitation.lastpage","681"],["dc.bibliographiccitation.volume","83"],["dc.contributor.author","Uter, Wolfgang"],["dc.contributor.author","Hegewald, Janice"],["dc.contributor.author","Pfahlberg, Annette"],["dc.contributor.author","Lessmann, Holger"],["dc.contributor.author","Schnuch, Axel"],["dc.contributor.author","Gefeller, Olaf"],["dc.date.accessioned","2018-11-07T08:40:49Z"],["dc.date.available","2018-11-07T08:40:49Z"],["dc.date.issued","2010"],["dc.description.abstract","To analyse the association between occupation (represented by job title) and contact allergy to thiuram vulcanising agents based on data of a clinical registry (IVDK, www.ivdk.org). Clinical, demographic and allergy patch test data of all patients tested between 1992 and 2006 with the thiuram mix (1% in petrolatum) as part of the baseline series was analysed (n = 121,051). Poisson regression analysis was used to quantify the association between different occupations (and other relevant factors) and a positive patch test reaction to the thiuram mix. Furthermore, the time trend of sensitisation prevalence was analysed in high-risk occupational subgroups identified. In comparison to a largely unexposed reference group (office workers and teachers), rubber manufacturers had a significantly elevated risk (prevalence ratio (PR): 5.1, 95% confidence interval (CI) 2.0-10.5). However, health care workers such as physicians and dentists (PR: 3.8, 95% CI: 3.0-4.8) or nursing staff (PR: 3.0, 95% CI: 2.5-3.6) as well as meat and fish processors (PR 3.5, 95% CI: 2.2-5.3) and cleaners (PR 3.1, 95% CI: 2.5-3.8) were found to have a high sensitisation risk as well. In case of health care workers, a significant downward trend during the study period was observed; while in food processors and cleaners, sensitisation prevalence remained largely stable. The adjusted multifactorial analysis identified occupations yet unknown to be associated with elevated thiuram contact allergy risk, e.g., food processors and cleaners. Thus, (i) further in-depth research can be targeted and (ii) efforts to prevent sensitisation to thiurams focussed, e.g., by limiting thiuram concentrations in products to a residual level which is technically inevitable."],["dc.identifier.doi","10.1007/s00420-009-0503-9"],["dc.identifier.isi","000279833900009"],["dc.identifier.pmid","20041260"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4990"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19322"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-0131"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Contact allergy to thiurams: multifactorial analysis of clinical surveillance data collected by the IVDK network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]