Wienands, Jürgen

[["dc.bibliographiccitation.artnumber","e100249"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","The EMBO Journal"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Setz, Corinna S."],["dc.contributor.author","Khadour, Ahmad"],["dc.contributor.author","Renna, Valerio"],["dc.contributor.author","Iype, Joseena"],["dc.contributor.author","Gentner, Eva"],["dc.contributor.author","He, Xiaocui"],["dc.contributor.author","Datta, Moumita"],["dc.contributor.author","Young, Marc"],["dc.contributor.author","Nitschke, Lars"],["dc.contributor.author","Wienands, Jürgen"],["dc.contributor.author","Maity, Palash C."],["dc.contributor.author","Reth, Michael"],["dc.contributor.author","Jumaa, Hassan"],["dc.date.accessioned","2019-07-09T11:51:55Z"],["dc.date.available","2019-07-09T11:51:55Z"],["dc.date.issued","2019"],["dc.description.abstract","In contrast to other B-cell antigen receptor (BCR) classes, the function of IgD BCR on mature B cells remains largely elusive as mature B cells co-express IgM, which is sufficient for development, survival, and activation of B cells. Here, we show that IgD expression is regulated by the forkhead box transcription factor FoxO1, thereby shifting the responsiveness of mature B cells towards recognition of multivalent antigen. FoxO1 is repressed by phosphoinositide 3-kinase (PI3K) signaling and requires the lipid phosphatase Pten for its activation. Consequently, Pten-deficient B cells expressing knock-ins for BCR heavy and light chain genes are unable to upregulate IgD. Furthermore, in the presence of autoantigen, Pten-deficient B cells cannot eliminate the autoreactive BCR specificity by secondary light chain gene recombination. Instead, Pten-deficient B cells downregulate BCR expression and become unresponsive to further BCR-mediated stimulation. Notably, we observed a delayed germinal center (GC) reaction by IgD-deficient B cells after immunization with trinitrophenyl-ovalbumin (TNP-Ova), a commonly used antigen for T-cell-dependent antibody responses. Together, our data suggest that the activation of IgD expression by Pten/FoxO1 results in mature B cells that are selectively responsive to multivalent antigen and are capable of initiating rapid GC reactions and T-cell-dependent antibody responses."],["dc.identifier.doi","10.15252/embj.2018100249"],["dc.identifier.pmid","31015337"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16227"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60039"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation","info:eu-repo/grantAgreement/EC/H2020/694992/EU//Autonomous CLL-BCRs"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/322972/EU//NANO-ISLANDS"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Pten controls B‐cell responsiveness and germinal center reaction by regulating the expression of IgD BCR"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A74"],["dc.bibliographiccitation.issue","Suppl 1"],["dc.bibliographiccitation.journal","Cell Communication and Signaling"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Engels, N."],["dc.contributor.author","König, L."],["dc.contributor.author","Heemann, C."],["dc.contributor.author","Tsubata, T."],["dc.contributor.author","Griep, S."],["dc.contributor.author","Schrader, V."],["dc.contributor.author","Wienands, J."],["dc.date.accessioned","2011-04-18T13:57:32Z"],["dc.date.accessioned","2021-10-27T13:22:40Z"],["dc.date.available","2011-04-18T13:57:32Z"],["dc.date.available","2021-10-27T13:22:40Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1186/1478-811X-7-S1-A74"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6162"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92115"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","The immunoglobulin tail tyrosine of membrane-bound IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched memory B cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A73"],["dc.bibliographiccitation.issue","Suppl 1"],["dc.bibliographiccitation.journal","Cell Communication and Signaling"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Engelke, M."],["dc.contributor.author","Li, X."],["dc.contributor.author","Manno, B."],["dc.contributor.author","Neumann, K."],["dc.contributor.author","Wienands, J."],["dc.date.accessioned","2011-04-18T14:05:52Z"],["dc.date.accessioned","2021-10-27T13:22:40Z"],["dc.date.available","2011-04-18T14:05:52Z"],["dc.date.available","2021-10-27T13:22:40Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1186/1478-811X-7-S1-A73"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92116"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","B cell antigen receptor-induced plasma membrane recruitment of the SH2 domain-containing inositol phosphatase is mediated by the protein tyrosine kinases Lyn and Syk"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A21"],["dc.bibliographiccitation.issue","Suppl 1"],["dc.bibliographiccitation.journal","Cell Communication and Signaling"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Oellerich, T."],["dc.contributor.author","Gronborg, M."],["dc.contributor.author","Neumann, K."],["dc.contributor.author","Hsiao, H.-H."],["dc.contributor.author","Urlaub, H."],["dc.contributor.author","Wienands, J."],["dc.date.accessioned","2011-04-15T08:34:37Z"],["dc.date.accessioned","2021-10-27T13:22:36Z"],["dc.date.available","2011-04-15T08:34:37Z"],["dc.date.available","2021-10-27T13:22:36Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1186/1478-811X-7-S1-A21"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6142"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92109"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Elucidation of the SLP-65 phosphorylation state in activated B lymphocytes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Immunological Reviews"],["dc.bibliographiccitation.lastpage","149"],["dc.bibliographiccitation.volume","232"],["dc.contributor.author","Neumann, Konstantin"],["dc.contributor.author","Oellerich, Thomas"],["dc.contributor.author","Urlaub, Henning"],["dc.contributor.author","Wienands, Jürgen"],["dc.date.accessioned","2011-04-21T09:31:50Z"],["dc.date.accessioned","2021-10-27T13:22:42Z"],["dc.date.available","2011-04-21T09:31:50Z"],["dc.date.available","2021-10-27T13:22:42Z"],["dc.date.issued","2009"],["dc.description.abstract","The growth factor receptor-bound protein 2 (Grb2) is a ubiquitously expressed and evolutionary conserved adapter protein possessing a plethora of described interaction partners for the regulation of signal transduction. In B lymphocytes, the Grb2-mediated scaffolding function controls the assembly and subcellular targeting of activating as well as inhibitory signalosomes in response to ligation of the antigen receptor. Also, integration of simultaneous signals from B-cell coreceptors that amplify or attenuate antigen receptor signal output relies on Grb2. Hence, Grb2 is an essential signal integrator. The key question remains, however, of how pathway specificity can be maintained during signal homeostasis critically required for the balance between immune cell activation and tolerance induction. Here, we summarize the molecular network of Grb2 in B cells and introduce a proteomic approach to elucidate the interactome of Grb2 in vivo."],["dc.identifier.doi","10.1111/j.1600-065X.2009.00845.x"],["dc.identifier.isi","000271057600011"],["dc.identifier.pmid","19909361"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6258"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92119"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1600-065X"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","B-Lymphocytes"],["dc.subject.mesh","GRB2 Adaptor Protein"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Immune Tolerance"],["dc.subject.mesh","Lymphocyte Activation"],["dc.subject.mesh","Protein Interaction Domains and Motifs"],["dc.subject.mesh","Protein Multimerization"],["dc.subject.mesh","Proteomics"],["dc.subject.mesh","Receptor Cross-Talk"],["dc.subject.mesh","Receptors, Antigen, B-Cell"],["dc.subject.mesh","Signal Transduction"],["dc.title","The B-lymphoid Grb2 interaction code."],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","A72"],["dc.bibliographiccitation.issue","Suppl 1"],["dc.bibliographiccitation.journal","Cell Communication and Signaling"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Engelke, M."],["dc.contributor.author","Hartig, R."],["dc.contributor.author","Goldbeck, I."],["dc.contributor.author","Manno, B."],["dc.contributor.author","Stirnweiß, A."],["dc.contributor.author","Zuschratter, W."],["dc.contributor.author","Schraven, B."],["dc.contributor.author","Wienands, J."],["dc.date.accessioned","2011-04-15T08:55:41Z"],["dc.date.accessioned","2021-10-27T13:22:37Z"],["dc.date.available","2011-04-15T08:55:41Z"],["dc.date.available","2021-10-27T13:22:37Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1186/1478-811X-7-S1-A72"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6144"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92111"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Real time monitoring of B cell antigen receptor-proximal events by fluorescence lifetime imaging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]