Schmidt, Holger

[["dc.bibliographiccitation.artnumber","e0003972"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","PLoS neglected tropical diseases"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Mwape, Kabemba E."],["dc.contributor.author","Blocher, Joachim"],["dc.contributor.author","Wiefek, Jasmin"],["dc.contributor.author","Schmidt, Kathie"],["dc.contributor.author","Dorny, Pierre"],["dc.contributor.author","Praet, Nicolas"],["dc.contributor.author","Chiluba, Clarance"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Phiri, Isaac K."],["dc.contributor.author","Winkler, Andrea S."],["dc.contributor.author","Gabriël, Sarah"],["dc.date.accessioned","2019-07-09T11:41:47Z"],["dc.date.available","2019-07-09T11:41:47Z"],["dc.date.issued","2015-08-01"],["dc.description.abstract","Zambia is endemic for Taenia solium taeniosis and cysticercosis. In this single-centered, cross-sectional, community-based study, the role of neurocysticercosis (NCC) as a cause of epilepsy was examined. People with epilepsy (PWE, n = 56) were identified in an endemic area using a screening questionnaire followed by in-depth interviews and neurological examination. Computed tomography (CT) was performed on 49 people with active epilepsy (PWAE) and their sera (specific antibody and antigen detection, n = 56) and stools (copro-antigen detection, n = 54) were analyzed. The CT scan findings were compared to a group of 40 CT scan controls. Of the PWE, 39.3% and 23.2% were positive for cysticercal antibodies and antigens, respectively, and 14.8% for coproantigens (taeniosis). Lesions highly suggestive of NCC were detected in 24.5% and definite NCC lesions in 4.1% of CT scans of PWAE. This compares to 2.5% and 0%, respectively, in the control CT scans. Using the Del Brutto diagnostic criteria, 51.8% of the PWAE were diagnosed with probable or definitive NCC and this rose to 57.1% when the adapted criteria, as proposed by Gabriël et al. (adding the sero-antigen ELISA test as a major criterion), were used. There was no statistically significant relationship between NCC, current age, age at first seizure and gender. This study suggests that NCC is the single most important cause of epilepsy in the study area. Additional large-scale studies, combining a community based prevalence study for epilepsy with neuroimaging and serological analysis in different areas are needed to estimate the true impact of neurocysticercosis in endemic regions and efforts should be instituted to the control of T. solium."],["dc.identifier.doi","10.1371/journal.pntd.0003972"],["dc.identifier.pmid","26285031"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58512"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1935-2735"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","354"],["dc.bibliographiccitation.journal","Epilepsy & Behavior"],["dc.bibliographiccitation.lastpage","359"],["dc.bibliographiccitation.volume","80"],["dc.contributor.author","Nau, Anne L."],["dc.contributor.author","Mwape, Kabemba E."],["dc.contributor.author","Wiefek, Jasmin"],["dc.contributor.author","Schmidt, Kathie"],["dc.contributor.author","Abatih, Emmanuel"],["dc.contributor.author","Dorny, Pierre"],["dc.contributor.author","Praet, Nicolas"],["dc.contributor.author","Chiluba, Clarance"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Phiri, Isaac K."],["dc.contributor.author","Winkler, Andrea S."],["dc.contributor.author","Gabriël, Sarah"],["dc.contributor.author","Blocher, Joachim"],["dc.date.accessioned","2020-12-10T15:21:46Z"],["dc.date.available","2020-12-10T15:21:46Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.yebeh.2017.10.042"],["dc.identifier.issn","1525-5050"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73156"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Cognitive impairment and quality of life of people with epilepsy and neurocysticercosis in Zambia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","139"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Holzgraefe, Manfred"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Blocher, Joachim"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.date.accessioned","2018-11-07T09:53:13Z"],["dc.date.available","2018-11-07T09:53:13Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Patients often report neurocognitive difficulties after neuroborreliosis (NB). The frequency and extent of cognitive problems in European patients have been studied incompletely. Methods: Sixty patients received a neurological and neuropsychological work-up 6 months or longer after treatment for proven NB. Quality of life, psychiatric symptom load, and brain atrophy were measured. All results were compared with a group of 30 healthy control persons adapted for age, gender and education being serologically negative for Borrelia burgdorferi senso latu. A cognitive sum score and a global sum score including cognitive, psychological results and quality of life data was calculated for both groups. Results: Patients after NB showed a lower (i.e. more impaired) score on the Scripps Neurological rating scale (SNRS), but the observed neurological deficits were generally mild (mean +/- SD: 97.1 +/- 4.7 vs. 99.1 +/- 2.4, p = 0.02). The mean neuropsychological domain results of the NB group were all within the normal range. However, a lower performance was found for the frontal executive function z-values (mean +/- SD-0.29 +/- 0.60 vs. 0.09 +/- 0.60; p = 0.0059) of NB patients. Comparing the global sum score (mean +/- SD 11.3 +/- 4.2(NB) vs. 14.3 +/- 2.9(control), p = 0.001) and the cognitive sum score of the NB group with those of the control group (mean +/- SD -0.15 +/- 0.42(NB) vs. 0.08 +/- 0.31(control), p = 0.0079), both differences were statistically different. The frequencies of impaired global sum scores and those of the pathological cognitive sum scores (p = 0.07) did not differ statistically. No significant differences were found for health-related quality of life (hrQoL), sleep, psychiatric symptom load, or brain atrophy. Conclusion: The mean cognitive functions of patients after proven NB were in the normal range. However, we were able to demonstrate a lower performance for the domain of frontal executive functions, for the mean cognitive sum score and the global sum score as a sign of subtle but measurable sequelae of neuroborreliosis. Brain atrophy is not a common consequence of neuroborreliosis."],["dc.identifier.doi","10.1186/s12883-015-0386-1"],["dc.identifier.isi","000361446200001"],["dc.identifier.pmid","26286440"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12505"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36286"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Neurocognitive functions and brain atrophy after proven neuroborreliosis: a case-control study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","128"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Neurology"],["dc.bibliographiccitation.lastpage","132"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Goerdt, Christoph"],["dc.contributor.author","Lange, Peter"],["dc.contributor.author","Blocher, Joachim"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Gerber, Joachim"],["dc.contributor.author","Spreer, Annette"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Otto, Markus"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2018-11-07T09:01:13Z"],["dc.date.available","2018-11-07T09:01:13Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Patients with meningitis are often difficult to classify into bacterial (BM) or benign viral (VM) meningitis. To facilitate the differential diagnosis, S100B and Tau protein in the cerebrospinal fluid (CSF) were measured and compared with standard laboratory parameters. Methods: S100B(CSF), Tau(CSF), and routine parameters (CSF leukocyte count, protein(CSF), lactate(CSF), serum C-reactive protein, blood leukocyte count and body temperature) were analyzed in 33 patients with microbiologically confirmed BM and in 19 with VM. Their classification accuracy, sensitivity and specificity were studied by receiver operating characteristic (ROC) curves. Results: S100B CSF concentrations were higher in BM than in VM patients (p = 0.03) and showed a promising accuracy (90%) for the differential diagnosis of BM versus VM. Its discriminative properties were comparable to routine parameters. Of all parameters, S100B CSF showed the highest specificity (100%) with an optimal cut-off of 3.1 ng/ml. Tau(CSF) concentrations were useless for the discrimination (p = 0.64). Conclusions: In contrast to Tau(CSF), S100B(CSF) concentrations >= 3.1 ng/ml are promising to discriminate bacterial from viral meningitis. Copyright (C) 2011 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000330566"],["dc.identifier.isi","000294547100002"],["dc.identifier.pmid","21865761"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8030"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24365"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0014-3022"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","The Use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: A Retrospective Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]