Schmidt, Holger

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Vascular Surgery"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Schnaudigel, Sonja"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Knauf, Jana"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Hildebrandt, Helmut"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T09:01:37Z"],["dc.date.available","2018-11-07T09:01:37Z"],["dc.date.issued","2011"],["dc.description.abstract","Purpose: Carotid angioplasty and stenting (CAS) is increasingly being used as a treatment alternative to endarterectomy (CEA) for patients with significant carotid stenosis. However, diffusion-weighted imaging (DWI) has indicated that CAS is associated with a significantly higher burden of microemboli. This study evaluated the potential effect on intellectual functions of new DWI lesions after CEA or CAS. Methods: This prospective study analyzed the neuropsychologic outcomes after revascularization in 24 CAS and 31 CEA patients with severe carotid stenosis compared with a control group of 27 healthy individuals. All patients underwent clinical examinations, magnetic resonance imaging scans, and a neuropsychologic test battery that assessed six major cognitive domains performed immediately before CEA or CAS, <= 72 hours after, and at 3 months. Results: New DWI lesions were detected among 15 of 21 (71%) of the CAS patients immediately after treatment but in only 1 of the 28 CEA patients (4%; P < .01). As a group, patients with new DWI lesions showed a decline in their performance in the cognitive domains, attention, and visuoconstructive functions within 72 hours of carotid revascularization. Individually, however, in none of the cognitive domains did the decreases reach a clinically relevant threshold of z < -1.5. Moreover, the cognitive performance was not significantly different between patients with and without new DWI lesions 3 months after treatment. The cognitive performance was similar between CEA and CAS patients at all points. Conclusions: The findings support the assumption that new brain lesions, as detected with DWI after CAS or CEA, do not affect cognitive performance in a manner that is long-lasting or clinically relevant. Despite the higher embolic load detected by DWI, CAS is not associated with a greater cognitive decline than CEA. (J Vasc Surg 2011;53:61-70.)"],["dc.identifier.doi","10.1016/j.jvs.2010.07.061"],["dc.identifier.isi","000286085200009"],["dc.identifier.pmid","20875716"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24474"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.relation.issn","0741-5214"],["dc.title","New brain lesions after carotid revascularization are not associated with cognitive performance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","6653"],["dc.bibliographiccitation.journal","Cases Journal"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Tönges, Lars"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Puls, Miriam"],["dc.contributor.author","Schmidt, Holger"],["dc.date.accessioned","2019-07-09T11:52:37Z"],["dc.date.available","2019-07-09T11:52:37Z"],["dc.date.issued","2009"],["dc.description.abstract","For prosthetic heart valves the risk of infection is much higher than for native heart valves. During the course of infective endocarditis 20-40% of all patients suffer from cerebrovascular complications such as ischaemic stroke or intracerebral haemorrhage. We present the case of a 57-year-old woman who had undergone surgery to mechanically replace an aortic heart valve 11 months ago and suffered from repeated ischaemic strokes with secondary haemorrhage. The initial antibiotic regimen was ineffective in treating the later diagnosed Staphylococcus aureus infection of the prosthetic valve. Escalation of the antibiotic treatment was not able to halt the clinical course that finally led to the patient's death. The case report emphasizes the importance of early identification of the aetiology of infection in patients with mechanical heart valve replacement. Without rapid and adequate treatment there is a considerable risk for the development of severe neurological sequelae and cardiac failure that can ultimately result in a fatal course of this clinical picture."],["dc.identifier.doi","10.4076/1757-1626-2-6653"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/5751"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60238"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.intern","In goescholar not merged with http://resolver.sub.uni-goettingen.de/purl?gs-1/13214 but duplicate"],["dc.rights","CC BY 3.0"],["dc.rights.access","openAccess"],["dc.rights.holder","et al.; licensee BioMed Central Ltd."],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.subject.ddc","610"],["dc.title","Septic embolic encephalitis after Staphylococcus aureus endocarditis of a prosthetic valve in a 57-year-old woman: a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2309"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","2318"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Hildebrandt, Helmut"],["dc.contributor.author","Groeschel, Sonja"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T09:04:12Z"],["dc.date.available","2018-11-07T09:04:12Z"],["dc.date.issued","2012"],["dc.description.abstract","Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on cognitive performance after either CEA or CAS using a comprehensive neuropsychological test battery with parallel test forms and a control group to exclude a learning effect. The neuropsychological outcomes after revascularization were determined in 19 CAS and 27 CEA patients with severe carotid stenosis. The patients were subdivided according to their median age (< 68 years and a parts per thousand yen68 years); 27 healthy subjects served as a control group. In all patients clinical examinations, MRI scans and a neuropsychological test battery that assessed four major cognitive domains were performed immediately before, within 72 h, and 3 months after CEA or CAS. While patients < 68 years of age showed no significant cognitive alteration after either CEA or CAS, a significant cognitive decline was observed in patients a parts per thousand yen68 years in both treatment groups (p = 0.001). Notably, this cognitive deterioration persisted in patients after CEA, whereas it was only transient in patients treated with CAS. These results demonstrate an age-dependent effect of CEA and CAS on cognitive functions. In contrast to the recently observed increased clinical complication rates in older subjects after CAS compared with CEA, CEA appears to be associated with a greater, persistent decline in cognitive performance than CAS in this subgroup of patients."],["dc.identifier.doi","10.1007/s00415-012-6491-9"],["dc.identifier.isi","000310472100006"],["dc.identifier.pmid","22527231"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8810"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25062"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Age-dependent effects of carotid endarterectomy or stenting on cognitive performance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]