Belle, Gijsbert Jacob Christiaan van

[["dc.bibliographiccitation.artnumber","299"],["dc.bibliographiccitation.journal","Frontiers in molecular neuroscience"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Niebert, Sabine"],["dc.contributor.author","van Belle, Gijsbert J."],["dc.contributor.author","Vogelgesang, Steffen"],["dc.contributor.author","Manzke, Till"],["dc.contributor.author","Niebert, Marcus"],["dc.date.accessioned","2019-07-09T11:44:34Z"],["dc.date.available","2019-07-09T11:44:34Z"],["dc.date.issued","2017"],["dc.description.abstract","Previously, we described the dysregulation of serotonin (5-HT) receptor subtype 5b (5-ht5b) in a mouse model of Rett syndrome (RTT). 5-ht5b has not been extensively studied, so we set out to characterize it in more detail. Unlike common cell surface receptors, 5-ht5b displays no membrane expression, while receptor clusters are located in endosomes. This unusual subcellular localization is at least in part controlled by glycosylation of the N-terminus, with 5-ht5b possessing fewer glycosylation sites than related receptors. We analyzed whether the localization to endosomes has any functional relevance and found that 5-ht5b receptors can specifically interact with 5-HT1A receptors and retain them in endosomal compartments. This interaction reduces 5-HT1A surface expression and is mediated by interactions between the fourth and fifth trans-membrane domain (TMD). This possibly represents a mechanism by which 5-ht5b receptors regulate the activity of other 5-HT receptor."],["dc.identifier.doi","10.3389/fnmol.2017.00299"],["dc.identifier.pmid","28983239"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14819"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59037"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1662-5099"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","The Serotonin Receptor Subtype 5b Specifically Interacts with Serotonin Receptor Subtype 1A."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]