Männer, Jörg

[["dc.bibliographiccitation.firstpage","425"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Annals of Anatomy - Anatomischer Anzeiger"],["dc.bibliographiccitation.lastpage","435"],["dc.bibliographiccitation.volume","193"],["dc.contributor.author","Happel, Christoph M."],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Thommes, Jan"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T09:00:42Z"],["dc.date.available","2018-11-07T09:00:42Z"],["dc.date.issued","2011"],["dc.description.abstract","High-resolution in vivo imaging of higher vertebrate embryos over short or long time periods under constant physiological conditions is a technically challenging task for researchers working on cardiovascular development. In chick embryos, for example, various studies have shown that without appropriate maintenance of temperature, as one of the main environmental factors, the embryonic heart rate drops rapidly and often results in an increase in regurgitant flow. Hemodynamic parameters are critical stimuli for cardiovascular development that, for a correct evaluation of their developmental significance, should be documented under physiological conditions. However, previous studies were mostly carried out outside of an incubator or under suboptimal environmental conditions. Here we present, to the best of our knowledge, the first detailed description of an optical coherence tomography (OCT) system integrated into an examination incubator to facilitate real-time in vivo imaging of cardiovascular development under physiological environmental conditions. We demonstrate the suitability of this OCT examination incubator unit for use in cardiovascular development studies by examples of proof of principle experiments. We, furthermore, point out the need for use of examination incubators for physiological OCT examinations by documenting the effects of room climate (22 degrees C) on the performance of the cardiovascular system of chick embryos (HH-stages 16/17). Upon exposure to room climate, chick embryos showed a fast drop in the heart rate and striking changes in the cardiac contraction behaviour and the blood flow through the vitelline circulation. We have documented these changes for the first time by M-mode OCT and Doppler M-mode OCT. (C) 2011 Elsevier GmbH. All rights reserved."],["dc.identifier.doi","10.1016/j.aanat.2011.04.006"],["dc.identifier.isi","000296953300006"],["dc.identifier.pmid","21641190"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24236"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.relation.issn","0940-9602"],["dc.title","Integration of an optical coherence tomography (OCT) system into an examination incubator to facilitate in vivo imaging of cardiovascular development in higher vertebrate embryos under stable physiological conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Happel, C. M."],["dc.contributor.author","Thommes, Jan"],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Ortmaier, Tobias"],["dc.contributor.author","Heimann, B."],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T08:52:34Z"],["dc.date.available","2018-11-07T08:52:34Z"],["dc.date.issued","2011"],["dc.format.extent","834"],["dc.identifier.isi","000294690900061"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22200"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.title","Rotationally acquired 4D optical coherence tomography (OCT) of embryonic chick hearts using retrospective gating on the common central A-scan"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3273"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","3284"],["dc.bibliographiccitation.volume","238"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Norozi, Kambiz"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T11:21:24Z"],["dc.date.available","2018-11-07T11:21:24Z"],["dc.date.issued","2009"],["dc.description.abstract","The cardiac cycle-related deformations of tubular embryonic hearts were traditionally described as concentric narrowing and widening of a tube of circular cross-section. Using optical coherence tomography (OCT), we have recently shown that, during the cardiac cycle, only the myocardial tube undergoes concentric narrowing and widening while the endocardial tube undergoes eccentric narrowing and widening, having an elliptic cross-section at end-diastole and a slit-shaped cross-section at end-systole. Due to technical limitations, these analyses were confined to early stages of ventricular development (chick embryos, stages 10-13). Using a modified OCT-system, we now document, for the first time, the cyclic changes in cross-sectional shape of beating embryonic ventricles at stages 14 to 17. We show that during these stages (1) a large area of diminished cardiac jelly appears at the outer curvature of the ventricular region associated with formation of endocardial pouches; (2) the ventricular endocardial lumen acquires a bell-shaped cross-section at end-diastole and becomes compressed like a fireplace bellows during systole; (3) the contracting portions of the embryonic ventricles display stretching along its baso-apical axis at end-systole. The functional significance of our data is discussed with respect to early cardiac pumping function. Developmental Dynamics 238:3273-3284, 2009. (C) 2009 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.22159"],["dc.identifier.isi","000272549100028"],["dc.identifier.pmid","19924823"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55763"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","In Vivo Imaging of the Cyclic Changes in Cross-sectional Shape of the Ventricular Segment of Pulsating Embryonic Chick Hearts at Stages 14 to 17: A Contribution to the Understanding of the Ontogenesis of Cardiac Pumping Function"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","15"],["dc.bibliographiccitation.journal","Journal of the American Heart Association"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Omer, Seham O."],["dc.contributor.author","Alhabshan, Fahad M."],["dc.contributor.author","Jijeh, Abdulraouf M. Z."],["dc.contributor.author","Caimbon, Natalia C."],["dc.contributor.author","Enriquez, Carmelita C."],["dc.contributor.author","Männer, Jörg"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2021-09-01T06:38:29Z"],["dc.date.available","2021-09-01T06:38:29Z"],["dc.date.issued","2021"],["dc.description.abstract","Background The pathogenesis of transposition of the great arteries (TGA) as a congenital heart defect of the outflow tract with discordant ventriculoarterial connections remains an enigma. TGA usually have parallel great arteries suggesting that deficient torsion of the embryonic arterial heart pole might cause discordant ventriculoarterial connections. It has been speculated that deficient elongation of the embryonic outflow tract might prevent its normal torsion resulting in TGA. The aim of our study was to clarify whether the intrapericardial portions of the great arteries in human patients with TGA might be indeed shorter than in normal hearts. Methods and Results Thirty‐four newborns with simple TGA and 35 newborns with normal hearts were analyzed by using images of the outflow tract in their echocardiograms and the following defined lengths of the great arteries were measured: aortic length 1, (AoL‐1) and aortic length 2 (AoL‐2) = distance between left and right aortic valve level and origin of the brachiocephalic artery, respectively. Pulmonary trunk length 1 (PTL‐1) and pulmonary trunk length 2 (PTL 2) = distance between left and right pulmonary valve level and origin of left and right pulmonary artery, respectively. All measurements of the AoL were significantly shorter in TGA compared to normal hearts (AoL‐1: 1.6±0.2 versus 2.05±0.1; P <0.0001; AoL‐2: 1.55±0.2 versus 2.13±0.1; P <0.0001). With regard to the pulmonary trunk (PT), PTL‐1 and PTL‐2 were found to be shorter and longer, respectively, in TGA compared with normal hearts, reflecting the differences in the spatial arrangement of the PT between the 2 groups as in TGA the PT is showing a mirror image of the normal anatomy. However, the overall length of the PT between the 2 groups did not differ. Conclusions Our data demonstrate that, compared with normal newborns, the ascending aorta is significantly shorter in newborns with TGA whereas the overall length of the PT does not differ between the 2 groups. This finding is in accord with the animal model‐based hypothesis that TGA may result from a growth deficit at the arterial pole of the embryonic heart."],["dc.description.abstract","Background The pathogenesis of transposition of the great arteries (TGA) as a congenital heart defect of the outflow tract with discordant ventriculoarterial connections remains an enigma. TGA usually have parallel great arteries suggesting that deficient torsion of the embryonic arterial heart pole might cause discordant ventriculoarterial connections. It has been speculated that deficient elongation of the embryonic outflow tract might prevent its normal torsion resulting in TGA. The aim of our study was to clarify whether the intrapericardial portions of the great arteries in human patients with TGA might be indeed shorter than in normal hearts. Methods and Results Thirty‐four newborns with simple TGA and 35 newborns with normal hearts were analyzed by using images of the outflow tract in their echocardiograms and the following defined lengths of the great arteries were measured: aortic length 1, (AoL‐1) and aortic length 2 (AoL‐2) = distance between left and right aortic valve level and origin of the brachiocephalic artery, respectively. Pulmonary trunk length 1 (PTL‐1) and pulmonary trunk length 2 (PTL 2) = distance between left and right pulmonary valve level and origin of left and right pulmonary artery, respectively. All measurements of the AoL were significantly shorter in TGA compared to normal hearts (AoL‐1: 1.6±0.2 versus 2.05±0.1; P <0.0001; AoL‐2: 1.55±0.2 versus 2.13±0.1; P <0.0001). With regard to the pulmonary trunk (PT), PTL‐1 and PTL‐2 were found to be shorter and longer, respectively, in TGA compared with normal hearts, reflecting the differences in the spatial arrangement of the PT between the 2 groups as in TGA the PT is showing a mirror image of the normal anatomy. However, the overall length of the PT between the 2 groups did not differ. Conclusions Our data demonstrate that, compared with normal newborns, the ascending aorta is significantly shorter in newborns with TGA whereas the overall length of the PT does not differ between the 2 groups. This finding is in accord with the animal model‐based hypothesis that TGA may result from a growth deficit at the arterial pole of the embryonic heart."],["dc.identifier.doi","10.1161/JAHA.120.019334"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88941"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","2047-9980"],["dc.title","Is Transposition of the Great Arteries Associated With Shortening of the Intrapericardial Portions of the Great Arterial Trunks? An Echocardiographic Analysis on Newborn Infants With Simple Transposition of the Great Arteries to Explore an Animal Model‐Based Hypothesis on Human Beings"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1035"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","1046"],["dc.bibliographiccitation.volume","239"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Wessel, Armin"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T08:44:27Z"],["dc.date.available","2018-11-07T08:44:27Z"],["dc.date.issued","2010"],["dc.description.abstract","The heart is the first organ to function in vertebrate embryos. The human heart, for example, starts beating around the 21st embryonic day. During the initial phase of its pumping action, the embryonic heart is seen as a pulsating blood vessel that is built up by (1) an inner endothelial tube lacking valves, (2) a middle layer of extracellular matrix, and (3) an outer myocardial tube. Despite the absence of valves, this tubular heart generates unidirectional blood flow. This fact poses the question how it works. Visual examination of the pulsating embryonic heart tube shows that its pumping action is characterized by traveling mechanical waves sweeping from its venous to its arterial end. These traveling waves were traditionally described as myocardial peristaltic waves. It has, therefore, been speculated that the tubular embryonic heart works as a technical peristaltic pump. Recent hemodynamic data from living embryos, however, have shown that the pumping function of the embryonic heart tube differs in several respects from that of a technical peristaltic pump. Some of these data suggest that embryonic heart tubes work as valveless \"Liebau pumps.\" In the present study, a review is given on the evolution of the two above-mentioned theories of early cardiac pumping mechanics. We discuss pros and cons for both of these theories. We show that the tubular embryonic heart works neither as a technical peristaltic pump nor as a classic Liebau pump. The question regarding how the embryonic heart tube works still awaits an answer. Developmental Dynamics 239:1035-1046, 2010. (C) 2010 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.22265"],["dc.identifier.isi","000276531200001"],["dc.identifier.pmid","20235196"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20204"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","How Does the Tubular Embryonic Heart Work? Looking for the Physical Mechanism Generating Unidirectional Blood Flow in the Valveless Embryonic Heart Tube"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","263"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","266"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Misske, Judith"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T11:00:23Z"],["dc.date.available","2018-11-07T11:00:23Z"],["dc.date.issued","2007"],["dc.description.abstract","The classical Hamburger and Hamilton (HH) paper demonstrates the normal stages of development of the chick embryo that have been extensively used as the basis of understanding normal and abnormal development of the chick embryo heart. Careful examination of the series of images published in this seminal paper indicates that the cardiac images of stage 16 embryo shown in this article may reflect an abnormally developed heart. In this article, the argument is presented that the embryo depicted in the HH paper is not normal, but instead inflicted with a conotruncal heart defect."],["dc.identifier.doi","10.1007/s00246-006-0109-x"],["dc.identifier.isi","000247464700004"],["dc.identifier.pmid","17578634"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50906"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0172-0643"],["dc.title","Does the stage 16 embryo in Hamburger-Hamilton's \"Series of normal stages in the development of the chick embryo\" have a potential \"conotruncal\" heart defect?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Norozi, K."],["dc.contributor.author","Misske, Judith"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Wuebbolt-Lehmann, P."],["dc.contributor.author","Reccius, K."],["dc.contributor.author","Wessel, Alok D."],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T10:58:48Z"],["dc.date.available","2018-11-07T10:58:48Z"],["dc.date.issued","2007"],["dc.format.extent","681"],["dc.identifier.isi","000249258500080"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50550"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Darmstadt"],["dc.relation.issn","1861-0684"],["dc.title","Heart defect in the chicken embryo reflects complex heart defects in the human: Double outlet right ventricle (DORV) with left-juxtaposition of the atria"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","953"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","961"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Thrane, Lars"],["dc.contributor.author","Norozi, Kambiz"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T11:16:26Z"],["dc.date.available","2018-11-07T11:16:26Z"],["dc.date.issued","2008"],["dc.description.abstract","The embryonic heart tube consists of an outer myocardial tube, a middle layer of cardiac jelly, and an inner endocardial tube. It is said that tubular hearts pump the blood by peristaltoid contractions. The traditional concept of cardiac peristalsis sees the cyclic deformations of pulsating heart tubes as concentric narrowing and widening of tubes of circular cross-section. We have visualized the cross-sectional deformations of contracting embryonic hearts in chick embryos (HH-stages 9-17) using real-time high-resolution optical coherence tomography. Cardiac contractions are detected from HH-stage 10 onward. During the cardiac cycle, the myocardial tube undergoes concentric narrowing and widening while the endocardial tube undergoes eccentric narrowing and widening, having an elliptic cross-section at end-diastole and a slit-shaped cross-section at end-systole. The eccentric deformation of the endocardial tube is the consequence of an uneven distribution of the cardiac jelly. Our data show that the cyclic deformations of pulsating embryonic heart tubes run other than originally thought. There is evidence that heart tubes of elliptic cross-section might pump blood with a higher mechanical efficiency than those of circular-cross section. The uneven distribution of cardiac jelly seems to prefigure the future AV and cono-truncal endocardial cushions."],["dc.identifier.doi","10.1002/dvdy.21483"],["dc.identifier.isi","000254903700008"],["dc.identifier.pmid","18330931"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54587"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","High-resolution in vivo Imaging of the cross-sectional deformations of contracting embryonic heart loops using optical coherence tomography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","204"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Microscopy and Microanalysis"],["dc.bibliographiccitation.lastpage","210"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Orhan, Giilay"],["dc.contributor.author","Baron, Stephan"],["dc.contributor.author","Norozi, Kambiz"],["dc.contributor.author","Maenner, Joerg"],["dc.contributor.author","Hornung, Oliver"],["dc.contributor.author","Blume, Holger"],["dc.contributor.author","Misske, Judith"],["dc.contributor.author","Heimann, Bodo"],["dc.contributor.author","Wessel, Armin"],["dc.contributor.author","Yelbuz, Talat Mesud"],["dc.date.accessioned","2018-11-07T11:02:03Z"],["dc.date.available","2018-11-07T11:02:03Z"],["dc.date.issued","2007"],["dc.description.abstract","Heart development, especially the critical phase of cardiac looping, is a complex and intricate process that has not yet been visualized \"live\" over long periods of time. We have constructed and established a new environmental incubator chamber that provides stable conditions for embryonic development with regard to temperature, humidity, and oxygen levels. We have integrated a video microscope in the chamber to visualize the developing heart in real time and present the first \"live\" recordings of a chick embryo in shell-less culture acquired over a period of 2 days. The time-lapse images we show depict a significant time window that covers the most critical and typical morphogenetic events during normal cardiac looping. Our system is of interest to researchers in the field of embryogenesis, as it can be adapted to a variety of animal models for organogenesis studies including heart and limb development."],["dc.identifier.doi","10.1017/S1431927607070390"],["dc.identifier.isi","000246814100009"],["dc.identifier.pmid","17490503"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51288"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.publisher.place","New york"],["dc.relation.conference","7th Regional Workshop of the European-Microbeam-Analysis-Society"],["dc.relation.eventlocation","Karlsruhe, GERMANY"],["dc.relation.issn","1431-9276"],["dc.title","Construction and establishment of a new environmental chamber to study real-time cardiac development"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]