Hahn, Nina

[["dc.bibliographiccitation.artnumber","223"],["dc.bibliographiccitation.journal","Frontiers in Molecular Neuroscience"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Knorr, Debbra Y."],["dc.contributor.author","Liebig, Johannes"],["dc.contributor.author","Wüstefeld, Liane"],["dc.contributor.author","Peters, Karsten"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Büscher, Marita"],["dc.contributor.author","Bucher, Gregor"],["dc.date.accessioned","2018-03-08T09:22:14Z"],["dc.date.available","2018-03-08T09:22:14Z"],["dc.date.issued","2017"],["dc.description.abstract","The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric “classical” Epo receptors, alternative receptors are involved in neuroprotection. However, their identity remains enigmatic due to complex cytokine ligand and receptor interactions and conflicting experimental results. Besides the classical Epo receptor, the family of type I cytokine receptors also includes the poorly characterized orphan cytokine receptor-like factor 3 (CRLF3) present in vertebrates including human and various insect species. By making use of the more simple genetic makeup of insect model systems, we studied whether CRLF3 is a neuroprotective Epo receptor in animals. We identified a single ortholog of CRLF3 in the beetle Tribolium castaneum, and established protocols for primary neuronal cell cultures from Tribolium brains and efficient in vitro RNA interference. Recombinant human Epo as well as the non-erythropoietic Epo splice variant EV-3 increased the survival of serum-deprived brain neurons, confirming the previously described neuroprotective effect of Epo in insects. Moreover, Epo completely prevented hypoxia-induced apoptotic cell death of primary neuronal cultures. Knockdown of CRLF3 expression by RNA interference with two different double stranded RNA (dsRNA) fragments abolished the neuroprotective effect of Epo, indicating that CRLF3 is a crucial component of the insect Epo-responsive receptor. This suggests that a common urbilaterian ancestor of the orphan human and insect cytokine receptor CRLF3 served as a neuroprotective receptor for an Epo-like cytokine. Our work also suggests that vertebrate CRLF3, like its insect ortholog, might represent a tissue protection-mediating receptor."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2017"],["dc.identifier.doi","10.3389/fnmol.2017.00223"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14838"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/12916"],["dc.language.iso","en"],["dc.notes.intern","GRO-Li-Import"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.publisher","Frontiers Media S.A."],["dc.relation.doi","10.3389/fnmol.2017.00223"],["dc.relation.eissn","1662-5099"],["dc.relation.issn","1662-5099"],["dc.relation.issn","1662-5099"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The Insect Ortholog of the Human Orphan Cytokine Receptor CRLF3 Is a Neuroprotective Erythropoietin Receptor"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.volume","256"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Geurten, Bart R. H."],["dc.contributor.author","Gurvich, Artem"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Kaestner, Anne"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Xing, Guanglin"],["dc.contributor.author","Xie, Wei"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2018-11-07T09:17:53Z"],["dc.date.available","2018-11-07T09:17:53Z"],["dc.date.issued","2013"],["dc.format.extent","690"],["dc.identifier.doi","10.1016/j.bbr.2013.08.019"],["dc.identifier.isi","000328094100084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28278"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-7549"],["dc.relation.issn","0166-4328"],["dc.title","Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour (vol 252, pg 450, 2013)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","American Journal of Hematology"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2018-11-07T09:53:58Z"],["dc.date.available","2018-11-07T09:53:58Z"],["dc.date.issued","2015"],["dc.format.extent","E160"],["dc.identifier.isi","000358483700021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36439"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1096-8652"],["dc.relation.issn","0361-8609"],["dc.title","Erythropoietin in insects: receptors, signaling pathways and neuroprotection"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","450"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","252"],["dc.contributor.author","Hahn, Nina"],["dc.contributor.author","Geurten, Bart"],["dc.contributor.author","Gurvich, Artem"],["dc.contributor.author","Piepenbrock, David"],["dc.contributor.author","Kästner, Anne"],["dc.contributor.author","Zanini, Damiano"],["dc.contributor.author","Xing, Guanglin"],["dc.contributor.author","Xie, Wei"],["dc.contributor.author","Göpfert, Martin C."],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2017-09-07T11:46:23Z"],["dc.date.available","2017-09-07T11:46:23Z"],["dc.date.issued","2013"],["dc.description.abstract","Autism spectrum disorders (ASDs) are characterized by deficits in social interactions, language development and repetitive behaviours. Multiple genes involved in the formation, specification and maintenance of synapses have been identified as risk factors for ASDs development. Among these are the neuroligin genes which code for postsynaptic cell adhesion molecules that induce the formation of presynapses, promote their maturation and modulate synaptic functions in both vertebrates and invertebrates. Neuroligin-deficient mice display abnormal social and vocal behaviours that resemble ASDs symptoms.Here we show for the fly Drosophila melanogaster that deletion of the dnl2 gene, coding for one of four Neuroligin isoforms, impairs social interactions, alters acoustic communication signals, and affects the transition between different behaviours. dnl2-Deficient flies maintain larger distances to conspecifics and males perform less female-directed courtship and male-directed aggressive behaviours while the patterns of these behaviours and general locomotor activity were not different from wild type controls. Since tests for olfactory, visual and auditory perception revealed no sensory impairments of dnl2-deficient mutants, reduced social interactions seem to result from altered excitability in central nervous neuropils that initiate social behaviours. Our results demonstrate that Neuroligins are phylogenetically conserved not only regarding their structure and direct function at the synapse but also concerning a shared implication in the regulation of social behaviours that dates back to common ancestors of humans and flies. In addition to previously described mouse models, Drosophila can thus be used to study the contribution of Neuroligins to synaptic function, social interactions and their implication in ASDs."],["dc.identifier.doi","10.1016/j.bbr.2013.06.020"],["dc.identifier.gro","3150491"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7261"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","chake"],["dc.subject","Drosophila melanogaster; Neuroligin; Social behaviour; Acoustic communication; Behavioural transition; Autism"],["dc.title","Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]