Lotz, Joachim

[["dc.bibliographiccitation.firstpage","W123"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","American Journal of Roentgenology"],["dc.bibliographiccitation.lastpage","W131"],["dc.bibliographiccitation.volume","211"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Kunze, Meike"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Beißbarth, Tim"],["dc.date.accessioned","2020-12-10T18:43:35Z"],["dc.date.available","2020-12-10T18:43:35Z"],["dc.date.issued","2018"],["dc.description.abstract","The purpose of this study is to evaluate the diagnostic performance of machine learning techniques for malignancy prediction at breast cone-beam CT (CBCT) and to compare them to human readers."],["dc.identifier.doi","10.2214/AJR.17.19298"],["dc.identifier.eissn","1546-3141"],["dc.identifier.issn","0361-803X"],["dc.identifier.pmid","29792725"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78197"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.eissn","1546-3141"],["dc.relation.issn","0361-803X"],["dc.relation.issn","1546-3141"],["dc.title","Novel Breast Imaging and Machine Learning: Predicting Breast Lesion Malignancy at Cone-Beam CT Using Machine Learning Techniques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9"],["dc.bibliographiccitation.journal","European Journal of Radiology"],["dc.bibliographiccitation.lastpage","16"],["dc.bibliographiccitation.volume","99"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Surov, Alexey"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Wienbeck, Susanne"],["dc.date.accessioned","2020-12-10T14:23:42Z"],["dc.date.available","2020-12-10T14:23:42Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.ejrad.2017.12.003"],["dc.identifier.issn","0720-048X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/72020"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Contrast-enhanced cone-beam breast-CT: Analysis of optimal acquisition time for discrimination of breast lesion malignancy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","599"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Translational oncology"],["dc.bibliographiccitation.lastpage","603"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Wienke, Andreas"],["dc.contributor.author","Meyer, Hans Jonas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Surov, Alexey"],["dc.date.accessioned","2019-07-09T11:43:26Z"],["dc.date.available","2019-07-09T11:43:26Z"],["dc.date.issued","2017-06-27"],["dc.description.abstract","PURPOSE: Recently, cone-beam breast computed tomography (CBCT) is established for the breast investigation. The purpose of the present study was to investigate possible associations between CBCT findings and histopathological features in breast cancer. METHODS: Overall, 59 female patients, mean age of 64.6 years with histological proven breast cancer were included into the study. In all cases, non-contrast CBCT examination was done. The diagnosis of the identified lesions was confirmed histologically by biopsy. Immunohistochemical staining against estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 was performed for every lesion. Collected data were evaluated by means of descriptive statistics. Spearman's correlation coefficient was used to analyze the association between CT density and Ki-67 values. P values <0.05 were taken to indicate statistical significance in all instances. RESULTS: The size of the lesion varied from 2.7 to 90.0, mean size, 15.88±13.0 mm. The mean value of CT density of the lesions was 63.95±38.18 HU. The density tended to be higher in tubular carcinoma. Correlation analysis identified no significant correlations between CT density and Ki-67 level (r=-0.031, P=.784). There were no statistically significant differences of CT density between tumors with different receptor status. CONCLUSIONS: No significant associations between CT density and receptor status in breast cancer. Tubular carcinoma tended to have higher CT density in comparison to other subtypes of breast carcinomas."],["dc.identifier.doi","10.1016/j.tranon.2017.05.004"],["dc.identifier.pmid","28666188"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14534"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58889"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1936-5233"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.subject.ddc","610"],["dc.title","Cone-beam Breast Computed Tomography: CT Density Does Not Reflect Proliferation Potential and Receptor Expression of Breast Carcinoma."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","50"],["dc.bibliographiccitation.journal","Clinical Imaging"],["dc.bibliographiccitation.lastpage","59"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Fischer, Uwe"],["dc.date.accessioned","2018-11-07T10:27:02Z"],["dc.date.available","2018-11-07T10:27:02Z"],["dc.date.issued","2017"],["dc.description.abstract","The dedicated cone-beam breast computed tomography (CBBCT) is a new and promising imaging modality which provides isotropic, 3D images of the breast with high spatial and contrast resolution. Non-contrast and contrast-enhanced CBBCT (CE-CBBCT) was superior to mammography for the visualization of breast masses, especially in patients with dense breast tissue. CE-CBBCT accurately detects DCIS and distinguishes it from benign causes of microcalcifications when compared with non-contrast CBBCT and mammography. The purpose of this report is to describe the technology and its possible indications, and to present the first results from recent clinical studies, illustrating these with our own image examples. (C) 2016 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.clinimag.2016.11.011"],["dc.identifier.isi","000394732700008"],["dc.identifier.pmid","27875762"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43164"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1873-4499"],["dc.relation.issn","0899-7071"],["dc.title","Review of clinical studies and first clinical experiences with a commercially available cone-beam breast CT in Europe"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e17082"],["dc.bibliographiccitation.issue","37"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","98"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Hellriegel, Martin"],["dc.contributor.author","von Fintel, Eva"],["dc.contributor.author","Kulenkampff, Dietrich"],["dc.contributor.author","Surov, Alexey"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Perske, Christina"],["dc.date.accessioned","2020-12-10T18:20:08Z"],["dc.date.available","2020-12-10T18:20:08Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1097/MD.0000000000017082"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16517"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75461"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Breast lesion size assessment in mastectomy specimens"],["dc.title.alternative","Correlation of cone-beam breast-CT, digital breast tomosynthesis and full-field digital mammography with histopathology"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1154"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","American Journal of Roentgenology"],["dc.bibliographiccitation.lastpage","1162"],["dc.bibliographiccitation.volume","208"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Fischer, Uwe"],["dc.date.accessioned","2020-12-10T18:43:06Z"],["dc.date.available","2020-12-10T18:43:06Z"],["dc.date.issued","2017"],["dc.description.abstract","OBJECTIVE. The feasibility of breast vacuum-assisted biopsy (VAB) guided by cone-beam CT (CBCT) was assessed. The initial clinical performance of CT-guided breast VAB was compared with that of established prone stereotactic VAB. MATERIALS AND METHODS. In this retrospective clinical trial, VABs were performed for women with mammographically suspicious breast lesions using a dedicated breast CBCT protocol. The technical success rate, total intervention time, and complications were documented and compared with examinations performed by prone stereotactic VAB. RESULTS. Between June 2015 and March 2016, 65 patients with 68 target lesions underwent image-guided VAB. CT-guided VAB was performed for 29 patients with 31 lesions. Thirty-six patients with 37 lesions underwent prone stereotactic VAB. The type of lesion was not different between the two groups (p = 0.135). Technical success rate was achieved in 31 of 33 lesions (93.9%) with CT-guided VAB versus 37 of 38 lesions (97.4%) with prone stereotactic VAB. The mean (+/- SD) total intervention time was 22.7 +/- 8.4 minutes for CT-guided VAB versus 28.8 +/- 9.4 minutes for prone stereotactic VAB (p < 0.05). Reidentifying and targeting lesions took about the same time for both systems (p = 0.362). The time for tissue sampling was significantly faster with CT-guided VAB (p < 0.05). No major complications were observed with either system. CONCLUSION. CT-guided VAB is safe and feasible using the currently available breast CBCT protocol. The mean total intervention time to complete VAB and the time for tissue sampling was significantly faster using CT-guided VAB in comparison with prone stereotactic VAB."],["dc.identifier.doi","10.2214/AJR.16.16760"],["dc.identifier.eissn","1546-3141"],["dc.identifier.isi","000400051200036"],["dc.identifier.issn","0361-803X"],["dc.identifier.pmid","28199139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78196"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Amer Roentgen Ray Soc"],["dc.relation.issn","1546-3141"],["dc.relation.issn","0361-803X"],["dc.title","Feasibility of Vacuum-Assisted Breast Cone-Beam CT–Guided Biopsy and Comparison With Prone Stereotactic Biopsy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1194"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Wienbeck, Susanne"],["dc.date.accessioned","2020-12-10T14:10:12Z"],["dc.date.available","2020-12-10T14:10:12Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00330-018-5711-9"],["dc.identifier.eissn","1432-1084"],["dc.identifier.issn","0938-7994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70676"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Diagnostic accuracy of cone-beam breast computed tomography: a systematic review and diagnostic meta-analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3141"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","3148"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Wienbeck, Susanne"],["dc.date.accessioned","2020-12-10T14:10:12Z"],["dc.date.available","2020-12-10T14:10:12Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s00330-018-5854-8"],["dc.identifier.eissn","1432-1084"],["dc.identifier.issn","0938-7994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70677"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Pre- and post-contrast versus post-contrast cone-beam breast CT: can we reduce radiation exposure while maintaining diagnostic accuracy?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","908"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Academic Radiology"],["dc.bibliographiccitation.lastpage","915"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Nowak, Carsten"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stamm, Georg"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Fischer, Uwe"],["dc.date.accessioned","2018-10-10T11:16:46Z"],["dc.date.available","2018-10-10T11:16:46Z"],["dc.date.issued","2017"],["dc.description.abstract","The purpose of this ex vivo study was to investigate artifacts in a cone-beam breast computed tomography (CBBCT) caused by breast tissue markers."],["dc.identifier.doi","10.1016/j.acra.2016.11.017"],["dc.identifier.gro","630667"],["dc.identifier.pmid","28130048"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15955"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1878-4046"],["dc.title","Artifacts Caused by Breast Tissue Markers in a Dedicated Cone-beam Breast CT in Comparison to Full-field Digital Mammography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","904"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Translational oncology"],["dc.bibliographiccitation.lastpage","910"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Fischer, Uwe"],["dc.contributor.author","von Fintel, Eva"],["dc.contributor.author","Stahnke, Vera"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Wienbeck, Susanne"],["dc.date.accessioned","2019-07-09T11:44:45Z"],["dc.date.available","2019-07-09T11:44:45Z"],["dc.date.issued","2017-12"],["dc.description.abstract","PURPOSE: To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS: This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant breast lesions was standardized to breast fat tissue contrast enhancement. All breast lesions were approved via image-guided biopsy or surgery. Immunohistochemical staining was conducted for expression of estrogen (ER), progesterone (PR), human epidermal growth factor receptor-2 (HER2) and Ki-67 index. Contrast enhancement of breast lesions was correlated with immunohistochemical breast cancer subtypes (Luminal A, Luminal B, HER2 positive, triple negative), receptor status and Ki-67 expression. RESULTS: Highest contrast enhancement was seen for Luminal A lesions (93.6 HU) compared to Luminal B lesions (47.6 HU, P=.002), HER2 positive lesions (83.5 HU, P=.359) and triple negative lesions (45.3 HU, P=.005). Contrast enhancement of HER2 positive lesions was higher than Luminal B lesions (P=.044) and triple negative lesions (P=.039). No significant difference was evident between Luminal B and triple negative lesions (P=.439). Lesions with high Ki-67 index showed lower contrast enhancement than those with low Ki-67 index (P=.0043). ER, PR and HER2 positive lesions demonstrated higher contrast enhancement than their receptor negative counterparts, although differences did not reach statistical significance (P=.1714; P=.3603; P=.2166). CONCLUSIONS: Contrast enhancement of malignant breast lesions on CBBCT correlates with immunohistochemical subtype and proliferative potential. Thereby, CBBCT might aid in selecting individualized treatment strategies for breast cancer patients based on pre-operative imaging."],["dc.identifier.doi","10.1016/j.tranon.2017.08.010"],["dc.identifier.pmid","28946110"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59085"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1936-5233"],["dc.rights","CC BY-NC 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/4.0"],["dc.subject.ddc","610"],["dc.title","Contrast Enhancement on Cone-Beam Breast-CT for Discrimination of Breast Cancer Immunohistochemical Subtypes."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]