Bohnert, Maria

[["dc.bibliographiccitation.artnumber","103512"],["dc.bibliographiccitation.journal","Insect Biochemistry and Molecular Biology"],["dc.bibliographiccitation.volume","133"],["dc.contributor.author","Chartschenko, Eugenia"],["dc.contributor.author","Hugenroth, Marie"],["dc.contributor.author","Akhtar, Irfan"],["dc.contributor.author","Droste, Andrea"],["dc.contributor.author","Kolkhof, Petra"],["dc.contributor.author","Bohnert, Maria"],["dc.contributor.author","Beller, Mathias"],["dc.date.accessioned","2022-07-11T08:57:47Z"],["dc.date.available","2022-07-11T08:57:47Z"],["dc.date.issued","2021"],["dc.description.abstract","The Seipin protein is a conserved key component in the biogenesis of lipid droplets (LDs). Recently, a cooperation between human Seipin and the Lipid droplet assembly factor 1 (LDAF1) was described. LDAF1 physically interacts with Seipin and the holocomplex safeguards regular LD biogenesis. The function of LDAF1 proteins outside mammals is less clear. In yeast, the lipid droplet organization (LDO) proteins, which also cooperate with Seipin, are the putative homologs of LDAF1. While certain functional aspects are shared between the LDO and mammalian LDAF1 proteins, the relationship between the proteins is under debate. Here, we identify the Drosophila melanogaster protein CG32803, which we re-named to dmLDAF1, as an insect member of this protein family. dmLDAF1 decorates LDs in cultured cells and in vivo and the protein is linked to the fly and mouse Seipin proteins. Altering the dmLDAF1 abundance affects LD size, number and overall lipid storage amounts. Our results suggest that the LDAF1 proteins thus fulfill an evolutionarily conserved function in the biogenesis and biology of LDs."],["dc.identifier.doi","10.1016/j.ibmb.2020.103512"],["dc.identifier.pmid","33307187"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112455"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/130"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P21: Funktionelle Rolle der LDO-Maschinerie in Lipidkörper-Organell Kontaktstellen"],["dc.relation.eissn","1879-0240"],["dc.relation.issn","0965-1748"],["dc.relation.workinggroup","RG Bohnert (Lipid Droplet Kommunikation)"],["dc.title","CG32803 is the fly homolog of LDAF1 and influences lipid storage in vivo"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","483"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Nature Reviews. Molecular Cell Biology"],["dc.bibliographiccitation.lastpage","484"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Bohnert, Maria"],["dc.contributor.author","Schuldiner, Maya"],["dc.date.accessioned","2022-07-11T15:20:59Z"],["dc.date.available","2022-07-11T15:20:59Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/s41580-018-0022-1"],["dc.identifier.pmid","29765158"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112466"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/88"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1471-0080"],["dc.relation.issn","1471-0072"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.relation.workinggroup","RG Bohnert (Lipid Droplet Kommunikation)"],["dc.title","Stepping outside the comfort zone of membrane contact site research"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","409"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Eisenberg-Bord, Michal"],["dc.contributor.author","Shai, Nadav"],["dc.contributor.author","Schuldiner, Maya"],["dc.contributor.author","Bohnert, Maria"],["dc.date.accessioned","2022-07-11T15:02:22Z"],["dc.date.available","2022-07-11T15:02:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Membrane contact sites enable interorganelle communication by positioning organelles in close proximity using molecular \"tethers.\" With a growing understanding of the importance of contact sites, the hunt for new contact sites and their tethers is in full swing. Determining just what is a tether has proven challenging. Here, we aim to delineate guidelines that define the prerequisites for categorizing a protein as a tether. Setting this gold standard now, while groups from different disciplines are beginning to explore membrane contact sites, will enable efficient cooperation in the growing field and help to realize a great collaborative opportunity to boost its development."],["dc.identifier.doi","10.1016/j.devcel.2016.10.022"],["dc.identifier.pmid","27875684"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112461"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/4"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel"],["dc.relation.eissn","1878-1551"],["dc.relation.issn","1534-5807"],["dc.relation.workinggroup","RG Bohnert (Lipid Droplet Kommunikation)"],["dc.relation.workinggroup","RG Schuldiner (Functional Genomics of Organelles)"],["dc.title","A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","212"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Cell"],["dc.bibliographiccitation.lastpage","225"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Bohnert, Maria"],["dc.date.accessioned","2022-07-11T15:34:17Z"],["dc.date.available","2022-07-11T15:34:17Z"],["dc.date.issued","2020"],["dc.description.abstract","Membrane contact sites (CSs) are specialized cellular regions where distinct organelles are actively positioned very close to each other, at a distance of just a few nanometers. Structurally, CS formation depends on tether proteins that physically link organellar membranes to each other. Functionally, these structures act as hotspots for communication and material transfer. In recent years, we are starting to understand that the cellular CS landscape is not static but instead responds dynamically to diverse metabolic cues. This review describes the interplay between cellular metabolism and CS-based organelle communication and discusses molecular mechanisms of contact modulation in cellular adaptation to changing metabolic requirements."],["dc.identifier.doi","10.1016/j.devcel.2020.06.026"],["dc.identifier.pmid","32693056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112469"],["dc.identifier.url","https://sfb1190.med.uni-goettingen.de/production/literature/publications/122"],["dc.language.iso","en"],["dc.relation","SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente"],["dc.relation","SFB 1190 | P21: Funktionelle Rolle der LDO-Maschinerie in Lipidkörper-Organell Kontaktstellen"],["dc.relation.eissn","1878-1551"],["dc.relation.issn","1534-5807"],["dc.relation.workinggroup","RG Bohnert (Lipid Droplet Kommunikation)"],["dc.title","Tether Me, Tether Me Not-Dynamic Organelle Contact Sites in Metabolic Rewiring"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","overview_ja"],["dspace.entity.type","Publication"]]