Schäper, Jörn

[["dc.bibliographiccitation.firstpage","236"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Neurocritical Care"],["dc.bibliographiccitation.lastpage","247"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Hernández-Durán, Silvia"],["dc.contributor.author","Salfelder, Clara"],["dc.contributor.author","Schaeper, Joern"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Mielke, Dorothee"],["dc.contributor.author","von der Brelie, Christian"],["dc.date.accessioned","2021-04-14T08:26:05Z"],["dc.date.available","2021-04-14T08:26:05Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s12028-020-01029-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81829"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1556-0961"],["dc.relation.issn","1541-6933"],["dc.title","Mechanical Ventilation, Sedation and Neuromonitoring of Patients with Aneurysmal Subarachnoid Hemorrhage in Germany: Results of a Nationwide Survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e56397"],["dc.bibliographiccitation.issue","131"],["dc.bibliographiccitation.journal","Journal of Visualized Experiments"],["dc.contributor.author","Schregel, Katharina"],["dc.contributor.author","Behme, Daniel"],["dc.contributor.author","Tsogkas, Ioannis"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Maier, Ilko"],["dc.contributor.author","Karch, André"],["dc.contributor.author","Mikolajczyk, Rafael"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Schäper, Jörn"],["dc.contributor.author","Hinz, José"],["dc.contributor.author","Liman, Jan"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.date.accessioned","2018-04-23T11:47:45Z"],["dc.date.available","2018-04-23T11:47:45Z"],["dc.date.issued","2018"],["dc.description.abstract","This manuscript describes a streamlined protocol for the management of patients with acute ischemic stroke, which aims at the minimization of time from hospital admission to reperfusion. Rapid restoration of cerebral blood flow is essential for the outcomes of patients with acute ischemic stroke. Endovascular treatment (EVT) has become the standard of care to accomplish this in patients with acute stroke due to large vessel occlusion (LVO). To achieve reperfusion of ischemic brain regions as fast as possible, all in-hospital time delays have to be carefully avoided. Therefore, management of patients with acute ischemic stroke was optimized with an interdisciplinary standard operating procedure (SOP). Stroke neurologists, diagnostic as well as interventional neuroradiologists, and anesthesiologists streamlined all necessary processes from patient admission and diagnosis to EVT of eligible patients. Target times for every step were established. Actually achieved times were prospectively recorded along with clinical data and imaging scores for all endovascularly treated stroke patients. These data were regularly analyzed and discussed in interdisciplinary team meetings. Potential issues were evaluated and all staff involved was trained to adhere to the SOP. This streamlined patient management approach and enhanced interdisciplinary collaboration reduced time from patient admission to reperfusion significantly and was accompanied by a beneficial effect on clinical outcomes."],["dc.identifier.doi","10.3791/56397"],["dc.identifier.gro","3142064"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13388"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.issn","1940-087X"],["dc.title","Optimized Management of Endovascular Treatment for Acute Ischemic Stroke"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","134"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","142"],["dc.bibliographiccitation.volume","118"],["dc.contributor.author","Schaeper, Joern"],["dc.contributor.author","Wagner, Antje"],["dc.contributor.author","Enigk, Fabian"],["dc.contributor.author","Brell, Bernhard"],["dc.contributor.author","Mousa, Shaaban A."],["dc.contributor.author","Habazettl, Helmut"],["dc.contributor.author","Schaefer, Michael"],["dc.date.accessioned","2018-11-07T09:30:51Z"],["dc.date.available","2018-11-07T09:30:51Z"],["dc.date.issued","2013"],["dc.description.abstract","Background: Endotoxin-induced activation of monocytes may lead to extravasation of cells, excessive production of nitric oxide, and subsequent epithelial injury in the gut. Regional sympathetic blockade by means of thoracic epidural anesthesia has been implicated to protect the epithelial barrier. This study tested the hypothesis that thoracic epidural anesthesia decreases epithelial permeability by attenuating monocytic production of nitric oxide and nitrosative stress. Methods: Rats were anesthetized, hemodynamically monitored, and mechanically ventilated. Endotoxemia was induced by an intravenous bolus injection of Escherichia coli lipopolysaccharide. Either lidocaine 2% or normal saline was injected as a bolus, followed by a continuous infusion via an epidural catheter. Three hundred minutes after injection of lipopolysaccharide or normal saline, gut epithelial permeability to fluorescein isothiocyanate-dextran (4 kDa), intestinal expression of inducible nitric oxide synthase by macrophages, and lipid peroxidation represented by 8-isoprostane tissue concentration were quantified. Results: Thoracic epidural anesthesia significantly attenuated the endotoxin-induced increases in gut epithelial permeability (437 [293, 492] vs. 628 [532, 1,042] ng/ml, median [quartiles], P = 0.03), expression of nitric oxide synthase (2 [1,2] vs. 7 [5,8] cells per 384 mu m(2), P = 0.003), macrophage infiltration, and lipid peroxidation (22,460 +/- 11,476 vs. 37,840 +/- 17,551 pg/ml, mean +/- SD, P = 0.05). Conclusions: Thoracic epidural anesthesia attenuates endotoxin-induced gut epithelial injury. This is likely due to a decrease in monocytic extravasation and intestinal nitrosative stress. As possible mechanisms, direct nerve-immune interplay, a reduction in plasma catecholamines, or a systemic lidocaine effect has to be considered."],["dc.identifier.doi","10.1097/ALN.0b013e3182784c93"],["dc.identifier.isi","000312536800019"],["dc.identifier.pmid","23221864"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31410"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0003-3022"],["dc.title","Regional Sympathetic Blockade Attenuates Activation of Intestinal Macrophages and Reduces Gut Barrier Failure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]