Großkopf, Birgit

[["dc.bibliographiccitation.firstpage","S179"],["dc.bibliographiccitation.journal","Osteoporosis International"],["dc.bibliographiccitation.lastpage","S180"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T09:55:28Z"],["dc.date.available","2018-11-07T09:55:28Z"],["dc.date.issued","2006"],["dc.identifier.isi","000245980600155"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36746"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Artington"],["dc.relation.eventlocation","Washington, DC"],["dc.relation.issn","0937-941X"],["dc.title","Prevalence of femoral osteoporosis in medieval humans from Dubovany cemetery (Western Slovakia): Macroscopic and microscopic examination"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","310"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","ANATOMIA HISTOLOGIA EMBRYOLOGIA-JOURNAL OF VETERINARY MEDICINE SERIES C"],["dc.bibliographiccitation.lastpage","315"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Ryban, L."],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.contributor.author","Fabis, M."],["dc.contributor.author","Chrenek, Peter"],["dc.date.accessioned","2018-11-07T09:08:08Z"],["dc.date.available","2018-11-07T09:08:08Z"],["dc.date.issued","2006"],["dc.description.abstract","The aim of this study was to investigate differences in compact bone tissue microstructure between New Zealand White transgenic rabbits with human blood clotting factor VIII gene and the non-transgenic ones. The transgene was under the transcriptional control of the whey acidic protein (WAP) promoter. Altogether, 42 femora were analysed. Specimens were prepared using standard histological equipment, producing thin sections approximately 80-100 mu m. Areas, perimeters, minimum and maximum diameters of vascular canals of primary osteons, Haversian canals and secondary osteons were measured. Our results indicate the basic structural pattern of the bone tissue was primary vascular longitudinal in both groups of rabbits. However, a fibrolamellar bone tissue was identified only in the transgenic rabbits. The measured variables of the vascular canals of the primary osteons, the Haversian canals and the secondary osteons were higher in transgenic rabbits in comparison with non-transgenic ones in most cases and the differences were often statistically significant (P < 0.01; P < 0.001). More significant differences were noticed in males (transgenic versus non-transgenic). However, it is not easy to find the real cause of the changes. Despite the fact that no hFVIII mRNA expression was found in the analysed bone of transgenic rabbits, we presume that the observed differences could be associated with transgenesis. In this article, we discuss possible associations between transgene integration as well as aneuploidy and/or observed microstructural changes in compact bone tissue."],["dc.identifier.doi","10.1111/j.1439-0264.2006.00690.x"],["dc.identifier.isi","000240401600007"],["dc.identifier.pmid","16968250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25957"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0340-2096"],["dc.title","Comparative study of compact bone tissue microstructure between non-transgenic and transgenic rabbits with WAP-hFVIII gene construct"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","140"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","FOLIA BIOLOGICA"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Chrenek, Peter"],["dc.contributor.author","Ryban, L."],["dc.contributor.author","Parkanyi, V."],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T08:38:59Z"],["dc.date.available","2018-11-07T08:38:59Z"],["dc.date.issued","2005"],["dc.description.abstract","Bone tissue microstructure of femur was investigated in transgenic New Zealand White rabbits with human factor VIII gene. Altogether 42 bones (24 from transgenic rabbits and 18 from non-transgenic ones) were analysed. Specimens were prepared using standard histological equipment, producing thin sections of approximately 80-100 mu m. For histomorphometrical analysis areas, perimeters, minimum and maximum diameters of osteons' vascular canals and of osteons were measured. We found out that the basic structural pattern of femoral bone tissue was primary vascular longitudinal in both groups of rabbits. However, a new type of the bone tissue - fibrolamellar - was identified only in the transgenic rabbits. The measured variables of the osteons' vascular canals were higher in transgenic individuals in comparison with the nontransgenie ones (except for maximal diameter) and the differences were statistically significant (P < 0.05; P < 0.01). We suppose that the observed differences could be associated with transgenesis. In an effort to explain these differences we compared the cytogenctic profile of bone marrow cells between transgenic and nontransgenic rabbits. A significantly higher rate of aneuploidy was observed in c-metaphase spreads of transgenic individuals as compared to non-transgenic ones (P < 0.001). Despite the fact that no hFVIII mRNA expression was found in the femur of transgenic rabbits, we discussed an association of transgene integration into the genome and microstructural changes in the bone. In any case, the results indicate that transgenesis can also produce changes in other tissues than in the target ones."],["dc.identifier.isi","000233052100004"],["dc.identifier.pmid","16285207"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18880"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Inst Molecular Genetics"],["dc.relation.issn","0015-5500"],["dc.title","Changes of femoral bone tissue microstructure in transgenic rabbits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S192"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Bone"],["dc.bibliographiccitation.lastpage","S193"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T11:01:39Z"],["dc.date.available","2018-11-07T11:01:39Z"],["dc.date.issued","2007"],["dc.identifier.isi","000247426100189"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51195"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","17th Scientific Meeting of the International-Bone-and-Mineral-Society"],["dc.relation.eventlocation","Montreal, CANADA"],["dc.relation.issn","8756-3282"],["dc.title","Age-related bone loss and frequency of femoral osteoporosis in medieval population from the territory of Slovakia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Bauerova, Maria"],["dc.contributor.author","Toman, Robert"],["dc.date.accessioned","2018-11-07T08:33:40Z"],["dc.date.available","2018-11-07T08:33:40Z"],["dc.date.issued","2009"],["dc.format.extent","202"],["dc.identifier.isi","000263442701121"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17634"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.publisher.place","Hoboken"],["dc.relation.conference","78th Annual Meeting of the American-Association-of-Physical-Anthropologists"],["dc.relation.eventlocation","Chicago, IL"],["dc.relation.issn","0002-9483"],["dc.title","Effect of cadmium on femoral bone structure in rats: an animal model for human exposure to this metal"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","409"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Veterinary Medical Science"],["dc.bibliographiccitation.lastpage","411"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T11:03:43Z"],["dc.date.available","2018-11-07T11:03:43Z"],["dc.date.issued","2007"],["dc.description.abstract","Histological sections of femoral diaphysis from adult sheep were investigated in this study. The qualitative characteristics in microstructure of the compact bone were examined in anterior, posterior, medial and lateral views; the quantitative ones were assessed using the software Scion Image. Areas, perimeters, minimum and maximum diameters of the Haversian canals, the Haversian systems and the primary osteons' vascular canals were measured. Our results indicate that ovine diaphysis of the femur is occupied mainly with primary vascular plexiform (laminar, fibrolamellar) tissue. In addition, irregular and dense Haversian bone tissues were observed. All measured variables disposed lower values in comparison with other artiodactyls (cattle and pig)."],["dc.identifier.doi","10.1292/jvms.69.409"],["dc.identifier.isi","000246726100012"],["dc.identifier.pmid","17485930"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51674"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Japan Soc Vet Sci"],["dc.relation.issn","0916-7250"],["dc.title","Histological analysis of ovine compact bone tissue"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","American Journal of Physical Anthropology"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Jancova, Alena"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T11:05:52Z"],["dc.date.available","2018-11-07T11:05:52Z"],["dc.date.issued","2007"],["dc.format.extent","166"],["dc.identifier.isi","000244656500460"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52165"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","0002-9483"],["dc.title","Variability in osteon and Haversian canal sizes between medieval and recent human populations from Slovakia."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Physiology and Pharmacology"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Kovacova, Veronika"],["dc.contributor.author","Sarocka, A."],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Bauerova, Maria"],["dc.contributor.author","Großkopf, Birgit"],["dc.contributor.author","Formicki, G."],["dc.contributor.author","Kolesarova, A."],["dc.contributor.author","Martiniakova, Monika"],["dc.date.accessioned","2020-04-03T13:56:54Z"],["dc.date.available","2020-04-03T13:56:54Z"],["dc.date.issued","2019-08"],["dc.description.abstract","Amygdalin is most commonly occurring cyanogenic glycoside. It is found in seeds of many plant species. Our study was aimed to reveal whether pure intramuscularly injected amygdalin or apricot seeds peroral exposure cause changes in bone microstructure of rabbits. Twenty clinically healthy 5 months-old male rabbits were segregated into five groups. Animals from groups A1 and A2 were intramuscularly injected with amygdalin at doses of 0.6 and 3 mg/kg b.w. daily for 28 days. The groups S1 and S2 received commercial feed for rabbits mixed with crushed bitter apricot seeds at doses of 60 and 300 mg/kg b.w. during 28 days. The control (C) group did not receive any amygdalin. Intramuscular and peroral amygdalin administration did not affect total body weight, femoral length and femoral weight of rabbits. Similarly, microcomputed tomography (3D analysis) has shown that amygdalin had insignificant effect on relative bone volume, bone mineral density, cortical bone thickness, bone surface, trabecular thickness, trabecular number, trabecular separation. However, histological (2D analysis) revealed evident changes in compact bone microstructure of amygdalin-exposed rabbits consistent with a different vascularization and changed biomechanical properties. We can conclude that subacute exposure to amygdalin (both intramuscular and peroral) at the doses used in our study influenced compact bone remodeling."],["dc.identifier.doi","10.26402/jpp.2019.4.15"],["dc.identifier.pmid","31741461"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/63647"],["dc.identifier.url","http://jpp.krakow.pl/journal/archive/08_19/pdf/10.26402/jpp.2019.4.15.pdf"],["dc.language.iso","en"],["dc.relation.eissn","1899-1505"],["dc.title","Subacute exposure to amygdalin influences compact bone remodeling of rabbits"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","82"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","International Journal of Osteoarchaeology"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Dammers, K."],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T11:06:43Z"],["dc.date.available","2018-11-07T11:06:43Z"],["dc.date.issued","2007"],["dc.description.abstract","The purpose of this investigation was to study compact bone tissue microstructure of some mammals in terms of qualitative and quantitative characteristics, with an emphasis on finding an adequate identification key. Altogether, 36 femora of adult pigs, cows, sheep and rabbits were analysed. The qualitative characteristics were examined according to the classification systems of Enlow & Brown (1956) and Ricqles et al. (11991) in anterior, posterior, media[ and lateral views of thin sections. The quantitative characteristics were assessed using the specific software Scion Image (Scion Corporation, US). We measured area, perimeter, and minimum and maximum diameter of the Haversian canals, the secondary osteons and the vascular canals of primary osteons. The observed data were first used to evaluate inter- and intra-species diversity. After that a discriminant function analysis was used for species determination. According to our results the basic structural pattern of the bone tissue was primary vascular plexiform in pigs, cows and sheep. We found dense Haversian bone tissue in all species. In addition, non-vascular bone tissue was identified in cows and/or primary vascular longitudinal tissue in rabbits. Many resorption lacunae were found between secondary osteons in pigs. The irregular Haversian bone tissue was localised at the periosteal and endosteal borders in sheep. Classification functions for all investigated species gave a correct classification in 73.83% of cases. The most discriminating variables for the compact bone tissue appeared to be perimeter and minimum diameter of primary osteon's vascular canals. The percentage value can be increased by integrating conclusions from the qualitative analysis, Copyright (c) 2006 John Wiley & Sons, Ltd."],["dc.identifier.doi","10.1002/oa.856"],["dc.identifier.isi","000244573900007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52379"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","John Wiley & Sons Ltd"],["dc.relation.issn","1047-482X"],["dc.title","Histological study of compact bone tissue in some mammals: A method for species determination"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1235"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Forensic Sciences"],["dc.bibliographiccitation.lastpage","1239"],["dc.bibliographiccitation.volume","51"],["dc.contributor.author","Martiniakova, Monika"],["dc.contributor.author","Grosskopf, Birgit"],["dc.contributor.author","Omelka, Radoslav"],["dc.contributor.author","Vondrakova, Maria"],["dc.contributor.author","Bauerova, Maria"],["dc.date.accessioned","2018-11-07T09:01:57Z"],["dc.date.available","2018-11-07T09:01:57Z"],["dc.date.issued","2006"],["dc.description.abstract","In order to develop an identification key for distinguishing between several mammalian species, bone structure of their compact bone tissue was analyzed using qualitative and quantitative characteristics. Ninety femora of adult male humans, pigs, cows, sheep, rabbits, and rats were studied. The average area, perimeter, minimum, and maximum diameter of 1863 Haversian canals and 1863 secondary osteons were measured using a digital image device. The observed data were first used to evaluate inter- and intraspecies diversity. After that, we applied a discriminant function analysis for differentiation of the species by these variables. Classification functions for investigated species give cross-validated correct classification rates for 76.17% of cases. This percentage value can be increased by integrating conclusions from the qualitative analysis."],["dc.identifier.doi","10.1111/j.1556-4029.2006.00260.x"],["dc.identifier.isi","000242833300002"],["dc.identifier.pmid","17199608"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24557"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0022-1198"],["dc.title","Differences among species in compact bone tissue microstructure of mammalian skeleton: Use of a discriminant function analysis for species identification"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]