Berg, Daniela

[["dc.bibliographiccitation.firstpage","340"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Zeitschrift für Gerontologie und Geriatrie"],["dc.bibliographiccitation.lastpage","346"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Jacobs, Andreas H."],["dc.contributor.author","Emmert, Kirsten"],["dc.contributor.author","Baron, Ralf"],["dc.contributor.author","Bartsch, Thorsten"],["dc.contributor.author","Bauer, Juergen"],["dc.contributor.author","Becker, Clemens"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Bergmann, Philipp"],["dc.contributor.author","Boetzel, Kai"],["dc.contributor.author","Bollheimer, Cornelius"],["dc.contributor.author","Deuschl, Guenther"],["dc.contributor.author","Djukic, Marija"],["dc.contributor.author","Drey, Michael"],["dc.contributor.author","Durwen, Herbert"],["dc.contributor.author","Ebersbach, Georg"],["dc.contributor.author","Elshehabi, Morad"],["dc.contributor.author","Geritz, Johanna"],["dc.contributor.author","Gisinger, Christoph"],["dc.contributor.author","Guennewig, Thomas"],["dc.contributor.author","Hauptmann, Bjoern"],["dc.contributor.author","Heppner, Hans-Juergen"],["dc.contributor.author","Hobert, Markus A."],["dc.contributor.author","Hofmann, Werner"],["dc.contributor.author","Huellemann, Philipp"],["dc.contributor.author","Jahn, Klaus"],["dc.contributor.author","Klucken, Jochen"],["dc.contributor.author","Kurth, Roland"],["dc.contributor.author","Lindner, Reinhard"],["dc.contributor.author","Lingor, Paul"],["dc.contributor.author","Lukas, Albert"],["dc.contributor.author","Maetzold, Sara"],["dc.contributor.author","Mokrusch, Thomas"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Nau, Roland"],["dc.contributor.author","Plate, Annika"],["dc.contributor.author","Polidori, Maria Cristina"],["dc.contributor.author","Prell, Tino"],["dc.contributor.author","Schellinger, Peter"],["dc.contributor.author","Spira, Dominik"],["dc.contributor.author","Stephani, Ulrich"],["dc.contributor.author","Studt, Simone"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Unger, Heinz L."],["dc.contributor.author","Urban, Peter"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.contributor.author","Warnecke, Tobias"],["dc.contributor.author","Weiss, Michael"],["dc.contributor.author","Wiedemann, Andreas"],["dc.contributor.author","Wirth, Rainer"],["dc.contributor.author","Witt, Karsten"],["dc.contributor.author","Dodel, Richard"],["dc.contributor.author","Maetzler, Walter"],["dc.date.accessioned","2020-12-10T14:10:21Z"],["dc.date.available","2020-12-10T14:10:21Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00391-020-01734-1"],["dc.identifier.eissn","1435-1269"],["dc.identifier.issn","0948-6704"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70733"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Neurogeriatrie – eine Vision für die verbesserte Versorgung und Forschung für geriatrische Patienten mit führend neurologischen Erkrankungen"],["dc.title.alternative","Neurogeriatrics—a vision for improved care and research for geriatric patients with predominating neurological disabilities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.journal","Parkinsonism & Related Disorders"],["dc.bibliographiccitation.lastpage","26"],["dc.bibliographiccitation.volume","75"],["dc.contributor.author","Hopfner, Franziska"],["dc.contributor.author","Mueller, Stefanie H."],["dc.contributor.author","Szymczak, Silke"],["dc.contributor.author","Junge, Olaf"],["dc.contributor.author","Tittmann, Lukas"],["dc.contributor.author","May, Sandra"],["dc.contributor.author","Lohmann, Katja"],["dc.contributor.author","Grallert, Harald"],["dc.contributor.author","Lieb, Wolfgang"],["dc.contributor.author","Strauch, Konstantin"],["dc.contributor.author","Müller-Nurasyid, Martina"],["dc.contributor.author","Berger, Klaus"],["dc.contributor.author","Schormair, Barbara"],["dc.contributor.author","Winkelmann, Juliane"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","Klein, Christine"],["dc.contributor.author","Höglinger, Günter U."],["dc.contributor.author","Gasser, Thomas"],["dc.contributor.author","Deuschl, Günther"],["dc.contributor.author","Franke, André"],["dc.contributor.author","Krawczak, Michael"],["dc.contributor.author","Dempfle, Astrid"],["dc.contributor.author","Kuhlenbäumer, Gregor"],["dc.date.accessioned","2021-04-14T08:25:55Z"],["dc.date.available","2021-04-14T08:25:55Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.parkreldis.2020.05.003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81769"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","1353-8020"],["dc.title","Private variants in PRKN are associated with late-onset Parkinson's disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.journal","Journal of Parkinson's Disease"],["dc.bibliographiccitation.lastpage","11"],["dc.contributor.author","Michels, Jennifer"],["dc.contributor.author","van der Wurp, Hendrick"],["dc.contributor.author","Kalbe, Elke"],["dc.contributor.author","Rehberg, Sarah Petra"],["dc.contributor.author","Storch, Alexander"],["dc.contributor.author","Linse, Katharina"],["dc.contributor.author","Schneider, Christine"],["dc.contributor.author","Gräber, Susanne"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Dams, Judith"],["dc.contributor.author","Reetz, Kathrin"],["dc.date.accessioned","2022-02-01T10:31:37Z"],["dc.date.available","2022-02-01T10:31:37Z"],["dc.date.issued","2022"],["dc.description.abstract","Background: Parkinson’s disease (PD) is associated with various non-motor symptoms, including cognitive deterioration. Objective: Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND). Methods: Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males). Results: Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention (β= –0.08, SE = 0.003, p <  0.006) and memory functions showing that PIGD-patients deteriorate per months by –0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living. Conclusion: Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype."],["dc.description.abstract","Background: Parkinson’s disease (PD) is associated with various non-motor symptoms, including cognitive deterioration. Objective: Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND). Methods: Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males). Results: Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention (β= –0.08, SE = 0.003, p <  0.006) and memory functions showing that PIGD-patients deteriorate per months by –0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living. Conclusion: Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype."],["dc.identifier.doi","10.3233/JPD-212787"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/98909"],["dc.notes.intern","DOI-Import GROB-517"],["dc.relation.eissn","1877-718X"],["dc.relation.issn","1877-7171"],["dc.title","Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson’s Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1245"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Movement Disorders"],["dc.bibliographiccitation.lastpage","1248"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Hopfner, Franziska"],["dc.contributor.author","Mueller, Stefanie H."],["dc.contributor.author","Szymczak, Silke"],["dc.contributor.author","Junge, Olaf"],["dc.contributor.author","Tittmann, Lukas"],["dc.contributor.author","May, Sandra"],["dc.contributor.author","Lohmann, Katja"],["dc.contributor.author","Grallert, Harald"],["dc.contributor.author","Lieb, Wolfgang"],["dc.contributor.author","Strauch, Konstantin"],["dc.contributor.author","Müller‐Nurasyid, Martina"],["dc.contributor.author","Berger, Klaus"],["dc.contributor.author","Schormair, Barbara"],["dc.contributor.author","Winkelmann, Juliane"],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Kasten, Meike"],["dc.contributor.author","Klein, Christine"],["dc.contributor.author","Höglinger, Günter U."],["dc.contributor.author","Gasser, Thomas"],["dc.contributor.author","Deuschl, Günther"],["dc.contributor.author","Franke, André"],["dc.contributor.author","Krawczak, Michael"],["dc.contributor.author","Dempfle, Astrid"],["dc.contributor.author","Kuhlenbäumer, Gregor"],["dc.date.accessioned","2021-04-14T08:26:16Z"],["dc.date.available","2021-04-14T08:26:16Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1002/mds.28037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81882"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1531-8257"],["dc.relation.issn","0885-3185"],["dc.title","Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.journal","Parkinsonism & Related Disorders"],["dc.bibliographiccitation.lastpage","97"],["dc.bibliographiccitation.volume","90"],["dc.contributor.author","Lillig, Robert"],["dc.contributor.author","Ophey, Anja"],["dc.contributor.author","Schulz, Jörg B."],["dc.contributor.author","Reetz, Kathrin"],["dc.contributor.author","Wojtala, Jennifer"],["dc.contributor.author","Storch, Alexander"],["dc.contributor.author","Liepelt-Scarfone, Inga"],["dc.contributor.author","Becker, Sara"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Balzer-Geldsetzer, Monika"],["dc.contributor.author","Kalbe, Elke"],["dc.date.accessioned","2021-09-01T06:42:59Z"],["dc.date.available","2021-09-01T06:42:59Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.parkreldis.2021.07.034"],["dc.identifier.pii","S1353802021002844"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89193"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.issn","1353-8020"],["dc.title","A new CERAD total score with equally weighted z-scores and additional executive and non-amnestic „CERAD-Plus“ tests enhances cognitive diagnosis in patients with Parkinson's disease: Evidence from the LANDSCAPE study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Movement Disorders"],["dc.contributor.author","Lerche, Stefanie"],["dc.contributor.author","Schulte, Claudia"],["dc.contributor.author","Wurster, Isabel"],["dc.contributor.author","Machetanz, Gerrit"],["dc.contributor.author","Roeben, Benjamin"],["dc.contributor.author","Zimmermann, Milan"],["dc.contributor.author","Deuschle, Christian"],["dc.contributor.author","Hauser, Ann‐Kathrin"],["dc.contributor.author","Böhringer, Judith"],["dc.contributor.author","Krägeloh‐Mann, Ingeborg"],["dc.contributor.author","Waniek, Katharina"],["dc.contributor.author","Lachmann, Ingolf"],["dc.contributor.author","Petterson, Xuan‐Mai T."],["dc.contributor.author","Chiang, Ruby"],["dc.contributor.author","Park, Hyejung"],["dc.contributor.author","Wang, Bing"],["dc.contributor.author","Liepelt‐Scarfone, Inga"],["dc.contributor.author","Maetzler, Walter"],["dc.contributor.author","Galasko, Douglas"],["dc.contributor.author","Scherzer, Clemens R."],["dc.contributor.author","Gasser, Thomas"],["dc.contributor.author","Mielke, Michelle M."],["dc.contributor.author","Hutten, Samantha J."],["dc.contributor.author","Mollenhauer, Brit"],["dc.contributor.author","Sardi, S. Pablo"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Brockmann, Kathrin"],["dc.date.accessioned","2021-04-14T08:29:23Z"],["dc.date.available","2021-04-14T08:29:23Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1002/mds.28472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82885"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1531-8257"],["dc.relation.issn","0885-3185"],["dc.title","The Mutation Matters: CSF Profiles of GCase , Sphingolipids, α‐Synuclein in PD GBA"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Parkinson's Disease"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Mestre, Tiago A."],["dc.contributor.author","Fereshtehnejad, Seyed-Mohammad"],["dc.contributor.author","Berg, Daniela"],["dc.contributor.author","Bohnen, Nicolaas I."],["dc.contributor.author","Dujardin, Kathy"],["dc.contributor.author","Erro, Roberto"],["dc.contributor.author","Espay, Alberto J."],["dc.contributor.author","Halliday, Glenda"],["dc.contributor.author","van Hilten, Jacobus J."],["dc.contributor.author","Marras, Connie"],["dc.date.accessioned","2021-06-01T10:48:44Z"],["dc.date.available","2021-06-01T10:48:44Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: In Parkinson’s disease (PD), there is heterogeneity in the clinical presentation and underlying biology. Research on PD subtypes aims to understand this heterogeneity with potential contribution for the knowledge of disease pathophysiology, natural history and therapeutic development. There have been many studies of PD subtypes but their impact remains unclear with limited application in research or clinical practice. Objective: To critically evaluate PD subtyping systems. Methods: We conducted a systematic review of PD subtypes, assessing the characteristics of the studies reporting a subtyping system for the first time. We completed a critical appraisal of their methodologic quality and clinical applicability using standardized checklists. Results: We included 38 studies. The majority were cross-sectional (n = 26, 68.4%), used a data-driven approach (n = 25, 65.8%), and non-clinical biomarkers were rarely used (n = 5, 13.1%). Motor characteristics were the domain most commonly reported to differentiate PD subtypes. Most of the studies did not achieve the top rating across items of a Methodologic Quality checklist. In a Clinical Applicability Checklist, the clinical importance of differences between subtypes, potential treatment implications and applicability to the general population were rated poorly, and subtype stability over time and prognostic value were largely unknown. Conclusion: Subtyping studies undertaken to date have significant methodologic shortcomings and most have questionable clinical applicability and unknown biological relevance. The clinical and biological signature of PD may be unique to the individual, rendering PD resistant to meaningful cluster solutions. New approaches that acknowledge the individual-level heterogeneity and that are more aligned with personalized medicine are needed."],["dc.identifier.doi","10.3233/JPD-202472"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86035"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1877-718X"],["dc.relation.issn","1877-7171"],["dc.title","Parkinson’s Disease Subtypes: Critical Appraisal and Recommendations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]