Beta, Carsten

[["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","119"],["dc.contributor.author","Hsu, Hsin-Fang"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Westendorf, Christian"],["dc.contributor.author","Gholami, Azam"],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Tarantola, Marco"],["dc.contributor.author","Beta, Carsten"],["dc.date.accessioned","2020-12-10T18:25:44Z"],["dc.date.available","2020-12-10T18:25:44Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1103/PhysRevLett.119.148101"],["dc.identifier.eissn","1079-7114"],["dc.identifier.issn","0031-9007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75806"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Variability and Order in Cytoskeletal Dynamics of Motile Amoeboid Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3853"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","3858"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Westendorf, Christian"],["dc.contributor.author","Negrete, Jose, Jr."],["dc.contributor.author","Bae, Albert J."],["dc.contributor.author","Sandmann, Rabea"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Beta, Carsten"],["dc.date.accessioned","2018-11-07T09:27:08Z"],["dc.date.available","2018-11-07T09:27:08Z"],["dc.date.issued","2013"],["dc.description.abstract","The rapid reorganization of the actin cytoskeleton in response to external stimuli is an essential property of many motile eukaryotic cells. Here, we report evidence that the actin machinery of chemotactic Dictyostelium cells operates close to an oscillatory instability. When averaging the actin response of many cells to a short pulse of the chemoattractant cAMP, we observed a transient accumulation of cortical actin reminiscent of a damped oscillation. At the single-cell level, however, the response dynamics ranged from short, strongly damped responses to slowly decaying, weakly damped oscillations. Furthermore, in a small subpopulation, we observed self-sustained oscillations in the cortical F-actin concentration. To substantiate that an oscillatory mechanism governs the actin dynamics in these cells, we systematically exposed a large number of cells to periodic pulse trains of different frequencies. Our results indicate a resonance peak at a stimulation period of around 20 s. We propose a delayed feedback model that explains our experimental findings based on a time-delay in the regulatory network of the actin system. To test the model, we performed stimulation experiments with cells that express GFP-tagged fusion proteins of Coronin and actin-interacting protein 1, as well as knockout mutants that lack Coronin and actin-interacting protein 1. These actin-binding proteins enhance the disassembly of actin filaments and thus allow us to estimate the delay time in the regulatory feedback loop. Based on this independent estimate, our model predicts an intrinsic period of 20 s, which agrees with the resonance observed in our periodic stimulation experiments."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [1128, 937]"],["dc.identifier.doi","10.1073/pnas.1216629110"],["dc.identifier.isi","000316377400046"],["dc.identifier.pmid","23431176"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30465"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Actin cytoskeleton of chemotactic amoebae operates close to the onset of oscillations"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","723"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Small"],["dc.bibliographiccitation.lastpage","726"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Schaefer, Edith"],["dc.contributor.author","Westendorf, Christian"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Beta, Carsten"],["dc.contributor.author","Geil, Burkhard"],["dc.contributor.author","Janshoff, Andreas"],["dc.date.accessioned","2018-11-07T08:58:03Z"],["dc.date.available","2018-11-07T08:58:03Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1002/smll.201001955"],["dc.identifier.isi","000288613000003"],["dc.identifier.pmid","21425455"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23551"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1613-6810"],["dc.title","Shape Oscillations of Dictyostelium discoideum Cells on Ultramicroelectrodes Monitored by Impedance Analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","148102"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","117"],["dc.contributor.author","Negrete, Jose"],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Hsu, Hsin-Fang"],["dc.contributor.author","Westendorf, Christian"],["dc.contributor.author","Tarantola, Marco"],["dc.contributor.author","Beta, Carsten"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.date.accessioned","2020-12-10T18:25:41Z"],["dc.date.available","2020-12-10T18:25:41Z"],["dc.date.issued","2016"],["dc.description.abstract","Biological systems with their complex biochemical networks are known to be intrinsically noisy. Here we investigate the dynamics of actin polymerization of amoeboid cells, which are close to the onset of oscillations. We show that the large phenotypic variability in the polymerization dynamics can be accurately captured by a generic nonlinear oscillator model in the presence of noise. We determine the relative role of the noise with a single dimensionless, experimentally accessible parameter, thus providing a quantitative description of the variability in a population of cells. Our approach, which rests on a generic description of a system close to a Hopf bifurcation and includes the effect of noise, can characterize the dynamics of a large class of noisy systems close to an oscillatory instability."],["dc.identifier.doi","10.1103/PhysRevLett.117.148102"],["dc.identifier.eissn","1079-7114"],["dc.identifier.isi","000385970600007"],["dc.identifier.issn","0031-9007"],["dc.identifier.pmid","27740793"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75792"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Physical Soc"],["dc.relation.issn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.title","Noisy Oscillations in the Actin Cytoskeleton of Chemotactic Amoeba"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]