Winkler, Michael

[["dc.bibliographiccitation.artnumber","e0189073"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.lastpage","19"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Brinkmann, Constantin"],["dc.contributor.author","Hoffmann, Markus"],["dc.contributor.author","Lübke, Anastasia"],["dc.contributor.author","Nehlmeier, Inga"],["dc.contributor.author","Krämer-Kühl, Annika"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2018-11-16T10:48:50Z"],["dc.date.accessioned","2021-10-27T13:13:15Z"],["dc.date.available","2018-11-16T10:48:50Z"],["dc.date.available","2021-10-27T13:13:15Z"],["dc.date.issued","2017"],["dc.description.abstract","Vesicular stomatitis virus (VSV) release from infected cells is inhibited by the interferon (IFN)-inducible antiviral host cell factor tetherin (BST-2, CD317). However, several viruses encode tetherin antagonists and it is at present unknown whether residual VSV spread in tetherin-positive cells is also promoted by a virus-encoded tetherin antagonist. Here, we show that the viral glycoprotein (VSV-G) antagonizes tetherin in transfected cells, although with reduced efficiency as compared to the HIV-1 Vpu protein. Tetherin antagonism did not involve alteration of tetherin expression and was partially dependent on a GXXXG motif in the transmembrane domain of VSV-G. However, mutation of the GXXXG motif did not modulate tetherin sensitivity of infectious VSV. These results identify VSV-G as a tetherin antagonist in transfected cells but fail to provide evidence for a contribution of tetherin antagonism to viral spread."],["dc.identifier.doi","10.1371/journal.pone.0189073"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15673"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/91764"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","1932-6203"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]