Hunneman, Donald H.

[["dc.bibliographiccitation.firstpage","113"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Inherited Metabolic Disease"],["dc.bibliographiccitation.lastpage","119"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Barmaki Pour, R."],["dc.contributor.author","Stockler-Ipsiroglu, S."],["dc.contributor.author","Hunneman, Donald H."],["dc.contributor.author","Gahr, M."],["dc.contributor.author","Korenke, Christoph"],["dc.contributor.author","Pabst, W."],["dc.contributor.author","Hanefeld, Folker"],["dc.contributor.author","Peters, A."],["dc.date.accessioned","2018-11-07T09:21:59Z"],["dc.date.available","2018-11-07T09:21:59Z"],["dc.date.issued","2000"],["dc.description.abstract","Lymphocytopenia and depression of natural killer cells have been observed in patients with adrenoleukodystrophy (ALD) treated with glycerol trioleate and glycerol trierucate ('Lorenzo's oil'). To investigate possible alterations of cellular immunoreactivity, we measured lymphocyte proliferation in response to mitogens (PHA, Con A, PWM, OKT3) in 27 patients on treatment and in 14 patients without treatment. In patients on treatment, lymphocyte proliferation in response to the mitogens PHA and Con A was significantly higher than in patients without treatment. Lymphocyte proliferation in patients without treatment was comparable to that of normal control lymphocytes. Additionally, we found increased concentrations of erucic acid, C-22:1, in lymphocytes from patients with treatment. The enhanced proliferation of lymphocytes in response to mitogens is an indication of increased reactivity of cellular immunity to unspecific immunological stimuli. Long-term side-effects on cellular immunoreactivity have to be considered in ALD patients treated with Lorenzo's oil."],["dc.identifier.doi","10.1023/A:1005657530372"],["dc.identifier.isi","000085803300003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29235"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic Publ"],["dc.relation.issn","0141-8955"],["dc.title","Enhanced lymphocyte proliferation in patients with adrenoleukodystrophy treated with erucic acid (22 : 1)-rich triglycerides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","4-5"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.lastpage","201"],["dc.bibliographiccitation.volume","163"],["dc.contributor.author","Korenke, Christoph"],["dc.contributor.author","Hunneman, Donald H."],["dc.contributor.author","Eber, S."],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:49:52Z"],["dc.date.available","2018-11-07T10:49:52Z"],["dc.date.issued","2004"],["dc.description.abstract","Vitamin B-12 deficiency is one of the major causes of megaloblastic anaemia with or without neurological symptoms. We report on a patient manifesting acute encephalopathy, epilepsy, microcephaly and megaloblastic anaemia at the age of 4 months. Vitamin B-12 deficiency in the patient was due to subclinical pernicious anaemia of the mother who exhibited neither haematological nor neurological symptoms. Mother and child both had elevated methylmalonic acid in their urine which is a sensitive parameter of vitamin B-12 deficiency. Vitamin B-12 therapy resulted in arrest of convulsions within 24 h. There were no further seizures although the patient showed moderate mental retardation at the age of 7 years but a normal head circumference. Long-term MRI follow-up, performed at the age of 7 years, showed moderate enlargement of the ventricles with reduction of myelin and hypoplasia of the corpus callosum. Conclusion:vitamin B-12 deficiency due to maternal pernicious anaemia should always be considered in the differential diagnosis of neurological symptoms in infants and especially in combination with megaloblastic anaemia. Since the age of onset and the duration of neurological symptoms may contribute to the development of long-term symptoms, early diagnosis and treatment is important for vitamin B-12 deficient children."],["dc.identifier.doi","10.1007/s00431-004-1402-4"],["dc.identifier.isi","000220298900003"],["dc.identifier.pmid","14762712"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48528"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-6199"],["dc.title","Severe encephalopathy with epilepsy in an infant caused by subclinical maternal pernicious anaemia: case report and review of the literature"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","162"],["dc.contributor.author","Baumann, M."],["dc.contributor.author","Korenke, Christoph"],["dc.contributor.author","Weddige-Diedrichs, A."],["dc.contributor.author","Wilichowski, E."],["dc.contributor.author","Hunneman, Donald H."],["dc.contributor.author","Wilken, Barbara"],["dc.contributor.author","Brockmann, Knut"],["dc.contributor.author","Klingebiel, T."],["dc.contributor.author","Niethammer, D."],["dc.contributor.author","Kuhl, J."],["dc.contributor.author","Ebell, Wolfram"],["dc.contributor.author","Hanefeld, Folker"],["dc.date.accessioned","2018-11-07T10:42:22Z"],["dc.date.available","2018-11-07T10:42:22Z"],["dc.date.issued","2003"],["dc.description.abstract","In an attempt to elucidate prognostic factors, the data on 12 boys who underwent haematopoietic stem cell transplantation (HSCT) for cerebral X-linked adrenoleukodystrophy were evaluated. Two further patients received HSCT but died from transplantation-related complications. The data included neurological examination, neuropsychological testing and magnetic resonance imaging (MRI). Follow-up after HSCT was up to 5.5 years. Six patients showed a moderate to severe clinical deterioration after HSCT including two who died within 6 months. In this group, a MRI severity score of 10 or higher before HSCT was associated with severe impairment and a score of more than 12 was followed by rapid deterioration and death after HSCT. The presence of neurological symptoms before HSCT also affected prognosis. Six patients showed no deterioration in neurological or neuropsychological assessment after HSCT. Conclusion: our data confirm that haematopoietic stem cell transplantation can stop the progress of demyelination when performed at a critical early stage of the disease. The prognosis in an individual patient for the clinical course after stem cell transplantation can in general be given based on the status before transplantation, although individual patients may show an unexpected course."],["dc.identifier.doi","10.1007/s00431-002-1097-3"],["dc.identifier.isi","000180613300002"],["dc.identifier.pmid","12486501"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46778"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-6199"],["dc.title","Haematopoietic stem cell transplantation in 12 patients with cerebral X-linked adrenoleukodystrophy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","369"],["dc.bibliographiccitation.lastpage","387"],["dc.bibliographiccitation.seriesnr","544"],["dc.contributor.author","Moser, H. W."],["dc.contributor.author","Raymond, G. V."],["dc.contributor.author","Koehler, Wolfgang"],["dc.contributor.author","Sokolowski, P."],["dc.contributor.author","Hanefeld, Folker"],["dc.contributor.author","Korenke, Christoph"],["dc.contributor.author","Green, A."],["dc.contributor.author","Loes, D. J."],["dc.contributor.author","Hunneman, Donald H."],["dc.contributor.author","Jones, R. O."],["dc.contributor.author","Lu, S. E."],["dc.contributor.author","Uziel, G."],["dc.contributor.author","Giros, M. L."],["dc.contributor.author","Roels, F."],["dc.contributor.editor","Roels, F."],["dc.date.accessioned","2018-11-07T10:42:51Z"],["dc.date.available","2018-11-07T10:42:51Z"],["dc.date.issued","2003"],["dc.description.sponsorship","NCRR NIH HHS [M01RR 00052]; NICHD NIH HHS [HD 10981]; PHS HHS [685-008]"],["dc.identifier.isi","000188894200048"],["dc.identifier.pmid","14713253"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/46898"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.publisher","Kluwer Academic/Plenum Publ"],["dc.publisher.place","New York"],["dc.relation.conference","International Symposium on Peroxisomal Disorders and Regulation of Genes"],["dc.relation.crisseries","Advances in Experimental Medicine and Biology"],["dc.relation.eventend","2002-09-27"],["dc.relation.eventlocation","Ghent, BELGIUM"],["dc.relation.eventstart","2002-09-25"],["dc.relation.isbn","0-306-48174-X"],["dc.relation.ispartof","Peroxisomal disorders and regulation of genes"],["dc.relation.ispartofseries","Advances in Experimental Medicine and Biology; 544"],["dc.relation.issn","0065-2598"],["dc.title","Evaluation of the preventive effect of glyceryl trioleate-trierucate (\"Lorenzo's oil\") therapy in X-linked adrenoleukodystrophy: Results of two concurrent trials"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]