Alves, Frauke

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Svetlove, Angelika"],["dc.contributor.author","Zschüntzsch, Jana"],["dc.contributor.author","Alves, Frauke"],["dc.date.accessioned","2022-09-01T09:50:08Z"],["dc.date.available","2022-09-01T09:50:08Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Retrospective gating (RG) is a well established technique in preclinical computed tomography (CT) to assess 3D morphology of the lung. In RG additional angular projections are recorded typically by performing multiple rotations. Consequently, the projections are sorted according to the expansion state of the chest and those sets are then reconstructed separately. Thus, the breathing motion artefacts are suppressed at a cost of strongly elevated X-ray dose levels. Here we propose to use the entire raw data to assess respiratory motion in addition to retrospectively gated 3D reconstruction that visualize anatomical structures of the lung. Using this RG based X-ray respiratory motion measurement approach, which will be referred to as RG based X-ray lung function measurement (rgXLF) on the example of the\n mdx\n mouse model of Duchenne muscle dystrophy (mdx) we accurately obtained both the 3D anatomical morphology of the lung and the thoracic bones as well as functional temporal parameters of the lung. Thus, rgXLF will remove the necessity for separate acquisition procedures by being able to reproduce comparable results to the previously established planar X-ray based lung function measurement approach in a single low dose CT scan."],["dc.identifier.doi","10.1038/s41598-022-17335-4"],["dc.identifier.pii","17335"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113630"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2045-2322"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","619"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Nature Nanotechnology"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Kreyling, Wolfgang G."],["dc.contributor.author","Abdelmonem, Abuelmagd M."],["dc.contributor.author","Ali, Zulqurnain"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Geiser, Marianne"],["dc.contributor.author","Haberl, Nadine"],["dc.contributor.author","Hartmann, Raimo"],["dc.contributor.author","Hirn, Stephanie"],["dc.contributor.author","Jimenez de Aberasturi, Dorleta"],["dc.contributor.author","Kantner, Karsten"],["dc.contributor.author","Khadem-Saba, Guelnaz"],["dc.contributor.author","Montenegro, Jose-Maria"],["dc.contributor.author","Rejman, Joanna"],["dc.contributor.author","Rojo, Teofilo"],["dc.contributor.author","Ruiz de Larramendi, Idoia"],["dc.contributor.author","Ufartes, Roser"],["dc.contributor.author","Wenk, Alexander"],["dc.contributor.author","Parak, Wolfgang J."],["dc.date.accessioned","2018-11-07T09:55:19Z"],["dc.date.available","2018-11-07T09:55:19Z"],["dc.date.issued","2015"],["dc.description.abstract","Inorganic nanoparticles are frequently engineered with an organic surface coating to improve their physicochemical properties, and it is well known that their colloidal properties(1) may change upon internalization by cells(2,3). While the stability of such nanoparticles is typically assayed in simple in vitro tests, their stability in a mammalian organism remains unknown. Here, we show that firmly grafted polymer shells around gold nanoparticles may degrade when injected into rats. We synthesized monodisperse radioactively labelled gold nanoparticles (Au-198)(4) and engineered an In-111-labelled polymer shell around them(5). Upon intravenous injection into rats, quantitative biodistribution analyses performed independently for Au-198 and In-111 showed partial removal of the polymer shell in vivo. While Au-198 accumulates mostly in the liver, part of the In-111 shows a non-particulate biodistribution similar to intravenous injection of chelated In-111. Further in vitro studies suggest that degradation of the polymer shell is caused by proteolytic enzymes in the liver. Our results show that even nanoparticles with high colloidal stability can change their physicochemical properties in vivo."],["dc.identifier.doi","10.1038/NNANO.2015.111"],["dc.identifier.isi","000357485600017"],["dc.identifier.pmid","26076469"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36714"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1748-3395"],["dc.relation.issn","1748-3387"],["dc.title","In vivo integrity of polymer-coated gold nanoparticles"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","1600253"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","BioEssays"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Pedersen, Stine F."],["dc.contributor.author","Novak, Ivana"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Schwab, Albrecht"],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2018-10-10T13:25:55Z"],["dc.date.available","2018-10-10T13:25:55Z"],["dc.date.issued","2017"],["dc.description.abstract","We present here the hypothesis that the unique microenvironmental pH landscape of acid-base transporting epithelia is an important factor in development of epithelial cancers, by rendering the epithelial and stromal cells pre-adapted to the heterogeneous extracellular pH (pHe ) in the tumor microenvironment. Cells residing in organs with net acid-base transporting epithelia such as the pancreatic ductal and gastric epithelia are exposed to very different, temporally highly variable pHe values apically and basolaterally. This translates into spatially and temporally non-uniform intracellular pH (pHi ) patterns. Disturbed pHe - and pHi -homeostasis contributes to essentially all hallmarks of cancer. Our hypothesis, that the physiological pHe microenvironment in acid-base secreting epithelia shapes cancers arising in these tissues, can be tested using novel imaging tools. The acidic tumor pHe in turn might be exploited therapeutically. Pancreatic cancers are used as our prime example, but we propose that this concept is also relevant for other cancers of acid-base transporting epithelia."],["dc.fs.pkfprnr","66887"],["dc.identifier.doi","10.1002/bies.201600253"],["dc.identifier.fs","631974"],["dc.identifier.pmid","28440551"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15964"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1521-1878"],["dc.title","Alternating pH landscapes shape epithelial cancer initiation and progression: Focus on pancreatic cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Pharmacology"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hartung, Franziska"],["dc.contributor.author","Krüwel, Thomas"],["dc.contributor.author","Shi, Xiaoyi"],["dc.contributor.author","Pfizenmaier, Klaus"],["dc.contributor.author","Kontermann, Roland"],["dc.contributor.author","Chames, Patrick"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Pardo, Luis A."],["dc.date.accessioned","2021-04-14T08:26:27Z"],["dc.date.available","2021-04-14T08:26:27Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3389/fphar.2020.00686"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81946"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1663-9812"],["dc.title","A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1163"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Synchrotron Radiation"],["dc.bibliographiccitation.lastpage","1172"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Nicolas, Jan-David"],["dc.contributor.author","Bernhardt, Marten"],["dc.contributor.author","Markus, Andrea"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Burghammer, Manfred"],["dc.contributor.author","Salditt, Tim"],["dc.date.accessioned","2018-04-23T11:48:57Z"],["dc.date.available","2018-04-23T11:48:57Z"],["dc.date.issued","2017"],["dc.description.abstract","A scanning X-ray diffraction study of cardiac tissue has been performed, covering the entire cross section of a mouse heart slice. To this end, moderate focusing by compound refractive lenses to micrometer spot size, continuous scanning, data acquisition by a fast single-photon-counting pixel detector, and fully automated analysis scripts have been combined. It was shown that a surprising amount of structural data can be harvested from such a scan, evaluating the local scattering intensity, interfilament spacing of the muscle tissue, the filament orientation, and the degree of anisotropy. The workflow of data analysis is described and a data analysis toolbox with example data for general use is provided. Since many cardiomyopathies rely on the structural integrity of the sarcomere, the contractile unit of cardiac muscle cells, the present study can be easily extended to characterize tissue from a diseased heart."],["dc.identifier.doi","10.1107/s1600577517011936"],["dc.identifier.gro","3142464"],["dc.identifier.pii","S1600577517011936"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/13614"],["dc.language.iso","en"],["dc.notes.intern","lifescience updates Crossref Import"],["dc.notes.status","final"],["dc.relation.eissn","1600-5775"],["dc.relation.issn","1600-5775"],["dc.relation.orgunit","Institut für Röntgenphysik"],["dc.relation.workinggroup","RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)"],["dc.rights.uri","http://journals.iucr.org/services/copyrightpolicy.html"],["dc.subject.gro","x-ray scattering"],["dc.title","Scanning X-ray diffraction on cardiac tissue: automatized data analysis and processing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","no"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Investigative Dermatology"],["dc.bibliographiccitation.volume","130"],["dc.contributor.author","Hippe, Andreas"],["dc.contributor.author","Schorr, Anne"],["dc.contributor.author","Mueller-Homey, Anja"],["dc.contributor.author","Seeliger, Stefan"],["dc.contributor.author","Jannasch, Katharina"],["dc.contributor.author","Buhren, Bettina Alexandra"],["dc.contributor.author","Sleeman, Jonathan"],["dc.contributor.author","Stoecklein, Nikolas H."],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Hoffmann, Thomas"],["dc.contributor.author","Homey, Bernhard"],["dc.date.accessioned","2018-11-07T08:39:51Z"],["dc.date.available","2018-11-07T08:39:51Z"],["dc.date.issued","2010"],["dc.format.extent","S51"],["dc.identifier.isi","000281110100300"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19099"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","New york"],["dc.relation.eventlocation","Helsinki, FINLAND"],["dc.relation.issn","0022-202X"],["dc.title","Tumor derived CCL20 production critically contributes to angiogenesis and tumor progression"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","703"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Optics and Spectroscopy"],["dc.bibliographiccitation.lastpage","707"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Sukhanova, A."],["dc.contributor.author","Ramos-Gomes, F."],["dc.contributor.author","Alves, F."],["dc.contributor.author","Chames, P."],["dc.contributor.author","Baty, D."],["dc.contributor.author","Nabiev, I."],["dc.date.accessioned","2020-12-10T18:37:09Z"],["dc.date.available","2020-12-10T18:37:09Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1134/S0030400X18110309"],["dc.identifier.eissn","1562-6911"],["dc.identifier.issn","0030-400X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76859"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","874"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Cellular and Molecular Medicine"],["dc.bibliographiccitation.lastpage","887"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Stangl, Stefan"],["dc.contributor.author","Gehrmann, Mathias"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Dullin, Christian"],["dc.contributor.author","Themelis, George"],["dc.contributor.author","Ntziachristos, Vasilis"],["dc.contributor.author","Staeblein, Eva"],["dc.contributor.author","Walch, Axel"],["dc.contributor.author","Winkelmann, Isabel"],["dc.contributor.author","Multhoff, Gabriele"],["dc.date.accessioned","2018-11-07T08:57:12Z"],["dc.date.available","2018-11-07T08:57:12Z"],["dc.date.issued","2011"],["dc.description.abstract","The major stress-inducible heat shock protein 70 (Hsp70) is frequently present on the cell surface of human tumours, but not on normal cells. Herein, the binding characteristics of the cmHsp70.1 mouse monoclonal antibody (mAb) were evaluated in vitro and in a syngeneic tumour mouse model. More than 50% of the CT26 mouse colon carcinoma cells express Hsp70 on their cell surface at 4 degrees C. After a temperature shift to 37 degrees C, the cmHsp70.1-fluorescein isothiocyanate mAb translocates into early endosomes and lysosomes. Intraoperative and near-infrared fluorescence imaging revealed an enrichment of Cy5.5-conjugated mAb cmHsp70.1, but not an identically labelled IgG1 isotype-matched control, in i.p. and s.c. located CT26 tumours, as soon as 30 min. after i.v. injection into the tail vein. Due to the rapid turnover rate of membrane-bound Hsp70, the fluorescence-labelled cmHsp70.1 mAb became endocytosed and accumulated in the tumour, reaching a maximum after 24 hrs and remained detectable at least up to 96 hrs after a single i.v. injection. The tumour-selective internalization of mAb cmHsp70.1 at the physiological temperature of 37 degrees C might enable a targeted uptake of toxins or radionuclides into Hsp70 membrane-positive tumours. The anti-tumoral activity of the cmHsp70.1 mAb is further supported by its capacity to mediate antibody-dependent cytotoxicity."],["dc.identifier.doi","10.1111/j.1582-4934.2010.01067.x"],["dc.identifier.isi","000290312700015"],["dc.identifier.pmid","20406322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23338"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1582-1838"],["dc.title","In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2906"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Molecular and Cellular Biology"],["dc.bibliographiccitation.lastpage","2917"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Vogel, Wolfgang F."],["dc.contributor.author","Aszodi, A."],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Pawson, T."],["dc.date.accessioned","2018-11-07T09:13:47Z"],["dc.date.available","2018-11-07T09:13:47Z"],["dc.date.issued","2001"],["dc.description.abstract","Various types of collagen have been identified as potential ligands for the two mammalian discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Here, we used a recombinant fusion protein between the extracellular domain of DDR1 and alkaline phosphatase to detect specific receptor binding sites during mouse development, Major sites of DDR1-binding activity, indicative of ligand expression, were found in skeletal bones, the skin, and the urogenital tract. Ligand expression in the uterus during implantation and in the mammary gland during pregnancy colocalized with the expression of the DDR1 receptor, The generation of DDR1-null mice by gene targeting yielded homozygous mutant animals that were viable but smaller in size than control littermates, The majority of mutant females were unable to bear offspring due to a lack of proper blastocyst implantation into the uterine wall, When implantation did occur, the mutant females were unable to lactate. Histological analysis showed that the alveolar epithelium failed to secrete milk proteins into the lumen of the mammary gland. The lactational defect appears to be caused by hyperproliferation and abnormal branching of mammary ducts. These results suggest that DDR1 is a key mediator of the stromal-epithelial interaction during ductal morphogenesis in the mammary gland."],["dc.identifier.doi","10.1128/MCB.21.8.2906-2917.2001"],["dc.identifier.isi","000167760000027"],["dc.identifier.pmid","11283268"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27248"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0270-7306"],["dc.title","Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","ChemNanoMat"],["dc.bibliographiccitation.lastpage","45"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Neumeier, B. Lilli"],["dc.contributor.author","Khorenko, Mikhail"],["dc.contributor.author","Alves, Frauke"],["dc.contributor.author","Goldmann, Oliver"],["dc.contributor.author","Napp, Joanna"],["dc.contributor.author","Schepers, Ute"],["dc.contributor.author","Reichardt, Holger M."],["dc.contributor.author","Feldmann, Claus"],["dc.date.accessioned","2022-03-01T11:45:18Z"],["dc.date.available","2022-03-01T11:45:18Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1002/cnma.201800310"],["dc.identifier.issn","2199-692X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103282"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.issn","2199-692X"],["dc.title","Fluorescent Inorganic-Organic Hybrid Nanoparticles"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]