Now showing 1 - 8 of 8
  • 2006Journal Article
    [["dc.bibliographiccitation.firstpage","W335"],["dc.bibliographiccitation.issue","Web Server"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","W339"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Mayer, C."],["dc.contributor.author","Remmert, M."],["dc.contributor.author","Söding, Johannes"],["dc.contributor.author","Lupas, A. N."],["dc.date.accessioned","2022-03-01T11:46:47Z"],["dc.date.available","2022-03-01T11:46:47Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1093/nar/gkl217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103799"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","The MPI Bioinformatics Toolkit for protein sequence analysis"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2010Journal Article
    [["dc.bibliographiccitation.firstpage","1348"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Molecular Biology and Evolution"],["dc.bibliographiccitation.lastpage","1358"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Remmert, M."],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Linke, D."],["dc.contributor.author","Lupas, A. N."],["dc.contributor.author","Söding, J."],["dc.date.accessioned","2022-06-08T07:59:09Z"],["dc.date.available","2022-06-08T07:59:09Z"],["dc.date.issued","2010"],["dc.identifier.doi","10.1093/molbev/msq017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110651"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1537-1719"],["dc.relation.issn","0737-4038"],["dc.title","Evolution of Outer Membrane β-Barrels from an Ancestral ββ Hairpin"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2006Journal Article
    [["dc.bibliographiccitation.firstpage","W137"],["dc.bibliographiccitation.issue","Web Server"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","W142"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Söding, Johannes"],["dc.contributor.author","Remmert, M."],["dc.contributor.author","Biegert, A."],["dc.date.accessioned","2022-03-01T11:46:47Z"],["dc.date.available","2022-03-01T11:46:47Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1093/nar/gkl130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103797"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","HHrep: de novo protein repeat detection and the origin of TIM barrels"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2008Journal Article
    [["dc.bibliographiccitation.firstpage","159"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","162"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Bateman, A."],["dc.contributor.author","Finn, R. D."],["dc.contributor.author","Sims, P. J."],["dc.contributor.author","Wiedmer, T."],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Söding, J."],["dc.date.accessioned","2022-06-08T07:59:07Z"],["dc.date.available","2022-06-08T07:59:07Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1093/bioinformatics/btn595"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110639"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2005Journal Article
    [["dc.bibliographiccitation.firstpage","W244"],["dc.bibliographiccitation.issue","Web Server"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","W248"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Söding, J."],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Lupas, A. N."],["dc.date.accessioned","2022-06-08T07:59:10Z"],["dc.date.available","2022-06-08T07:59:10Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1093/nar/gki408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110659"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","The HHpred interactive server for protein homology detection and structure prediction"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2008Journal Article
    [["dc.bibliographiccitation.firstpage","807"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Bioinformatics"],["dc.bibliographiccitation.lastpage","814"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Söding, J."],["dc.date.accessioned","2022-06-08T07:59:07Z"],["dc.date.available","2022-06-08T07:59:07Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1093/bioinformatics/btn039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110638"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1460-2059"],["dc.relation.issn","1367-4803"],["dc.title","De novo identification of highly diverged protein repeats by probabilistic consistency"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2009Journal Article
    [["dc.bibliographiccitation.firstpage","3770"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Proceedings of the National Academy of Sciences of the United States of America"],["dc.bibliographiccitation.lastpage","3775"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Söding, J."],["dc.date.accessioned","2022-06-08T07:58:54Z"],["dc.date.available","2022-06-08T07:58:54Z"],["dc.date.issued","2009"],["dc.description.abstract","Sequence alignment and database searching are essential tools in biology because a protein's function can often be inferred from homologous proteins. Standard sequence comparison methods use substitution matrices to find the alignment with the best sum of similarity scores between aligned residues. These similarity scores do not take the local sequence context into account. Here, we present an approach that derives context-specific amino acid similarities from short windows centered on each query sequence residue. Our results demonstrate that the sequence context contains much more information about the expected mutations than just the residue itself. By employing our context-specific similarities (CS-BLAST) in combination with NCBI BLAST, we increase the sensitivity more than 2-fold on a difficult benchmark set, without loss of speed. Alignment quality is likewise improved significantly. Furthermore, we demonstrate considerable improvements when applying this paradigm to sequence profiles: Two iterations of CSI-BLAST, our context-specific version of PSI-BLAST, are more sensitive than 5 iterations of PSI-BLAST. The paradigm for biological sequence comparison presented here is very general. It can replace substitution matrices in sequence- and profile-based alignment and search methods for both protein and nucleotide sequences."],["dc.identifier.doi","10.1073/pnas.0810767106"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110565"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.eissn","1091-6490"],["dc.relation.issn","0027-8424"],["dc.title","Sequence context-specific profiles for homology searching"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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  • 2006Journal Article
    [["dc.bibliographiccitation.firstpage","W374"],["dc.bibliographiccitation.issue","Web Server"],["dc.bibliographiccitation.journal","Nucleic Acids Research"],["dc.bibliographiccitation.lastpage","W378"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Söding, Johannes"],["dc.contributor.author","Remmert, M."],["dc.contributor.author","Biegert, A."],["dc.contributor.author","Lupas, A. N."],["dc.date.accessioned","2022-03-01T11:46:47Z"],["dc.date.available","2022-03-01T11:46:47Z"],["dc.date.issued","2006"],["dc.identifier.doi","10.1093/nar/gkl195"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103798"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1362-4962"],["dc.relation.issn","0305-1048"],["dc.title","HHsenser: exhaustive transitive profile search using HMM-HMM comparison"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]
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