Ludwig, Hans-Christoph

[["dc.bibliographiccitation.firstpage","1853-1857"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Oncology Letters"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Böhrnsen, Florian"],["dc.contributor.author","Enders, Christina"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Brück, Wolfgang"],["dc.contributor.author","Füzesi, Laszlo"],["dc.contributor.author","Gutenberg, Angelika"],["dc.date.accessioned","2018-06-26T08:12:45Z"],["dc.date.available","2018-06-26T08:12:45Z"],["dc.date.issued","2015-09"],["dc.description.abstract","Tumors of the pineal region (PR) are rare and can be subdivided into four main histomorphological groups: Pineal-parenchymal tumors (PPT), germ cell tumors (GCT), glial tumors and miscellaneous tumors. The appropriate pathological classification and grading of these malignancies is essential for determining the clinical management and prognosis. However, an early diagnosis is often delayed due to unspecific clinical symptoms, and histological support is not always decisive to identify the diversity of tumors of the PR. The present study aimed to characterize 18 tumors of the PR using comparative genomic hybridization. All the tumors were primarily surgically resected without any previous irradiation or chemotherapy. In addition to chromosomal aberrations in PPT and different GCTs of the PR, the present study described, for the first time, the chromosomal changes in a few rare entities (solitary-fibrous and neuroendocrine tumors) of the PR. The tumors in the study, regardless of histology and World Health Organization grade, were characterized by frequent gains at 7, 9q, 12q, 16p, 17 and 22q, and losses at 13q. While the detection of chromosomal aberrations in these tumors appears not to be indicative enough of histological entities and their grade of malignancy, the present data may be of use to select genes of interest for higher resolution genomic analyses."],["dc.identifier.doi","10.3892/ol.2015.3383"],["dc.identifier.pmid","26622764"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15149"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.title","Common molecularcytogenetic alterations in tumors originating from the pineal region"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","841"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Bock, Hans C."],["dc.contributor.author","Dreha-Kulaczewski, Steffi F."],["dc.contributor.author","Alaid, Awad"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Ludwig, Hans C."],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1007/s00381-019-04119-x"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70732"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Upward movement of cerebrospinal fluid in obstructive hydrocephalus—revision of an old concept"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","ONS411"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Schaller, Bernhard J."],["dc.contributor.author","Gruber, Rudolf Matthias"],["dc.contributor.author","Merten, Hans-Albert"],["dc.contributor.author","Kruschat, Thomas"],["dc.contributor.author","Schliephake, Henning"],["dc.contributor.author","Buchfelder, Michael"],["dc.contributor.author","Ludwig, H.-C."],["dc.date.accessioned","2018-11-07T10:55:32Z"],["dc.date.available","2018-11-07T10:55:32Z"],["dc.date.issued","2005"],["dc.description.abstract","OBJECTIVE: Piezoelectric surgery represents an innovative, ultrasonic surgery technique for performing a safe and effective osteotomy or osteoplasty that contrasts with the traditional hard and soft tissue management methods with rotating instruments. METHODS: Because of its physical and mechanical properties, the definitive clinical advantage of piezoelectric bone surgery with regard to precision cutting lies in the sparing of vital neurovascular bundles or general soft tissue and better visualization of the surgical field, thus suggesting its great safety. Piezoelectric bone surgery has been previously described only in oral and maxillofacial operative procedures in adults. RESULTS: Five children between the age of 6 and 84 months were operated on for craniosynostosis, tethered cord, and an extraconal intraorbital tumor. The usefulness of piezoelectric bone surgery during neurosurgical procedures is presented for these cases. This technique is especially recommended when there are anatomic difficulties because of poor intraoperative visibility or the presence of delicate anatomic structures. CONCLUSION: The present preliminary report (comprising illustrative case reports) demonstrates and introduces for the first time the utility of piezoelectric bone surgery in cranial base and spinal surgery in children. Until now, there has been no documented neurosurgical experience of this technique even in adults."],["dc.identifier.doi","10.1227/01.NEU.0000176700.77461.C9"],["dc.identifier.isi","000208209000069"],["dc.identifier.pmid","16234663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49806"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","PIEZOELECTRIC BONE SURGERY: A REVOLUTIONARY TECHNIQUE FOR MINIMALLY INVASIVE SURGERY IN CRANIAL BASE AND SPINAL SURGERY? TECHNICAL NOTE"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","von Philipp, Gottberg"],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.date.accessioned","2021-07-05T15:00:52Z"],["dc.date.available","2021-07-05T15:00:52Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Objective Shunt treatment for hydrocephalus in children should aim for sustainable flexibility in regard to optional, perspective pressure level adjustment during advancing physical and mental development. Gravitation-assisted shunt valves are designed to prevent hydrostatic over-drainage frequently observed in the long course of shunt-treated hydrocephalus. We prospectively studied and analyzed the implication, safety, and feasibility for an adjustable gravitational unit combined with a fixed differential-pressure (DP) valve for neonates and infants primary shunted within the first 12 months of life. Methods Clinical course of hydrocephalic neonates and infants who received initial VP-shunt insertion in the early post-natal phase were monitored prospectively on the basis of our digital institutional Hydrocephalus & Shunt Registry. All patients were equipped with a fixed DP valve combined with a programmable gravitational unit activated in upright body position. Patients with a minimum shunt follow-up of 24 months were considered for further statistical analysis regarding hydrocephalus etiology, surgical setting, pre- and post-operative ventricular enlargement, head circumference, valve pressure setting, implication for the adjustment option of the gravitational unit, type and number of shunt complications, and revision-free shunt and valve survival. Results Seventy-eight pediatric patients received primary VP-shunt insertion at a mean age of 10 weeks with age gestationally corrected for preterm neonates. Hydrocephalus was related to perinatal IVH (64%), CNS malformation (11%), spina bifida (9%), congenital aqueductal stenosis (9%), and idiopathic (4%) or post-infectious etiology (3%). Fifty-two patients (70%) presented with history of prematurity (gestational age 23–36 weeks). Regular follow-up carried out for a mean period of 63 months demonstrated that ventricular enlargement decreased significantly after applied treatment and excessive head growth could be counteracted effectively. At least one pressure level adjustment was performed in 31% of all patients after 12 months, in 42% after 24 months, and in 64% at the time of last clinical follow-up since initial shunt insertion. Pressure level adjustments were successful in cases of clinical or radiographic signs of under- or over-drainage for individual patients of various ages during entire clinical course. Mean pressure setting for upright position was 24.1 cm H 2 O at the time of initial shunt insertion and increased to 26.4 cmH 2 O at the time of last clinical follow-up. Revision-free shunt-survival rates after 12 and 24 months were 79% and 70% and valve-survival rates 91% and 90%, respectively. Conclusion The combination of a fixed DP valve with an adjustable gravitational unit utilized as first-line shunt regimen was feasible and safe in a highly vulnerable subgroup of hydrocephalic infants. The adjustment option for the gravitational unit showed frequent and increasing implication over time and was beneficial even during the very early developmental stage of limited autonomous mobility. To our knowledge this is the first ever reported long-term investigation of an age-consistent pediatric patient collective primary shunted with an adjustable gravitational valve system."],["dc.description.abstract","Abstract Objective Shunt treatment for hydrocephalus in children should aim for sustainable flexibility in regard to optional, perspective pressure level adjustment during advancing physical and mental development. Gravitation-assisted shunt valves are designed to prevent hydrostatic over-drainage frequently observed in the long course of shunt-treated hydrocephalus. We prospectively studied and analyzed the implication, safety, and feasibility for an adjustable gravitational unit combined with a fixed differential-pressure (DP) valve for neonates and infants primary shunted within the first 12 months of life. Methods Clinical course of hydrocephalic neonates and infants who received initial VP-shunt insertion in the early post-natal phase were monitored prospectively on the basis of our digital institutional Hydrocephalus & Shunt Registry. All patients were equipped with a fixed DP valve combined with a programmable gravitational unit activated in upright body position. Patients with a minimum shunt follow-up of 24 months were considered for further statistical analysis regarding hydrocephalus etiology, surgical setting, pre- and post-operative ventricular enlargement, head circumference, valve pressure setting, implication for the adjustment option of the gravitational unit, type and number of shunt complications, and revision-free shunt and valve survival. Results Seventy-eight pediatric patients received primary VP-shunt insertion at a mean age of 10 weeks with age gestationally corrected for preterm neonates. Hydrocephalus was related to perinatal IVH (64%), CNS malformation (11%), spina bifida (9%), congenital aqueductal stenosis (9%), and idiopathic (4%) or post-infectious etiology (3%). Fifty-two patients (70%) presented with history of prematurity (gestational age 23–36 weeks). Regular follow-up carried out for a mean period of 63 months demonstrated that ventricular enlargement decreased significantly after applied treatment and excessive head growth could be counteracted effectively. At least one pressure level adjustment was performed in 31% of all patients after 12 months, in 42% after 24 months, and in 64% at the time of last clinical follow-up since initial shunt insertion. Pressure level adjustments were successful in cases of clinical or radiographic signs of under- or over-drainage for individual patients of various ages during entire clinical course. Mean pressure setting for upright position was 24.1 cm H 2 O at the time of initial shunt insertion and increased to 26.4 cmH 2 O at the time of last clinical follow-up. Revision-free shunt-survival rates after 12 and 24 months were 79% and 70% and valve-survival rates 91% and 90%, respectively. Conclusion The combination of a fixed DP valve with an adjustable gravitational unit utilized as first-line shunt regimen was feasible and safe in a highly vulnerable subgroup of hydrocephalic infants. The adjustment option for the gravitational unit showed frequent and increasing implication over time and was beneficial even during the very early developmental stage of limited autonomous mobility. To our knowledge this is the first ever reported long-term investigation of an age-consistent pediatric patient collective primary shunted with an adjustable gravitational valve system."],["dc.identifier.doi","10.1007/s00381-021-05250-4"],["dc.identifier.pii","5250"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87925"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1433-0350"],["dc.relation.issn","0256-7040"],["dc.title","An adjustable gravitational valve for initial VP-shunt treatment in hydrocephalic preterm neonates and infants below 1 year of age"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","287"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Craniofacial Surgery"],["dc.bibliographiccitation.lastpage","291"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hönig, Johannes Franz"],["dc.contributor.author","Merten, Hans Albert"],["dc.contributor.author","Ludwig, Hans"],["dc.contributor.author","Bebnke-Mursch, Juliane"],["dc.date.accessioned","2021-06-01T10:46:49Z"],["dc.date.available","2021-06-01T10:46:49Z"],["dc.date.issued","2001"],["dc.description.abstract","Extensive cranioorbital surgery for craniosynostosis in young children can produce excessive blood loss. Thus, to overcome the disadvantage of unappropriated blood loss and translocation of the osteosynthesis material, we performed a subgaleal dissection in infants and compared the subperiosteal with the subgaleal surgical approach in 29 children who underwent surgery for craniosynostosis. The treatment goal of correction of the deformity was accomplished in each ease. Fronto-orbital deformities were significantly improved in all patients. Blood loss was less in the group with subgaleal elevation of the forehead (mean = 163 ml) compared with the subperiosteal group, which had a mean 266 ml blood loss. The subgaleal dissection caused less bleeding and tethering of the advanced bone."],["dc.identifier.doi","10.1097/00001665-200105000-00016"],["dc.identifier.isi","000168481800016"],["dc.identifier.pmid","11358104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85396"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1049-2275"],["dc.title","Subgaleal Versus Subperiosteal Dissection in Fronto-Orbital Advancement Procedures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","457"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Child's Nervous System"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Kanzler, Maximilian"],["dc.contributor.author","Thomale, Ulrich-Wilhelm"],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.date.accessioned","2020-12-10T14:10:20Z"],["dc.date.available","2020-12-10T14:10:20Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00381-017-3654-0"],["dc.identifier.eissn","1433-0350"],["dc.identifier.issn","0256-7040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70730"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Implementing a digital real-time Hydrocephalus and Shunt Registry to evaluate contemporary pattern of care and surgical outcome in pediatric hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","224"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Acta Neuropathologica"],["dc.bibliographiccitation.lastpage","230"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Gutenberg, Angelika"],["dc.contributor.author","Bruck, Wolfgang W."],["dc.contributor.author","Buchfelder, Michael"],["dc.contributor.author","Ludwig, H.-C."],["dc.date.accessioned","2018-11-07T10:45:40Z"],["dc.date.available","2018-11-07T10:45:40Z"],["dc.date.issued","2004"],["dc.description.abstract","The progression of malignancy from astrocytomas to glioblastomas remains clinically as well as histopathologically unpredictable. The focal adhesion kinase (FAK) and the proline-rich tyrosine kinase (Pyk2) show a high expression in glioma cell lines and have an influence on increased cell proliferation and migration of glioma cells in vitro and in vivo. The aim of this study was to correlate the coexpression of FAK and Pyk2 to the WHO grade of malignancy in human astrocytomas. Immunohistochemical staining scores of FAK and Pyk2 were analyzed in 331 astrocytomas and correlated to each other and to the WHO grade. Significant coexpression of FAK and Pyk2 in astrocytomas was demonstrated. Pyk2 expression occurred much more frequently and with higher expression scores within the different WHO grades. Beyond this, a significant correlation between the WHO grade of malignancy of astrocytomas and the expression of FAK, as well as of Pyk2, was detected. This connection and the roles of these two tyrosine kinases in the progression of tumors should be confirmed by further studies."],["dc.identifier.doi","10.1007/s00401-004-0886-3"],["dc.identifier.isi","000223123000008"],["dc.identifier.pmid","15221336"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47555"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0001-6322"],["dc.title","Expression of tyrosine kinases FAK and Pyk2 in 331 human astrocytomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","04"],["dc.bibliographiccitation.journal","Neuropediatrics"],["dc.bibliographiccitation.lastpage","241"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Ludwig, Hans C."],["dc.contributor.author","Bock, Hans C."],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Schiller, Stina"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2021-08-12T07:45:08Z"],["dc.date.available","2021-08-12T07:45:08Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease."],["dc.description.abstract","Abstract New experimental and clinical findings question the historic view of hydrocephalus and its 100-year-old classification. In particular, real-time magnetic resonance imaging (MRI) evaluation of cerebrospinal fluid (CSF) flow and detailed insights into brain water regulation on the molecular scale indicate the existence of at least three main mechanisms that determine the dynamics of neurofluids: (1) inspiration is a major driving force; (2) adequate filling of brain ventricles by balanced CSF upsurge is sensed by cilia; and (3) the perivascular glial network connects the ependymal surface to the pericapillary Virchow–Robin spaces. Hitherto, these aspects have not been considered a common physiologic framework, improving knowledge and therapy for severe disorders of normal-pressure and posthemorrhagic hydrocephalus, spontaneous intracranial hypotension, and spaceflight disease."],["dc.identifier.doi","10.1055/s-0041-1731981"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88375"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.relation.eissn","1439-1899"],["dc.relation.issn","0174-304X"],["dc.title","Hydrocephalus Revisited: New Insights into Dynamics of Neurofluids on Macro- and Microscales"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology Neurosurgery & Psychiatry"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, Cornelia"],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Spei, Andreas"],["dc.contributor.author","Weber, Friedrich"],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Stenger, Dirk"],["dc.date.accessioned","2018-11-07T09:21:29Z"],["dc.date.available","2018-11-07T09:21:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Objectives To investigate whether gravitational valves reduce the risk of overdrainage complications compared with programmable valves in ventriculoperitoneal (VP) shunt surgery for idiopathic normal pressure hydrocephalus (iNPH). Background Patients with iNPH may benefit from VP shunting but are prone to overdrainage complications during posture changes. Gravitational valves with tantalum balls are considered to reduce the risk of overdrainage but their clinical effectiveness is unclear. Methods We conducted a pragmatic, randomised, multicentre trial comparing gravitational with nongravitational programmable valves in patients with iNPH eligible for VP shunting. The primary endpoint was any clinical or radiological sign (headache, nausea, vomiting, subdural effusion or slit ventricle) of overdrainage 6 months after randomisation. We also assessed disease specific instruments (Black and Kiefer Scale) and Physical and Mental Component Scores of the Short Form 12 (SF-12) generic health questionnaire. Results We enrolled 145 patients (mean (SD) age 71.9 (6.9) years), 137 of whom were available for endpoint analysis. After 6 months, 29 patients in the standard and five patients in the gravitational shunt group developed overdrainage (risk difference -36%, 95% Cl -49% to -23%; p<0.001). This difference exceeded predetermined stopping rules and resulted in premature discontinuation of patient recruitment. Disease specific outcome scales did not differ between the groups although there was a significant advantage of the gravitational device in the SF-12 Mental Component Scores at the 6 and 12 month visits. Conclusions Implanting a gravitational rather than another type of valve will avoid one additional overdrainage complication in about every third patient undergoing VP shunting for iNPH."],["dc.description.sponsorship","Aesculap AG, Tuttlingen, Germany."],["dc.identifier.doi","10.1136/jnnp-2012-303936"],["dc.identifier.isi","000329909200008"],["dc.identifier.pmid","23457222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29116"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1468-330X"],["dc.relation.issn","0022-3050"],["dc.title","Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neurosurgery. Pediatrics"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Haberl, Ernst-Johannes"],["dc.contributor.author","Ludwig, Hans"],["dc.contributor.author","Thomale, Ulrich-W."],["dc.date.accessioned","2018-11-07T08:33:12Z"],["dc.date.available","2018-11-07T08:33:12Z"],["dc.date.issued","2009"],["dc.description.abstract","Object. The goal of this report was to describe the authors' initial experiences with in adjustable gravity-assisted valve (GAV) called the ProGAV in treating childhood hydrocephalus. Methods. The ProGAV was implanted in 53 children (29 boys and 24 girls, median age 7.3 years) with hydrocephalus of various origins. The ProGAV consists of a differential-pressure unit with adjustable opening pressures and a gravitational unit with a fixed opening pressure. Results. The mean follow-up period was 15.2 months (range 6-44 months). The authors did not observe any valve-related complications. Four infections (7.5%) Occurred, warranting the removal of the shunt. In 19 children. the opening pressure was changed at least once during the follow-up period. for underdrainage in 10, overdrainage in 8, and shunt weaning in 1, with substantial clinical improvement in 18 children. Overall, good clinical results were obtained in 47 (88.7%) of the 53 valve placements. Conclusions. With an overall success rate of 88.7%. the first experiences with the ProGAV in childhood hydrocephalus are promising and justify its further use in the pediatric Population. (DOI: 10.3171/2008.11.PEDS08154)"],["dc.identifier.doi","10.3171/2008.11.PEDS08154"],["dc.identifier.isi","000262788400002"],["dc.identifier.pmid","19278305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17519"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0707"],["dc.title","First experiences with an adjustable gravitational valve in childhood hydrocephalus Clinical article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]