Ludwig, Hans-Christoph

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology Neurosurgery & Psychiatry"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, Cornelia"],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Spei, Andreas"],["dc.contributor.author","Weber, Friedrich"],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Stenger, Dirk"],["dc.date.accessioned","2018-11-07T09:21:29Z"],["dc.date.available","2018-11-07T09:21:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Objectives To investigate whether gravitational valves reduce the risk of overdrainage complications compared with programmable valves in ventriculoperitoneal (VP) shunt surgery for idiopathic normal pressure hydrocephalus (iNPH). Background Patients with iNPH may benefit from VP shunting but are prone to overdrainage complications during posture changes. Gravitational valves with tantalum balls are considered to reduce the risk of overdrainage but their clinical effectiveness is unclear. Methods We conducted a pragmatic, randomised, multicentre trial comparing gravitational with nongravitational programmable valves in patients with iNPH eligible for VP shunting. The primary endpoint was any clinical or radiological sign (headache, nausea, vomiting, subdural effusion or slit ventricle) of overdrainage 6 months after randomisation. We also assessed disease specific instruments (Black and Kiefer Scale) and Physical and Mental Component Scores of the Short Form 12 (SF-12) generic health questionnaire. Results We enrolled 145 patients (mean (SD) age 71.9 (6.9) years), 137 of whom were available for endpoint analysis. After 6 months, 29 patients in the standard and five patients in the gravitational shunt group developed overdrainage (risk difference -36%, 95% Cl -49% to -23%; p<0.001). This difference exceeded predetermined stopping rules and resulted in premature discontinuation of patient recruitment. Disease specific outcome scales did not differ between the groups although there was a significant advantage of the gravitational device in the SF-12 Mental Component Scores at the 6 and 12 month visits. Conclusions Implanting a gravitational rather than another type of valve will avoid one additional overdrainage complication in about every third patient undergoing VP shunting for iNPH."],["dc.description.sponsorship","Aesculap AG, Tuttlingen, Germany."],["dc.identifier.doi","10.1136/jnnp-2012-303936"],["dc.identifier.isi","000329909200008"],["dc.identifier.pmid","23457222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29116"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1468-330X"],["dc.relation.issn","0022-3050"],["dc.title","Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","90"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Neurosurgery. Pediatrics"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Haberl, Ernst-Johannes"],["dc.contributor.author","Ludwig, Hans"],["dc.contributor.author","Thomale, Ulrich-W."],["dc.date.accessioned","2018-11-07T08:33:12Z"],["dc.date.available","2018-11-07T08:33:12Z"],["dc.date.issued","2009"],["dc.description.abstract","Object. The goal of this report was to describe the authors' initial experiences with in adjustable gravity-assisted valve (GAV) called the ProGAV in treating childhood hydrocephalus. Methods. The ProGAV was implanted in 53 children (29 boys and 24 girls, median age 7.3 years) with hydrocephalus of various origins. The ProGAV consists of a differential-pressure unit with adjustable opening pressures and a gravitational unit with a fixed opening pressure. Results. The mean follow-up period was 15.2 months (range 6-44 months). The authors did not observe any valve-related complications. Four infections (7.5%) Occurred, warranting the removal of the shunt. In 19 children. the opening pressure was changed at least once during the follow-up period. for underdrainage in 10, overdrainage in 8, and shunt weaning in 1, with substantial clinical improvement in 18 children. Overall, good clinical results were obtained in 47 (88.7%) of the 53 valve placements. Conclusions. With an overall success rate of 88.7%. the first experiences with the ProGAV in childhood hydrocephalus are promising and justify its further use in the pediatric Population. (DOI: 10.3171/2008.11.PEDS08154)"],["dc.identifier.doi","10.3171/2008.11.PEDS08154"],["dc.identifier.isi","000262788400002"],["dc.identifier.pmid","19278305"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17519"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Neurological Surgeons"],["dc.relation.issn","1933-0707"],["dc.title","First experiences with an adjustable gravitational valve in childhood hydrocephalus Clinical article"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","195"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Neurosurgical Review"],["dc.bibliographiccitation.lastpage","201"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Kruschat, Thomas"],["dc.contributor.author","Knobloch, T."],["dc.contributor.author","Teichmann, H.-O."],["dc.contributor.author","Rostasy, Kevin"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T11:01:13Z"],["dc.date.available","2018-11-07T11:01:13Z"],["dc.date.issued","2007"],["dc.description.abstract","Nd:YAG, argon and diode lasers have been used in neurosurgical procedures including neuroendoscopy. However, many neurosurgeons are reluctant to use these lasers because of their inappropriate wavelength and uncontrollable tissue interaction, which has the potential to cause serious complications. Recently, a 2.0-mu m near infrared laser with adequate wavelength and minimal tissue penetration became available. This laser was developed for endoscopic neurosurgical procedures. It is the aim of the study to report the initial experiences with this laser in neuroendoscopic procedures. We have performed 43 laser-assisted neuroendoscopic procedures [multicompartmental congenital, posthaemorrhagic or postinfectious hydrocephalus (n=17), tumour biopsies (n=6), rescue of fixed and allocated ventricular catheters (n=2), endoscopic third ventriculostomy (ETV, n=17) and aqueductoplasty (n=1)] in 41 patients aged between 3 months and 80 years. The laser beam was delivered through a 365-mu m bare silica fibre introduced through the working channel of a rigid endoscope. It was used for the opening of cysts, perforating the third ventricular floor, and for coagulation prior to and after biopsy. The therapeutic goals [creating unhindered cerebrospinal fluid (CSF) flow between cysts, ventricles and cisterns, sufficient tissue samples for histopathological diagnosis and catheter rescue] were achieved in 40 patients by the first and in 2 patients by a second neuroendoscopic operation. In one child, a CSF shunt was later required despite patency of the created stoma proven by magnetic resonance imaging (MRI). In another patient ETV was abandoned due to a tiny third ventricle. There was neither mortality nor transient or permanent morbidity. The authors conclude that the use of the 2.0-mu m near infrared laser enables safe and effective procedures in neuroendoscopy."],["dc.identifier.doi","10.1007/s10143-007-0078-4"],["dc.identifier.isi","000247185100009"],["dc.identifier.pmid","17479304"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51098"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0344-5607"],["dc.title","First experiences with a 2.0-mu m near infrared laser system for neuroendoscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Pediatric Neurosurgery"],["dc.bibliographiccitation.lastpage","68"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Gutenberg, Angelika"],["dc.contributor.author","Schulten, Hans-Juergen"],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Larsen, Joerg"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T08:35:20Z"],["dc.date.available","2018-11-07T08:35:20Z"],["dc.date.issued","2009"],["dc.description.abstract","We present the very unusual case of a young woman suffering from a brain tumor 22 years after a stage IV spinal neuroblastoma as an infant, demonstrating the difficulties of differentiating late neuroblastoma relapse from secondary supratentorial primitive neuroectodermal tumor (sPNET). Lacking specific immunohistochemical features, the first cerebral tumor at the age of 21 was regarded as sPNET, and we pursued a therapeutic approach consisting of neurosurgical resection as well as irradiation and high-dose alkylatorbased chemotherapy according to the HIT2000 protocol. Two years later the patient suffered from a diffusely infiltrating local recurrence, changing its imaging appearance as well as its immunohistochemical characteristics, now revealing disseminated positivity for neuron-specific enolase and neural cell adhesion molecule. Moreover, the lack of PNET-specific translocations (EWS/FLI1 gene fusion) in both brain tumors as well as the development of hepatic metastases was more compatible with the diagnosis of a very late relapse 22 years after initial stage IV spinal neuroblastoma. Copyright (C) 2009 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000204906"],["dc.identifier.isi","000264024300011"],["dc.identifier.pmid","19258732"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9331"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18037"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1016-2291"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","CNS Tumor 22 Years after Spinal Neuroblastoma IV: Diagnostic Dilemma between Recurrence and Secondary Malignancy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1054"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","1060"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Stengel, Dirk"],["dc.contributor.author","Mueller, Cornelia"],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, Friedrich"],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Lemcke, Johannes"],["dc.date.accessioned","2018-11-07T09:16:43Z"],["dc.date.available","2018-11-07T09:16:43Z"],["dc.date.issued","2013"],["dc.description.abstract","BACKGROUND: Little is known about variables associated with overdrainage complications and neurofunctional and health-related quality of life outcomes in idiopathic normal-pressure hydrocephalus (iNPH) patients after shunt surgery. OBJECTIVE: To identify candidate demographic and disease-specific predictors of overdrainage and patient-related outcomes, allowing for more personalized care of patients with iNPH. METHODS: This was a secondary analysis of the dataset of the SVASONA study, a multicenter randomized trial comparing gravitational and conventional gravitational valves for treating iNPH. We evaluated the association between baseline items and the incidence of overdrainage, using different endpoint definitions. RESULTS: We identified only a few variables associated with a possible increased risk of overdrainage. Apart from using conventional rather than gravitational valves, longer duration of surgery and female sex were associated with a higher risk of clinical signs and symptoms suggestive of overdrainage (hazard ratio: 1.02, 95% confidence interval: 1.01-1.04 and 1.84, 95% confidence interval: 0.81-4.16). The occurrence of clinical symptoms of overdrainage, and the need for exchanging a programmable by a gravitational valve may adversely affect disease-specific outcomes like the Kiefer score. CONCLUSION: Few, if any, baseline and treatment characteristics may be helpful in estimating the individual risk of complications and clinical outcomes after shunt surgery for iNPH. Patients should be informed that longer surgery for any reason may increase the risk of later overdrainage. Also, women should be counseled about a sex-associated increased risk of the development of clinical symptoms of overdrainage, although the latter cannot be distinguished from a generally higher prevalence of headaches in the female population."],["dc.identifier.doi","10.1227/NEU.0000000000000155"],["dc.identifier.isi","000330478600042"],["dc.identifier.pmid","24257332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27997"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","Predictors of Subsequent Overdrainage and Clinical Outcomes After Ventriculoperitoneal Shunting for Idiopathic Normal Pressure Hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T09:06:17Z"],["dc.date.available","2018-11-07T09:06:17Z"],["dc.date.issued","2012"],["dc.format.extent","154"],["dc.identifier.isi","000309359700289"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25517"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","16th Congress of the European-Federation-of-Neurological-Societies (EFNS)"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1351-5101"],["dc.title","Outcome analysis of the randomized multi-center study on idiopathic normal pressure hydrocephalus (SVASONA)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T11:23:33Z"],["dc.date.available","2018-11-07T11:23:33Z"],["dc.date.issued","2009"],["dc.format.extent","351"],["dc.identifier.isi","000269804100731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56220"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","13th Congress of the European-Federation-of-Neurological-Societies"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","1351-5101"],["dc.title","Protocol for randomized controlled SVASONA trial (ISRCTN51046698): shunt valves plus shunt assistant versus shunt valves alone for controlling over-drainage in iNPH in adults"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","63"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Neurochirurgica"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","159"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Kallenberg, Kai"],["dc.contributor.author","Psychogios, Marios-Nikos"],["dc.contributor.author","Schatlo, Bawarjan"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.contributor.author","Bock, Hans Christoph"],["dc.date.accessioned","2018-11-07T10:29:10Z"],["dc.date.available","2018-11-07T10:29:10Z"],["dc.date.issued","2017"],["dc.description.abstract","Background Obstruction is a common cause of ventriculoperitoneal shunt failure. Head computed tomography and plain x-ray examinations of shunt tubing (\"shunt series\") are routinely used in patients readmitted for reemerging symptoms but are of limited value. The validity of shunt series can be improved by applying contrast agent into the system (contrast-enhanced shunt series, a.k.a.a \"shuntogram\" or \"shuntography\"). We hypothesized that contrast-enhanced shunt series have a high predictive value for shunt revision surgeries. Methods We retrospectively re-evaluated 107 contrast-enhanced shunt series and reviewed the patient histories. We defined outcome parameters for calculating the utility of a pathological contrast-enhanced shunt series in predicting revision surgery. Results Of 107 contrast-enhanced shunt series, 41 examinations were positive for obstruction, mainly of the ventricular (36.5 %) and the peritoneal catheter (48.8 %). Within 30 days, 35 successful revision surgeries and 3 revision surgeries without resolution of symptoms were performed. In two cases the shunt tubing was found to be patent. Sixty-six negative examinations resulted in two revision surgeries, in addition to ten surgeries not attempting to restore patency. After 30 days, the specificity of contrast-enhanced shunt series for shunt failure identification was calculated at 92.8 %, the sensitivity at 94.7 %, the positive predictive value at 87.8 %, and the negative predictive value at 97.0 %. Conclusions The contrast-enhanced shunt series method is a highly specific examination with a negative predictive value exceeding that of head computed tomography and plain shunt series. Compared to radionuclide marker studies, contrastenhanced shunt series demonstrate better spatiotemporal resolution, enabling focused local surgical repair."],["dc.identifier.doi","10.1007/s00701-016-3007-x"],["dc.identifier.isi","000393022000012"],["dc.identifier.pmid","27817007"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43586"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","0942-0940"],["dc.relation.issn","0001-6268"],["dc.title","Contrast-enhanced shunt series (\"shuntography\") compare favorably to other shunt imaging modalities in detecting shunt occlusion"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T09:06:16Z"],["dc.date.available","2018-11-07T09:06:16Z"],["dc.date.issued","2012"],["dc.format.extent","146"],["dc.identifier.isi","000309359700274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","16th Congress of the European-Federation-of-Neurological-Societies (EFNS)"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1351-5101"],["dc.title","Less complications in shunt surgery: gravitational valves are proven to be effective in the therapy of the idiophatic normal pressure hydrocephalus (SVASONA)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","132"],["dc.bibliographiccitation.journal","Clinical Neurology and Neurosurgery"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","137"],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Wagner, Wolfgang"],["dc.contributor.author","Tschan, Christoph A."],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans C."],["dc.contributor.author","Gliemroth, Jan"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Thomale, Ulrich-W."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Krauss, Joachim K."],["dc.contributor.author","Mirzayan, M. Javad"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Huthmann, Alexandra"],["dc.date.accessioned","2018-11-07T09:51:01Z"],["dc.date.available","2018-11-07T09:51:01Z"],["dc.date.issued","2015"],["dc.description.abstract","Objective: Cerebrospinal fluid (CSF) overdrainage is a major problem in shunt therapy for hydrocephalus. The adjustable gravitational valve proSA allows for the first time a targeted compensation for overdrainage in the upright position without interfering with the differential pressure valve. To evaluate benefit, safety and reliability, the multicenter prospective registry PROSAIKA was conducted in 10 German neurosurgical centers. Methods: Between March 2009 and July 2010, 120 hydrocephalic patients undergoing first time shunt implantation or shunt revision using proSA entered the study. 93 patients completed the 12 months follow-up. Results: Hydrocephalus symptoms were improved in 86%, unchanged in 9% and deteriorated in 3%. In 51%, the proSA opening pressure was readjusted one or several times to treat suspected suboptimal shunt function, this resulted in clinical improvement in 55%, no change in 25%, and deterioration in 20% of these patients. The 1 year censored proSA shunt survival rate was 89%. Device related shunt failure was seen in two cases. Conclusions: This is the first clinical report on the implantation of the adjustable gravitational valve proSA with a follow-up of 12 months in a substantial number of patients. Irrespective of different hydrocephalus etiologies and indications for shunt surgery, the overall results after 12 months were very satisfying. The high frequency of valve readjustments underlines the fact that preoperative selection of the appropriate valve opening pressure is difficult. The low number of revisions and complications compared to other valves proves that proSA implantation adds no further risk; this valve is reliable, helpful and safe. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Braun/Aesculap"],["dc.identifier.doi","10.1016/j.clineuro.2015.07.002"],["dc.identifier.isi","000361921000027"],["dc.identifier.pmid","26196478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35828"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-6968"],["dc.relation.issn","0303-8467"],["dc.title","PROSAIKA: A prospective multicenter registry with the first programmable gravitational device for hydrocephalus shunting"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]