Ludwig, Hans-Christoph

[["dc.bibliographiccitation.artnumber","10"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Fluids and Barriers of the CNS"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Aktas, Gökmen"],["dc.contributor.author","Kollmeier, Jost M."],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2019-07-09T11:50:48Z"],["dc.date.available","2019-07-09T11:50:48Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present study was to elucidate the sensitivity of CSF flow along the spinal canal to forced thoracic versus abdominal respiration. Methods Eighteen subjects without known illness were studied using real-time phase-contrast flow MRI at 3 T in the aqueduct and along the spinal canal at levels C3, Th1, Th8 and L3. Subjects performed a protocol of forced breathing comprising four cycles of 2.5 s inspiration and 2.5 s expiration. Results The quantitative results for spinal CSF flow rates and volumes confirm previous findings of an upward movement during forced inspiration and reversed downward flow during subsequent exhalation—for both breathing types. However, the effects were more pronounced for abdominal than for thoracic breathing, in particular at spinal levels Th8 and L3. In general, CSF net flow volumes were very similar for both breathing conditions pointing upwards in all locations. Conclusions Spinal CSF dynamics are sensitive to varying respiratory performances. The different CSF flow volumes in response to deep thoracic versus abdominal breathing reflect instantaneous adjustments of intrathoracic and intraabdominal pressure, respectively. Real-time MRI access to CSF flow in response to defined respiration patterns will be of clinical importance for patients with disturbed CSF circulation like hydrocephalus, pseudotumor cerebri and others."],["dc.identifier.doi","10.1186/s12987-019-0130-0"],["dc.identifier.pmid","30947716"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59832"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Spinal CSF flow in response to forced thoracic and abdominal respiration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2568"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kollmeier, Jost M."],["dc.contributor.author","Gürbüz-Reiss, Lukas"],["dc.contributor.author","Sahoo, Prativa"],["dc.contributor.author","Badura, Simon"],["dc.contributor.author","Ellebracht, Ben"],["dc.contributor.author","Keck, Mathilda"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2022-04-01T10:00:47Z"],["dc.date.available","2022-04-01T10:00:47Z"],["dc.date.issued","2022"],["dc.description.abstract","Venous system pathologies have increasingly been linked to clinically relevant disorders of CSF circulation whereas the exact coupling mechanisms still remain unknown. In this work, flow dynamics of both systems were studied using real-time phase-contrast flow MRI in 16 healthy subjects during normal and forced breathing. Flow evaluations in the aqueduct, at cervical level C3 and lumbar level L3 for both the CSF and venous fluid systems reveal temporal modulations by forced respiration. During normal breathing cardiac-related flow modulations prevailed, while forced breathing shifted the dominant frequency of both CSF and venous flow spectra towards the respiratory component and prompted a correlation between CSF and venous flow in the large vessels. The average of flow magnitude of CSF was increased during forced breathing at all spinal and intracranial positions. Venous flow in the large vessels of the upper body decreased and in the lower body increased during forced breathing. Deep respiration couples interdependent venous and brain fluid flow—most likely mediated by intrathoracic and intraabdominal pressure changes. Further insights into the driving forces of CSF and venous circulation and their correlation will facilitate our understanding how the venous system links to intracranial pressure regulation and of related forms of hydrocephalus."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-06361-x"],["dc.identifier.pii","6361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105509"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Deep breathing couples CSF and venous flow dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]