Ludwig, Hans-Christoph

[["dc.bibliographiccitation.firstpage","850"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Neurology Neurosurgery & Psychiatry"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, Cornelia"],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Spei, Andreas"],["dc.contributor.author","Weber, Friedrich"],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Stenger, Dirk"],["dc.date.accessioned","2018-11-07T09:21:29Z"],["dc.date.available","2018-11-07T09:21:29Z"],["dc.date.issued","2013"],["dc.description.abstract","Objectives To investigate whether gravitational valves reduce the risk of overdrainage complications compared with programmable valves in ventriculoperitoneal (VP) shunt surgery for idiopathic normal pressure hydrocephalus (iNPH). Background Patients with iNPH may benefit from VP shunting but are prone to overdrainage complications during posture changes. Gravitational valves with tantalum balls are considered to reduce the risk of overdrainage but their clinical effectiveness is unclear. Methods We conducted a pragmatic, randomised, multicentre trial comparing gravitational with nongravitational programmable valves in patients with iNPH eligible for VP shunting. The primary endpoint was any clinical or radiological sign (headache, nausea, vomiting, subdural effusion or slit ventricle) of overdrainage 6 months after randomisation. We also assessed disease specific instruments (Black and Kiefer Scale) and Physical and Mental Component Scores of the Short Form 12 (SF-12) generic health questionnaire. Results We enrolled 145 patients (mean (SD) age 71.9 (6.9) years), 137 of whom were available for endpoint analysis. After 6 months, 29 patients in the standard and five patients in the gravitational shunt group developed overdrainage (risk difference -36%, 95% Cl -49% to -23%; p<0.001). This difference exceeded predetermined stopping rules and resulted in premature discontinuation of patient recruitment. Disease specific outcome scales did not differ between the groups although there was a significant advantage of the gravitational device in the SF-12 Mental Component Scores at the 6 and 12 month visits. Conclusions Implanting a gravitational rather than another type of valve will avoid one additional overdrainage complication in about every third patient undergoing VP shunting for iNPH."],["dc.description.sponsorship","Aesculap AG, Tuttlingen, Germany."],["dc.identifier.doi","10.1136/jnnp-2012-303936"],["dc.identifier.isi","000329909200008"],["dc.identifier.pmid","23457222"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29116"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1468-330X"],["dc.relation.issn","0022-3050"],["dc.title","Safety and efficacy of gravitational shunt valves in patients with idiopathic normal pressure hydrocephalus: a pragmatic, randomised, open label, multicentre trial (SVASONA)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1054"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Neurosurgery"],["dc.bibliographiccitation.lastpage","1060"],["dc.bibliographiccitation.volume","73"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Stengel, Dirk"],["dc.contributor.author","Mueller, Cornelia"],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, Friedrich"],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Lemcke, Johannes"],["dc.date.accessioned","2018-11-07T09:16:43Z"],["dc.date.available","2018-11-07T09:16:43Z"],["dc.date.issued","2013"],["dc.description.abstract","BACKGROUND: Little is known about variables associated with overdrainage complications and neurofunctional and health-related quality of life outcomes in idiopathic normal-pressure hydrocephalus (iNPH) patients after shunt surgery. OBJECTIVE: To identify candidate demographic and disease-specific predictors of overdrainage and patient-related outcomes, allowing for more personalized care of patients with iNPH. METHODS: This was a secondary analysis of the dataset of the SVASONA study, a multicenter randomized trial comparing gravitational and conventional gravitational valves for treating iNPH. We evaluated the association between baseline items and the incidence of overdrainage, using different endpoint definitions. RESULTS: We identified only a few variables associated with a possible increased risk of overdrainage. Apart from using conventional rather than gravitational valves, longer duration of surgery and female sex were associated with a higher risk of clinical signs and symptoms suggestive of overdrainage (hazard ratio: 1.02, 95% confidence interval: 1.01-1.04 and 1.84, 95% confidence interval: 0.81-4.16). The occurrence of clinical symptoms of overdrainage, and the need for exchanging a programmable by a gravitational valve may adversely affect disease-specific outcomes like the Kiefer score. CONCLUSION: Few, if any, baseline and treatment characteristics may be helpful in estimating the individual risk of complications and clinical outcomes after shunt surgery for iNPH. Patients should be informed that longer surgery for any reason may increase the risk of later overdrainage. Also, women should be counseled about a sex-associated increased risk of the development of clinical symptoms of overdrainage, although the latter cannot be distinguished from a generally higher prevalence of headaches in the female population."],["dc.identifier.doi","10.1227/NEU.0000000000000155"],["dc.identifier.isi","000330478600042"],["dc.identifier.pmid","24257332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27997"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0148-396X"],["dc.title","Predictors of Subsequent Overdrainage and Clinical Outcomes After Ventriculoperitoneal Shunting for Idiopathic Normal Pressure Hydrocephalus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T09:06:17Z"],["dc.date.available","2018-11-07T09:06:17Z"],["dc.date.issued","2012"],["dc.format.extent","154"],["dc.identifier.isi","000309359700289"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25517"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","16th Congress of the European-Federation-of-Neurological-Societies (EFNS)"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1351-5101"],["dc.title","Outcome analysis of the randomized multi-center study on idiopathic normal pressure hydrocephalus (SVASONA)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T11:23:33Z"],["dc.date.available","2018-11-07T11:23:33Z"],["dc.date.issued","2009"],["dc.format.extent","351"],["dc.identifier.isi","000269804100731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56220"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.publisher.place","Malden"],["dc.relation.conference","13th Congress of the European-Federation-of-Neurological-Societies"],["dc.relation.eventlocation","Florence, ITALY"],["dc.relation.issn","1351-5101"],["dc.title","Protocol for randomized controlled SVASONA trial (ISRCTN51046698): shunt valves plus shunt assistant versus shunt valves alone for controlling over-drainage in iNPH in adults"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e81"],["dc.bibliographiccitation.journal","World Neurosurgery"],["dc.bibliographiccitation.lastpage","e88"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Kural, Cahit"],["dc.contributor.author","Lalla, Lisanne"],["dc.contributor.author","Ebner, Florian H."],["dc.contributor.author","Bock, Christoph"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.date.accessioned","2020-12-10T15:21:43Z"],["dc.date.available","2020-12-10T15:21:43Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.wneu.2018.09.064"],["dc.identifier.issn","1878-8750"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73127"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Two-Micron Continuous-Wave Laser-Assisted Neuroendoscopy: Clinical Experience of Two Institutions in 524 Procedures"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Neurology"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Mueller, C."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Speil, Andreas"],["dc.contributor.author","Weber, F."],["dc.contributor.author","Remenez, Victor"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, H.-C."],["dc.contributor.author","Stengel, Dirk"],["dc.date.accessioned","2018-11-07T09:06:16Z"],["dc.date.available","2018-11-07T09:06:16Z"],["dc.date.issued","2012"],["dc.format.extent","146"],["dc.identifier.isi","000309359700274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25516"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","16th Congress of the European-Federation-of-Neurological-Societies (EFNS)"],["dc.relation.eventlocation","Stockholm, SWEDEN"],["dc.relation.issn","1351-5101"],["dc.title","Less complications in shunt surgery: gravitational valves are proven to be effective in the therapy of the idiophatic normal pressure hydrocephalus (SVASONA)"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","132"],["dc.bibliographiccitation.journal","Clinical Neurology and Neurosurgery"],["dc.bibliographiccitation.lastpage","136"],["dc.bibliographiccitation.volume","137"],["dc.contributor.author","Kehler, Uwe"],["dc.contributor.author","Kiefer, Michael"],["dc.contributor.author","Eymann, Regina"],["dc.contributor.author","Wagner, Wolfgang"],["dc.contributor.author","Tschan, Christoph A."],["dc.contributor.author","Langer, Niels"],["dc.contributor.author","Rohde, Veit"],["dc.contributor.author","Ludwig, Hans C."],["dc.contributor.author","Gliemroth, Jan"],["dc.contributor.author","Meier, Ullrich"],["dc.contributor.author","Lemcke, Johannes"],["dc.contributor.author","Thomale, Ulrich-W."],["dc.contributor.author","Fritsch, Michael J."],["dc.contributor.author","Krauss, Joachim K."],["dc.contributor.author","Mirzayan, M. Javad"],["dc.contributor.author","Schuhmann, Martin U."],["dc.contributor.author","Huthmann, Alexandra"],["dc.date.accessioned","2018-11-07T09:51:01Z"],["dc.date.available","2018-11-07T09:51:01Z"],["dc.date.issued","2015"],["dc.description.abstract","Objective: Cerebrospinal fluid (CSF) overdrainage is a major problem in shunt therapy for hydrocephalus. The adjustable gravitational valve proSA allows for the first time a targeted compensation for overdrainage in the upright position without interfering with the differential pressure valve. To evaluate benefit, safety and reliability, the multicenter prospective registry PROSAIKA was conducted in 10 German neurosurgical centers. Methods: Between March 2009 and July 2010, 120 hydrocephalic patients undergoing first time shunt implantation or shunt revision using proSA entered the study. 93 patients completed the 12 months follow-up. Results: Hydrocephalus symptoms were improved in 86%, unchanged in 9% and deteriorated in 3%. In 51%, the proSA opening pressure was readjusted one or several times to treat suspected suboptimal shunt function, this resulted in clinical improvement in 55%, no change in 25%, and deterioration in 20% of these patients. The 1 year censored proSA shunt survival rate was 89%. Device related shunt failure was seen in two cases. Conclusions: This is the first clinical report on the implantation of the adjustable gravitational valve proSA with a follow-up of 12 months in a substantial number of patients. Irrespective of different hydrocephalus etiologies and indications for shunt surgery, the overall results after 12 months were very satisfying. The high frequency of valve readjustments underlines the fact that preoperative selection of the appropriate valve opening pressure is difficult. The low number of revisions and complications compared to other valves proves that proSA implantation adds no further risk; this valve is reliable, helpful and safe. (C) 2015 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Braun/Aesculap"],["dc.identifier.doi","10.1016/j.clineuro.2015.07.002"],["dc.identifier.isi","000361921000027"],["dc.identifier.pmid","26196478"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35828"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1872-6968"],["dc.relation.issn","0303-8467"],["dc.title","PROSAIKA: A prospective multicenter registry with the first programmable gravitational device for hydrocephalus shunting"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]