Ludwig, Hans-Christoph

[["dc.bibliographiccitation.artnumber","10"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Fluids and Barriers of the CNS"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Aktas, Gökmen"],["dc.contributor.author","Kollmeier, Jost M."],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2019-07-09T11:50:48Z"],["dc.date.available","2019-07-09T11:50:48Z"],["dc.date.issued","2019"],["dc.description.abstract","Background Respiration-induced pressure changes represent a powerful driving force of CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic resonance imaging (MRI). The purpose of the present study was to elucidate the sensitivity of CSF flow along the spinal canal to forced thoracic versus abdominal respiration. Methods Eighteen subjects without known illness were studied using real-time phase-contrast flow MRI at 3 T in the aqueduct and along the spinal canal at levels C3, Th1, Th8 and L3. Subjects performed a protocol of forced breathing comprising four cycles of 2.5 s inspiration and 2.5 s expiration. Results The quantitative results for spinal CSF flow rates and volumes confirm previous findings of an upward movement during forced inspiration and reversed downward flow during subsequent exhalation—for both breathing types. However, the effects were more pronounced for abdominal than for thoracic breathing, in particular at spinal levels Th8 and L3. In general, CSF net flow volumes were very similar for both breathing conditions pointing upwards in all locations. Conclusions Spinal CSF dynamics are sensitive to varying respiratory performances. The different CSF flow volumes in response to deep thoracic versus abdominal breathing reflect instantaneous adjustments of intrathoracic and intraabdominal pressure, respectively. Real-time MRI access to CSF flow in response to defined respiration patterns will be of clinical importance for patients with disturbed CSF circulation like hydrocephalus, pseudotumor cerebri and others."],["dc.identifier.doi","10.1186/s12987-019-0130-0"],["dc.identifier.pmid","30947716"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59832"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Spinal CSF flow in response to forced thoracic and abdominal respiration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Pediatric Neurosurgery"],["dc.bibliographiccitation.lastpage","68"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Gutenberg, Angelika"],["dc.contributor.author","Schulten, Hans-Juergen"],["dc.contributor.author","Gunawan, Bastian"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Brueck, Wolfgang"],["dc.contributor.author","Larsen, Joerg"],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T08:35:20Z"],["dc.date.available","2018-11-07T08:35:20Z"],["dc.date.issued","2009"],["dc.description.abstract","We present the very unusual case of a young woman suffering from a brain tumor 22 years after a stage IV spinal neuroblastoma as an infant, demonstrating the difficulties of differentiating late neuroblastoma relapse from secondary supratentorial primitive neuroectodermal tumor (sPNET). Lacking specific immunohistochemical features, the first cerebral tumor at the age of 21 was regarded as sPNET, and we pursued a therapeutic approach consisting of neurosurgical resection as well as irradiation and high-dose alkylatorbased chemotherapy according to the HIT2000 protocol. Two years later the patient suffered from a diffusely infiltrating local recurrence, changing its imaging appearance as well as its immunohistochemical characteristics, now revealing disseminated positivity for neuron-specific enolase and neural cell adhesion molecule. Moreover, the lack of PNET-specific translocations (EWS/FLI1 gene fusion) in both brain tumors as well as the development of hepatic metastases was more compatible with the diagnosis of a very late relapse 22 years after initial stage IV spinal neuroblastoma. Copyright (C) 2009 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000204906"],["dc.identifier.isi","000264024300011"],["dc.identifier.pmid","19258732"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9331"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18037"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","1016-2291"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","CNS Tumor 22 Years after Spinal Neuroblastoma IV: Diagnostic Dilemma between Recurrence and Secondary Malignancy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3555"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hell, Anna K."],["dc.contributor.author","Kühnle, Ingrid"],["dc.contributor.author","Lorenz, Heiko M."],["dc.contributor.author","Braunschweig, Lena"],["dc.contributor.author","Lüders, Katja A."],["dc.contributor.author","Bock, Hans Christoph"],["dc.contributor.author","Kramm, Christof M."],["dc.contributor.author","Ludwig, Hans Christoph"],["dc.contributor.author","Tsaknakis, Konstantinos"],["dc.date.accessioned","2021-04-14T08:27:47Z"],["dc.date.available","2021-04-14T08:27:47Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/cancers12123555"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82404"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2072-6694"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Spinal Deformities after Childhood Tumors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jnr.24935"],["dc.bibliographiccitation.firstpage","2804"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neuroscience Research"],["dc.bibliographiccitation.lastpage","2821"],["dc.bibliographiccitation.volume","99"],["dc.contributor.affiliation","Dreha‐Kulaczewski, Steffi; 2\r\nDivision of Pediatric Neurology\r\nDepartment of Pediatrics and Adolescent Medicine\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.affiliation","Bock, Hans C.; 1\r\nDivision of Pediatric Neurosurgery\r\nDepartment of Neurosurgery\r\nUniversity Medical Center Göttingen\r\nGöttingen Germany"],["dc.contributor.author","Ludwig, Hans C."],["dc.contributor.author","Dreha‐Kulaczewski, Steffi"],["dc.contributor.author","Bock, Hans C."],["dc.date.accessioned","2021-09-01T06:42:48Z"],["dc.date.available","2021-09-01T06:42:48Z"],["dc.date.issued","2021"],["dc.date.updated","2022-03-21T02:54:16Z"],["dc.description.abstract","Abstract With the advent of real‐time MRI, the motion and passage of cerebrospinal fluid can be visualized without gating and exclusion of low‐frequency waves. This imaging modality gives insights into low‐volume, rapidly oscillating cardiac‐driven movement as well as sustained, high‐volume, slowly oscillating inspiration‐driven movement. Inspiration means a spontaneous or artificial increase in the intrathoracic dimensions independent of body position. Alterations in thoracic diameter enable the thoracic and spinal epidural venous compartments to be emptied and filled, producing an upward surge of cerebrospinal fluid inside the spine during inspiration; this surge counterbalances the downward pooling of venous blood toward the heart. Real‐time MRI, as a macroscale in vivo observation method, could expand our knowledge of neurofluid dynamics, including how astrocytic fluid preloading is adjusted and how brain buoyancy and turgor are maintained in different postures and zero gravity. Along with these macroscale findings, new microscale insights into aquaporin‐mediated fluid transfer, its sensing by cilia, and its tuning by nitric oxide will be reviewed. By incorporating clinical knowledge spanning several disciplines, certain disorders—congenital hydrocephalus with Chiari malformation, idiopathic intracranial hypertension, and adult idiopathic hydrocephalus—are interpreted and reviewed according to current concepts, from the basics of the interrelated systems to their pathology."],["dc.description.sponsorship","Mrs. L Grun Funds, Universitätsmedizin Göttingen"],["dc.identifier.doi","10.1002/jnr.24935"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/89146"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-455"],["dc.relation.eissn","1097-4547"],["dc.relation.issn","0360-4012"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.title","Neurofluids—Deep inspiration, cilia and preloading of the astrocytic network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","2568"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Kollmeier, Jost M."],["dc.contributor.author","Gürbüz-Reiss, Lukas"],["dc.contributor.author","Sahoo, Prativa"],["dc.contributor.author","Badura, Simon"],["dc.contributor.author","Ellebracht, Ben"],["dc.contributor.author","Keck, Mathilda"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.date.accessioned","2022-04-01T10:00:47Z"],["dc.date.available","2022-04-01T10:00:47Z"],["dc.date.issued","2022"],["dc.description.abstract","Venous system pathologies have increasingly been linked to clinically relevant disorders of CSF circulation whereas the exact coupling mechanisms still remain unknown. In this work, flow dynamics of both systems were studied using real-time phase-contrast flow MRI in 16 healthy subjects during normal and forced breathing. Flow evaluations in the aqueduct, at cervical level C3 and lumbar level L3 for both the CSF and venous fluid systems reveal temporal modulations by forced respiration. During normal breathing cardiac-related flow modulations prevailed, while forced breathing shifted the dominant frequency of both CSF and venous flow spectra towards the respiratory component and prompted a correlation between CSF and venous flow in the large vessels. The average of flow magnitude of CSF was increased during forced breathing at all spinal and intracranial positions. Venous flow in the large vessels of the upper body decreased and in the lower body increased during forced breathing. Deep respiration couples interdependent venous and brain fluid flow—most likely mediated by intrathoracic and intraabdominal pressure changes. Further insights into the driving forces of CSF and venous circulation and their correlation will facilitate our understanding how the venous system links to intracranial pressure regulation and of related forms of hydrocephalus."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.1038/s41598-022-06361-x"],["dc.identifier.pii","6361"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/105509"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-530"],["dc.relation.eissn","2045-2322"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Deep breathing couples CSF and venous flow dynamics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Scientific Reports"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Dreha-Kulaczewski, Steffi"],["dc.contributor.author","Konopka, Mareen"],["dc.contributor.author","Joseph, Arun A"],["dc.contributor.author","Kollmeier, Jost"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Ludwig, Hans-Christoph"],["dc.contributor.author","Gärtner, Jutta"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2020-12-10T18:10:09Z"],["dc.date.available","2020-12-10T18:10:09Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1038/s41598-018-23908-z"],["dc.identifier.eissn","2045-2322"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15427"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73869"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Respiration and the watershed of spinal CSF flow in humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]