Walliser, Karoline

[["dc.bibliographiccitation.artnumber","122"],["dc.bibliographiccitation.journal","Scandinavian Journal of Trauma Resuscitation and Emergency Medicine"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Kunze-Szikszay, Nils"],["dc.contributor.author","Krack, Lennart A."],["dc.contributor.author","Wildenauer, Pauline"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Heyne, Tim"],["dc.contributor.author","Walliser, Karoline"],["dc.contributor.author","Spering, Christopher"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Roessler, Markus"],["dc.date.accessioned","2018-11-07T10:07:07Z"],["dc.date.available","2018-11-07T10:07:07Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: Hyperfibrinolysis (HF) is a major contributor to coagulopathy and mortality in trauma patients. This study investigated (i) the rate of HF during the pre-hospital management of patients with multiple injuries and (ii) the effects of pre-hospital tranexamic acid (TxA) administration on the coagulation system. Methods: From 27 trauma patients with pre-hospital an estimated injury severity score (ISS) >= 16 points blood was obtained at the scene and on admission to the emergency department (ED). All patients received 1 g of TxA after the first blood sample was taken. Rotational thrombelastometry (ROTEM) was performed for both blood samples, and the results were compared. HF was defined as a maximum lysis (ML) >15 % in EXTEM. Results: The median (min-max) ISS was 17 points (4-50 points). Four patients (15 %) had HF diagnosed via ROTEM at the scene, and 2 patients (7.5 %) had HF diagnosed via ROTEM on admission to the ED. The median ML before TxA administration was 11 % (3-99 %) vs. 10 % after TxA administration (4-18 %; p > 0.05). TxA was administered 37 min (10-85 min) before ED arrival. The ROTEM results before and after TxA administration did not significantly differ. No adverse drug reactions were observed after TxA administration. Discussion: HF can be present in severely injured patients during pre-hospital care. Antifibrinolytic therapy administered at the scene is a significant time saver. Even in milder trauma fibrinogen can be decreased to critically low levels. Early administration of TxA cannot reverse or entirely stop this decrease. Conclusions: The pre-hospital use of TxA should be considered for severely injured patients to prevent the worsening of trauma-induced coagulopathy and unnecessarily high fibrinogen consumption."],["dc.identifier.doi","10.1186/s13049-016-0314-4"],["dc.identifier.isi","000384950400003"],["dc.identifier.pmid","27724970"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13894"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39223"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1757-7241"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","The pre-hospital administration of tranexamic acid to patients with multiple injuries and its effects on rotational thrombelastometry: a prospective observational study in pre-hospital emergency medicine"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]