Prestle, Jürgen

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Kussebi, N."],["dc.contributor.author","Kania, A."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Prestle, J."],["dc.date.accessioned","2018-11-07T08:41:05Z"],["dc.date.available","2018-11-07T08:41:05Z"],["dc.date.issued","2001"],["dc.format.extent","149"],["dc.identifier.isi","000170988300577"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19393"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.publisher.place","London"],["dc.relation.issn","0195-668X"],["dc.title","Gene expression of FK506-binding proteins (FKBPs) in the human heart. Identification of an alternatively spliced transcript of FKBP12.6"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","A13"],["dc.bibliographiccitation.journal","Heart"],["dc.bibliographiccitation.lastpage","A14"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Reynolds, D."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Smith, Godfrey L."],["dc.date.accessioned","2018-11-07T10:39:12Z"],["dc.date.available","2018-11-07T10:39:12Z"],["dc.date.issued","2003"],["dc.identifier.isi","000182474700037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45987"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","B M J Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","Annual Scientific Conference of the British-Cardiac-Society"],["dc.relation.eventlocation","GLASGOW, SCOTLAND"],["dc.relation.issn","1355-6037"],["dc.title","Measurement of intra-SR calcium concentration in isolated cardiac myocytes using a targeted aequorin probe"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Kania, A."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Teucher, N."],["dc.contributor.author","Wagner, S."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:49:54Z"],["dc.date.available","2018-11-07T09:49:54Z"],["dc.date.issued","2002"],["dc.format.extent","224"],["dc.identifier.isi","000179142701168"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35595"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.eventlocation","CHICAGO, ILLINOIS"],["dc.relation.issn","0009-7322"],["dc.title","Mutation of the calcineurin binding site in the 12.6 kDa FK-506 binding protein (FKBP12.6) leads to loss of the FKBP12.6 mediated increase in myocardial contractile performance"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Teucher, N."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Elliott, E."],["dc.contributor.author","Reynolds, D."],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Wagner, S."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Inesi, G."],["dc.contributor.author","Bers, Donald M."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Smith, Godfrey L."],["dc.date.accessioned","2018-11-07T10:35:23Z"],["dc.date.available","2018-11-07T10:35:23Z"],["dc.date.issued","2003"],["dc.format.extent","181"],["dc.identifier.isi","000186360600918"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45087"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","76th Annual Scientific Session of the American-Heart-Association"],["dc.relation.eventlocation","ORLANDO, FLORIDA"],["dc.relation.issn","0009-7322"],["dc.title","Impaired contractile performance due to excessive SERCA expression and increased sarcoplasmic reticulum ca(2+)-uptake"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","299"],["dc.bibliographiccitation.issue","2-3"],["dc.bibliographiccitation.journal","European Journal of Pharmacology"],["dc.bibliographiccitation.lastpage","304"],["dc.bibliographiccitation.volume","430"],["dc.contributor.author","Milting, Hendrik"],["dc.contributor.author","Janssen, PML"],["dc.contributor.author","Wangemann, T."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Domeier, E."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Hakim, K."],["dc.contributor.author","Grapow, M."],["dc.contributor.author","Zeitz, O."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Zerkowski, H. R."],["dc.date.accessioned","2018-11-07T11:24:39Z"],["dc.date.available","2018-11-07T11:24:39Z"],["dc.date.issued","2001"],["dc.description.abstract","FK506 (tacrolimus) is a new immunosuppressant being used in cardiac allograft transplantation. While cyclosporine A has been shown to exert an acute negative inotropic effect on isolated heart muscle preparations, little is known of the inotropic, influence of FK506. The Ca2+ release channel of human skeletal muscle and cardiac muscle is associated with FK506 binding proteins (FKBP), FKBP12 and FKBP12.6, respectively. FKBPs can be dissociated by treatment with FK506. As a consequence of FK506 exposure, isolated skeletal muscle and cardiac muscle ryanodine receptors show altered gating characteristics. Therefore, we analyzed the direct inotropic effect of FK506 exposure to isolated, intact heart muscle preparations from the human and rabbits. Experiments were performed on isolated, electrically stimulated right atrial auricular muscle strips obtained from human myocardium during elective open heart surgery and on intact right ventricular trabeculae from rabbit hearts. The human preparations were exposed to concentrations of 8 X 10(-9), 8 X 10(-8) and 8 X 10(-6) M FK506 followed by a cumulative dose-response curve with isoprenaline as a non-selective beta -adrenoceptor agonist. Our data suggest that FK506 does not exert any positive or negative inotropic effect in either human or rabbit myocardium. (C) 2001 Elsevier Science B.V. All rights reserved."],["dc.identifier.doi","10.1016/S0014-2999(01)01387-5"],["dc.identifier.isi","000172359300022"],["dc.identifier.pmid","11711047"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56453"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0014-2999"],["dc.title","FK506 does not affect cardiac contractility and adrenergic response in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Teucher, N."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Smith, Godfrey L."],["dc.contributor.author","Inesi, G."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T10:12:59Z"],["dc.date.available","2018-11-07T10:12:59Z"],["dc.date.issued","2002"],["dc.format.extent","253"],["dc.identifier.isi","000179753300951"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40343"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.publisher.place","London"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0195-668X"],["dc.title","Dose-dependent effect of SERCA1-expression in rabbit isolated ventricular cardiomyocytes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Kania, A."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Teucher, N."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T10:13:37Z"],["dc.date.available","2018-11-07T10:13:37Z"],["dc.date.issued","2002"],["dc.format.extent","542"],["dc.identifier.isi","000179753302021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40469"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.publisher.place","London"],["dc.relation.conference","Congress of the European-Society-of-Cardiology"],["dc.relation.eventlocation","BERLIN, GERMANY"],["dc.relation.issn","0195-668X"],["dc.title","Mutation of the calcineurin binding site in FKBP12.6 leads to loss of the FKBP12.6 mediated increase in contractile performance"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3553"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","3559"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Teucher, Niels"],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Currie, S."],["dc.contributor.author","Elliott, E. B."],["dc.contributor.author","Reynolds, D. F."],["dc.contributor.author","Schott, Peter"],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Kogler, H."],["dc.contributor.author","Inesi, G"],["dc.contributor.author","Bers, Donald M."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Smith, Godfrey L."],["dc.date.accessioned","2017-09-07T11:43:06Z"],["dc.date.available","2017-09-07T11:43:06Z"],["dc.date.issued","2004"],["dc.description.abstract","Background - Increasing sarcoplasmic/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) uptake activity is a promising therapeutic approach for heart failure. We investigated the effects of different levels of SERCA1a expression on contractility and Ca2+ cycling. We tested whether increased SERCA1a expression levels enhance myocyte contractility in a gene-dose - dependent manner. Methods and Results - Rabbit isolated cardiomyocytes were transfected at different multiplicities of infection (MOIs) with adenoviruses encoding SERCA1a (or beta-galactosidase as control). Myocyte relaxation half-time was decreased by 10% (P = 0.052) at SERCA1a MOI 10 and by 28% at MOI 50 (P < 0.05). Myocyte fractional shortening was increased by 12% at MOI 10 (P < 0.05) but surprisingly decreased at MOI 50 (-22%, P < 0.05) versus control. SR Ca2+ uptake (in permeabilized myocytes) demonstrated a gene-dose - dependent decrease in Km by 29% and 46% and an increase in V-max by 37% and 72% at MOI 10 and MOI 50, respectively (all P < 0.05 versus control). Ca2+ transient amplitude was increased in Ad-SERCA1a- infected myocytes at MOI 10 (by 121%, P < 0.05), but at MOI 50, the Ca2+ transient amplitude was not significantly changed. Caffeine-induced Ca2+ transients indicated significantly increased SR Ca2+ content in Ad-SERCA1a- infected cells, by 72% at MOI 10 and by 87% at MOI 50. Mathematical simulations demonstrate that the functional increase in SR Ca2+-ATPase uptake activity at MOI 50 (and increased cytosolic Ca2+ buffering) is sufficient to curtail the Ca2+ transient amplitude and explain the reduced contraction. Conclusions - Moderate SERCA1a gene transfer and expression improve contractility and Ca2+ cycling. However, higher SERCA1a expression levels can impair myocyte shortening because of higher SERCA activity and Ca2+ buffering."],["dc.identifier.doi","10.1161/01.CIR.0000145161.48545.B3"],["dc.identifier.gro","3143920"],["dc.identifier.isi","000225556200010"],["dc.identifier.pmid","15505097"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/1487"],["dc.notes.intern","WoS Import 2017-03-10 / Funder: NHLBI NIH HHS [HL-30077]"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0009-7322"],["dc.title","Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Kussebi, N."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.date.accessioned","2018-11-07T09:01:36Z"],["dc.date.available","2018-11-07T09:01:36Z"],["dc.date.issued","2000"],["dc.format.extent","202"],["dc.identifier.isi","000090072300978"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24467"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Fkbp9: An alternative splice variant of the FK506-binding protein FKBP12.6 expressed in the human heart."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","19"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Seidler, Tim"],["dc.contributor.author","Zibrova, D."],["dc.contributor.author","Reynolds, D."],["dc.contributor.author","Loughrey, C. M."],["dc.contributor.author","Kania, A."],["dc.contributor.author","Teucher, N."],["dc.contributor.author","Wagner, S."],["dc.contributor.author","Prestle, J."],["dc.contributor.author","Kogler, Harald"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Smith, Godfrey L."],["dc.date.accessioned","2018-11-07T09:49:51Z"],["dc.date.available","2018-11-07T09:49:51Z"],["dc.date.issued","2002"],["dc.format.extent","224"],["dc.identifier.isi","000179142701171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35584"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.eventlocation","CHICAGO, ILLINOIS"],["dc.relation.issn","0009-7322"],["dc.title","FKBP12 overexpression in isolated rabbit cardiomyocytes enhances intracellular Ca2+ transients, SR Ca2+ content and contractility"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]