Großmann, Marius

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JOURNAL OF CARDIOVASCULAR SURGERY"],["dc.bibliographiccitation.lastpage","537"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortomann, P."],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Schoendube, A."],["dc.date.accessioned","2018-11-07T11:12:30Z"],["dc.date.available","2018-11-07T11:12:30Z"],["dc.date.issued","2008"],["dc.description.abstract","Aim. Valuable models of chronic heart failure to perform histological studies are scarce. The authors aimed at investigating histological changes of the heart, lung, liver and kidneys in a stable and reproducible animal model of chronic heart failure in sheep. Methods. In 8 sheep (N.=8, 77 +/- 2 kg) chronic heart failure was induced by multiple sequential microembolization through bolus injection of polysterol microspheres (90 mu m, N=25 000) into the left main coronary artery. Microembolization (ME) was repeated up to three times in two to three week intervals until animals started to develop stable signs of heart failure. Therefore, clinical and hemodynamic parameters were measured (Troponin T, heart and respiratory rate, cardiac output) after each embolization. Clinical examination was carried out by a veterinarian. All animals were followed for 3 months after first microembolization and then euthanized for histological examination. Histological data of the heart, lung, liver and the kidneys were analyzed in hematoxylin-eosin (HE) stains (10x, 25x, 100x) at baseline (control group) and at 3 months after first ME. Additionally preperations of heart tissue were stained with Picro-Sirius-Red (PSR) for planimetric quantification. A score from 0 to 4 according to Rassler et al. (2005) was used to assess the degree of lung injury. Results. All animals developed histological signs of heart failure as indicated by island-like, patchy fibrosis of the heart Planimetric quantification (PSR stain) of the heart revealed a significant increase of the total amount of fibrosis from 8 +/- 2% (base) to 21 +/- 4% (3 months) (P<0.05), which was distributed homogenously throughout the left ventricle (20 +/- 3% left ventricular [LV] anterior wall, 21 +/- 4% LV posterior wall, 20 +/- 4% septum). Histologic analysis of the lung demonstrated a moderate degree of interstitial edema and pronounced peribronchial processes of inflammation with beginning proliferation of fibrotic tissue. Liver tissue showed histological changes in terms of pericentral adiposis as sign of hypoxia in course of lacking perfusion. Signs of liver congestion could be detected histological in form of central-venous accumulation of erythrocytes and dissolution of liver tissue in proximity of the central veins. Kidney preparations illustrated loss of endothelial function and vascular occlusions, caused by microspheres, with decline of renal parenchyma particularly of the tubules. Conclusion Multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with histological signs of chronic ischemic cardiomyopathy and pathological changes of lung, liver and kidney, which can directly be coursed by chronic heart failure. Thus, the present model may be suitable in experimental work on heart failure and LV assist devices, e.g. for studying the impact of mechanical unloading, mechanisms of recovery and reverse remodeling."],["dc.identifier.isi","000260851100015"],["dc.identifier.pmid","18665118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edizioni Minerva Medica"],["dc.relation.issn","0021-9509"],["dc.title","Histological changes in a model of chronic heart failure induced by multiple sequential coronary microembolization in sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","386"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Kubbe, Eric"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Mirzaie, Masoud"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:12:28Z"],["dc.date.available","2018-11-07T11:12:28Z"],["dc.date.issued","2008"],["dc.description.abstract","After a fulfilled life, Norman E. Shumway, the great pioneer of cardiac transplantation, died of lung cancer 1 day after his 83rd birthday in Palo Alto, California, USA. Already at the beginning of the 1960s, he and his colleague Richard R. Lower did revolutionary experimental work on developing and establishing the technique of orthotopic cardiac transplantation in dogs. Several studies on cardiac transplantation were carried out in his department and a few years later, Shumway and his team were on their way to perform the worldwide first human-to-human cardiac transplantation. On December 3,1967, Christiaan Neethling Barnard, a cardiac surgeon from South Africa, forestalled Shumway and performed this operation in Cape Town, South Africa. This event initiated a global boom of cardiac transplantations in the following years.\" Many heart centers started their own cardiac transplant programs but high mortality rates led again to stagnancy of transplant activities. Shumway remained stable in believing in good results of cardiac transplantation and continued his program steadily At the beginning of the 1970s, he and his group were responsible for most cardiac transplantations worldwide."],["dc.identifier.doi","10.1007/s00059-008-3026-3"],["dc.identifier.isi","000258535100009"],["dc.identifier.pmid","18773164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0340-9937"],["dc.title","Norman Edward Shumway - Pioneer of cardiac surgery (February 9,1923 to February 10, 2006)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The International Journal of Artificial Organs"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Hintze, Erik"],["dc.contributor.author","Gielok, C."],["dc.contributor.author","Gupta, S. N."],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:00:06Z"],["dc.date.available","2018-11-07T11:00:06Z"],["dc.date.issued","2007"],["dc.format.extent","694"],["dc.identifier.isi","000249654300024"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50855"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wichtig Editore"],["dc.publisher.place","Milan"],["dc.relation.issn","0391-3988"],["dc.title","Histological changes in a sheep model of chronic heart failure induced by multiple sequential coronary microembolization"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","The International Journal of Artificial Organs"],["dc.bibliographiccitation.volume","30"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Juettner, W."],["dc.contributor.author","Landrath, J."],["dc.contributor.author","Merkel, I."],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:00:05Z"],["dc.date.available","2018-11-07T11:00:05Z"],["dc.date.issued","2007"],["dc.format.extent","692"],["dc.identifier.isi","000249654300017"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50854"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wichtig Editore"],["dc.publisher.place","Milan"],["dc.relation.issn","0391-3988"],["dc.title","Linear blood pump - First results in mock circulation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ASAIO Journal"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Akdis, Mustafa"],["dc.contributor.author","Alekuzei, Haidar"],["dc.contributor.author","Steinke, Katja"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Mirzaie, Masoud"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:15:19Z"],["dc.date.available","2018-11-07T11:15:19Z"],["dc.date.issued","2008"],["dc.description.abstract","We evaluated the newly developed miniaturized HIA microdiagonal blood pump (MDP) as a continuous flow left ventricular assist device. In a sheep model (n = 6), the MDP was implanted through left lateral thoracotomy and placed paracorporeally with inflow conduit to left atrium and outflow conduit to descending aorta. The sheep were pumped at a mean flow rate of 2.5 L/min for 7 days. Anticoagulation was applied by intravenous heparin administration. Postoperatively, activated clotting time was held stable with values of 200 seconds. During follow-up, blood samples (creatinine kinase, creatinine, glutamic-oxaloacetic transaminase (aspartate aminotransferase) (GOT), glutamate dehydrogenase (GLDH), gamma-GT, plasma-free hemoglobin, and hemoglobine) were taken daily. After 7 days, the sheep were killed for macroscopic examination. Systemic artery pressures remained stable during the whole test period. Because of operative reasons, the hemoglobin value (7.5 +/- 0.61 g/dl) decreased perioperatively, but recovered within the test period, whereas creatinine kinase increased initially after thoracotomy, but decreased to normal within days. Renal and liver functions were slightly impaired perioperatively, indicated by temporarily enhanced values of GOT, gamma-GT, GLDH, and creatinine. The MDP did not produce significant hemolysis as measured by plasma-free hemoglobin levels. Wound infections did not occur. We conclude that the MDP ran successfully as an left ventricular assist device for 7 days in sheep has potential for long-term support, and may serve as an alternative to current technologies. Presented data were not obtained in a clinical trial; however, the results are promising enough to proceed with longer duration animal studies."],["dc.identifier.doi","10.1097/MAT.0b013e318175258e"],["dc.identifier.isi","000256186600003"],["dc.identifier.pmid","18496271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54340"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1058-2916"],["dc.title","Miniaturized HIA microdiagonal pump as left ventricular assist device in a sheep model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]