Großmann, Marius

[["dc.bibliographiccitation.firstpage","1433"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Annals of Thoracic Surgery"],["dc.bibliographiccitation.lastpage","1439"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Popov, Aron"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:22:21Z"],["dc.date.available","2018-11-07T11:22:21Z"],["dc.date.issued","2009"],["dc.description.abstract","Background. Emergent coronary artery bypass graft surgery (CABG) for acute myocardial infarction is associated with an increased operative risk. For estimation of mortality risk, the European System for Cardiac Operative Risk Evaluation (EuroSCORE) is appropriate up to a medium risk score (<6 points). To predict mortality risk more accurately in cases of higher EuroSCORE, additional cardiac data can be helpful. Methods. Over a 3-year period, patient data including acute myocardial infarction and emergent CABG were retrospectively reviewed. Univariate and multivariate analysis for in-hospital mortality was performed. The EuroSCORE analysis and follow-up was investigated. Results. Overall in-hospital mortality was 18.3%. Preoperative cardiac related predictors for in-hospital mortality were cardiogenic shock (p < 0.001), very poor left ventricular function (p = 0.001), and ST-segment elevation (p = 0.012). In multivariate regression analysis, age, cardiogenic shock, and pulmonary hypertension were independent preoperative risk factors. According to the EuroSCORE, we could define three statistically different groups: intermediate-risk, high-risk, and very high risk, with an observed mortality of 3.3%, 20.0%, and 63.2%, respectively. The EuroSCORE correlates with but overestimates the mortality risk. In subgroup analysis, the creatine kinase-myocardial band/hour ratio for the intermediate-risk group and ST-segment elevation for the high-risk group were additional cardiac risk factors. Conclusions. Patients with an acute myocardial infarction and emergency aortocoronary CABG have an elevated operative risk. Logistic EuroSCORE overestimates the mortality rate. Three different risk groups can be defined, in which creatine kinase-MB/h-ratio and ST-segment elevation can more accurately predict operative risk. (Ann Thorac Surg 2009;88:1433-9) (C) 2009 by The Society of Thoracic Surgeons"],["dc.identifier.doi","10.1016/j.athoracsur.2009.06.059"],["dc.identifier.isi","000271215700007"],["dc.identifier.pmid","19853087"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55978"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","0003-4975"],["dc.title","A Three-Group Model to Predict Mortality in Emergent Coronary Artery Bypass Graft Surgery"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","533"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JOURNAL OF CARDIOVASCULAR SURGERY"],["dc.bibliographiccitation.lastpage","537"],["dc.bibliographiccitation.volume","49"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortomann, P."],["dc.contributor.author","Vorkamp, Tobias"],["dc.contributor.author","Heidrich, Florian"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Ramadori, Giuliano"],["dc.contributor.author","Schoendube, A."],["dc.date.accessioned","2018-11-07T11:12:30Z"],["dc.date.available","2018-11-07T11:12:30Z"],["dc.date.issued","2008"],["dc.description.abstract","Aim. Valuable models of chronic heart failure to perform histological studies are scarce. The authors aimed at investigating histological changes of the heart, lung, liver and kidneys in a stable and reproducible animal model of chronic heart failure in sheep. Methods. In 8 sheep (N.=8, 77 +/- 2 kg) chronic heart failure was induced by multiple sequential microembolization through bolus injection of polysterol microspheres (90 mu m, N=25 000) into the left main coronary artery. Microembolization (ME) was repeated up to three times in two to three week intervals until animals started to develop stable signs of heart failure. Therefore, clinical and hemodynamic parameters were measured (Troponin T, heart and respiratory rate, cardiac output) after each embolization. Clinical examination was carried out by a veterinarian. All animals were followed for 3 months after first microembolization and then euthanized for histological examination. Histological data of the heart, lung, liver and the kidneys were analyzed in hematoxylin-eosin (HE) stains (10x, 25x, 100x) at baseline (control group) and at 3 months after first ME. Additionally preperations of heart tissue were stained with Picro-Sirius-Red (PSR) for planimetric quantification. A score from 0 to 4 according to Rassler et al. (2005) was used to assess the degree of lung injury. Results. All animals developed histological signs of heart failure as indicated by island-like, patchy fibrosis of the heart Planimetric quantification (PSR stain) of the heart revealed a significant increase of the total amount of fibrosis from 8 +/- 2% (base) to 21 +/- 4% (3 months) (P<0.05), which was distributed homogenously throughout the left ventricle (20 +/- 3% left ventricular [LV] anterior wall, 21 +/- 4% LV posterior wall, 20 +/- 4% septum). Histologic analysis of the lung demonstrated a moderate degree of interstitial edema and pronounced peribronchial processes of inflammation with beginning proliferation of fibrotic tissue. Liver tissue showed histological changes in terms of pericentral adiposis as sign of hypoxia in course of lacking perfusion. Signs of liver congestion could be detected histological in form of central-venous accumulation of erythrocytes and dissolution of liver tissue in proximity of the central veins. Kidney preparations illustrated loss of endothelial function and vascular occlusions, caused by microspheres, with decline of renal parenchyma particularly of the tubules. Conclusion Multiple sequential intracoronary microembolization can effectively induce myocardial dysfunction with histological signs of chronic ischemic cardiomyopathy and pathological changes of lung, liver and kidney, which can directly be coursed by chronic heart failure. Thus, the present model may be suitable in experimental work on heart failure and LV assist devices, e.g. for studying the impact of mechanical unloading, mechanisms of recovery and reverse remodeling."],["dc.identifier.isi","000260851100015"],["dc.identifier.pmid","18665118"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53681"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Edizioni Minerva Medica"],["dc.relation.issn","0021-9509"],["dc.title","Histological changes in a model of chronic heart failure induced by multiple sequential coronary microembolization in sheep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","180"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","184"],["dc.bibliographiccitation.volume","61"],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Sellin, Christian"],["dc.contributor.author","Bury, Maike-Corinna"],["dc.contributor.author","Drescher, Andreas"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T09:26:35Z"],["dc.date.available","2018-11-07T09:26:35Z"],["dc.date.issued","2013"],["dc.description.abstract","Background Deep sternal wound infections (DSWI) remain a devastating complication in cardiac surgery applying full sternotomy. As the risk profile in cardiac surgery changed toward an older and sicker population, the incidence of DSWI increases. Platelet rich plasma (PRP) holds promise in tissue regeneration with respect to bone regeneration, reduction of bleeding, and accelerated wound healing. The effect of PRP on DSWI was investigated in high-risk patients undergoing cardiac surgery with full sternotomy. Methods 196 consecutive patients at risk of DSWI were randomized to application of autologous PRP before sternal wiring (n = 97) or control (n = 99). All patients underwent cardiac surgery on cardiopulmonary bypass with cardioplegic cardiac arrest. Endpoint was occurrence of DSWI requiring revision surgery. Results Demographic, intraoperative, and perioperative variables as well as risk factors were comparable between groups. Incidence of DSWI was not different between the PRP-group and the control-group (6/97 (6.2%) vs. 3/99 (3.0%); n.s.). Conclusions Local application of autologous PRP in cardiac surgery patients with full sternotomy at high risk for sternal complications did not reduce the incidence of DSWI."],["dc.description.sponsorship","Biomet Deutschland GmbH, Berlin, Germany"],["dc.identifier.doi","10.1055/s-0032-1304537"],["dc.identifier.isi","000317175800002"],["dc.identifier.pmid","22547304"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30332"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0171-6425"],["dc.title","Incidence of Deep Sternal Wound Infection Is Not Reduced with Autologous Platelet Rich Plasma in High-Risk Cardiac Surgery Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","386"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Herz"],["dc.bibliographiccitation.lastpage","388"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Kubbe, Eric"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Mirzaie, Masoud"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:12:28Z"],["dc.date.available","2018-11-07T11:12:28Z"],["dc.date.issued","2008"],["dc.description.abstract","After a fulfilled life, Norman E. Shumway, the great pioneer of cardiac transplantation, died of lung cancer 1 day after his 83rd birthday in Palo Alto, California, USA. Already at the beginning of the 1960s, he and his colleague Richard R. Lower did revolutionary experimental work on developing and establishing the technique of orthotopic cardiac transplantation in dogs. Several studies on cardiac transplantation were carried out in his department and a few years later, Shumway and his team were on their way to perform the worldwide first human-to-human cardiac transplantation. On December 3,1967, Christiaan Neethling Barnard, a cardiac surgeon from South Africa, forestalled Shumway and performed this operation in Cape Town, South Africa. This event initiated a global boom of cardiac transplantations in the following years.\" Many heart centers started their own cardiac transplant programs but high mortality rates led again to stagnancy of transplant activities. Shumway remained stable in believing in good results of cardiac transplantation and continued his program steadily At the beginning of the 1970s, he and his group were responsible for most cardiac transplantations worldwide."],["dc.identifier.doi","10.1007/s00059-008-3026-3"],["dc.identifier.isi","000258535100009"],["dc.identifier.pmid","18773164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.relation.issn","0340-9937"],["dc.title","Norman Edward Shumway - Pioneer of cardiac surgery (February 9,1923 to February 10, 2006)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","21"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Thoracic and Cardiovascular Surgeon"],["dc.bibliographiccitation.lastpage","24"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.contributor.author","Zenker, Dieter"],["dc.contributor.author","Didilis, Vassilios N."],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:59:39Z"],["dc.date.available","2018-11-07T08:59:39Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE) are an increasing problem in deep sternal wound infections (DSWI) after cardiac surgery. Methods: Between 2005 and 2009, recalcitrant methicillin-resistant Staphylococcus was found in 21 patients with complicated DSWI, and a transposition of the greater omentum (TGO) was finally performed. A positive microbial culture at the time of procedure was present in all patients. The hospital course was reviewed discretely for MRSA and MRSE. Results: Median patient age was 72.3 years (range 60.8-79.7); 76% of patients were male. Time from the first sternal revision until consecutive open wound therapy due to re-infection and total hospital stay was longer for MRSA compared to MRSE (38 vs. 14 days, p = 0.003, and 141 vs. 91 days, p = 0.007, respectively). The period from cardiac surgery to TGO was likewise prolonged for MRSA (78 vs. 55 days, p = 0.045), whereas in-hospital mortality and one-year mortality rate did not differ. Conclusion: TGO remains a good treatment option for DSWI type IV. Microbial findings determine the clinical course; nevertheless in-hospital mortality remains low for both MRSA and MRSE infection."],["dc.identifier.doi","10.1055/s-0030-1250373"],["dc.identifier.isi","000286310200004"],["dc.identifier.pmid","21243567"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23955"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","39th Annual Meeting of the German-Society-for-Thoracic-and-Cardiovascular-Surgery"],["dc.relation.eventlocation","Stuttgart, GERMANY"],["dc.relation.issn","0171-6425"],["dc.title","Transposition of Greater Omentum in Deep Sternal Wound Infection Caused by Methicillin-Resistant Staphylococci, with Differing Clinical Course for MRSA and MRSE"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","ASAIO Journal"],["dc.bibliographiccitation.lastpage","236"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Ortmann, Philipp"],["dc.contributor.author","Akdis, Mustafa"],["dc.contributor.author","Alekuzei, Haidar"],["dc.contributor.author","Steinke, Katja"],["dc.contributor.author","Kolat, Philipp"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Waldmann-Beushausen, Regina"],["dc.contributor.author","Mirzaie, Masoud"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Seipelt, Ralf G."],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T11:15:19Z"],["dc.date.available","2018-11-07T11:15:19Z"],["dc.date.issued","2008"],["dc.description.abstract","We evaluated the newly developed miniaturized HIA microdiagonal blood pump (MDP) as a continuous flow left ventricular assist device. In a sheep model (n = 6), the MDP was implanted through left lateral thoracotomy and placed paracorporeally with inflow conduit to left atrium and outflow conduit to descending aorta. The sheep were pumped at a mean flow rate of 2.5 L/min for 7 days. Anticoagulation was applied by intravenous heparin administration. Postoperatively, activated clotting time was held stable with values of 200 seconds. During follow-up, blood samples (creatinine kinase, creatinine, glutamic-oxaloacetic transaminase (aspartate aminotransferase) (GOT), glutamate dehydrogenase (GLDH), gamma-GT, plasma-free hemoglobin, and hemoglobine) were taken daily. After 7 days, the sheep were killed for macroscopic examination. Systemic artery pressures remained stable during the whole test period. Because of operative reasons, the hemoglobin value (7.5 +/- 0.61 g/dl) decreased perioperatively, but recovered within the test period, whereas creatinine kinase increased initially after thoracotomy, but decreased to normal within days. Renal and liver functions were slightly impaired perioperatively, indicated by temporarily enhanced values of GOT, gamma-GT, GLDH, and creatinine. The MDP did not produce significant hemolysis as measured by plasma-free hemoglobin levels. Wound infections did not occur. We conclude that the MDP ran successfully as an left ventricular assist device for 7 days in sheep has potential for long-term support, and may serve as an alternative to current technologies. Presented data were not obtained in a clinical trial; however, the results are promising enough to proceed with longer duration animal studies."],["dc.identifier.doi","10.1097/MAT.0b013e318175258e"],["dc.identifier.isi","000256186600003"],["dc.identifier.pmid","18496271"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/54340"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1058-2916"],["dc.title","Miniaturized HIA microdiagonal pump as left ventricular assist device in a sheep model"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]