Großmann, Marius

[["dc.bibliographiccitation.artnumber","14"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Unsoeld, Bernhard W."],["dc.contributor.author","Wachter, R. Rolf"],["dc.contributor.author","Perl, Thorsten"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Popov, Aron Frederik"],["dc.date.accessioned","2018-11-07T10:01:53Z"],["dc.date.available","2018-11-07T10:01:53Z"],["dc.date.issued","2015"],["dc.description.abstract","Giant-cell myocarditis (GCM) is known as a rare, rapidly progressive, and frequently fatal myocardial disease in young and middle-aged adults. We report about a 76 year old male patient who underwent implantation with a biventricular Berlin Heart Excor system at the age of 74 due to acute biventricular heart failure caused by giant-cell myocarditis. The implantation was without any surgical problems; however, a difficulty was the immunosuppressive therapy after implantation. Meanwhile the patient is 76 years old and lives with circulatory support for about 3 years without major adverse events. Also, in terms of mobility in old age there are no major limitations. It seems that in even selected elderly patients an implantation of a long term support with the biventricular Berlin Heart Excor is a useful therapeutic option with an acceptable outcome."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2015"],["dc.identifier.doi","10.1186/s13019-015-0218-9"],["dc.identifier.isi","000350433300001"],["dc.identifier.pmid","25637129"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13464"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38121"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Long term biventricular support with Berlin Heart Excor in a Septuagenarian with giant-cell myocarditis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","642"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","651"],["dc.bibliographiccitation.volume","79"],["dc.contributor.author","Kockskaemper, Jens"],["dc.contributor.author","Khafaga, Mounir"],["dc.contributor.author","Grimm, Michael"],["dc.contributor.author","Elgner, Andreas"],["dc.contributor.author","Walther, Stefanie"],["dc.contributor.author","Kockskaemper, Anke"],["dc.contributor.author","von Lewinski, Dirk"],["dc.contributor.author","Post, Heiner"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Doerge, Hilmar"],["dc.contributor.author","Gottlieb, Philip A."],["dc.contributor.author","Sachs, Frederick"],["dc.contributor.author","Eschenhagen, Thomas"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Pieske, Burkert M."],["dc.date.accessioned","2018-11-07T11:11:08Z"],["dc.date.available","2018-11-07T11:11:08Z"],["dc.date.issued","2008"],["dc.description.abstract","Aims Stretch is an important regulator of atrial function. The functional effects of stretch on human atrium, however, are poorly understood. Thus, we characterized the stretch-induced force response in human atrium and evaluated the underlying cellular mechanisms. Methods and results Isometric twitch force of human atrial trabeculae (n = 252) was recorded (37 C, 1 Hz stimulation) following stretch from 88 (L88) to 98% (L98) of optimal length. [Na(+)](i) and pH(i) were measured using SBFI and BCECF epifluorescence, respectively. Stretch induced a biphasic force increase: an immediate increase [first-phase, Frank-Starting mechanism (FSM)] to similar to 190% of force at L88 followed by an additional slower increase [5-10 min; stow force response (SFR)] to similar to 120% of the FSM. FSM and SFR were unaffected by gender, age, ejection fraction, and pre-medication with major cardiovascular drugs. There was a positive correlation between the amplitude of the FSM and the SFR. [Na(+)](i) rose by similar to 1 mmol/L and pH(i) remained unchanged during the SFR. Inhibition of Na(+)/H(+)-exchange (3 mu M HOE642), Na(+)/Ca(2+)-exchange (5 mu M KB-R7943), or stretch-activated channels (0.5 mu M, GsMtx-4 and 80 mu M streptomycin) did not reduce the SFR. Inhibition of angiotensin-II (AngII) receptors (5 mu M saralasin and 0.5 mu M PD123319) or pre-application of 0.5 mu M AngII, however, reduced the SFR by similar to 40-60%. Moreover, stretch increased phosphorylation of myosin tight chain 2 (MLC2a) and inhibition of MLC kinase (10 mu M ML-7 and 5 mu M wortmannin) decreased the SFR by similar to 40-85%. Conclusion Stretch elicits a SFR in human atrium. The atrial SFR is mediated by stretch-induced release and autocrine/paracrine actions of AngII and increased myofilament Ca(2+) responsiveness via phosphorylation of MLC2a by MLC kinase."],["dc.identifier.doi","10.1093/cvr/cvn126"],["dc.identifier.isi","000259301600014"],["dc.identifier.pmid","18503051"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6310"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53362"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","0008-6363"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Bougioukas, Ioannis"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schoendube, Friedrich A."],["dc.contributor.author","Danner, Bernhard Christoph"],["dc.date.accessioned","2018-10-10T09:54:39Z"],["dc.date.available","2018-10-10T09:54:39Z"],["dc.date.issued","2017-01-25"],["dc.description.abstract","Re-exploration for bleeding accounts for increased morbidity and mortality after major cardiac operations. The use of temporary epicardial pacemaker wires is a common procedure at many departments. The removal of these wires postoperatively can potentially lead to a serious bleeding necessitating intervention. From Jan 2011 till Dec 2015 a total of 4244 major cardiac procedures were carried out at our department. We used temporary epicardial pacemaker wires in all cases. We collected all re-explorations for bleeding and pericardial tamponade from our surgical database and then we focused on the late re-explorations, meaning on the 4th postoperative day and thereafter, trying to identify the removal of the temporary pacemakerwires as the definite cause of bleeding. Patients’ records and medication were examined. Thirty-nine late re-explorations for bleeding, consisting of repeat sternotomies, thoracotomies and subxiphoid pericardial drainages, were gathered. Eight patients had an acute bleeding incidence after removal ofthe temporary wires (0.18%). In four of these patients, a pericardial drainage was inserted, whereas the remaining patients were re-explorated through a repeat sternotomy. Two patients died of the acute pericardial tamponade,three had a blood transfusion and one had a wound infection. Seven out of eight patients were either on dualantiplatelet therapy or on combination of aspirin and vitamin K antagonist. A need for re-exploration due to removal of the temporary pacemaker wires is a very rare complication, which however increases morbidity and mortality. Adjustment of the postoperative anticoagulation therapy at the time of removal of the wires could further minimize or even prevent this serious complication."],["dc.identifier.doi","10.1186/s13019-017-0569-5"],["dc.identifier.gro","633982"],["dc.identifier.pmid","28122567"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14188"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15938"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1749-8090"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Is there a correlation between late re-exploration after cardiac surgery and removal of epicardial pacemaker wires?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","21"],["dc.bibliographiccitation.journal","Frontiers in Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Schöndube, Friedrich A."],["dc.contributor.author","Bräuer, Anselm"],["dc.date.accessioned","2019-07-09T11:43:19Z"],["dc.date.available","2019-07-09T11:43:19Z"],["dc.date.issued","2017"],["dc.description.abstract","Kawasaki disease is very rare in Western Europe. The disease may involve coronary art eries. A 2-year-old boy diagnosed with Kawasaki disease had had seizure-like symp toms. Further evaluation revealed recurrent myocardial ischemia and myocardial infarction. Due to extraordinary extension of the coronary disease, myocardial revascularization was not feasible and the toddler underwent successful heart transplantation after 97 days on waiting list."],["dc.identifier.doi","10.3389/fsurg.2017.00021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58859"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-875X"],["dc.relation.issn","2296-875X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Heart Transplantation in a Toddler with Cardiac Kawasaki Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Pediatric Transplantation"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Schoendube, Friedrich A."],["dc.date.accessioned","2021-04-14T08:27:28Z"],["dc.date.available","2021-04-14T08:27:28Z"],["dc.date.issued","2020-01-27"],["dc.identifier.doi","10.1111/petr.13661"],["dc.identifier.eissn","1399-3046"],["dc.identifier.issn","1397-3142"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82298"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1399-3046"],["dc.relation.issn","1397-3142"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited."],["dc.title","Biventricular mechanical support bridging to heart transplantation in children and infants: Results from a low‐volume transplant center"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]